Secreted signaling molecules act as morphogens to control patterning and growth in many developing tissues. Since locally produced morphogens spread to form a concentration gradient in the surrounding tissue, spreading is generally thought to be the key step in the non‐autonomous actions. Here, we review recent advances in tool development to investigate morphogen function using the role of decapentaplegic (Dpp)/bone morphogenetic protein (BMP)‐type ligand in the Drosophila wing disc as an example. By applying protein binder tools to distinguish between the (...) roles of Dpp spreading and local Dpp signaling, we found that Dpp signaling in the source cells is important for wing patterning and growth but Dpp spreading from this source cells is not as strictly required as previously thought. Given recent studies showing unexpected requirements of long‐range action of different morphogens, manipulating endogenous morphogen gradients by synthetic protein binder tools could shed more light on how morphogens act in developing tissues. (shrink)

Die Untersuchung von Strukturen des Exemplarischen ist in den letzten Jahren vermehrt in den Fokus geisteswissenschaftlicher Forschung gerückt. Der Band beleuchtet in systematischer und historischer Perspektive Funktionen der Verwendung von Bildern als Beispielen, Illustrationen und Exempla. Im Mittelpunkt des Buches steht die Frage, wie Bilder in epistemologische, kunsttheoretische und philosophische Diskurse eingebunden sind. Die grundlegende Annahme lautet: Der theoretische Umgang mit Bildern gehorcht einer Logik des Exemplarischen, welche die Allgemeinheit der Argumente an die konkrete Gegebenheit eines Anschaulichen bindet. 'Logik' wird (...) dabei in einem weiten, inklusiven Sinn verstanden, der die lange Tradition der Rhetorik, aber auch Kants Überlegungen zum reflexiven ästhetischen Urteil und die psychoanalytische Analyse des singulären Falls umfasst. (shrink)

Resenha do livro "Morte", de Giovanni Casertano.

We present an argument against physicalism in two steps: 1) Physics reduces the world to a mathematical structure; 2) The notion of 'structure' only makes sense when carried by something and interpreted by something else. Physicalism does not allow such a carrier and interpreter at a fundamental level, hence it must be wrong. An extended notion of Mind is presented as the fundamental 'hardware' which is necessary by the argument. In particular, qualia correspond to the 'monitor component' of mind. Some (...) ideas are presented on how to extend this mind-matter relation to a more elaborate picture: (1) A system of two complementary reductionisms (one physical, the other mental) may hint toward a deeper reality in which mind and the physical world are closely entangled. (2) A division of mind into a conscious 'monitor' and an unconscious 'processor' is suggested using the analogy of dreams. Finally, the problem of Solipsism and the existence of 'minds other than my own' is discussed. (shrink)

This interview deals with the major themes in the work of Ruth Millikan. Her most fundamental idea is that the intentionality of inner and outer representations can be understood in analogy to biological functions. Another innovative feature is the view that thought and language stand parallel to each other. Thirdly, the basic ideas concerning the ontology and the epistemology of concepts are explained. Millikan aims at clarifying her position by contrasting it with Dretske, Fodor, Sellars, and Brandom. Finally, the interview (...) addresses topics that pose problems for her account as well as questions she does not treat in her work. (shrink)

It is the nature of powerful ideas that they can summarize a ground-breaking concept in a plain and simple message. In this sense, the concept of sustainability is a very powerful idea. However, although the sustainability debate has already brought about considerable conceptual progress, a pivotal dimension to sustainable development has so far been widely neglected. This article argues that in addition to the ecological, economic, and social dimension, sustainability critically depends on the moral dimension of institutional legitimacy. Against the (...) backdrop of globalization, conventional models of creating and legitimizing institutions are increasingly challenged. Therefore, it is also business that is to play an ever more important role in contributing to fair and functioning institutions. The article discusses “corporate citizenship” as an economic concept as a useful starting point for this new understanding of the business of business. In effect, the underlying objective of this paper is to present a theoretical link between the concepts of sustainability and corporate citizenship. The central thesis is that private enterprises who cooperatively take responsibility for their institutional environment strengthen the moral dimension of institutional legitimacy: They actively contribute to empowering sustainability by corporate citizenship. (shrink)

Das Buch weist in exemplarischen Fallstudien von der Antike bis zur Gegenwart die zentrale Rolle von Bildern für Prozesse der Vergemeinschaftung auf. Gegen Ende des 20. Jahrhunderts setzt in der akademischen Diskussion eine verstärkte Rückwendung zum Konzept der Gemeinschaft ein.

This work was awarded the John Templeton Award for Theological Promise 2009.

Ausgehend von historischen und sozialtheoretischen Befunden rekonstruieren wir zunächst in skizzenhafter Form, wie es zu einer Konstruktion von Behinderungen als Verkörperungen einer Mangelhaftigkeit anthropologischen Ausmaßes gekommen ist. In Anschluss hieran vertreten wir die These, dass Behinderung eine kulturelle Norm darstellt, die der Kultur selbst Grenzen setzt. Nicht der Mensch stellt das „eigentliche“ Mängelwesen dar, sondern die gesellschaftliche Kultur vorenthaltener oder eingeschränkter Teilhabe sowie die pädagogische Kultur mangelhafter Bildungsmaßnahmen. In ethischer Hinsicht begründen wir diese These von der Verantwortung gegenüber dem Anderen (...) her, dessen Andersheit wir als irreduzibel bzw. radikal fassen. Wir schließen mit einer kurzen Reflexion über die Frage, wie sich dieser veränderte Zugang zu Menschen mit Behinderungen bildungstheoretisch fassen lässt. (shrink)

Studies involving direct language imitation tasks have shown that pronunciation ability is related to musical competence and working memory capacities. However, this type of task may measure individual differences in many different linguistic dimensions, other than just phonetic ones. The present study uses an indirect imitation task by asking participants to a fake a foreign accent in order to specifically target individual differences in phonetic abilities. Its aim is to investigate whether musical expertise and working memory capacities relate to phonological (...) awareness (i.e., participants’ implicit knowledge about the phonological system of the target language and its structural properties at the segmental, suprasegmental and phonotactic levels) as measured on this task. To this end, French native listeners (N = 36) graded how well German native imitators (N = 25) faked a French accent while speaking in German. The imitators also performed a musicality test, a self-assessment of their singing abilities and working memory tasks. The results indicate that the ability to fake a French accent correlates with singing ability and musical perceptual abilities, but not with working memory capacities. This suggests that heightened musical abilities may lead to an increased phonological awareness probably by providing participants with highly efficient memorization strategies and highly accurate long-term phonetic representations of foreign sounds. Comparison with data of previous studies shows that working memory could be implicated in the pronunciation learning process which direct imitation tasks target, whereas musical expertise influences both storing of knowledge and later retrieval here assessed via an indirect imitation task. (shrink)

Zusammenfassung Dieser Beitrag beschäftigt sich am Beispiel des islamischen Diskursfeldes mit der metasprachlichen Beschreibung objektsprachlicher Ab- und Ausgrenzungsdiskurse. Dies bringt zwangsläufig eine Auseinandersetzung mit den Dynamiken zwischen objekt- und metasprachlicher Begriffsebene mit sich. Der Artikel diskutiert in einem ersten Schritt Talal Asads Konzeption islamischer Orthodoxie und den ihr zugrundeliegenden Traditionsbegriff. In einem zweiten Schritt werden anhand von Beispielen aus dem nordamerikanischen Sufidiskurs und dem modernen türkischen Religionsdiskurs objektsprachliche Grenzziehungsdynamiken innerhalb des islamischen Diskursfeldes analysiert. Der letzte Teil des Aufsatzes widmet sich (...) der Metaebene und führt, in Abgrenzung zum statischen Stammbaummodell, einen dynamischen Begriff von religiöser Tradition ein, der es ermöglichen soll, Überlagerungen zwischen religiösen Formationen niedrigen Verdichtungsgrades sowie Prozesse der Religionisierung ins Blickfeld zu nehmen. (shrink)

The idea of levels of organization plays a central role in the philosophy of the life sciences. In this article, I first examine the explanatory goals that have motivated accounts of levels of organization. I then show that the most state-of-the-art and scientifically plausible account of levels of organization, the account of levels of mechanism proposed by Bechtel and Craver, is fundamentally problematic. Finally, I argue that the explanatory goals can be reached by adopting a deflationary approach, where levels of (...) organization give way to more well-defined and fundamental notions, such as scale and composition. (shrink)

This article responds to one of Thaddeus Metz's criticisms of the theory that the meaning of life is to fulfil a purpose assigned by God. In particular, it addresses the argument that only an atemporal God could ground meaning but that an atemporal God could not assign a purpose. In order to do this, the article first argues that Metz's criticisms misread the relevant sense of purpose. It then argues that on a more plausible reading of 'purpose', we can see (...) that it is in fact the kind of thing that an atemporal God could assign. (shrink)

This paper combines two ideas: (1) That the Lewisian best system analysis of lawhood (BSA) can cope with laws that have exceptions (cf. Braddon-Mitchell in Noûs 35(2):260–277, 2001; Schrenk in The metaphysics of ceteris paribus laws. Ontos, Frankfurt, 2007). (2) That a BSA can be executed not only on the mosaic of perfectly natural properties but also on any set of special science properties (cf., inter alia, Schrenk 2007, Selected papers contributed to the sections of GAP.6, 6th international congress of (...) the society for analytical philosophy. Mentis, Paderborn/Münster, 2008; Cohen and Callender in Philos Stud 145:1–34, 2009, Erkenntnis 73:427–447, 2010). Bringing together (1) and (2) results in an analysis of special science ceteris paribus laws. (shrink)

Recent years have seen an explosion of empirical data concerning arithmetical cognition. In this paper that data is taken to be philosophically important and an outline for an empirically feasible epistemological theory of arithmetic is presented. The epistemological theory is based on the empirically well-supported hypothesis that our arithmetical ability is built on a protoarithmetical ability to categorize observations in terms of quantities that we have already as infants and share with many nonhuman animals. It is argued here that arithmetical (...) knowledge developed in such a way cannot be totally conceptual in the sense relevant to the philosophy of arithmetic, but neither can arithmetic understood to be empirical. Rather, we need to develop a contextual a priori notion of arithmetical knowledge that preserves the special mathematical characteristics without ignoring the roots of arithmetical cognition. Such a contextual a priori theory is shown not to require any ontologically problematic assumptions, in addition to fitting well within a standard framework of general epistemology. (shrink)