The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

v. 1. Qian Sugeladi zhe xue yan jiu, Sugeladi ji qi zhe xue si xiang -- v. 2. Si, shi, shi.

ABSTRACTAccording to the Dogmatism Puzzle presented by Gilbert Harman, knowledge induces dogmatism because, if one knows that p, one knows that any evidence against p is misleading and therefore one can ignore it when gaining the evidence in the future. I try to offer a new solution to the puzzle by explaining why the principle is false that evidence known to be misleading can be ignored. I argue that knowing that some evidence is misleading doesn't always damage the credential of (...) the evidence, and therefore it doesn't always entitle one to ignore it. I also explain in what kind of cases and to what degree such knowledge allows one to ignore evidence. Hopefully, through the discussion, we can not only understand better where the dogmatism puzzle goes wrong, but also understand better in what sense rational believers should rely on their evidence and when they can ignore it. (shrink)

Collected works of Dge-lugs-pa scholar predominantly on doctrines, commentary on Vasubandhu's Abhidharmakośa, study on Abhisamayālaṅkāra of Pañcaviṃśatisāhasrikā Prajñāparāmitā, Buddhist logic, philosophy, rituals, etc.

In this article, we examine the empirical association between firm value and CSR engagement for firms in sinful industries, such as tobacco, gambling, and alcohol, as well as industries involved with emerging environmental, social, or ethical issues, i.e., weapon, oil, cement, and biotech. We develop and test three hypotheses, the window-dressing hypothesis, the value-enhancement hypothesis, and the value-irrelevance hypothesis. Using an extesive US sample from 1995 to 2009, we find that CSR engagement of firms in controversial industries positively affects firm (...) value after controlling for various firm characteristics. To address the potential endogeneity problem, we further estimate a system of equations and change regression and continue to find a positive relation between CSR engagement and firm value. Our findings support the value-enhancement hypothesis and are consistent with the premise that the top management of US firms in controversial industries, in general, considers social responsibility important even though their products are harmful to human being, society, or environment. (shrink)

The Value of Evidence thesis (VE) tells us to gather evidence before deciding in any decision problem, if the evidence is free. This appar- ently plausible principle faces two problems. First, it fails on evidence externalism or nonclassical decision theories. Second, it’s not general enough: it tells us to prefer gaining free evidence to gaining no evi- dence, but it doesn’t tell us to prefer gaining more informative evidence to gaining less informative evidence when both are free. This paper defends (...) an alternative value-of-evidence principle that solves the above two problems. We call it ‘the Comparative Value of Evidence for the Resolute (CVER).’ CVER not only generalizes VE to the comparative case but is also compatible with evidence externalism and nonclassical decision theories. Our argument, if successful, broadens the scope of the value-of-evidence principle and shows that it’s more robust than previously imagined. (shrink)

In the life of an individual as well as the whole of society, the worldview is one and the foundation of their spiritual life and its highest manifestation. Paraphrasing the well-known expression of Hegel's philosophy, It is possible to say with greater certainty that the worldview itself is a flower and a product, a factor and a consequence of the culture of the nation. In the historical past, the dominant worldview of mankind was a religious outlook; in other words - (...) in the spiritual world of humanity, religion was undivided. This pattern is quite relevant to our, Ukrainian, people. (shrink)

We empirically examine the impact of corporate social responsibility (CSR) on CEO compensation using a large sample of the US firms from 1996 to 2010. We develop and test two hypotheses, the overinvestment hypothesis based on agency theory and the conflict–resolution hypothesis based on stakeholder theory. We find that the lag of CSR adversely affects both total compensation and cash compensation, after controlling for various firm and board characteristics. Our estimates show that an interquartile increase in CSR is followed by (...) a 4.35% (2.78%) decrease in total (cash) compensation. We also find an inverse association between lagged employee relations and CEO compensation. Our results are robust to the correction for endogeneity using instrumental variable approach. Taken together, our results support the conflict–resolution hypothesis, but not the CSR overinvestment argument. (shrink)

On the basis of the combination of single-valued neutrosophic sets and hesitant fuzzy sets, this article proposes a single-valued neutrosophic hesitant fuzzy set as a further generalization of the concepts of fuzzy set, intuitionistic fuzzy set, single-valued neutrosophic set, hesitant fuzzy set, and dual hesitant fuzzy set. Then, we introduce the basic operational relations and cosine measure function of SVNHFSs. Also, we develop a single-valued neutrosophic hesitant fuzzy weighted averaging operator and a single-valued neutrosophic hesitant fuzzy weighted geometric operator and (...) investigate their properties. Furthermore, a multiple-attribute decision-making method is established on the basis of the SVNHFWA and SVNHFWG operators and the cosine measure under a single-valued neutrosophic hesitant fuzzy environment. Finally, an illustrative example of investment alternatives is given to demonstrate the application and effectiveness of the developed approach. (shrink)

Richard Foley has presented a puzzle purporting to show that all attempts in trying to find a sufficient condition of rationality are doomed. The puzzle rests on two plausible assumptions. The first is a level-connecting principle: if one rationally believes that one's belief that p is irrational, then one's belief that p is irrational. The second is a claim about a structural feature shared by all promising sufficient conditions of rationality: for any such condition, it is possible that one's belief (...) satisfies it and yet one rationally believes that it doesn’t. With the two assumptions, Foley argues that a sufficient condition of rationality is impossible. I explain how exactly the puzzle goes and I try to offer a solution. If my solution works, all theorists of rationality who accept certain level-connecting principles need to add an extra condition to their favourite rationality-making condition. (shrink)

The debate between Uniqueness and Permissivism concerns whether a body of evidence sometimes allows multiple doxastic attitudes towards a proposition. An important motivation for Uniqueness is the so-called ‘arbitrariness argument,’ which says that Permissivism leads to some unacceptable arbitrariness with regard to one's beliefs. An influential response to the argument says that the arbitrariness in beliefs can be avoided by invoking epistemic standards. In this paper, I argue that such a response to the arbitrariness argument is unsuccessful. Then I defend (...) a new response: contrary to common conception, the arbitrariness resulted by Permissivism is acceptable. The basic idea is that the arbitrariness resulted by Permissivism is analogous to the arbitrariness in permissive actions and the latter arbitrariness is intuitively acceptable. I answer three possible objections against this analogy, which are all motivated by the thought that beliefs aim at the truth. In addressing the last objection, I draw inspiration from the recent debate on transformative experience. (shrink)

Selected works of author's on critical analysis on different concepts of Buddhist doctrines and philosophy.

本书包括:中西文化之“会通和合”;写在《中国审美意识的探讨》出版之际;学者的使命;“诗言志”小注等内容。.

Study on Am̥rtānubhava, philosophical classic by Jñānadeva, fl. 1290, Marathi religious leader.

The constitutional provision for the separation of the Church and the State has been in existence for over 200 years. They are now referring to it, no longer remembering how it came about. The fact is that the French Revolution of 1789 was anti-feudal and anticlerical. It separated the affairs of the state from the ecclesiastical so that bishops and cardinals would govern the Church, not the state. The 1917 revolution in Russia also tore the triumvirate of "statehood, orthodoxy, nationality." (...) The state and the Church should have existed separately. The Bolsheviks rejected the old state and the Church, but in their legislation in 1919 the Decree recorded the separation of the Church from the state and the school from the Church. Because they disregarded law, morality and religion and absolutized the state, the state, and especially its punitive organs, trampled on morality, ethics, religion, clergy and their defenders... (shrink)

Philosophy and Phenomenological Research, EarlyView.

We experimentally investigate whether donation motive attribution influences individual investors' judgments of the donating firm's future earnings prospects and whether individual moral orientation, that is, perceived importance of social goodwill (PISG), moderates this effect. We find that investors forecast higher future earnings per share (EPS) when the donation motive is believed to be altruistic or win–win rather than egoistic; the EPS forecasts for altruistic and win–win motives are not different. However, this motive attribution effect holds only for higher-PISG investors. A (...) further examination finds that when the donation motive is believed to be egoistic and/or when investors have lower PISG, doing good is no better than doing nothing, but no backfire effect occurs. Our findings indicate that the positive effect of corporate donation on investors' judgments is generated only when higher-PISG investors believe that the donation motive is not purely egoistic; corporate donation will not generate negative effects on investors' judgments even under less favorable conditions. (shrink)

Noise will be inevitably mixed with music signals in the recording process. To improve the quality of music signals, it is necessary to reduce noise as much as possible. This article briefly introduces noise, the masking effect, and the spectral subtraction method for reducing noise in reverberant music. The spectral subtraction method was improved by the human ear masking effect to enhance its noise reduction performance. Simulation experiments were carried out on the traditional and improved spectral subtraction methods. The results (...) showed that the improved spectral subtraction method could reduce the noise in reverberant music more effectively; under an objective evaluation criterion, the signal-to-noise ratio, the de-reverberated music signal processed by the improved spectral subtraction method had a higher signal-to-noise ratio; under a subjective evaluation criterion, mean opinion score, the de-reverberated music signal processed by the improved spectral subtraction method also had a better evaluation. (shrink)

With the rapid development of Internet technology, sports media consumption is migrating toward streaming. The online streaming of sporting events has become the important way of copyrights holders to engage sports fans, especially young fans. Therefore, it is vital to understanding users' willingness to pay. Given that previous studies of the livestream sports broadcasts online have not dealt with users' payment intention, the originality of this study is that it explore users' motivation by combining information system research with the consumer (...) demand theory. The study aimed to examine the factors that influence users' payment intention to stream online sports by using the extended Technology Acceptance Model. Data from questionnaires completed by 330 Chinese respondents determined how perceived usefulness, ease, enjoyment, and satisfaction, influence users' WTP. Satisfaction positively correlated with users' payment intentions, impacted WTP values, mediated ease of use. The analysis also revealed the necessity for broadcast platforms to improve satisfaction and to increase payment intentions. (shrink)

The way of our living and working has changed intensely throughout the past half-century. The era we live in is interlinked with rapid technological changes, paving the way for digitalization. The students are considered digital natives and are expected to have e-learning abilities to improve their academic effectiveness. However, digital readiness is an important factor that can play a valuable role in boosting students’ e-learning abilities and satisfaction. The previous studies of students’ e-learning abilities revealed the lack of students’ digital (...) readiness for academic achievements. Therefore, the present study aims to examine the role of digital readiness in the e-learning satisfaction of students. Based on the theory of motivation, the present study attempts to check the association of digital readiness with e-learning satisfaction. The current study also determines the relationship of digital readiness with entrepreneur psychological capital. Further, this study examines the correlation of entrepreneur psychological capital with e-learning satisfaction. The present study also assumes the mediating role entrepreneur of psychological capital and moderating role of mindfulness. For empirical analyses, this study gathered data from 376 music learning students of entrepreneur training institutes in China through a structured questionnaire method using a convenient sampling technique. This study applied partial least square structural equation modeling for empirical analyses using Smart PLS software. The present study confirmed that digital readiness positively correlates with e-learning satisfaction and psychological capital. The findings also acknowledged that psychological capital positively enhances e-learning satisfaction. The results also confirmed that psychological capital mediates the association between digital readiness and e-learning satisfaction. However, the outcomes revealed that mindfulness does not moderate the association between digital readiness and e-learning satisfaction. On the other hand, the findings acknowledged that mindfulness moderates the relationship between psychological capital and e-learning satisfaction. In addition, this study’s findings also serve the literature by providing important theoretical and practical implications. This study points out that digital readiness is an important antecedent to increasing students’ learning satisfaction and performance. The findings also suggest that students’ mindfulness could play a bridging role in enhancing their performance. (shrink)

Extant research has identified various effects of leader humor on subordinates and work groups. In contrast, less research has explored the influence of leader humor on leaders themselves and leaders’ subsequent behaviors. To address these issues, we drew from ego depletion theory and investigated when and how leader humor impacted leader workplace deviance. We argued that leader humor along with high impression management motive would bring increased ego depletion to leaders themselves and ultimately result in more leader workplace deviance. We (...) tested our theoretical model using a three-wave time-lagged field survey data collected from 103 leaders and 595 subordinates, as well as an experiment involving 487 leader participants, which provided overall support for our hypotheses. Our findings revealed the possible dark side of leader humor influencing both leaders themselves and organizations. Theoretical contributions and new avenues for future research are addressed. (shrink)

Lung nodules are an early symptom of lung cancer. The earlier they are found, the more beneficial it is for treatment. However, in practice, Chinese doctors are likely to cause misdiagnosis. Therefore, deep learning is introduced, an improved target detection network is used, and public datasets are used to diagnose and identify lung nodules. This paper selects the Mask-RCNN network and uses the dense block structure of Densenet and the channel shuffle convolution method to improve the Mask-RCNN network. The experimental (...) results prove that proposed algorithm is extremely effective. (shrink)

Amid the COVID-19 pandemic, fear has run rampant across the globe. To curb the spread of the virus, several governments have taken measures to drastically transition businesses, work, and schooling to virtual settings. While such transitions are warranted and well-intended, these measures may come with unforeseen consequences. Namely, one’s fear of COVID-19 may more readily manifest as aggressive behaviors in an otherwise incognito virtual social ecology. In the current research, a moderated mediation model examined the mechanisms underlying the relation between (...) fear of COVID-19 and overt and relational aggressive online behavior among Chinese college students. Utilizing a large sample of Chinese college students, results indicated that moral disengagement mediated the effect of fear of COVID-19 on college students’ overt and relational online aggressive behavior. A positive family cohesion buffered the effect of moral disengagement on relational aggressive behavior, but only for females. The findings, theoretical contributions, and practical implications of the present paper are also discussed. (shrink)

Commented article: HU, J. Embodiment and inspiration of Chinese philosophy of life in traditional music education. Trans/Form/Ação: revista de filosofia da Unesp, v. 47, n. 5, “Eastern thought 2”, e02400152, 2024. Available at: https://revistas.marilia.unesp.br/index.php/transformacao/article/view/15092.

Journal of Chinese Philosophy, EarlyView.

A robust adaptive fuzzy nonlinear controller based on dynamic surface and integral sliding mode control strategy is proposed to realize trajectory tracking for a class of quadrotor UAVs. In this study, the composite factors including parametric uncertainties and external disturbances are added to controller design, which make it more realistic. The quadrotor model is divided into two subsystems of attitude and position that make the control design become feasible. The main contributions of the proposed ADSISMC strategy are as follows: The (...) combination of dynamic surface and integral sliding mode makes the system always in sliding stage by finding the appropriate initial position compared with the common sliding mode, and the complexity of explosion in backstepping method is eliminated. By introducing the fuzzy system, the unknown functions and uncertainties can be approximated which significantly improves the robustness and the tracking performance. The switching control strategy is utilized to compensate for the errors between estimated and ideal inputs; the tracking performance of the whole system has been significantly improved. The simulation results show the effectiveness of the proposed control method. (shrink)

This paper explores how to explain the applicability of classical mathematics to the physical world in a radically naturalistic and nominalistic philosophy of mathematics. The applicability claim is first formulated as an ordinary scientific assertion about natural regularity in a class of natural phenomena and then turned into a logical problem by some scientific simplification and abstraction. I argue that there are some genuine logical puzzles regarding applicability and no current philosophy of mathematics has resolved these puzzles. Then I introduce (...) a plan for resolving the logical puzzles of applicability. (shrink)

Constructive (productive) thinking in the critical philosophy of Hermann Cohen differs significantly from the seemingly similar speculative thinking in J. G. Fichte’s Science of Knowledge (Wissenschaftslehre) (1794/95). The fundamental characteristics of scientific thinking in Cohen’s teaching include: purity, focus on the “fact of science”, the origin (Ursprung), the infinitesimal method, continuity, movement, production, correlation, intensive magnitude, interrelation of thinking and being. According to Cohen, scientific thinking can only be pure and generated by the origin. The origin is continuous action (movement) (...) of thinking to separate the united and bind the divided content. In this process, thinking and being are correlative. Infinitely small reality contains thinking and being simultaneously as a union and in a divided form. The infinitesimal method is thinking that continuously carries out a) the operations of opposing itself as pure thinking to the results of its own production; b) the coincidence of itself with the products of its own generation. Infinitesimal thinking seeks to eliminate the difference between self and being. Nevertheless, being constantly retains autonomy. Being does not merge with thinking and is not absorbed by it. In Fichte’s Science of Knowledge pure thinking moves in a logical circle, having no access into real being. In an effort to break out of this circle and find its causality, thinking turns not to the being of the world of phenomena, but to the Absolute I. Such a speculative approach to consciousness, thinking and being has little in common with Cohen’s critical position. (shrink)

In their article,1 Jecker et al highlight a widespread and hotly debated issue in the current application of artificial intelligence (AI) in medicine: whether we should develop more powerful AI. There are many perspectives on this question. I would like to address it from the perspective of the fundamental purpose of medicine. Since its inception, medicine has been dedicated to alleviating human suffering and ensuring health equity. For thousands of years, we have made great efforts and conducted many investigations to (...) eliminate human suffering and have achieved remarkable results. However, the reality of achieving health equity falls far short of expectations. The WHO considers health equity to be a fundamental human right, meaning that there should be no unjustified, avoidable or remediable differences among the population as a whole, whether those differences result from social, economic, demographic or geographic factors, or from other forms of inequality such as gender, race, disability or sexual orientation.2 Health equity means reducing and ultimately eliminating disparities in health outcomes between vulnerable groups and others, caused by health risk factors and difficulties in accessing quality health services. This means that we must strive to reduce structural social bias. It is well known that the traditional healthcare system is riddled with various health inequities. …. (shrink)

In Sahan et al ’s article,1 they present the ethical challenges faced by clinical laboratory scientists in genetic medicine, including labour allocation and responsibility, interpretation and accuracy of results with new technologies, and the need for better standardisation and ethical consistency. At the same time, they also propose a potential solution to the aforementioned challenges: ethical preparedness(EP). Along with their vivid case discussions and insightful analysis, I would like to propose two more points that are worth further examination and discussion (...) to aid stakeholders in better comprehending the ethical issues that clinical laboratory scientists face in the practice of genetic medicine. The case 1 reported by Sahan et al raises concerns about who should be responsible for tracking families or individuals with genetic results, particularly in the absence of mainstream services to track future risks. However, this should not be a factor influencing the decision to inform gene carriers. If there is a clear division of responsibilities in current practice, clinical laboratory scientists can report detected gene carriers without psychological burden. However, the decision to report gene carriers should be based on who is being served when clinical laboratory scientists face genetic problems in clinical practice and who is being considered when …. (shrink)