The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

A growing interest across disciplines in the nature of empathy has sparked a debate over the place of empathy in morality. Proponents are eager to capitalize on the apparent close connection between empathy and altruism, while critics point to serious problems in our exercise of empathy - we are naturally biased, empathize too much or too little, and prone to making all sorts of mistakes in empathizing. The proponents have a promising response, that it is not empathy simpliciter, but empathy (...) in some “proper” form, that does the work they claim for it. This paper aims to propose a cautiously optimistic position for the proponent by rethinking the suggested approach. I argue that empathy plays two important roles in morality, one epistemic and the other relational, but the proponent must be careful not to exaggerate the contribution that empathy, even in its “proper” form, can make to our moral life. (shrink)

This paper gives a new and richer account of open-mindedness as a moral virtue. I argue that the main problem with existing accounts is that they derive the moral value of open-mindedness entirely from the epistemic role it plays in moral thought. This view is overly intellectualist. I argue that open-mindedness as a moral virtue promotes our flourishing alongside others in ways that are quite independent of its role in correcting our beliefs. I close my discussion by distinguishing open-mindedness from (...) what some might consider its equivalent: empathy and tolerance. (shrink)

The global signal, which was once regarded as a nuisance of functional magnetic resonance imaging, has been proven to convey valuable neural information. This raised the following question: what is a GS represented in local brain regions? In order to answer this question, the GS topography was developed to measure the correlation between global and local signals. It was observed that the GS topography has an intrinsic structure characterized by higher GS correlation in sensory cortices and lower GS correlation in (...) higher-order cortices. The GS topography could be modulated by individual factors, attention-demanding tasks, and conscious states. Furthermore, abnormal GS topography has been uncovered in patients with schizophrenia, major depressive disorder, bipolar disorder, and epilepsy. These findings provide a novel insight into understanding how the GS and local brain signals coactivate to organize information in the human brain under various brain states. Future directions were further discussed, including the local-global confusion embedded in the GS correlation, the integration of spatial information conveyed by the GS, and temporal information recruited by the connection analysis. Overall, a unified psychopathological framework is needed for understanding the GS topography. (shrink)

From reviews of the hardback edition: a deep study of 20th century field ... of the conceptual origins and development of twentieth century field theories, ...

Background With the deepening trend of global aging, the issue of dignity of older adults has received widespread attention. The research on the dignity of older adults in nursing homes in China has only just begun, and it is necessary to further explore the dignity experience of older adults in nursing homes. Research Objective To investigate the thematic features of dignity experiences of older adults residing in nursing homes in mainland China. Furthermore, it may serve as a starting point for (...) further research that formulates intervention strategies. Research Design This is a qualitative descriptive study. Twenty older adults living in one of two private nursing homes between September and November 2022 were selected as participants. For each patient, we conducted semi-structured interviews, from which we extracted and assessed information using qualitative content analysis method. SRQR reporting guidelines were used. Ethical considerations ‘Ethical considerations' with information regarding ethical review, informed consent process and confidentiality. Results Five themes and eight subthemes emerged from the transcripts: (1) self-esteem (sense of self-worth and becoming a burden), (2) perceived value to society (being respected and belonging), (3) interpersonal relationships (relationships with others and respectful behavior toward others), (4) autonomy (control of daily life and participation in decision-making), and (5) acceptance and adaptation. Conclusion Dignity in older adults can be preserved by realizing self-worth, relieving the burden of self-perceived, promoting belonging, strengthening social ties, enhancing autonomy, and engaging in activities. (shrink)

Studies suggest that reward and emotion are interdependent. However, there are discrepancies regarding the interaction between these variables. Some researchers speculate that the inconsistent findings may be due to different targets being used. Although reward and emotion both affect attention, it is not clear whether their impacts are independent. This study examined the impact of reward anticipation on emotion processing for different targets. A cue-target paradigm was used, and behavior and eye-tracking data were recorded in an emotion or sex recognition (...) task under the conditions of reward and non-reward anticipation. The results showed that when the target was related to the emotional attribute of the stimulus, the reward promoted the processing target information, thereby generating reward-oriented attention. When the target was unrelated to the emotional attributes of the stimulus, the reward did not promote the processing target information, and at the same time, individuals had negative emotional biases toward the emotional faces. The results revealed that, in addition to affecting the attention to emotional faces independently, the target regulated the promotion of reward anticipation to emotional attention and attention bias towards negative stimuli. (shrink)

In Toward a Good Society, the authors theorize a mutually empowering and growth-fostering society. They begin this journey in relational psychology, then depart along nine paths reconstructed from nine classic social science theories. This leads them to propose a new Golden Rule as simple as it is profound.

Roger Ames in this book tries to further construct an alternative to a foundational individualism by concocting person, individual and personhood into an ethical conceptual regimen, as a substantia...

Based on elaboration likelihood model, this paper introduces the central route and peripheral route of online comments and constructs a conceptual model affecting consumers’ clothing impulse buying behavior in live broadcast. A total of 737 questionnaires were collected, and 709 valid questionnaires were used for questionnaire analysis. According to the ELM, there are central route and peripheral route of online comments. The results show that in addition to the commentator credibility, the comment quality, comment comprehensiveness, and comment quantity have a (...) significant positive impact on impulse buying behavior. Fashion involvement plays a moderating role in the relationship between online comments and impulse buying behavior. This paper will provide theoretical support for live broadcast clothing marketing and provide suggestions for the development and design of live broadcast. (shrink)

This study addresses the problem of output quasisynchronization for coupled complex-valued memristive reaction-diffusion complex networks via the distributed event-triggered control scheme. First, by using the separate method, set value mapping, and intermediate value theorem, the complex-valued memristive reaction-diffusion complex networks can be transferred into two semi-uncertain real-valued reaction-diffusion complex networks. Second, a distributed output piecewise event-triggered control scheme with spatial sampled-data is first proposed including a spatial sampling event-triggered generator and spatiotemporal sampling state feedback controller. Furthermore, this scheme can effectively (...) save the measurement resources and lower the update rate of controllers in spatial and time domain. Third, the synchronization analysis is considered by utilizing an appropriate Lyapunov function, the Halanay inequality, and the improved Wirtinger inequality. Subsequently, several output event-triggered quasisynchronization criteria are derived. The relations among event trigger conditions, spatial sampling interval, convergence rate, and control gain are given by rigorous mathematical derivation. Finally, multiple simulations are compared to substantiate the validation of the OPETC scheme. (shrink)

“Entire philosophy, especially the basic important point of contemporary philosophy, is the connected point between logic and existence.” The top, basic and key point is logic and existence or spirit and matter. How to understand this point becomes the important symbol of different development stages and different philosophy schools, one’s essence of world outlook as well. Philosophy, which belongs to thinking field, pertains to “software system”, is the platform for scientific research of other subjects. Formula One, the universe is rooted (...) in matter, united in spirit; Formula Two, the universe is potential energy. Formula Three, the universe is function. Modernization is digital! Digital philosophy! Digital spirit world! (shrink)

By means of questionnaire and quantitative research, this article aims at investigating the effects on students' mastery of vocabulary by studying teachers' adoption of seven kinds of common vocabulary teaching strategies and the usage of analyzing strategies in intensive English in order to improve vocabulary teaching strategies and to help enlarge students' vocabulary.

The centriole is a widely conserved organelle required for the assembly of centrosomes, cilia, and flagella. Its striking feature – the nine‐fold symmetrical structure, was discovered over 70 years ago by transmission electron microscopy, and since elaborated mostly by cryo‐electron microscopy and super‐resolution microscopy. Here, we review the discoveries that led to the current understanding of how the nine‐fold symmetrical structure is built. We focus on the recent findings of the centriole structure in high resolution, its assembly pathways, and its (...) nine‐fold distributed components. We propose a model that the assembly of the nine‐fold symmetrical centriole depends on the concerted efforts of its core proteins. Also see the video abstract here:https://youtu.be/m4h_3II_WJo. (shrink)

Longitudinal diagnostic classification models (DCMs) with hierarchical attributes can characterize learning trajectories in terms of the transition between attribute profiles for formative assessment. A longitudinal DCM for hierarchical attributes was proposed by imposing model constraints on the transition DCM. To facilitate the applications of longitudinal DCMs, this paper explored the critical topic of the Q-matrix design with a simulation study. The results suggest that including the transpose of the R-matrix in the Q-matrix improved the classification accuracy; ten-item tests measuring three (...) linear attributes across three time points provided satisfactory classification accuracy for low-stakes assessment. Educational implications and future directions were discussed. (shrink)

Reviewing a recent book about early medieval Chinese geographical writings, this essay asks what sort of historical contextualization is needed for historical study, and suggests looking at multiple factors, including the material conditions of textual production, that may be responsible for the proliferation of texts. It cautions against embracing a single story to account for a long historical period, especially if that story fits our modern concerns too neatly; even more importantly, we have to allow the primary sources to take (...) the lead, rather than looking for and presenting only evidence that serves a particular agenda. (shrink)

本书主要是对朱陈书信的逐段义疏，义疏的方式包括对字句文脉的梳理、义理的阐发、朱陈其他相关书信文章语录的旁证、已有研究的回应以及作者案语总结，试图兼顾考据、辞章、义理以及前人研究，结语部分归纳双方论点， 并对某些问题略发余论。.

대부분의 연구자들은 주염계의 「태극도설」에 대한 주자의 해석서인 「태극해의」가 이기론을 기반으로 이루어졌다고 주장한다. 그러나 「태극해의」에서 ‘태극=리’라고 명시적으로 주장한 구절은 찾아볼 수 없으며 체계적인 이기론이 나타나지도 않는다. 이와 같은 사실에 비추어 볼 때에 조선유학자들이 이기론을 사용하여 「태극도설」을 해석한 것은 의미가 있다. 남당은 ‘모두 같은 본연지성’과 ‘모두 다른 기질지성’이라는 기존의 이분법적 성론만으로는 인간과 사물의 차이를 본질적으로, 그리고 명실상부하게 분별할 수 없으며, 인간이 도덕적 주체로서 가지는 고유한 지위를 확보하기 어렵다고 보았다. 이와 같은 문제의식에서 남당은 본연지성을 ‘초형기의 본연지성’과 ‘인기질의 본연지성’으로 나누고, 因氣質의 ‘人性과 物性이 다른 (...) 本然之性’이라는 독창적 개념을 토대로 「태극도설」을 해석하였다. 그리고 이 성론에 기반을 둔 ‘一原分殊’의 논리로 「태극도설」에 통일적인 체계를 부여하였다. 그는 리와 기의 분별을 매우 강조하고 있다. 이 분별의 논리가 인물성동이론에 적용될 때 인/물의 본연지성이 다르며 성인과 범인의 마음이 다르다는 ‘차이’의 이론이 정립된다. 그리고 이를 토대로 ‘차이의 형이상학’이 구축된다. 남당은 이 ‘차이의 형이상학’을 기반으로 「태극도설」을 해석하여 통일적인 체계성을 부여한 것이다. 이와 같은 남당의 해석이 ‘동아시아 유학자들의 「태극도설」 해석사에 있어서 어떠한 위상을 차지하고 있는가’라는 문제는 앞으로 중요한 연구과제가 될 것이다. 성리학의 핵심적 쟁점들은 「태극도설」과 밀접한 관계에 있기 때문이다. (shrink)

This paper investigates links between social capital and symbolic capital and responsible entrepreneurship in the context of small and medium enterprises (SMEs). The source of the primary data was 144 ‘Business Profiles’, written by the owner-managers of small businesses in application for a Small Business Awards competition in 2005. Included in each of these narratives were claims relating to the firms’ contributions to wider society, relationships with customers, employees and stakeholders. These narratives were coded and classified in a framework drawn (...) from Nahapiet and Ghoshal’s (1998, Academy of Management Review 23(2), 242–266) categorisation of social capital. The analysis revealed a range of strategic orientations towards the development of social and symbolic capital, along a conceptual continuum ranging from being responsible for oneself to being responsible for others. Overall, the evidence demonstrates the significance of the power inherent in the social relations of SMEs as a force for ethical behaviour, and suggests that normative theories of the development of social capital may provide ‘competitive advantage’ through responsible behaviour for small business in the global economy. (shrink)

Scholarly interest in employees’ voluntary pro-environmental behavior has begun to emerge. While this research is beginning to shed light on the predictors of workplace pro-environmental behavior, our understanding of the psychological mechanisms linking the various antecedents to employees’ environmentally responsible behavior and the circumstances under which any such effects are enhanced and/or attenuated is incomplete. The current study seeks to fill this gap by examining: the effects of perceived corporate social responsibility on employees’ voluntary pro-environment behavior; an underlying mechanism that (...) links CSR perceptions to these behaviors; and a boundary condition to these relationships. Data from 183 supervisor-subordinate dyads employed in large- and medium-sized casinos and hotels in Guangdong China and Macau revealed that employees’ corporate social responsibility perceptions indirectly affect their engagement in voluntary pro-environmental behavior through organizational identification, and these effects are stronger for employees high in empathy. (shrink)

A multiphase study tested a proposed mediated moderation model for the joint effects of ethical pressure and power distance orientation on accountants’ ethical judgments of earnings management. Results based on a sample of 354 accountants from China indicated that the relationship between ethical pressure and ethical judgments of earnings management is contingent on the accountants’ power distance orientation. That is, the relationship between ethical pressure and ethical judgments of earnings management was stronger for accountants with a high power distance orientation. (...) The results also demonstrated that ethical beliefs in support of the company serve as a mediator for the interaction effect of ethical pressure and power distance orientation on the outcome. These results are discussed in terms of viewing earnings management as a form of unethical pro-organizational behavior which can be effectively investigated within the framework of the person-situation interactionist model. (shrink)

Face attractiveness can influence memory for previously seen faces. This effect has been shown to differ for young and older perceivers. Two parallel studies examined the moderation of both the age...

An athlete has faith in her unathletic partner to run a marathon, a teacher has faith in her currently poor-performing students to improve in the future, and your friend has faith in you to succeed in the difficult project that you have been pursuing, even, and especially, when your chance of failing is non-trivial. This paper develops and defends a relational view of interpersonal faith by considering four interesting phenomena: first, in virtue of placing faith in someone, we stand in (...) solidarity with that person; second, interpersonal faith is called for during moments of difficulty, but it can seem inappropriate during moments of ease; third, one’s faith in others can feel unwelcomed, and can be rejected; and fourth, when interpersonal faith is frustrated, disappointment, rather than resentment, is warranted. I propose that when the faithor (e.g., your friend) places faith in the faithee (e.g., you) to φ, the faithor does something close to inviting the faithee to (re)commit to φ-ing. This invitation-like move, once properly taken up by the faithee, puts both sides of the faith in a new kind of normative relationship that is in the same broad family as a promissory relationship, albeit with a different normative profile. (shrink)

The creation of QCD is one of greatest achievements in the history of science. It has radically changed our conception of the fundamental ontology of the physical world and its underlying dynamics. What it has discovered are more than new particles and a new force, but rather a deeper level of physical reality, a new kind of entities. Dynamically, the strong nuclear forces are no longer taken to be fundamental, but are relegated to the status of the un-cancelled residue of (...) far stronger long range force mediated by gluon. From a long term perspective, perhaps more important than these discoveries is that it breaks a new path to explore many novel features of an unknown layer of the physical world, such as instanton, the theta vacuum and effective energy. The notion of effective energy allows us to conceptualize the mysterious quantum number flow and hadronization. Although the metaphysical status of effective energy is not quite clear at this moment, but a window is open for conceptualizing the physical world that is in complex processes of transmutations in a unified way. (shrink)

Motivated by the developments in contemporary mathematical physics and the related interpretive and historiographical works on these developments, a structuralist and historically constitutive and constructive approach to scientific realism (SHASR) is proposed to address the challenges Thomas Kuhn raised against scientific realism, and to remove the defects of the currently available dissatisfactory responses the structuralists put forward to the challenges. The paper shows that SHASR productively exploits the insights from both Kuhn’s historicism and his critics’ structuralism, while avoids the traps (...) in both traditions. Then, after a brief comparison between SHASR and the increasingly popular neo-Kantian post-Kuhnian philosophy of science recommended and defended by Michael Freedman and some others, it concludes with a big picture about the science-world relationship derived from the notion of emergence conceptualized within the framework of SHASR, whose bearings on the Kantian question of the phenomenal - noumenal relationship are worth further explorations. (shrink)