© The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved.Cell walls of grasses, including cereal crops and biofuel grasses, comprise the majority of plant biomass and intimately influence plant growth, development and physiology. However, the functions of many cell wall synthesis genes, and the relationships among and the functions of cell wall components remain obscure. To better understand the patterns of cell wall accumulation and identify genes that act in grass (...) cell wall biosynthesis, we characterized 30 samples from aerial organs of rice at 10 developmental time points, 3-100 d post-germination. Within these samples, we measured 15 cell wall chemical components, enzymatic digestibility and 18 cell wall polysaccharide epitopes/ligands. We also used quantitative reverse transcription-PCR to measure expression of 50 glycosyltransferases, 15 acyltransferases and eight phenylpropanoid genes, many of which had previously been identified as being highly expressed in rice. Most cell wall components vary significantly during development, and correlations among them support current understanding of cell walls. We identified 92 significant correlations between cell wall components and gene expression and establish nine strong hypotheses for genes that synthesize xylans, mixed linkage glucan and pectin components. This work provides an extensive analysis of cell wall composition throughout rice development, identifies genes likely to synthesize grass cell walls, and provides a framework for development of genetically improved grasses for use in lignocellulosic biofuel production and agriculture. (shrink)

The Role Ethics of Epictetus: Stoicism in Ordinary Life offers an original interpretation of Epictetus’s ethics and how he bases his ethics on an appeal to our roles in life. Epictetus's role theory is a complete ethical theory, one that has been both misunderstood and under-appreciated in the literature.

Kant's lectures on anthropology capture him at the height of his intellectual power. They are immensely important for advancing our understanding of Kant's conception of anthropology, its development, and the notoriously difficult relationship between it and the critical philosophy. This 2003 collection of essays by some of the leading commentators on Kant offers a systematic account of the philosophical importance of this material that should nevertheless prove of interest to historians of ideas and political theorists. There are two broad approaches (...) adopted: a number of the essays consider the systematic relations of the anthropology to critical philosophy, especially speculative knowledge and ethics. Other essays focus on the anthropology as a major source for the clarification of both the content and development of Kant's work. The volume also serves as an interpretative complement to the translation of the lectures in the Cambridge Edition of the Works of Immanuel Kant. (shrink)

In this paper I look at three challenges to the very possibility of an ethics of belief and then show how they can be met. The first challenge, from Thomas Kelly, says that epistemic rationality is not a form of instrumental rationality. If this claim is true, then it will be difficult to develop an ethics of belief that does not run afoul of naturalism. The second challenge is the Non-Voluntarism Argument, which holds that because we cannot believe at will (...) and because ought implies can, there can be no ethics of belief. The third challenge comes from Richard Feldman, who claims that there is no such thing as ought all-things-considered. He says, for example, that moral oughts can be weighed against other moral oughts and that epistemic oughts can be compared to each other, but that there is no way to weigh moral oughts against epistemic oughts. If this is true, then norms about what one ought to believe are not nearly as important as one might have hoped or as philosophers have traditionally thought. In answering these three challenges, I try to show how and why the project of developing epistemic norms might be a promising avenue of research, despite claims to the contrary. (shrink)

Neuroscience was the basic science behind Freud's psychoanalytic theory and technique. He worked as a neurologist for 20 years before being aware that a new approach to understand complex diseases, namely the hysterias, was needed. Solms coined the term neuropsychoanalysis to affirm that neuroscience still belongs in psychoanalysis. The neuropsychoanalytic field has continued Freud's original ideas as stated in 1895. Developments in psychoanalysis that have been created or revised by the neuropsychoanalysis movement include pain/relatedness/opioids, drive, structural model, dreams, cathexis, and (...) dynamic unconscious. Neuroscience has contributed to the development of new psychoanalytic theory, such as Bazan's ( 2011 ) description of anxiety driven by unconscious intentions or “phantoms.” Results of adopting the “dual aspect monism” approach of idiographic psychoanalytic clinical observation combined with nomothetic investigation of related human phenomena include clarification and revision of theory, restoration of the scientific base of psychoanalysis, and improvement of clinical treatments. By imbricating psychoanalytic thinking with neuroscience, psychoanalysts are also positioned to make contributions to neuroscience research. Freud's original Project for a Scientific Psychology/Psychology for Neurologists can be carried forward in a way that moves psychoanalysis into the twenty-first century as a core contemporary science (Kandel, 1999 ). Neuroscience as the basic science of psychoanalysis both improves the field, and enhances its scientific and cultural status. (shrink)

Bioethics, Volume 36, Issue 3, Page 260-266, March 2022.

Enactivist accounts of language use generally treat concrete words in terms of motor intentionality systems and affordances for action. There is less consensus, though, regarding how abstract words are to be understood in enactivist terms. I draw on Merleau-Ponty’s later philosophy to argue, against the representationalist paradigm that has dominated the cognitive scientific and philosophical traditions, that language is fundamentally a mode of participation in our world. In particular, language orients us within our milieus in a manner that extends into (...) the depth of the idea-endowed world. This conceptualization of language allows us to see that abstract words orient us bodily just as surely as concrete words do, albeit in a manner that is more diffuse across the entirety of given situations, as I will show with an example of abstract language use in Don DeLillo’s novel Underworld. These insights are applied to some of the recent enactivist discourse to suggest some ways in which representationalism maintains a latent presence in this discourse. I conclude by pointing to developments in conceptual metaphor theory that can enrich our sense of how abstract language is involved in embodied understanding. (shrink)

Medical Humanities the journal started life in 2000 as a special edition of the JME. However, the intellectual taproots of the medical humanities as a field of enquiry can be traced to two developments: calls made in the 1920s for the development of multidisciplinary perspectives on the sciences that shed historical light on their assumptions, methods and practices; refusals to assimilate all medical phenomena to a biomedical worldview. Medical humanities the term stems from a desire to situate the significance of (...) medicine as a product of culture. But despite growing usage over half a century the term defies a unifying encapsulation and continues to conjure up a multitude of discourse communities, including scholars working at the interfaces of health and humanities, arts and health, and medical education and bioethics. The field is intellectually capacious and polymorphous, forming and reforming around critical new research questions and teaching tasks spanning disciplines. (shrink)

The neuropsychoanalytic approach solves important aspects of how to use our understanding of the brain to treat patients. We describe the neurobiology underlying motivation for healthy behaviors and psychopathology. We have updated Freud’s original concepts of drive and instinct using neuropsychoanalysis in a way that conserves his insights while adding information that is of use in clinical treatment. Drive (Trieb) is a pressure to act on an internal stimulus. It has a motivational energic source, an aim, an object, and is (...) terminated by the satisfaction of a surge of serotonin. An instinct (Instinkt) is an inherited pattern of behavior that varies little from species to species. Drives are created by internal/ventral brain factors. Instincts require input from the outside that arrive through dorsal brain structures. In our model unpleasure is the experience of unsatisfied drives while pleasure if fueled by a propitious human environment. Motivational concepts can be used guide clinical work. Sometimes what had previously described psychoanalytically as, “Internal conflict,” can be characterized neurobiologically as conflicts between different motivational systems. These motivational systems inform treatment of anxiety and depression, addiction in general and specific problems of opioid use disorder. Our description of motivation in addictive illness shows that the term, “reward system,” is incorrect, eliminating a source of stigmatizing addiction by suggesting that it is hedonistic. Understanding that motivational systems that have both psychological and brain correlates can be a basis for treating various disorders. Over many papers the authors have described the biology of drives, instincts, unpleasure and pleasure. We will start with a summary of our work, then show its clinical application. (shrink)

The essays in this collection demonstrate American philosopher John Dewey's wide-ranging influence on rhetoric in an intellectual tradition that addresses the national culture's fundamental conflicts between self and society, freedom and responsibility, and individual advancement and the common good. Editors Brian Jackson and Gregory Clark propose that this influence is at work both in theoretical foundations, such as science, pragmatism, and religion, and in Dewey's debates with other public intellectuals, such as Jane Addams, Walter Lippmann, James Baldwin, and W.E.B. (...) Du Bois. Jackson and Clark seek to establish Dewey as an essential source for those engaged in teaching others how to compose timely, appropriate, useful, and eloquent responses to the diverse and often-contentious rhetorical situations that develop in a democratic culture. What prepares people to intervene constructively in such situations is instruction in those rhetorical practices of democratic interaction that is implicit throughout Dewey's work. Dewey's writing provides a rich framework on which a distincly American tradition of a democratic rhetorical practice can be built - a tradition that combines the most useful concepts of classical rhetoric with those of modern progressive civic engagement. Jackson and Clark believe Dewey's practice takes rhetoric beyond the traditional emphasis on political democracy to provide connections to rich veins of American thought such as individualism, liberalism, progressive education, collectivism, pragmatism, and postindustrial science and communication. They frame Dewey's work as constituting a modern expression of continuing education for the "trained capacities" required to participate in democratic culture. -- from back cover. (shrink)

Recent psychological research on the connection between culture and thought could have dire consequences for the idea that there are objective standards of reasoning and that meaningful cross-cultural discussion is possible. The problems are particularly acute if research shows that the Law of Noncontradiction (LNC) is not a universal of folk epistemology. It is extremely difficult to provide a non-circular justification for the LNC, and yet the LNC seems to act as a basic standard for reasoning in the West. If (...) non-Western cultures do not believe the LNC holds, then meaningful cross-cultural discussion and debate will be very difficult, to say the least. In this paper it is argued that the distinction between belief and acceptance is important in analyzing cross-cultural studies on the way people reason. Studies conducted by Richard Nisbett and Kaiping Peng concerning differences between East Asians and Westerners are analyzed. The distinction between belief and acceptance is used to demonstrate that the empirical data currently available fail to show that the LNC is not a universal of folk epistemology. A brief proposal for further research is presented. (shrink)

Bioethics case reports generally treat aspects of moral fathomability, characterised and addressed in different ways. This paper reads the case as a textual model of scenarios and draws attention to its structure, narrative shape, linguistic register, and the effects of tone and temporality on reader expectation and responsiveness. Such textual elements of case composition reflect authorial purpose and influence the interpretation, including moral and ethical interpretation, of bioethics cases.

The main rationale for adopting the epistemological approach to argumentation seems to take the form of a criticism of the consensus theory. This criticism says that some instances of clearly bad argumentation count as acceptable instances of argumentation on the consensus theory. Supposedly, the epistemological approach does not have this problem. I suggest that the kind of normativity argumentation theorists should be concerned with is the normativity associated with giving real-world advice on how to partake in a critical discussion. I (...) try to show that when we understand the normativity of argumentative standards in this way, the main criticism of the consensus theory falls short, and the epistemological approach does not really have the advantages over the consensus theory that it is purported to have. If I am right, then the main reason offered for adopting the epistemological approach fails, and we should stick with the consensus theory. (shrink)

While some branches of complexity theory are advancing rapidly, the same cannot be said for our understanding of emergence. Despite a complete knowledge of the rules underlying the interactions between the parts of many systems, we are often baffled by their sudden transitions from simple to complex. Here I propose a solution to this conceptual problem. Given that emergence is often the result of many interactions occurring simultaneously in time and space, an ability to intuitively grasp it would require the (...) ability to consciously think in parallel. A simple exercise is used to demonstrate that we do not possess this ability. Our surprise at the behaviour of cellular automata models, and the natural cases of pattern formation they mimic, is then explained from this perspective. This work suggests that the cognitive limitations of the mind can be as significant a barrier to scientific progress as the limitations of our senses. (shrink)

This essay concerns Heidegger’s assertion that the biography of the poet is unimportant when interpreting great works of poetry. I approach the question in three ways. First, I consider its merits as a principle of literary interpretation and contrast Heidegger’s view with those of other Trakl interpreters. This allows me to clarify his view as a unique variety of non-formalistic interpretation and raise some potential worries about his approach. Second, I consider Heidegger’s view in the context of his broader philosophical (...) project. Viewed this way, Heidegger’s decision to neglect the poet’s biography seems quite reasonable and consistent with his inquiry into the being of language. Finally, I consider Heidegger’s suggestion that Trakl is a kind of mad genius. I recast this paradigmatic figure in terms of what I call the ‘wretched prophet’ and consider some ways in which its appeal sheds light on the crisis of modernity and the aestheticization of politics. (shrink)

In this paper I focus on the role that cyberspace should play in social or political protest, and, in particular, in acts of civil disobedience. I have two main purposes in doing so. First, I want to address the question, “When is hacktivism civil disobedience?” I answer the question by including a more complete and explicit analysis of civil disobedience, as it is affected by information technology, than is currently done in the literature on hacktivism. This allows a clearer answer (...) to the question posed here than currently provided in the relevant literature. Second, I analyze James Moor’s claim that information technology transforms old processes, as this claim applies to the context of civil disobedience. As we will see, while information technology may exacerbate certain issues, little transformation seems required in this case. (shrink)

The primary purpose of this study is to identify differences in at­tainment of learning outcomes for ethics courses delivered using two distinct teaching approaches. The first approach uses a case based method in the context of applied moral issues within medical practice. The second approach surveys moral theories in the context of applied moral issues. Significant differences are found in the attainment of learner outcomes between the two groups. In particular, attainment of outcomes related to moral decision-making is higher in (...) those students who take the course with a case based method. In contrast, attainment of outcomes related to personal beliefs about applied moral issues is higher in those students who take an introductory ethics course surveying moral theories in the context of applied issues. Neither of these results is especially surprising. What may be surprising, however, is that students in the case-based course do not appear attain learner outcomes with regard to applied moral issues despite studying those issues in detail. Finally, the assessment tool developed and refined through this study may be of use for assessment in a variety of ethics courses. (shrink)

Many discussions of Merleau-Ponty’s treatment of the bodily experience of space turn to his opus Phenomenology of Perception, where he most explicitly takes up the theme. Yet in Merleau-Ponty’s own view this treatment, while providing rich and valuable insights into spatial experience, remains unsatisfying: ultimately Phenomenology of Perception does not escape a dualism that, despite the work’s inestimable contributions to the philosophy of embodied experience, situates it within a flawed tradition running back through Husserl, Kant, and Descartes. As Merleau-Ponty himself (...) puts it, “The problems posed in Ph.P. are insoluble because I start there from the ‘consciousness’-‘object’ distinction.” 1 Only in his later philosophy, particularly with his development of the ontology of the flesh, did he approach the fulfillment of his goal to leave this distinction and all its Cartesian corollaries behind once and for all. (shrink)

Forty years ago Amartya Sen delivered his Tanner Lecture, 'Equality of What?', in which he introduced to the world a novel approach to the idea of equality by way of the notion of 'basic capability' as 'a morally relevant dimension'. We can now see with hindsight that Sen's argument - that we should focus upon equality of basic capabilities ('a person being able to do certain basic things') - launched what has become an academic armada now proceeding under the flag (...) of 'the capability approach'. While that flag has ventured far and wide and engaged many area of inquiry, this volume of essays is the first to explore how the capability approach (the CA) might shed light upon labour law. Three dimensions of the CA's potential for illuminating labour law are examined. Part I enquires into the nature of the basic relationship between CA and labour law - do they share common ground or disagree about what is important? Can the CA provide a normative 'foundation' for labour law? Part II goes further by examining the relationship of the CA and other well-established perspectives on labour law, including economics, history, critical theory, restorative justice, and human rights. Part III examines the possible relevance of the CA to a range of specific labour law issues, such as freedom of association, age discrimination in the workplace, trade, employment policy, and sweatshop goods. (shrink)

This article provides an explanation of Anselm’s understanding of necessity. Anselm did not write much about modality, and what he did write is puzzling. The dominant readings of Anselm see him as having two concepts of necessity, one merely physical or causal, the other logical or “alethic.” This article argues that Anselm has just one concept of necessity, which corresponds best to what is now called broadly logical or absolute necessity, but whose metaphysics is in terms of powers and lacks (...) of power. The rival interpretations of A. D. Smith, Thomas Williams, and Sandra Visser are discussed and criticized in detail. (shrink)

Practical reasoners are resource-bounded—in particular they require time to derive consequences of their knowledge. Building on the Timed Reasoning Logics (TRL) framework introduced in [1], we show how to represent the time required by an agent to reach a given conclusion. TRL allows us to model the kinds of rule application and conflict resolution strategies commonly found in rule-based agents, and we show how the choice of strategy can influence the information an agent can take into account when making decisions (...) at a particular point in time. We prove general completeness and decidability results for TRL, and analyse the impact of communication in an example system consisting of two agents which use different conflict resolution strategies. (shrink)

The Ozark Highlands’ karst topography of caves and hollows has provided refuge and escape for myriad peoples seeking to evade mainstream society throughout history, ranging from displaced Native Americans to counter-cultural back-to-the-landers. This ethnographic and ethnohistorical research moves beyond the popular misconception that the back-to-the-land movement merely represented an offshoot of the countercultural revolution of the 1960s and 1970s, and situates it within a deeper historical context. In this paper, I present the Arcadian evocations in various Ozark-related media and how (...) they relate to homesteading in the region, and demonstrate the shared agrarian values among diverse waves of agrarian Ozark homesteaders, recent and historical. (shrink)

Since physicians began to formally professionalize in the 19th century, we have sought to set ourselves apart from other occupations through the adoption (and variable enforcement) of codes of ethi...

Many religious freedom laws provide exemptions to persons who refuse to comply with certain laws on religious grounds. But these exemptions are increasingly used (by claimants and others) to advance political goals. For example, religious freedom lawsuits helped to undermine the Affordable Care Act’s guarantee of coverage for contraceptives. And the recent Masterpiece Cakeshop case was part of a broader effort to protest the right to same-sex marriage. This paper argues that the state should not grant religious exemptions when they (...) are used to advance political goals. A religious exemption creates a legal inequality between citizens that can only be justified if the protection is not used politically. As such, the state should ensure that laws providing religious exemptions are written, interpreted, and enforced so as to prevent their political misuse. (shrink)

This paper describes the results of a multi-country survey of governance approaches for the use of digital contact tracing (DCT) in response to the COVID-19 pandemic. We argue that the countries in our survey represent two distinct models of DCT governance, both of which are flawed. The “data protection model” emphasizes privacy protections at the expense of public health benefit, while the “emergency response model” sacrifices transparency and accountability, prompting concerns about excessive governance surveillance. The ethical and effective use of (...) DCT in the future requires a new governance approach that is better suited to this novel use of mobile phone data to promote public health.”. (shrink)

This paper examines and critiques the ethical issues in postmortem sperm retrieval and the use of postmortem sperm to create new life. The article was occasioned by the recent request of the parents of a West Point cadet who died in a skiing accident at the Academy to retrieve and use his sperm to honor his memory and perpetuate the family name. The request occasioned national media attention. A trial court judge in New York in a two-page order authorized both (...) the retrieval and use of the postmortem sperm. (shrink)

In, it was argued that Professor David Kaplan's model of S-explanation could be formulated so as to provide a unified framework for three types of explanation, viz., potential, rationally acceptable, and true. In this note I correct an error in the statement of the conditions for a potential direct S-explanans, show that the corrected version leads to a further simplification in the conditions of the model, and propose a fourth type of explanation which the framework of S-explanation can accommodate.