BackgroundAlthough the Life-Sustaining Treatment (LST) Decision Act was enforced in 2018 in Korea, data on whether it is well established in actual clinical settings are limited. Hospital-acquired pneumonia (HAP) is a common nosocomial infection with high mortality. However, there are limited data on the end-of-life (EOL) decision of patients with HAP. Therefore, we aimed to examine clinical characteristics and outcomes according to the EOL decision for patients with HAP.MethodsThis multicenter study enrolled patients with HAP at 16 referral hospitals retrospectively from (...) January to December 2019. EOL decisions included do-not-resuscitate (DNR), withholding of LST, and withdrawal of LST. Descriptive and Kaplan–Meier curve analyses for survival were performed.ResultsOf 1,131 patients with HAP, 283 deceased patients with EOL decisions (105 cases of DNR, 108 cases of withholding of LST, and 70 cases of withdrawal of LST) were analyzed. The median age was 74 (IQR 63–81) years. The prevalence of solid malignant tumors was high (32.4% vs. 46.3% vs. 54.3%, P = 0.011), and the ICU admission rate was lower (42.9% vs. 35.2% vs. 24.3%, P = 0.042) in the withdrawal group. The prevalence of multidrug-resistant pathogens, impaired consciousness, and cough was significantly lower in the withdrawal group. Kaplan–Meier curve analysis revealed that 30-day and 60-day survival rates were higher in the withdrawal group than in the DNR and withholding groups (log-rank P = 0.021 and 0.018). The survival of the withdrawal group was markedly decreased after 40 days; thus, the withdrawal decision was made around this time. Among patients aged below 80 years, the rates of EOL decisions were not different (P = 0.430); however, mong patients aged over 80 years, the rate of withdrawal was significantly lower than that of DNR and withholding (P = 0.001).ConclusionsAfter the LST Decision Act was enforced in Korea, a DNR order was still common in EOL decisions. Baseline characteristics and outcomes were similar between the DNR and withholding groups; however, differences were observed in the withdrawal group. Withdrawal decisions seemed to be made at the late stage of dying. Therefore, advance care planning for patients with HAP is needed. (shrink)

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

Current COVID-19 pandemic and previous SARS/MERS outbreaks have caused a series of major crises to global public health. We must integrate the large and exponentially growing amount of heterogeneous coronavirus data to better understand coronaviruses and associated disease mechanisms, in the interest of developing effective and safe vaccines and drugs. Ontologies have emerged to play an important role in standard knowledge and data representation, integration, sharing, and analysis. We have initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO). (...) As an Open Biomedical Ontology (OBO) library ontology, CIDO is an open source and interoperable with other existing OBO ontologies. In this article, the general architecture and the design patterns of the CIDO are introduced, CIDO representation of coronaviruses, phenotypes, anti-coronavirus drugs and medical devices (e.g. ventilators) are illustrated, and an application of CIDO implemented to identify repurposable drug candidates for effective and safe COVID-19 treatment is presented. (shrink)

Priority Theory is an increasingly popular view in metaphysics. By seeing metaphysical questions as primarily concerned with what explains what, instead of merely what exists, it promises not only an interesting approach to traditional metaphysical issues but also the resolution of some outstanding disputes. In a recent paper, Louis deRosset argues that Priority Theory isn’t up to the task: Priority Theory is committed to there being explanations that violate a formal constraint on any adequate explanation. This paper critically examines deRosset’s (...) challenge to Priority Theory. We argue that deRosset’s challenge ultimately fails: his proposed constraint on explanation is neither well-motivated nor a general constraint. Nonetheless, lurking behind his criticism is a deep problem for prominent ways of developing Priority Theory, a problem which we develop. (shrink)

Teacher behaviors are one of the most significant factors influencing student learning. Students from different cultures may have different interpretations of their teachers’ behaviors. This study compared the associations between teacher strictness, teacher feedback, and students’ motivational beliefs using data from six Western countries (the United States, the United Kingdom, Finland, Norway, Australia, and New Zealand) and six East Asian regions (Japan, Korea, mainland China, Hong Kong, Macau, and Taiwan) in the Program for International Student Assessment (PISA) 2015. A (...) total of 89,869 15-year-old students were included in data analysis. The findings indicate that (i) teacher strictness was negatively associated with Western students’ motivation, but positively related to that of East Asian students; (ii) teacher feedback had significant positive associations with the motivational beliefs of both Western and East Asian students; and (iii) there was a positive relationship between teacher strictness and teacher feedback in East Asian context. These results highlight the need to consider cultural factors when interpreting students’ reactions to teacher behaviors. (shrink)

This chapter contains sections titled: References Further reading.

In behavioral research, exploring bivariate relationships between variables X and Y based on the concept of probability-of-superiority (PS) has received increasing attention. Unlike the conventional, linear-based bivariate relationship (e.g., Pearson's correlation), PS defines that X and Y can be related based on their likelihood—e.g., a student who is above mean in SAT has 63% likelihood of achieving an above-mean college GPA. Despite its increasing attention, the concept of PS is restricted to a simple bivariate scenario ( X - Y pair), (...) which hinders the development and application of PS in popular multivariate modeling such as structural equation modeling (SEM). Therefore, this study addresses an empirical-based simulation study that explores the potential of detecting PS-based relationship in SEM, called PS-SEM. The simulation results showed that the proposed PS-SEM method can detect and identify PS-based when data follow PS-based relationships, thereby providing a useful method for researchers to explore PS-based SEM in their studies. Conclusions, implications, and future directions based on the findings are also discussed. (shrink)

Cells contain a myriad of membraneless ribonucleoprotein (RNP) condensates with distinct compositions of proteins and RNAs. RNP condensates participate in different cellular activities, including RNA storage, mRNA translation or decay, stress response, etc. RNP condensates are assembled via liquid‐liquid phase separation (LLPS) driven by multivalent interactions. Transition of RNP condensates into bodies with abnormal material properties, such as solid‐like amyloid structures, is associated with the pathogenesis of various diseases. In this review, we focus on how RNAs regulate multiple aspects of (...) RNP condensates, such as dynamic assembly and/or disassembly and biophysical properties. RNA properties – including concentration, sequence, length and structure – also determine the phase behaviors of RNP condensates. RNA is also involved in specifying autophagic degradation of RNP condensates. Unraveling the role of RNA in RNPs provides novel insights into pathological accumulation of RNPs in various diseases. This new understanding can potentially be harnessed to develop therapeutic strategies. (shrink)

This work of 'systematic parapsychology' aims to construct a framework and system of parapsychology, taking a comprehensive approach to the field. The book states that parapsychology has a different philosophical background from the existing science and religions, and posits that pantheism could be the theoretical basis of parapsychology.

In September 2008, the European Organization for Nuclear Research (CERN) scientists successfully switched on the historic biggest physics device, the Large ...

A passive brain–computer interface based upon functional near-infrared spectroscopy brain signals is used for earlier detection of human drowsiness during driving tasks. This BCI modality acquired hemodynamic signals of 13 healthy subjects from the right dorsolateral prefrontal cortex of the brain. Drowsiness activity is recorded using a continuous-wave fNIRS system and eight channels over the right DPFC. During the experiment, sleep-deprived subjects drove a vehicle in a driving simulator while their cerebral oxygen regulation state was continuously measured. Vector phase analysis (...) was used as a classifier to detect drowsiness state along with sleep stage-based threshold criteria. Extensive training and testing with various feature sets and classifiers are done to justify the adaptation of threshold criteria for any subject without requiring recalibration. Three statistical features along with six VPA features were used. The average accuracies for the five classifiers are 90.9% for discriminant analysis, 92.5% for support vector machines, 92.3% for nearest neighbors, 92.4% for both decision trees, and ensembles over all subjects’ data. Trajectory slopes of CORE vector magnitude and angle: m and m are the best-performing features, along with ensemble classifier with the highest accuracy of 95.3% and minimum computation time of 40 ms. The statistical significance of the results is validated with a p-value of less than 0.05. The proposed passive BCI scheme demonstrates a promising technique for online drowsiness detection using VPA along with sleep stage classification. (shrink)

The unethical behavior of a business founder often leads to negative publicity which substantially affects positive corporate image. The amount of negative publicity relating to business founders’ unethical behavior is on the rise in the age of online social media in China. Based on the stimulus–response theory and balance theory, this paper developed a theoretical model to examine how negative publicity about a business founder’s unethical behavior affects corporate image. The proposed model was tested by the partial least squares technique. (...) Results show that perceived severity, publicity intensity and recovery performance are predictors of corporate image: perceived severity has a negative impact on positive corporate image; publicity intensity and recovery performance have positive impacts on positive corporate image; and founder image mediates the relationships between the three predictors and corporate image. Moreover, initial consumer impression of business founders has a positive impact on positive corporate image. (shrink)

洪耀勳是誰？是否有臺灣哲學？何謂臺灣哲學？何以洪耀勳的思想與實存哲學、日本哲學有深刻的關聯？哲學在東亞的接受與發展脈絡和洪耀勳的哲學思想有何關聯？洪耀勳的哲學思想能以何種形式和東亞的哲學發展產生關聯？ 其哲學思想有何種當代性意義？ 本書收錄洪耀勳日治時期的八篇哲學文章，撰寫年代在1934至1943十年之間，其中或隱或顯地援用日本京都學派哲學作為其哲學思索的資源。洪耀勳援引西田幾多郎「我和你」的理論，針對當時哲學發展的脈動，提出貼 近當代哲學需求的歷史實存概念。此外，他在探索臺灣文學創作的哲學理論時，亦以實存概念出發，主張新康德學派的價值哲學應與歷史實存形成呼應，藉以超越形而上學的價值世界。實存概念經洪耀勳的哲學探索，使得和辻哲 郎的風土論、務臺理作「表現世界的邏輯」、田邊元的「種的邏輯」等哲學資源，以一種「個別、特殊、普遍」的臺灣歷史實存姿態出現，並在異文化的臺灣，得到特殊性的發展。 Who is Hung Yao-hsün? Is there Taiwanese philosophy? What is Taiwanese philosophy? Why is Hung Yao-hsün’s thought deeply related to philosophy of existence and Japanese philosophy? What is the relationship between the reception and development of philosophy in East Asia and Hung Yao-hsün’s philosophical thought? In what form can Hung Yao-hsün’s philosophical thoughts be related to the development of philosophy in East Asia? What is the contemporary significance of his philosophical thinking? This book contains eight philosophical articles written (...) by Hung Yao-hsün between1934-1943, when Taiwan was under Japanese rule. These papers show implicit and explicit references to Kyoto School philosophy, which is a resource for his philosophical thinking. In response to the philosophical development at that time, Hung develops the notion of historical existence by citing Nishida’s theory of I and Thou. Besides, he explores the concept of existence as the philosophical foundation of Taiwanese literature, and argues the philosophy of value of Neo-Kantianism should echo the historical reality in order to overcome the metaphysical world of value. Hung’s philosophy deepens the concept of existence, and transforms the philosophical resources of Watsuji’s theory of Fūdo, Mutai Risaku’s logic of world expression and Tanabe’s logic of species into Taiwan’s historical reality of “individuality, particularity and universality;” these philosophies developed into a new dimension in Taiwan, a culture alien to Japan. (shrink)

Emergence is a notorious philosophical term of art. A variety of theorists have appropriated it for their purposes ever since George Henry Lewes gave it a philosophical sense in his 1875 Problems of Life and Mind. We might roughly characterize the shared meaning thus: emergent entities (properties or substances) ‘arise’ out of more fundamental entities and yet are ‘novel’ or ‘irreducible’ with respect to them. (For example, it is sometimes said that consciousness is an emergent property of the brain.) Each (...) of the quoted terms is slippery in its own right, and their specifications yield the varied notions of emergence that we discuss below. There has been renewed interest in emergence within discussions of the behavior of complex systems and debates over the reconcilability of mental causation, intentionality, or consciousness with physicalism. (shrink)

This paper develops an account of intersectional feminist theory by critically examining the notion of identity implicitly assumed in major critiques of intersectionality. Critics take intersectionality to fragment women along the lines of identity categories such as race, class, and sexuality. Underlying this interpretation, I argue, is the metaphysical assumption that identity is a fixed entity. This is a misunderstanding of identity that neglects how identity is actually lived. By exploring how Asian American women experience their “Asian” identity in their (...) everyday lives (e.g., the “Asian-as-patriarchal vs. White-as-gender-progressive” stereotype, growing anti-Asian racism amid COVID-19, and Asian-Black feminist solidarities), I demonstrate that Asian identity is not fixed but changing according to how it is related to power. I identify and discuss three characteristic types of the identity-power relationship: manifestation of power-as-oppression through the construction of identity, reproduction of power-as- oppression, and creation of new forms of power, namely resistance and solidarity, through the reconstruction of identity. The lives of multiply-oppressed women (e.g., Asian women) can be understood as the locus at which the identity-power relationship is worked out, that is, the power dynamics of oppression are manifested, reproduced, and resisted through the (re)construction of identity. Building on this analysis and engaging discussions on non-ideal theory in social/political philosophy, I argue that intersectional feminist theory can be best explained as a non-ideal theory in a strong sense: a theory that, by focusing on the lives of the multiply oppressed, presents the intersecting dynamics of oppression as central and theory-guiding. (shrink)

Richard Rorty, a neo-pragmatist well known for his anti-universalist philosophy, applies his anti-universalist approach to feminism in the paper titled “Feminism and Pragmatism” (1991). In this paper, Rorty claims that universalism is not helpful for feminists in making changes to a masculinist society. In contrast, the main point of my paper is to defend universalism as appropriate to feminism. It is not, however, argued in the form of advocacy for all versions of universalism. I will classify universalism into two distinguished (...) types, ahistoricist-essentialist universalism and historicist, anti-essentialist universalism, and I will defend the latter as consonant with feminism and with Rorty’s own pragmatist approach. (shrink)

Feminist critics of evolutionary psychology are often accused of committing the naturalistic fallacy, that is, of inferring certain normative conclusions from evolutionary psychology’s purely descriptive accounts. This article refutes the accusation of the naturalistic fallacy, by showing that evolutionary psychology’s accounts of human behavior are not purely descriptive, but rather grounded on biased value judgments. A paradigmatic example is Randy Thornhill and Craig Palmer’s well-known book A Natural History of Rape. I argue that at least three biased judgments are at (...) work in Thornhill and Palmer’s evolutionary psychology account of rape: (1) adaptationist approaches to evolution, (2) willful ignorance of cultural and social context, and (3) binary understanding of gender and sex. In that Thornhill and Palmer’s account cannot hold without the three biased value judgments, it is not a purely factual description of rape. Therefore, feminist concerns over its normative implications do not commit the naturalistic fallacy, as it is not the case that they infer a normative conclusion from a pure description. (shrink)

According to the reports in the past decade, some Asian subcontractors, mainly Taiwan, Hong Kong and Korea transnational corporations, tend to be labor abusive in their overseas investment destinations like China or Southeast Asia. Taking Vietnam as an example, this paper raises questions as to why Taiwanese transnational companies can control workplace unions in a trade-union-supportive regime. Given the government s constraint of political rights, and the individualized workplace unions, the function of trade unions in Vietnam is destined to (...) be limited. The trade unions turn out be an arm of management, rather than representing workers interests in these transnational companies. This article also explores the influence of the newly developed codes of conducts from Western buyers. In the survey of three companies which are required to follow the codes of conduct by buyers, trade unions had no more freedom than those in companies without codes of conduct. The paper discusses the implications of this research, offering strategies for labor rights improvements. (shrink)

This dissertation addresses the question of how to reconceptualize “women” in order to do a more intersectional feminism. Intersectionality—the idea that gender, race, class, sexuality, and so on operate not as separate entities but as mutually constructing phenomena—has become a gold standard in contemporary feminist scholarship. In particular, intersectionality has achieved success in showing that the old conception of women as a single, uniform concept marginalizes women and others who exist at the intersecting axes of multiple oppressions (e.g., women of (...) color, women in the global South, working-class women, and/or queer and trans people), and thus, demonstrating the need to develop a new way of conceptualizing women. However, the question of what such a new conception would be remains unanswered. Specifically, if feminist theory today is to destabilize the old notion of “women” that relegates multiply oppressed women to the margin of feminism, and yet still needs to use some notion of “women” to critically analyze how the social structure of sexist oppression operates to subordinate women and to dismantle this oppression, how should the concept “women” be reformulated? In this dissertation, I argue that we need to understand women as a concept that is open to constant redefinition, which is socio-historically situated in the actualities of oppression. This is what I refer to as the “situated redefinition” model of women, which is formulated in more detail as follows: -/- The Situated Redefinition Model of Women (SR) – The concept “women” should be always open to being redefined in a way that it could better serve political goals grounded in the actual, daily lives of the marginalized. That is, “women” should be always open to new meanings and provisional definitions that the marginalized would find more useful to achieve political goals, which grow out of their concrete experiences in the current intersecting structures of oppression. -/- My central argument is that we need to understand the concept “women” according to the situated redefinition model, in order to employ this concept for doing intersectional feminism. To support this thesis, the dissertation is divided into two main parts. By engaging with the intersectionality literature, critical race feminisms, Asian/American feminisms, and recent critiques of intersectionality, the first part of the dissertation elucidates what exactly it means for feminism to be more “intersectional.” The second part develops the situated redefinition model and articulates why this model is needed to do intersectional feminism, drawing on the social/political philosophy literature on non-ideal theory, postmodern discussions of universality, and feminist discussions of identity politics. Broadly, this dissertation seeks to shed new light on how we understand and use the concept women for feminist ends. My conceptual model offers a way for feminist scholar-activists to subvert the essentialist/exclusionary notion of “women” without abandoning altogether feminist-political deployments of the concept “women” for the purpose of ending sexist and intersecting oppressions. (shrink)

The purpose is to improve the teaching and learning efficiency of college Innovation and Entrepreneurship Education. Firstly, from the perspective of aesthetic education, this work designs the teacher and student sides of the Computer-aided Instruction system. Secondly, the CAI model is implemented based on the weight sharing and local perception of the Convolutional Neural Network. Finally, the performance of the CNN-based CAI model is tested. Meanwhile, it analyses students’ IEE experience under the proposed CAI model through a case study of (...) Music Majors from Xi’an Conservatory of Music. The experimental data show that the CNN-based CAI model can respond quickly and stably when users access different functional modules, such as webpage browsing. The proposed CAI model increases students’ entrepreneurial interest, skills, and knowledge by 55.62, 57.32, and 72.12%, respectively. Students’ entrepreneurial practice ability has been improved by over 50.00%; such an increase in entrepreneurial practice ability has also shown individual differences. Thus, the proposed Music Majors-oriented IEE-infiltrated CAI model based on CNN improves students’ entrepreneurial practice ability and reflects the positive experience of Music Majors on IEE. The finding provides references for the step-by-step identification of the CNN-based CAI model and has certain guiding significance for analyzing the effect of college IEE. (shrink)

Does intersectionality divide marginalized groups (e.g., women) along identity lines (e.g., race, class, and sexuality)? In response to the criticism that intersectional approaches to feminist and critical race theories lead to fragmentation and division, this paper notes that it relies on an ontological (mis)understanding of identity as a fixed entity. I argue against this notion of identity by engaging in a detailed case study of how Asian American women experience their Asian identity. The case study demonstrates that identity is lived (...) not as a pre-given static object but rather as a fluid and flexible process: what Asian identity means varies according to how this identity is related to the dynamics of power. I propose a tripartite taxonomy of identity-power relationships exhibited in Asian American women’s lives, in which identities are 1) constructed by and 2) used to reproduce power as oppression, as well as 3) used to build power as resistance. In particular, I explore Black and Asian feminist solidarities to show that those at the margins recreate their identities and, in doing so, build positive forms of power such as resistance and solidarity. The criticism that intersectionality leads to fragmentation does not hold, as it is grounded in a flawed notion of identity that fails to consider how identities are actually lived in their changing relationships to power—especially how marginalized groups, such as women of color, build solidarity to resist oppression by recreating their identities, rather than being fragmented into smaller and mutually exclusive subgroups. (shrink)

The author explores the metaphysics of social identities by using non-ideal theory as a method. She aims to understand what social identities are by examining the experiences of marginalized people – the experiences of people having a social identity as X (e.g., “Latina,” “Muslim woman”) in the non-ideal world, where they are marginalized by virtue of being X. To this end, the author delves into the decolonial feminist philosophies of Uma Narayan, Mariana Ortega, and María Lugones, and engages their conceptual (...) frameworks with Asian and Asian American experiences. Drawing on these analyses, she develops an account of social identities as processes of navigating power: A social identity as X can be best understood as the process as a whole, in which the subject lives as an X by navigating power dynamics, bargaining with them, and highlighting different meanings of being X. By employing non-ideal theory, which centers on power-as-oppression as a factor shaping marginalized people’s lives, we can achieve this nuanced understanding of social identity. Ideal theory, by excluding power from its analysis, is incapable of capturing how social identity is experienced as a process. (shrink)

Matarese (2022) argued in a commentary that Machery’s (2020) resampling account of replication (RAR) is unsatisfactory because it was too quick to abolish the distinction between direct and conceptual replications. Although Matarese agrees with Machery that some interpretations of conceptual replications are misconceived, she offers an interpretation which purports to show that direct and conceptual replications have different functions, and this justifies preserving the distinction. In this commentary, I will defend the RAR from Matarese’s argument. Most importantly, I will argue (...) that Matarese’s interpretation of conceptual replications is conceptually impossible. Thus, I conclude that the direct–conceptual distinction was rightly abolished by Machery. (shrink)