This paper deals with the debates over _kālamṛtyu_ (“timely death” or human death at the end of the life span) and _akālamṛtyu_ (“untimely death” or premature death that occurs when the life span still remains). In cultural areas like ancient India, where the _karman_ doctrine or the law of _karman_ is firmly rooted, such “timely death” and “untimely death” have seemed to be the catalysts for the philosophical and ethical debates. Assuming that a person’s life itself would be affected by (...) the person’s past _karman_s, each life span and death of individual persons would have been predetermined by their past _karman_s, and consequently, any efforts for preserving or prolonging life span in this world would have no meaning. If it were so, in the first place, does the _karman_ doctrine leave room for “untimely death”? This paper discusses how Buddhist literature, especially the _Questions of King Milinda_ (_Milindapañha_), and the Āyurvedic literature approach the above issues. (shrink)

Very few attempts have been made to survey patient opinions, particularly regarding the use of residual biospecimens and health information in research, to clarify their values. We conducted a questionnaire survey that targeted outpatients of a university hospital to gauge their awareness levels and understand patient perspectives on research that uses these items. Few patients felt that obtaining individual consent for each research study was necessary. Most patients expressed the view that researchers should be obligated to inform them about the (...) research use of their items and be subject to self-directed rules. The research community should try to obtain “societal consent regarding an opt-out system” from the public. A salient value-sharing-based governance structure is necessary for obtaining public trust. (shrink)

This year marks the tenth anniversary of the world's first transplantation of tissue generated from induced pluripotent stem cells (iPSCs). There is now a growing number of clinical trials worldwide examining the efficacy and safety of autologous and allogeneic iPSC‐derived products for treating various pathologic conditions. As we patiently wait for the results from these and future clinical trials, it is imperative to strategize for the next generation of iPSC‐based therapies. This review examines the lessons learned from the development of (...) another advanced cell therapy, chimeric antigen receptor (CAR) T cells, and the possibility of incorporating various new bioengineering technologies in development, from RNA engineering to tissue fabrication, to apply iPSCs not only as a means to achieve personalized medicine but also as designer medical applications. (shrink)

The Second Conference of the International Society for the Study of Time was held at Hotel Mt. Fuji, near Lake Yamanaka, Japan, on July I to 7,1973. The present volume is the proceedings at that Con ference and constitutes the second volume in The Study of Time series. * At the closing session of our First Conference in Oberwolfach, Germany, in 1969, I was honored by being elected to the Presidency of the Society, following Dr. J. G. Whitrow, our (...) fIrst President. My mandate was to organize a Second Conference, consistent with the aim of the Society, which is the holding of interdisciplinary conferences for the presentation and discussion of papers on various as pects of time. Several participants expressed to me their wish to have a second conference held in Japan so as to emphasize the international and intercultural dedication of this Society. Dr. Fraser carefully evaluated this and many other suggestions, weighed the possible conference sites and our chances of raising the necessary funds to convene a meeting at such sites, and concurred with my conclusions that we should go ahead with the plans for a Japanese meeting. For the difficult and complicated task of raising funds and organizing a conference in Japan, I had to select and rely heavily on somebody both capable and reliable and also living in Japan. Thus, I asked the Reverend Michael Mutsuo Yanase, S. J. (shrink)

In 2006, Shinya Yamanaka and colleagues discovered how to reprogram terminally differentiated somatic cells to a pluripotent stem cell state. The resulting induced pluripotent stem cells (iPSCs) made a paradigm shift in the field, further nailing down the disproval of the long‐held dogma that differentiation is unidirectional. The prospect of using iPSCs for patient‐specific cell‐based therapies has been enticing. This promise, however, has been questioned in the last two years as several studies demonstrated intrinsic epigenetic and genomic anomalies in (...) these cells. Here, we not only review the recent critical studies addressing the genome integrity during the reprogramming process, but speculate about the underlying mechanisms that could create de novo genome damage in iPSCs. Finally, we discuss how much an elevated mutation load really matters considering the safety of future therapies with cells heavily cultured in vitro. (shrink)

Stem cell biology is driven by experiment. Its major achievements are striking experimental productions: "immortal" human cell lines from spare embryos (Thomson et al. 1998); embryo-like cells from "reprogrammed" adult skin cells (Takahashi and Yamanaka 2006); muscle, blood and nerve tissue generated from stem cells in culture (Lanza et al. 2009, and references therein). Well-confirmed theories are not so prominent, though stem cell biologists do propose and test hypotheses at a profligate rate. 1 This paper aims to characterize the (...) role of experiment in stem cell biology, so as to answer the following question: how do experiments contribute to our knowledge of stem cells and related phenomena? The .. (shrink)

The starting point for the considerations in the article is the statement of Keiko Yamanaka that the Japanese know nothing about resistance to the bacterium represented by another human being. In the article, however, we put forward the thesis that Japanese culture has developed a collective immune system resulting not from individual but from shared systemic immunology in connection with the performance of family, professional and social functions. The analysis of Japanese ‘cultural immunology’ includes an examination of the ways (...) of functioning of the body in contemporary Japanese culture. To this end, we first discuss the relationship between humans and nature in Japanese religious-ethical tradition. Next, we examine the Japanese relationship to the body as a special part of nature. Then we analyze the tension in the Japanese culture between individual and sociocultural bodies. In conclusion, we show what the sociocultural body is and how it functions in the system of ‘cultural immunology’ in contemporary Japan. (shrink)

Scientific breakthroughs rarely yield the potential to engage a foundational ethical question. Recent studies on direct reprogramming of human skin cells reported by the Yamanaka lab in Japan and the Thomson lab in Wisconsin suggest that scientists may have crossed both a scientific and an ethical threshold. The fascinating science of direct nuclear reprogramming highlights empirical data that may clarify the ontological status of cellular activity in the early stages of what could become a human fetus and justify ethical (...) options for research in this controversial field. The ontological and ethical implications that accrue here are connected with the biological or natural potentiality of these cells. (shrink)

The phenomenal proliferation of scientific studies into the nature of induced pluripotent stem (iPS) cells following publication of the findings of Takahashi and Yamanaka little more than 2 years ago, have significantly expanded our understanding of cellular mechanisms relating to cell lineage, differentiation, and proliferation. While the full potential of iPS cell lineages for both scientific tool and therapeutic applications is as yet unclear, findings from several lines of investigation suggests that multipotential and terminally differentiated cells from an array (...) of cell types are competent to undergo epigenetic reprogramming to a pluripotential state. The nature of this pluripotential state appears to be similar to, but not identical with that previously described for embryonic stem (ES) cells. Understanding the nature of this induced reprogrammed state will be critical to determining the full potential of iPS cells. Recently, this issue has been examined through an integrated analysis of the genome in fully and partially reprogrammed iPS cell lineages. These results provide a window onto the temporal components of reprogramming and suggest mechanisms by which the efficacy of reprogramming can be enhanced. (shrink)

For centuries psychologists have been trying to explain how a man or an animal could perceive space. They have thought of space as having three dimensions and the difficulty was how an observer could see the third dimension. For depth, as Bishop Berkeley asserted at the outset of the New Theory of Vision (1709), “is a line endwise to the eye which projects only one point in the fund of the eye.” Space was its dimensions. It was empty save for (...) a collection of objects or bodies. For an observer, the objects were in different directions at various distances and the question was how these distances could be detected. For two hundred and fifty years we have tried to answer this question and failed. The explanations have been controversial, contradictory, and confused. (shrink)

The mediate aim of this essay is to make good two related claims: that phenomenology in Husserl’s sense is adequate to the task of describing the most concrete structures of subjectivity; and that the universal may be apprehended directly through the concrete.

Experience of matter can be described in the context of time and space, whereas, some people say, experience of mind may be described according to time only. Accordingly, though time and space together are regarded as objective forms, one may have a propensity for treating time alone as a particular form of the subjective consciousness. For space is indeed referred to the self-evidence of being, while time is thought to belong rather to the self-evidence of our own consciousness. According to (...) my opinion, however, even the spatial description is indispensable for the state of “mind”. For instance, the contents of our consciousness can be described only in terms of the localized phases of their images. Contrary to Kant, who regarded time and space together as forms of the outer intuition (i.e. as conditions of sensation), and time alone as form of the inner sense, I have a firm intention to assert them both as two forms of objective being because it is the being itself that can be the ultimate object of any of our cognitive powers — sensation, understanding and reason. Time and space are not forms proper to a particular “being” such as conscious existence like ours; they are also, nay, above all, two objective forms of being in general that transcends all such limited existences. It follows that these forms themselves, once abstracted in our mind, must, first of all, be valid for material beings; after that, i.e. derivatively and analogically, they may also be valid for mind-beings. The main aim of this paper is “dialectically” to elucidate that fact on the subject of time in particular. (shrink)

The experience of time, and more particularly of duration, has been studied rather separately from its functional fundament: the memory process. Yet, in the past few years some rather intriguing patterns of connection have emerged. Especially the effect of the usual distinction between immediate memory (IM), short term memory (STM) and long term memory (LTM) (Shiffrin and Atkinson 1969; Norman 1970) seems to provide some conceptual cement to link the two fields: time and memory.

At first sight the interrelation between the two main themes of this paper, time structuring and time measurement, seems to be simple enough. Time is something that we measure and that we measure with. But what is it that we measure and how is it constructed that we come to think of it as being measurable? As Leach has pointed out, in any society the prevailing ideas about the nature of time and space are closely linked up with the kinds (...) of measuring scales which are thought to be appropriate. If we alter the scales and dimensions with which we measure, we seem to alter the nature of that which is being measured, as well. (shrink)