Based on recent insight into the thalamocortical system and its role in perception and conscious experience, a unified pathophysiological framework for hallucinations in neurological and psychiatric conditions is proposed, which integrates previously unrelated neurobiological and psychological findings. Gamma-frequency rhythms of discharge activity from thalamic and cortical neurons are facilitated by cholinergic arousal and resonate in networks of thalamocortical circuits, thereby transiently forming assemblies of coherent gamma oscillations under constraints of afferent sensory input and prefrontal attentional mechanisms. If perception is based (...) on synchronisation of intrinsic gamma activity in the thalamocortical system, then sensory input to specific thalamic nuclei may merely play a constraining role. Hallucinations can be regarded as underconstrained perceptions that arise when the impact of sensory input on activation of thalamocortical circuits and synchronisation of thalamocortical gamma activity is reduced. In conditions that are accompanied by hallucinations, factors such as cortical hyperexcitability, cortical attentional mechanisms, hyperarousal, increased noise in specific thalamic nuclei, and random sensory input to specific thalamic nuclei may, to a varying degree, contribute to underconstrained activation of thalamocortical circuits. The reticular thalamic nucleus plays an important role in suppressing random activity of relay cells in specific thalamic nuclei, and its dysfunction may be implicated in the biological vulnerability to hallucinations in schizophrenia. Combined with general activation during cholinergic arousal, this leads to excessive disinhibition in specific thalamic nuclei, which may allow cortical attentional mechanisms to recruit thalamic relay cells into resonant assemblies of gamma oscillations, regardless of their actual sensory input, thereby producing an underconstrained perceptual experience. Key Words: Charles Bonnet syndrome; gamma oscillations; hallucinations; late paraphrenia; Lewy body dementia; perception; schizophrenia; thalamocortical system. (shrink)

The commentators provide a wealth of additional neurobiological data that ought to be integrated in a comprehensive model. This response article, however, focuses on clarification of conceptual queries, thereby outlining the proposed theory of hallucinations more sharply, discussing its relationship with schizophrenia, and explaining why underconstrained thalamocortical activation may well be a candidate mechanism responsible for acute schizophrenic symptoms other than hallucinations.

We suggest that in the particular context of medical education, ethics can be considered in a similar way to other kinds of knowledge that are categorised and shaped by academics in the context of wider society. Moreover, the study of medical ethics education is translational in a manner loosely analogous to the study of medical education as adjunct to translational medicine. Some have suggested there is merit in the idea that much as translational research attempts to connect the laboratory scientist's (...) work to its implications for patient care, translational ethics focuses on bringing ethics scholarship into the sphere of personal and public action. We distinguish the term ‘translational ethics’ (the study of ethics being translated between academy, classroom and clinic) from other prominent definitions in the bioethics literature. To do this, we build off a notion of knowledge translation that focuses on the nonlinear movement of information that comes to professionals through multiple competing sources. We suggest that this knowledge, and particularly knowledge about ethics, becomes embodied by the individual. It is through a reflective practice that internally embedded ethics knowledge might be modified, and this work might be best carried out with a moral community that maintains a sense of practical wisdom. Applying this translational approach to the study of medical ethics education can be both academically relevant and practically useful. This view of translation can help bridge the evident, multidirectional relationships between research, education and performance. It might also create further opportunities to develop medical ethics education theory. (shrink)

This work builds on the Volterra series formalism presented in Dreisigmeyer and Young to model nonconservative systems. Here we treat Lagrangians and actions as ‘time dependent’ Volterra series. We present a new family of kernels to be used in these Volterra series that allow us to derive a single retarded equation of motion using a variational principle.

Increasing emphasis on genetic research means that growing numbers of human research projects in Australia will involve complex issues related to genetic privacy, familial information and genetic epidemiology. The Office of Population Health Genomics (Department of Health, Western Australia) hosted an interactive workshop to explore the ethical issues involved in the disclosure of genetic information, where researchers and members of human research ethics committees (HRECs) were asked to consider several case studies from an ethical perspective. Workshop participants used a variety (...) of approaches to examine the complex ethical issues encountered, but did not consistently refer to the values and principles outlined in the National Statement on Ethical Conduct in Human Research (NHMRC 2007) or apply rational ethical approaches. Overall, the data suggested that both researchers and HREC members may benefit from further education and support regarding the application of ethical frameworks to the issues encountered in genetic research. (shrink)

Raimon Panikkar: A Companion to his Life and Thought is a guide to the life, work and thought of Raimon Panikkar, a self-professed Buddhist-Christian-Hindu philosopher and theologian. A man of deep and wide learning and an extremely prolific author, Panikkar is equally at home in various religious and cultural traditions and embodies in himself the ideals of intercultural, intrareligious, and interreligious dialogues. This book explicates Panikkar’s basic vision of life as the harmonious rhythm of divinity, humanity, and the cosmos, which (...) he terms "cosmotheandrism," and shows how it permeates and illumines his articulations of the central Christian doctrines. Given the complexity and difficulty of Panikkar’s thought this book is a welcome companion for a course on Panikkar and for a general reader who wishes to understand one of the most profound and orginal thinkers of our time. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

The practice of psychotherapy, or any form of counseling, inevitably requires an anthropological foundation from which to work. Defining the nature of personhood is a task which necessitates an explanation of the various aspects of the self, and the relationships between those aspects. In particular, it is crucial to delineate how the person is both an individual being and a relational being, for we intuitively experience life in both dimensions. These are two characteristics which have often been presented in opposition (...) to each other, however. What is needed is a theory which balances the individual character of personhood with the social character of personhood. The task at hand is to develop such a balance which can serve as a foundation for a Christian psychology. ;C. Stephen Evans, a philosopher and post-empirical critic of modern psychology, has emphasized the individual aspects of personhood. Soren Kierkegaard has influenced Evans' view of the self. Thus, Evans conceives of the person as fundamentally an agent, who chooses freely, acts purposefully and reasonably, and is responsible for the consequences of those choices and actions. ;Ray S. Anderson has developed a theological anthropology and on that basis has articulated a theoretical view of Christian counseling. His theory of the nature of personhood, influenced by the theologies of Karl Barth and Dietrich Bonhoeffer, is a thoroughly social perspective. The person is essentially relational, such that one is social before one is psychological. ;The present work constructs an integrative theory which balances the individual and social insights from Evans' and Anderson's views, respectively. It is accomplished through an analysis of the self across two ontological statuses and three orientations . A biblical paradigm is developed to illustrate the grounding of that theory in a Christian framework. Implications for therapeutic interventions are provided. (shrink)

This book's importance is derived from three sources: careful conceptualization of teacher induction from historical, methodological, and international perspectives; systematic reviews of research literature relevant to various aspects of teacher induction including its social, cultural, and political contexts, program components and forms, and the range of its effects; substantial empirical studies on the important issues of teacher induction with different kinds of methodologies that exemplify future directions and approaches to the research in teacher induction.

What were Shakespeare's final thoughts on history, tragedy, and comedy? Shakespeare's Last Plays focuses much needed scholarly attention on Shakespeare's "Late Romances." The work--a collection of newly commissioned essays by leading scholars of classical political philosophy and literature--offers careful textual analysis of Pericles, Prince of Tyre, Cymbeline, The Winter's Tale, The Tempest, All is True, and The Two Noble Kinsmen. The essays reveal how Shakespeare's thought in these final works compliments, challenges, fulfills, or transforms previously held conceptions of the playwright (...) and his political-philosophical views. (shrink)

Based on a time-lag model, this study tested for changes in young children’s home access and use of digital media in the 2012–2018 period as well as in their parents’ views on such media. What it found was that in only a few years the digital devices available to children have become more mobile, more accessible, and more numerous in these children’s bedrooms, especially in single-parent households. Also, on average children have strongly increased their daily media use—up to 102 (...) minutes. This is especially true for both younger children and children in middle to highly educated households. Our findings support the complementary media adoption theory more than the displacement theory. Over the years parents have tended more and more to use digital media as ‘babysitters’, while they also found it increasingly difficult to stop their children from using such media, which may have major implications for parenting support activities. (shrink)

The UK government has recently committed to adopting a new policy—dubbed ‘Martha’s Rule’—which has been characterised as providing patients the right to rapidly access a second clinical opinion in urgent or contested cases. Support for the rule emerged following the death of Martha Mills in 2021, after doctors failed to admit her to intensive care despite concerns raised by her parents. We argue that framing this issue in terms of patient rights is not productive, and should be avoided. Insofar as (...) the ultimate goal of Martha’s Rule is the provision of a clinical service that protects patient safety, an approach that focuses on the obligations of the health system—rather than the individual rights of patients—will better serve this goal. We outline an alternative approach that situates rapid clinical review as part of a suite of services aimed at enhancing and protecting patient care. This approach would make greater progress towards addressing the difficult systemic issues that Martha’s Rule does not, while also better engaging with the constraints of clinical practice. (shrink)

Young people have an enormous stake in the present and future state of Earth. Almost half of the human population is under the age of 25. If young people’s resources of energy, time, and knowledge are misdirected towards violence, terrorism, socially-isolating technologies, and unsustainable consumption, civilization risks destabilization. Yet, there is a powerful opportunity for society if young people can participate positively in all aspects of sustainable development. In order to do so, young people need education, (...) political support, resources, skills, and hope. This volume offers a global perspective on education initiatives by and for young people that promote a transition to sustainability. It includes 38 essays co-authored by 68 contributors from 25 nations, representing a diversity of geography, gender, and generation. "The development of youth leadership has been a central concern of my professional work. Young people have a lot to offer to sustainable development and should participate in planning for our planet’s future. This rich collection of theoretical and practical approaches captures the growing response of young people to this challenge. I am particularly pleased with the attention paid to the role of often-underrepresented regions of the world, to the role of women, and to the Earth Charter in the creating of a peaceful and sustainable future." Julia Marton-Lefèvre, Director General of IUCN (International Union for Conversation of Nature), and former Rector of the University for Peace "This book is a rich, global tapestry depicting the inter-linkages among youth, education and sustainable development. What is particularly interesting is that it shows how education, at all levels, can be a powerful engine for promoting sustainability. This work is an important contribution to the United Nations Decade of Education for Sustainable Development." Goolam Mohamedbhai, Secretary-General, Association of African Universities, and Past President, International Association of Universities "This important and skillfully-prepared book comes at a critical time.... A great strength of this volume is that it blends together theoretical and practical insights regarding education for sustainable development by and for young people. It is written from diverse cultural perspectives from all world regions. Readers, from many fields, especially young people and their teachers, will find it timely and relevant. I hope that it will inspire the younger generation to get involved in seeking solutions to the challenges we face." James Gustave Speth, Former Administrator of the United Nations Development Programme, and Dean Emeritus of the School of Forestry and Environmental Studies at Yale University "It is my hope that you are inspired, as I have been, by Young People, Education, and Sustainable Development: Exploring Principles, Perspectives, and Praxis, for the stories in this volume are full of the possibilities that emerge when we honor and support young people." Ruud Lubbers, Former Prime Minister of The Netherlands, and past United Nations High Commissioner for Refugees. (shrink)

Several prominent philosophers of music, including Lydia Goehr and Peter Kivy, maintain that the experience of music changed drastically in about 1800. According to the great divide hypothesis, prior to 1800 audiences often scarcely attended to music. At other times, music was appreciated as part of social, civic, or religious ceremonies. After the great divide, audiences began to appreciate music as an exclusive object of aesthetic experience. The great divide hypothesis is false. The musicological record reveals that prior to (...) the great divide music was often the exclusive object of aesthetic experience. (shrink)

Children from various countries have been acknowledged and studied for their ability to philosophize, while, unfortunately, Filipino children have not received similar recognition. In this paper, I make a rather unpopular claim that Filipino children can and already are doing philosophy in their efforts to make sense of their existential conditions. “Doing philosophy” here refers to the act of being perplexed by one's own or other people's experiences and making an effort to comprehend them. Filipino children, are a vast and (...) diverse group, coming from various backgrounds, speaking different or even multiple languages, and representing rich cultures and unique circumstances. This diversity adds richness to the wide array of experiences from which existential questions can emerge. However, to truly comprehend the philosophical thinking of Filipino children, they need opportunities and guidance to explore their existential questions and solutions, regardless of how tentative or rudimentary these may seem to adults. Without such opportunities, it remains unclear to what extent their thinking engages with philosophical themes and issues. This not only offers Filipino adults a view of children’s inner worlds but also brings fresh perspectives to commonly held assumptions. (shrink)

Can young children such as 3-year-olds represent the world objectively? Some prominent developmental psychologists—such as Perner and Tomasello—assume so. I argue that this view is susceptible to a prima facie powerful objection: To represent objectively, one must be able to represent not only features of the entities represented but also features of objectification itself, which 3-year-olds cannot do yet. Drawing on Burge's work on perceptual constancy, I provide a response to this objection and motivate a distinction between three different (...) kinds of objectivity. This distinction helps advance current research on both objectivity and teleological action explanations in young children. (shrink)

In 1931, the young Kurt Gödel published his First Incompleteness Theorem, which tells us that, for any sufficiently rich theory of arithmetic, there are some arithmetical truths the theory cannot prove. This remarkable result is among the most intriguing in logic. Gödel also outlined an equally significant Second Incompleteness Theorem. How are these Theorems established, and why do they matter? Peter Smith answers these questions by presenting an unusual variety of proofs for the First Theorem, showing how to (...) prove the Second Theorem, and exploring a family of related results. The formal explanations are interwoven with discussions of the wider significance of the two Theorems. This book will be accessible to philosophy students with a limited formal background. It is equally suitable for mathematics students taking a first course in mathematical logic. (shrink)

Various dichotomies have been proposed to characterize the nature and development of human mindreading capacities, especially in light of recent evidence of mindreading in infants aged 7 to 18 months. This article will examine these suggestions, arguing that none is currently supported by the evidence. Rather, the data support a modular account of the domain-specific component of basic mindreading capacities. This core component is present in infants from a very young age and does not alter fundamentally thereafter. What alters (...) with development are the interactions between core mindreading and other systems, including executive systems, and forms of learning that do not require radical conceptual change. (shrink)

In 1972, the young philosopher Peter Singer published "Famine, Affluence and Morality," which rapidly became one of the most widely discussed essays in applied ethics. Through this article, Singer presents his view that we have the same moral obligations to those far away as we do to those close to us. He argued that choosing not to send life-saving money to starving people on the other side of the earth is the moral equivalent of neglecting to save drowning (...) children because we prefer not to muddy our shoes. If we can help, we must--and any excuse is hypocrisy. Singer's extreme stand on our moral obligations to others became a powerful call to arms and continues to challenge people's attitudes towards extreme poverty. Today, it remains a central touchstone for those who argue we should all help others more than we do. As Bill and Melinda Gates observe in their foreword, in the age of today's global philanthropy, Singer's essay is as relevant now as it ever was. This attractively packaged, concise edition collects the original article, two of Singer's more recent popular writings on our obligations to others around the world, and a new introduction by Singer that discusses his current thinking. (shrink)

J. H. van 't Hoff's 1874 Dutch pamphlet, in which he proposed the spatial arrangement of atoms in a molecule, is one of the most significant documents in the history of chemistry. This essay presents a new narrative of Van 't Hoff's early life and places the appearance of the pamphlet within the context of the 'second golden age' of Dutch science. We argue that the combination of the reformed educational system in The Netherlands, the emergence of graphical molecular modelling (...) within the theoretical and practical culture of chemistry during the 1860s and 1870s, as well as Van 't Hoff's own personal research trajectory, formed the background to his unprecedented attribution of spatial meaning to the traditional concept of atomic 'arrangement'. We also present a new English translation of the pamphlet, for we have found that the existing translation, published by G. M. Richardson in 1901, contains many errors, changes and omissions. The new version offers a more accurate rendition in English of Van 't Hoff's style and argument. (shrink)

Our ability to rapidly distinguish new from already stored information is important for behavior and decision making, but the underlying processes remain unclear. Here, we tested the hypothesis that contextual cues lead to a preselection of information and, therefore, faster recognition. Specifically, on the basis of previous modeling work, we hypothesized that recognition time depends on the amount of relevant content stored in long-term memory, i.e., set size, and we explored possible age-related changes of this relationship in older humans. In (...) our paradigm, subjects learned by heart four different word lists written in different colors. On the day of testing, a color cue indicated with a probability of 50% that a subsequent word might be from the corresponding list or from a list of new words. The old/new status of the word had to be distinguished via button press. As a main finding, we can show in a sample of n = 49 subjects, including 26 younger and 23 older humans, that response times increased linearly and logarithmically as a function of set size in both age groups. Conversely, corrected hit rates decreased as a function of set size with no statistically significant differences between both age groups. As such, our findings provide empirical evidence that contextual information can lead to a preselection of relevant information stored in long-term memory to promote efficient recognition, possibly by cyclical top-down and bottom-up processing. (shrink)

This highly acclaimed, prize-winning biography of one of the foremost political philosophers of the twentieth century is here reissued in a trade paperback edition for a new generation of readers. In a new preface the author offers an account of writings by and about Arendt that have appeared since the book's 1982 publication, providing a reassessment of her subject's life and achievement. Praise for the earlier edition: “Both a personal and an intellectual biography... It represents biography at its best.”—Peter (...) Berger, front page, The New York Times Book Review “A story of surprising drama.... At last, we can see Arendt whole.”—Jim Miller, Newsweek “Indispensable to anyone interested in the life, the thought, or... the example of Hannah Arendt.”—Mark Feeney, Boston Globe “An adventure story that moves from pre-Nazi Germany to fame in the United States, and... a study of the influences that shaped a sharp political awareness.”—Richmond (Va.) Times-Dispatch Cover drawing by David Schorr. (shrink)

ABSTRACT For a distribution of health care resources to be fair, it should consider the consequences for the whole lives of the affected persons and not just how badly off they are at the present moment. Since, other things being equal, a person is worse off if he dies young than if he dies old, it is fair to give scarce vital health care resources to young rather than to old persons. In the paper this ageist view is (...) restated and defended against a number of objections raised by John Harris. According to Harris' so‐called anti‐ageist argument the only relevant consideration in the distribution of vital health care resources is people's desire to go on living. On reflection, this is highly counterintuitive. Instead, it is argued that both present desires to go on living and possible future happiness should weigh together with considerations of fairness. Both fairness and possible future happiness will in most cases speak in favour of saving the young before the old. A number of other problems for the ageist view are discussed, and solutions are suggested. (shrink)

The case of very young children is a test case for the plausibility of reductionism about testimonial warrant. Reductionism requires reductive reasons, reductively justified and actively deployed for testimonial justification. Though nascent language-users enjoy warranted testimony based beliefs, they do not meet these three reductionist demands. This paper clearly formulates reductionism and the infant/child objection. Two rejoinders are discussed: an influential conceptual argument from Jennifer Lackey’s paper “Testimony and the Infant/Child Objection” and the growing empirical evidence from developmental psychology (...) on selective trust in children. Neither Lackey’s argument nor the empirical evidence vindicate reductionism. (shrink)

Assumptions about the tirocinium fori are based on claims by Joachim Marquardt that it was a form of training for young elite Romans at about the age of 16, that it lasted for one year, and that it consisted of mentorship by a distinguished elder. Though there is little evidence to support these claims, the theory of a tirocinium fori continues to influence discussions of oratory in the age of Cicero, where it gives a false picture of the process (...) by which aspiring young orators made the transition from the school of rhetoric to practice in the courts. (shrink)

Tyler Burge claims in a recent high-profile publication that none of the existing evidence for mental-state attribution by children prior to the age of four or five really supports such a conclusion; and he makes this claim, not just for beliefs, but for mental states of all sorts. In its place, he offers an explanatory framework according to which infants and young children attribute mere information-registering states and teleologically-characterized motivational states, which are said to lack the defining properties of (...) the mental. I argue that Burge’s claims are poorly motivated and irrelevant to the goals of developmental psychology. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 62.4 (2001) 593-610 [Access article in PDF] The Desire to Know the Secrets of the World Edward Peters I. The letter to Ferdinand and Isabella that Christopher Columbus intended to serve as the preface to the Libro de las profecías began with a remarkable observation about his own career and the particular temperament it had shaped in him: From a very young (...) age I began to navigate the seas, and I have continued to do so until today. This art inclines those who follow it to desire to know the secrets of this world. 1Although Columbus was certainly not unlearned, there is an artlessness and directness about his remark that suggest that whatever Columbus may have meant by "the secrets of the world" and the desire of navigators to know them, he was probably not speaking reconditely or mystically. 2 [End Page 593]Nor was Columbus the only early sixteenth-century practical man who spoke this way. The letters of Hernán Cortés, hardly a philosopher or a navigator, pointed out to correspondents that it was "a universal condition of man to want to know," and that he was first of all desirous of knowledge "of the secrets of these parts"; that "many new secrets" had been learned from the discoveries; of a volcano, "I wished to know the secret of this, which seemed something of a miracle." 3If practical folk could speak thus at the turn of the sixteenth century, it is not surprising that in the course of that century their rulers should appropriate the language of secrets, including the secrets of distant places, and the desire to know them and in doing so to transform their realms into information-gathering states, using detailed questionaires to assemble and organize new data just as they assembled cabinets of curiosities, libraries, zoos, observatories, and botanical gardens. As J. H. Elliott put it: But curiosity also had its due place within a wider Christian framework. At the end of the century, José de Acosta, in his great Natural and Moral History of the Indies, likened men to ants in their refusal to let themselves be deterred, once they had set out on their quest for facts. "And the high and eternal wisdom of the Creator uses this natural curiosity of men to communicate the light of His holy gospel to peoples who still live in the darkness of their errors." This assumption, that all knowledge was subordinated to a higher purpose and fitted into a providential design, was crucial for the assimilation of the New World of America by sixteenth-century Christendom. 4Elliott's characterization of an honorific Christian intellectual curiosity represented a very small part of a very complex semantic universe that centered on the Latin term curiositas and its vernacular cognates, not all of whose meanings were neutral or honorific. Just three years before Acosta wrote there had, after all, appeared the first printed history of Doctor Faustus, another sixteenth-century practical man who was also interested in the secrets of the world. 5 And not [End Page 594] too many years after Acosta wrote, another practical being, Milton's Lucifer, also went forth boldly to seek new worlds. 6 Only in a restricted sense could the desire to know the secrets of the world be understood in the way that Columbus, Cortés, Philip II, and Acosta celebrated it. In many cases it had to be extricated from a semantic universe in which it had long been identified with less honorable motives and more dangerous or ephemeral objects.The most influential exploration of part of that semantic universe appeared in Hans Blumenberg's long essay entitled, "The 'Trial' of Theoretical Curiosity," first published as part of a larger work in 1966, later slightly revised and separately reprinted, and translated into English in 1983. 7 Blumenberg's particular understanding of the history of philosophy, however, and his narrow focus on the natural sciences as the arena of "theoretical" curiosity limited both his conceptualization and his argument. In... (shrink)