This year marks the tenth anniversary of the world's first transplantation of tissue generated from induced pluripotent stem cells (iPSCs). There is now a growing number of clinical trials worldwide examining the efficacy and safety of autologous and allogeneic iPSC‐derived products for treating various pathologic conditions. As we patiently wait for the results from these and future clinical trials, it is imperative to strategize for the next generation of iPSC‐based therapies. This review examines the lessons learned from the development of (...) another advanced cell therapy, chimeric antigen receptor (CAR) T cells, and the possibility of incorporating various new bioengineering technologies in development, from RNA engineering to tissue fabrication, to apply iPSCs not only as a means to achieve personalized medicine but also as designer medical applications. (shrink)

In 2006, Shinya Yamanaka and colleagues discovered how to reprogram terminally differentiated somatic cells to a pluripotent stem cell state. The resulting induced pluripotent stem cells (iPSCs) made a paradigm shift in the field, further nailing down the disproval of the long‐held dogma that differentiation is unidirectional. The prospect of using iPSCs for patient‐specific cell‐based therapies has been enticing. This promise, however, has been questioned in the last two years as several studies demonstrated intrinsic epigenetic and genomic anomalies (...) in these cells. Here, we not only review the recent critical studies addressing the genome integrity during the reprogramming process, but speculate about the underlying mechanisms that could create de novo genome damage in iPSCs. Finally, we discuss how much an elevated mutation load really matters considering the safety of future therapies with cells heavily cultured in vitro. (shrink)

Peter-Paul Verbeek elaborates on the concept of “relational freedom” in Moralizing Technology (2011). In this paper, I propose to extend and reinterpret it as a concept of personal autonomy. Generally, studies of autonomy do not examine the use of technology thoroughly, because these studies mainly focus on an individual’s mental process regarding reasons or motives. Consequently, these studies fail to understand technological aspects that contribute to the agent’s actions and decisions. When we take into consideration that our autonomous behaviors and (...) lives are highly intertwined with technologies, it becomes necessary to clarify the aspect of autonomy that relates to the use of technology. This is where Verbeek’s relational freedom comes into play. This is because it refers to the set of capacities to constitute one’s subjectivity in the process of deliberately using technological means. However, some conceptual analysis and critical discussion are necessary. The former includes whether it is a procedural or substantive notion. The latter consists of the problem concerning the correspondence between human participant(s) and a hybrid agent, and the difference between the hybrid agent and a moral subject. (shrink)

This paper aims to examine the role of self-awareness ( svasaṃvedana ) for the Sautrāntika epistemological tenet known as the doctrine that cognition has a form ( sākārajñānavāda ). According to this theory, we perceive external objects indirectly through the mental forms that these objects throw into our minds, and this cognitive act is interpreted as self-awareness. However, if one were to interpret the cognitive act such that the subjective mental form ( grāhakākāra/svābhāsa ) grasps the objective mental form, the (...) position of the subjective mental form becomes problematic—it becomes superfluous, as can be demonstrated with reference to Dignāga’s explanation of the Sautrāntika’s pramāṇa-pramāṇaphala argument. As a result, self-awareness itself becomes precarious. In connection with this problem, an argument on the relationship between self-awareness and the yogic perception of other minds given by Dharmakīrti leads us to discover that self-awareness is important for establishing subjectivity, in order to avoid another person’s access to one’s own mental states. Through examining Pramāṇavārttika 3.448–459, this paper tries to find a way to interpret the svābhāsa -factor without relating to its object-factor ( grāhyākāra ), and to shed new light on the problem of subjectivity in the Sautrāntika epistemology. (shrink)

This article examines whether democracy affects quality of life. Scholars have conducted surveys to investigate whether democracy is likely to lead to good quality of life. There are two contested views to the relationship: some suggest that democracy has a positive causal effect on quality of life, whereas others contend that democracy does not play such a role. Previous findings are supported by cross-national statistical analysis with aggregated survey data. However, aggregated survey data may cause ecological fallacy. Also, in order (...) to ascertain the extant research, it would be beneficial to test the hypothesis by incorporating both individual- and country-level variables. Therefore, this paper applied hierarchical modeling to investigate the regularity. Both individual-level perception of democracy and country-level political regime data were incorporated in our empirical model. Our findings suggest that individual-level satisfaction with democracy has positive causal effect on one's quality of life, whereas the country-level characteristic of the political regime has no effect. (shrink)

The paper aims to clarify Ratnākaraśānti?s epistemological theory that mental images in a cognition are false (*alīkākāravāda) in comparison with Śāntarakṣita?s criticism of the Yogācāra position. Although Ratnākaraśānti frequently uses the neither-one-nor-many argument for explaining his Yogācāra position, the argument, unlike Śāntarakṣita?s original one, does not function for refuting the existence of awareness itself as the basis of mental images. This point is examined in the first two sections of this paper by analyzing Ratnākaraśānti?s proof of the selflessness of entities (...) (dharmanairātmya) and his application of the neither-one-nor-many argument for demonstrating the falsehood of mental images. On the other hand, the last section investigates into his defense of the alīkākāravāda against Śāntarakṣita?s severe criticism of it. Here, too, we can find his tactical usage of the neither-one-nor-many argument, or more precisely, one of its variants: the neither-identical-nor-different argument. Through the above procedure, we can see how Yogācāra philosophy survived in the late period of Indian Buddhism by blending the Madhyamaka opponent?s argument with its own thought. (shrink)

Secreted signaling molecules act as morphogens to control patterning and growth in many developing tissues. Since locally produced morphogens spread to form a concentration gradient in the surrounding tissue, spreading is generally thought to be the key step in the non‐autonomous actions. Here, we review recent advances in tool development to investigate morphogen function using the role of decapentaplegic (Dpp)/bone morphogenetic protein (BMP)‐type ligand in the Drosophila wing disc as an example. By applying protein binder tools to distinguish between the (...) roles of Dpp spreading and local Dpp signaling, we found that Dpp signaling in the source cells is important for wing patterning and growth but Dpp spreading from this source cells is not as strictly required as previously thought. Given recent studies showing unexpected requirements of long‐range action of different morphogens, manipulating endogenous morphogen gradients by synthetic protein binder tools could shed more light on how morphogens act in developing tissues. (shrink)

This study reports an ecologic analysis of the relationship between mean birth weight (MBW) and nutritional, medical and social variables, using 1982 data for 47 prefectures in Japan.

The Association of South East Asian Nations (ASEAN) countries has fostered economic growth recently but in the process has encountered a number of serious problems regarding environmental destruction, such as the air and water pollution. In addition, due to rapid population growth and urbanization, there are emerging concerns about decline of the environment in those countries in the near future. One of the surveys that tries to measure the attitudes of ASEAN citizens on environmental issues is the ASEAN Barometer survey (...) conducted in 2009. This paper aims to unfold how ASEAN citizens evaluate environmental problems and what underlie their evaluations using the aforementioned ASEAN Barometer survey. The results of analysis will mainly reveal the next three points: (1) Filipinos showed higher environmental consciousness; (2) people in a less developed country were more likely to worry about environment deterioration and showed more commitment to the environmental movement, but, at the same time, they were more reticent about their immediate ecological activities; (3) those who thought that central governments needed to commit more to environmental problems and should take greater responsibility for environmental deterioration. Those who expected regional international organizations to take more measures were more inclined to engage in environmental activities. (shrink)

Very few attempts have been made to survey patient opinions, particularly regarding the use of residual biospecimens and health information in research, to clarify their values. We conducted a questionnaire survey that targeted outpatients of a university hospital to gauge their awareness levels and understand patient perspectives on research that uses these items. Few patients felt that obtaining individual consent for each research study was necessary. Most patients expressed the view that researchers should be obligated to inform them about the (...) research use of their items and be subject to self-directed rules. The research community should try to obtain “societal consent regarding an opt-out system” from the public. A salient value-sharing-based governance structure is necessary for obtaining public trust. (shrink)

This paper deals with the debates over _kālamṛtyu_ (“timely death” or human death at the end of the life span) and _akālamṛtyu_ (“untimely death” or premature death that occurs when the life span still remains). In cultural areas like ancient India, where the _karman_ doctrine or the law of _karman_ is firmly rooted, such “timely death” and “untimely death” have seemed to be the catalysts for the philosophical and ethical debates. Assuming that a person’s life itself would be affected by (...) the person’s past _karman_s, each life span and death of individual persons would have been predetermined by their past _karman_s, and consequently, any efforts for preserving or prolonging life span in this world would have no meaning. If it were so, in the first place, does the _karman_ doctrine leave room for “untimely death”? This paper discusses how Buddhist literature, especially the _Questions of King Milinda_ (_Milindapañha_), and the Āyurvedic literature approach the above issues. (shrink)

This paper explores the evolving landscape of business ethics in Japan, with a particular focus on recent research trends and methodologies. It begins by examining historical influences on Japanese corporate governance and business ethics, but places greater emphasis on findings from a survey of Japanese business ethics scholars. Conducted as part of the Global Survey for Business Ethics (GSBE), the survey targeted researchers affiliated with the Japan Society for Business Ethics (JABES) from 1994 to 2022. This paper discusses how business (...) ethics research has developed in Japan, largely conducted in Japanese, and highlights key areas of focus such as compliance, CSR, and corporate governance. Using text analysis of research paper titles, it identifies trends across different decades, noting a shift toward more empirical studies and topics like AI ethics, human rights, and sustainability in recent years. The survey also reveals the broader roles of Japanese business ethics researchers, ranging from academic teaching to consulting and policy development. Looking ahead, the chapter highlights emerging research themes, including the ethical implications of artificial intelligence, transparency, and supply chain management, while acknowledging that Japan’s unique corporate context adds distinct dimensions to these global issues. (shrink)

Tool use is a central topic in research on cognitive evolution and behavioral ecology in non-human animals. Originally thought to be a uniquely human phenomenon, many other species have been observed making and using tools for a variety of purposes, starting with Goodall’s groundbreaking work with chimpanzees in Gombe. Despite the frequent attention and great research interest in animal tool use, and ubiquity of the behavior, we argue here that chewing sticks by dogs should be included as a case of (...) tool use. We discuss alternate possible explanations and then propose several testable predictions regarding this hypothesis. We suggest that tool use may be more common than is often assumed and that many cases of animal tool use may be overlooked. (shrink)

Background The concept of career identity is integral to nursing practices and forms the basis of the nursing professions. Positive career identity is essential for providing high-quality care, optimizing patient outcomes, and enhancing the retention of health professionals. Therefore, there is a need to explore potential influencing variables, thereby developing effective interventions to improve career identity. Objectives To investigate the relationship between moral distress, moral courage, and career identity, and explore the mediating role of moral courage between moral distress and (...) career identity among nurses. Design A quantitative, cross-sectional study. Methods A convenient sample of 800 nurses was recruited from two tertiary care hospitals between February and March 2022. Participants were assessed using the Moral Distress Scale-revised, Nurses’ Moral Courage Scale, and Nursing Career Identity Scale. This study was described in accordance with the STROBE statement. Ethical consideration Research ethics approval was obtained from the researcher’s university and hospital where this study was conducted prior to data collection. Findings Moral distress is negatively associated while moral courage is positively associated with career identity among nurses. Moral courage partially mediates the relationship between moral distress and career identity ( β = −0.230 to −0.163, p < 0.01). Discussion The findings reveal a relationship between moral distress, moral courage, and career identity among nurses. Conclusion By paying attention to nurses’ moral distress and courage, healthcare providers can contribute to the development of effective interventions to improve career identity, and subsequently performance, among nurses. (shrink)

Motor skills of professional musicians can be regarded as a model to investigate human skill acquisition after prolonged practice. Although rhythmic tapping skills of musicians such as drummers and pianists were investigated previously, the tapping performance of hand percussionists is still largely unknown. In this study, we investigated the tapping performance of professional and amateur darbuka players. Three tapping tasks were performed: single-, double-, and triple-finger tapping tasks. The participants were asked to tap as fast as possible for 12 s (...) in the single-finger tapping task while they tapped as fast and alternate/even as possible in the double- and triple-finger tapping tasks. The tapping speed and variability of inter-tap interval and tapping amplitude were assessed for each task. In the single-finger and triple-finger tapping tasks, there was no significant difference in the tapping speed between the professional and amateur darbuka players. In the double-finger tapping task, the tapping speed was significantly faster in the professional players than the amateur players. Interestingly, the professional players showed faster tapping speed in both familiar and unfamiliar patterns of finger coordination. The tapping speed of the double-finger tapping task was significantly correlated with the duration and the age of commencement of darbuka training. The professional players also showed less variability of ITI and tapping amplitude compared to the amateur players. These results suggest that prolonged practice of the hand percussion increases the performance stability and coordination speed of both familiar and unfamiliar patterns. (shrink)

Disaster scholars have long complained that their field is theory light: they are much better at doing and saying than analyzing. The paucity of theory doubtless reflects an understandable focus on case studies and practical solutions. Yet this works against big picture thinking. Consequently, both our comprehension of social suffering and our ability to mitigate it are fragmented. Communitas is exemplary here. This refers to the improvisational acts of mutual help, collective feeling and utopian desires that emerge in the wake (...) of disasters. It has been observed for as long as there has been a sociology of disasters. Within the field, there have been numerous efforts to name and describe it. Yet there has been far less enthusiasm to theorize it, which means that the disaster literature has not adequately explained the social conditions under which communitas arises (or fails to). In this article, we synthesize numerous case studies to do so. This takes us beyond simple statements of what communitas is and what it should be called, to considerations of the conditions under which it emerges, how it should be conceptualized, the factors that might prevent communitas, and how we might encourage it. While primarily a theoretical work, the identification of communitas’ facilitators and barriers have practical import for disaster risk reduction (DRR) policy as communitas has frequently proven to be a positive and potent force. (shrink)

Own-age bias is a well-known bias reflecting the effects of age, and its role has been demonstrated, particularly, in face recognition. However, it remains unclear whether an own-age bias exists in facial impression formation. In the present study, we used three datasets from two published and one unpublished functional magnetic resonance imaging study that employed the same pleasantness rating task with fMRI scanning and preferential choice task after the fMRI to investigate whether healthy young and older participants showed own-age effects (...) in face preference. Specifically, we employed a drift-diffusion model to elaborate the existence of own-age bias in the processes of preferential choice. The behavioral results showed higher rating scores and higher drift rate for young faces than for older faces, regardless of the ages of participants. We identified a young-age effect, but not an own-age effect. Neuroimaging results from aggregation analysis of the three datasets suggest a possibility that the ventromedial prefrontal cortex was associated with evidence accumulation of own-age faces; however, no clear evidence was provided. Importantly, we found no age-related decline in the responsiveness of the vmPFC to subjective pleasantness of faces, and both young and older participants showed a contribution of the vmPFC to the parametric representation of the subjective value of face and functional coupling between the vmPFC and ventral visual area, which reflects face preference. These results suggest that the preferential choice of face is less susceptible to the own-age bias across the lifespan of individuals. (shrink)

Right-ear advantage refers to the observation that when two different speech stimuli are simultaneously presented to both ears, listeners report stimuli more correctly from the right ear than the left. It is assumed to result from prominent projection along the auditory pathways to the contralateral hemisphere and the dominance of the left auditory cortex for the perception of speech elements. Our study aimed to investigate the role of attention in the right-ear advantage. We recorded magnetoencephalography data while participants listened to (...) pairs of Japanese two-syllable words. The amplitudes of the stimuli were modulated at 35 Hz in one ear and 45 Hz in the other. Such frequency-tagging allowed the selective quantification of left and right auditory cortex responses to left and right ear stimuli. Behavioral tests confirmed the right-ear advantage, with higher accuracy for stimuli presented to the right ear than to the left. The amplitude of the auditory steady-state response was larger when attending to the stimuli compared to passive listening. We detected a correlation between the attention-related increase in the amplitude of the auditory steady-state response and the laterality index of behavioral accuracy. The right-ear advantage in the free-response dichotic listening was also found in neural activities in the left auditory cortex, suggesting that it was related to the allocation of attention to both ears. (shrink)