The study of intellectual humility is still in its early stages and issues of definition and measurement are only now being explored. To inform and guide the process of defining and measuring this important intellectual virtue, we conducted a series of studies into the implicit theory – or ‘folk’ understanding – of an intellectually humble person, a wise person, and an intellectually arrogant person. In Study 1, 350 adults used a free-listing procedure to generate a list of descriptors, one for (...) each person-concept. In Study 2, 335 adults rated the previously generated descriptors by how characteristic each was of the target person-concept. In Study 3, 344 adults sorted the descriptors by similarity for each person-concept. By comparing and contrasting the three person-concepts, a complex portrait of an intellectually humble person emerges with particular epistemic, self-oriented, and other-oriented dimensions. (shrink)

Current theories of breast cancer progression have been greatly influenced by the development and refinement of mouse transgenic and gene targeting technologies. Early transgenic mouse models confirmed the involvement of oncogenes, previously implicated in human breast cancer, by establishing a causal relationship between overexpression or activation of these genes and mammary tumorigenesis. More recently, the importance of genes located at sites of loss of heterozygosity in human breast cancer have been examined in mice by their targeted disruption via homologous recombination. (...) The union of these two approaches allows the generation of complex animal models that more accurately reflect the multistep nature of human breast cancer. This review will examine how the study of transgenic mice has increased our understanding of the molecular events responsible for oncogenic transformation of the mammary gland. BioEssays 22:554–563, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Business schools, and universities providing business education, from across the globe have increasingly engaged in responsible management education (RME), that is in embedding social, environmental and ethical topics in their teaching and research. However, we still do not fully understand the institutional pressures that have led to the adoption of RME, in particular concerning under-researched regions like Central and Eastern Europe (CEE). Hence, we undertook what is to our knowledge the most comprehensive study into the adoption of RME in CEE (...) to date (including 13 countries: Belarus, Bulgaria, Croatia, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Russia, Slovenia and Ukraine). We find that, with regard to RME, isomorphic pressures seem to shape teaching and research in different ways, which suggests that the idea of a holistic approach to RME, promoted by, for example, the Principles of Responsible Management Education (PRME), needs to be revisited; rather, different trajectories of organizational engagement may emerge for each principle. As a contribution to institutional theory, we discuss how a highly fragmented organizational field—like RME with its multiple dimensions—impacts on notions of actor centrality, where actors achieve centrality with regard to some dimensions of the field but fail to do so for others. In particular, we found that the European Union holds centrality in the area of RME teaching, but not in RME research. Our findings thus suggest that the concept of field centrality needs further clarification. (shrink)

Asbestos-related illnesses contribute to the deaths of more than 100,000 people worldwide (ILO 2006) and the plight of sufferers of these illnesses has become a global ethical issue. A leading, Australian building products corporation, James Hardie, created a complex corporate structure that included the establishment of a “Victims Compensation Fund”, and moved its corporate headquarters to the Netherlands to reduce its liabilities. Hardie claimed that this move was tax minimization (Haigh 2006). In this study case, a number of ethical issues (...) provides the opportunity to discuss many business-society questions. These include the duties of the company towards a wide range of stakeholders affected in some way by Hardie’s earlier production of asbestos-related products and its subsequent responses to the question of compensation. (shrink)

Following our [6], though with somewhat different methods here, further variants of Goodstein sequences are introduced in terms of parameterized Ackermann–Péter functions. Each of the sequences is shown to terminate, and the proof-theoretic strengths of these facts are calibrated by means of ordinal assignments, yielding independence results for a range of theories: PRA, PA,$\Sigma ^1_1$-DC$_0$, ATR$_0$, up to ID$_1$. The key is the so-called “Hardy hierarchy” of proof-theoretic bounding finctions, providing a uniform method for associating Goodstein-type sequences with parameterized normal (...) form representations of positive integers. (shrink)

Peter Widdowson, Hardy in History: A Study in Literary Sociology. London and New York: Routledge, 1989. £8.95, 260 pp. Simon During, Foucault and Literature: Towards a Genealogy of Writing. London and New York: Routledge, 1992. £35.00/£10.99, 259 pp.

Peter Adamson offers an accessible, humorous tour through a period of eight hundred years when some of the most influential of all schools of thought were formed: from the third century BC to the sixth century AD. He introduces us to Cynics and Skeptics, Epicureans and Stoics, emperors and slaves, and traces the development of Christian and Jewish philosophy and of ancient science. Chapters are devoted to such major figures as Epicurus, Lucretius, Cicero, Seneca, Plotinus, and Augustine. But in (...) keeping with the motto of the series, the story is told 'without any gaps, ' providing an in-depth look at less familiar topics that remains suitable for the general reader. For instance, there are chapters on the fascinating but relatively obscure Cyrenaic philosophical school, on pagan philosophical figures like Porphyry and Iamblichus, and extensive coverage of the Greek and Latin Christian Fathers who are at best peripheral in most surveys of ancient philosophy. A major theme of the book is in fact the competition between pagan and Christian philosophy in this period, and the Jewish tradition also appears in the shape of Philo of Alexandria. Ancient science is also considered, with chapters on ancient medicine and the interaction between philosophy and astronomy. Considerable attention is paid also to the wider historical context, for instance by looking at the ascetic movement in Christianity and how it drew on ideas from Hellenic philosophy. From the counter-cultural witticisms of Diogenes the Cynic to the subtle skepticism of Sextus Empiricus, from the irreverent atheism of the Epicureans to the ambitious metaphysical speculation of Neoplatonism, from the ethical teachings of Marcus Aurelius to the political philosophy of Augustine, the book gathers together all aspects of later ancient thought in an accessible and entertaining way. (shrink)

In the history of philosophy, few topics are so relevant to today's cultural and political landscape as philosophy in the Islamic world. Yet, this remains one of the lesser-known philosophical traditions. In this Very Short Introduction, Peter Adamson explores the history of philosophy among Muslims, Jews, and Christians living in Islamic lands, from its historical background to thinkers in the twentieth century.Introducing the main philosophical themes of the Islamic world, Adamson integrates ideas from the Islamic and Abrahamic faiths to (...) consider the broad philosophical questions that continue to invite debate: What is the relationship between reason and religious belief? What is the possibility of proving God's existence? What is the nature of knowledge? Drawing on the most recent research in the field, this book challenges the assumption of the cultural decline of philosophy and science in the Islamic world by demonstrating its rich heritage and overlap with other faiths and philosophies. (shrink)

Peter Adamson presents an engaging and wide-ranging introduction to the thinkers and movements of two great intellectual cultures: Byzantium and the Italian Renaissance. First he tells the story of philosophy in the Eastern Christian world, from such early figures as John of Damascus in the eighth century to the late Byzantine scholars of the fifteenth century. Then he explores the rebirth of philosophy in Italy in the fifteenth and sixteenth centuries, the era ofMachiavelli, Giordano Bruno, and Galileo. This is (...) the sixth volume in Adamson's History of Philosophy Without Any Gaps, taking us to the threshold of the early modern era. (shrink)

In this account of his mature thinking, Peter Marshall develops a dynamic and organic philosophy for the coming millennium which he calls liberation ecology. Liberation ecology is holistic in viewing the world as a harmonious whole and all beings and things as interwoven threads in nature's web. It is intuitive in recognizing intuition as the main source of knowledge and the imagination as the great organ of morality. It is ecological in seeing human beings as fellow voyagers with other (...) species in the magnificent odyssey of evolution. Above all, it is libertarian in seeking to release humanity, society and nature from their existing burdens so that they can unfurl and realize together their full potential. Exploring our strengths and possibilities, this book presents the ideas and values needed to ride the winds of change at this crucial stage in our development and in the history of the world. It provides a new philosophy for a new era, an uplifting and inspired vision which combines ancient wisdom and modern insights, reason and feeling, science and poetry, myth and the marvellous. It offers a guide for the future on how to rive in the most fulfilling way and how to create a genuinely free and sustainable society in harmony with nature. (shrink)

Peter Adamson offers an accessible, humorous tour through a period of eight hundred years when some of the most influential of all schools of thought were formed. He introduces us to Cynics and Skeptics, Epicureans and Stoics, emperors and slaves, and traces the development of early Christian philosophy and of ancient science. A major theme of the book is in fact the competition between pagan and Christian philosophy in this period, and the Jewish tradition appears in the shape of (...) Philo of Alexandria. Ancient science is also considered, with chapters on ancient medicine and the interaction between philosophy and astronomy. Considerable attention is paid also to the wider historical context, for instance by looking at the ascetic movement in Christianity and how it drew on ideas from Hellenic philosophy. From the counter-cultural witticisms of Diogenes the Cynic to the subtle skepticism of Sextus Empiricus, from the irreverent atheism of the Epicureans to the ambitious metaphysical speculation of Neoplatonism, from the ethical teachings of Marcus Aurelius to the political philosophy of Augustine, the book gathers together all aspects of later ancient thought in an accessible and entertaining way. (shrink)

La traducción que al inglés hace el ilustre profesor norteamericano Harold Raley (cuya filosofía sigue a Ortega y a Marías) resulta excelente. El profesor Harold Cecil RALEY nació el año 1934 en el Estado de Alabama (USA), en cuya Universidad se doctoró en Lenguas y Literaturas Románicas, y quiso especializarse en la obra de José Ortega y Gasset. Casado y padre de varios hijos, ha sido catedrático de Lengua y Literatura españolas de la Universidad del Estado de Oklahoma desde 1964; (...) también catedrático y decano de Bellas Artes y Humanidades en la Houston Baptist University (nombrado por ella Distinguished Professor). Entre otros libros, es autor de los siguientes: "Ortega y Gasset, filósofo de la unidad europea" (Prólogo de Julián Marías. Revista de Occidente. Madrid, 1977; edición inglesa: "José Ortega y Gasset, the Philosopher of European Unity". The University of Alabama Press. USA, 1971); "La visión responsable. La filosofía de Julián Marías" (Prólogo de José Luis Pinillos. Espasa-Calpe. Madrid, 1977; edición inglesa: "Responsible Vision: The Philosophy of Julián Marías". The American Hispanist. Clear Creek, Indiana. USA, 1980); "Julián Marías. Una filosofía desde dentro" (Alianza Editorial. Madrid, 1997; edición inglesa: "A Watch over Mortality: the Philosophical Story of Julián Marías". The State University of New York Press. USA, 1997); "El espíritu de España" (Prólogo de Julián Marías. Alianza Editorial. Madrid, 2003; edición inglesa: "The Spirit of Spain". Halcyon Press. Houston. USA, 2002); "The Light of Eden. A Christian Worldview" (John M. Hardy Publishing. Houston. USA, 2008); "Language Oddities. Quirks and Curiosities of English and Other Languages" (Kingsle. Houston. USA, 2011); "Louisiana Rogue. The Life and Times of Pierre Prospère-Tourmoulin translated by Peter Tourmoulin" (Lamar University Press. Beaumont. USA, 2013); "The Unknown God: Mysteries of Deity, Time, Space, and Creation" (Charleston, SC, USA, 2011. También es autor de más de un centenar de estudios y artículos sobre temas filosóficos y literarios. Además ha traducido al inglés algunos de los libros de Julián Marías. (shrink)

An attempt to show that in the seventeenth century philosophers believed that if we apply one and the same method of the subject matter of any discipline in which we e4xpect to gain knowledge, we will be successful in that discipline.

Changing Ideals in Modern Architecture revolutionized the understanding of modernism in architecture, pushing back the sense of its origin from the early twentieth century to the 1750s and thus placing architectural thought within the a broader context of Western intellectual history. This new edition of Peter Collins's ground-breaking study includes all seventy-two illustrations of the original hard cover edition, which has been out of print since 1967, and restores the large format.

The Anglican Church of Kenya (ACK) is the oldest church in Kenya and the largest protestant denomination in the country. Since religions were liberalized after the attainment of political independence in AD 1964, the church has experienced declining congregations due to the registration of new denominations, especially the Pentecostal ones. The decline has been noticeable from the beginning of the 21st Century but there are no reports of strategies to resolve the phenomenon. Since congregation members are the customers for a (...) church, the declining phenomenon indicates a marketing problem that requires a marketing strategy. This research investigated how the ACK is operationalizing a marketing strategy and its influence on its sustainability. The ACK operates on standardized structures and a diocese is the highest independent unit. This research was conducted in the diocese of Kirinyaga as the unit of analysis with Wanguru Archdeaconry as the unit of observation. The independent variables were the elements of the marketing mix, namely Product, Promotion, Position and Price strategies while the dependent variable was the church sustainability. Data collection involved 308 participants drawn from the 19 parishes in the Wanguru archdeaconry and included the church leadership and the congregation members. The research instruments were a semi-structured questionnaire and interviews. For the Product variable, the research applied the Maslow Hierarchy of needs theory while for the promotion variable, it was the AIDA Model (Attention, Interest, Desire and Action). For the positioning strategy, the Segmentation, Targeting and Positioning (STP) Model was applied while the Value-Based Pricing theory was used for the price strategy. For church sustainability, the research applied the Triple Bottom Line model. Data analysis was conducted using Structural Package for Social Sciences (SPSS). The results indicated that the ACK has not operationalized an effective marketing strategy for while the Gospel as the marketing product of the church was highly rated, there were low scores for Promotion, Position and Price strategies. (shrink)

_Stranger Cities_ explores the nature of Australia’s distinctive urban civilization with its portal ontology, axial metaphysics, ambidextrous style of thinking, architectonic spirit, and happy phlegmatic outlook. This classic ethos is offset by various choleric and melancholic strands of Australian romanticism.

This volume offers a comprehensive overview of architectures, languages, methods, and techniques for analysing, modelling, and constructing information systems in organisations. Numerous approaches are surveyed coming from computer science, information systems, and business administration among others. With more than 30 contributions, the book is an authoritative source of information for professional researchers and graduate students. It also provides a reference source for problem solvers in business, industry, and government.

One of the fundamental aims of nursing is to safeguard or promote patients' "quality of life." Perspectives on Quality of Life examines existing ways of defining the concept and argues that nurses need to adopt a fresh approach, which more accurately reflects patients' concerns and helps them to develop practical ways of promoting the well-being of people in their care. Part One provides an analysis of statistical approaches to quality of life, including social indicators, the Quality Adjusted Life Year (QALY), (...) and the medical outcomes literature. Part Two proposes an alternative, qualitative approach to organizing care, which respects the patients' choice and individuality. Part three presents the findings of new research into the quality of life of older people in hospital wards. (shrink)

Ellerton, Peter So what is the scientific method, and why do so many people, sometimes including those trained in science, get it so wrong? The first thing to understand is that there is no one method in science, no one way of doing things. This is intimately connected with how we reason in general.

Journal Name: Philologus Issue: Ahead of print.