Secreted signaling molecules act as morphogens to control patterning and growth in many developing tissues. Since locally produced morphogens spread to form a concentration gradient in the surrounding tissue, spreading is generally thought to be the key step in the non‐autonomous actions. Here, we review recent advances in tool development to investigate morphogen function using the role of decapentaplegic (Dpp)/bone morphogenetic protein (BMP)‐type ligand in the Drosophila wing disc as an example. By applying protein binder tools to distinguish between the (...) roles of Dpp spreading and local Dpp signaling, we found that Dpp signaling in the source cells is important for wing patterning and growth but Dpp spreading from this source cells is not as strictly required as previously thought. Given recent studies showing unexpected requirements of long‐range action of different morphogens, manipulating endogenous morphogen gradients by synthetic protein binder tools could shed more light on how morphogens act in developing tissues. (shrink)

Die Untersuchung von Strukturen des Exemplarischen ist in den letzten Jahren vermehrt in den Fokus geisteswissenschaftlicher Forschung gerückt. Der Band beleuchtet in systematischer und historischer Perspektive Funktionen der Verwendung von Bildern als Beispielen, Illustrationen und Exempla. Im Mittelpunkt des Buches steht die Frage, wie Bilder in epistemologische, kunsttheoretische und philosophische Diskurse eingebunden sind. Die grundlegende Annahme lautet: Der theoretische Umgang mit Bildern gehorcht einer Logik des Exemplarischen, welche die Allgemeinheit der Argumente an die konkrete Gegebenheit eines Anschaulichen bindet. 'Logik' wird (...) dabei in einem weiten, inklusiven Sinn verstanden, der die lange Tradition der Rhetorik, aber auch Kants Überlegungen zum reflexiven ästhetischen Urteil und die psychoanalytische Analyse des singulären Falls umfasst. (shrink)

Resenha do livro "Morte", de Giovanni Casertano.

We present an argument against physicalism in two steps: 1) Physics reduces the world to a mathematical structure; 2) The notion of 'structure' only makes sense when carried by something and interpreted by something else. Physicalism does not allow such a carrier and interpreter at a fundamental level, hence it must be wrong. An extended notion of Mind is presented as the fundamental 'hardware' which is necessary by the argument. In particular, qualia correspond to the 'monitor component' of mind. Some (...) ideas are presented on how to extend this mind-matter relation to a more elaborate picture: (1) A system of two complementary reductionisms (one physical, the other mental) may hint toward a deeper reality in which mind and the physical world are closely entangled. (2) A division of mind into a conscious 'monitor' and an unconscious 'processor' is suggested using the analogy of dreams. Finally, the problem of Solipsism and the existence of 'minds other than my own' is discussed. (shrink)

The doctrine that meanings are entitieswith a determinate and independent reality is often believed tohave been undermined by Quine's thought experiment of radicaltranslation, which results in an argument for the indeterminacy oftranslation. This paper argues to the contrary. Starting fromQuine's assumption that the meanings of observation sentences arestimulus meanings, i.e., set-theoretical constructions of neuronalstates uniquely determined by inter-subjectively observable facts,the paper shows that this meaning assignment, up to isomorphism,is uniquely extendable to all expressions that occur inobservation sentences. To do so, (...) a theorem recently proven byHodges is used. To derive the conclusion, one only has to assumethat languages are compositional, abide by a generalized contextprinciple and by what I call the category principle. Theseassumptions originating in Frege and Husserl are coherent withQuine's overall position. It is concluded that Quine'snaturalistic approach does not justify scepticism with regard tomeaning, but should rather result in a view that affiliatessemantics with neuroscience. (shrink)

This interview deals with the major themes in the work of Ruth Millikan. Her most fundamental idea is that the intentionality of inner and outer representations can be understood in analogy to biological functions. Another innovative feature is the view that thought and language stand parallel to each other. Thirdly, the basic ideas concerning the ontology and the epistemology of concepts are explained. Millikan aims at clarifying her position by contrasting it with Dretske, Fodor, Sellars, and Brandom. Finally, the interview (...) addresses topics that pose problems for her account as well as questions she does not treat in her work. (shrink)

Das Buch weist in exemplarischen Fallstudien von der Antike bis zur Gegenwart die zentrale Rolle von Bildern für Prozesse der Vergemeinschaftung auf. Gegen Ende des 20. Jahrhunderts setzt in der akademischen Diskussion eine verstärkte Rückwendung zum Konzept der Gemeinschaft ein.

This work was awarded the John Templeton Award for Theological Promise 2009.

Starting from the premise that what calls for and happens in the work and thinking of translation is inseparable from the experience of reading Heidegger’sphilosophy, this article suggests that translation in Heidegger’s work is a philosophical problem fundamentally implicated in the thinking of Being. The article first examines Heidegger’s distinction between Übersetzen—a form of translation that seeks correspondences between words of different languages, and Übersetzen—a translation within one’s own language that seeks to respond to the “claim” of language itself. The (...) second part of the article links translation with Heidegger’s later reflections on language in Unterwegs zur Sprache, arguing that what is at stake in the work of translation is a thinking of our relation to language. Focusing on the notion of “usage/Brauch,” it concludes with the suggestion that insofar as thinking translation according to Heidegger requires a “response” to the claim of language, it also calls for a more sustained engagement with the question of how the human is claimed and used by language. (shrink)

According to Marin Cureau de La Chambre—steering a middleway between the Aristotelian and the Cartesian conception of the soul—everything that lives cognizes and everything that cognizes is alive. Cureau sticks with the general tripart distinction of vegetative, sensitive, and intellectual soul. Each part of the soul has its own cognition. Cognition is the way in which living beings regulate bodily equilibirum and environmental navigation. This regulative activity is gouverned by acquired or by innate images. Natural cognition (or instinct) is cognition (...) by innate images only. Cureau develops a highly originel theory of natural (or 'specialized') instinct. His theory attempts to explain five features of instinct (innateness, specialization, species-specifitiy, coerciveness, teleological nature). According to my interpretation, Cureau proposes a species of what is called a 'teleosemantic theory' of innate cognition. (shrink)

Sind die Menschenrechte primär Ausdruck einer politischen Praxis und die Idee der Menschenrechte eine Art „Überbau“, den die Praxis epiphänomenal hervorbringt? Oder ist die Praxis der Menschenrechte das Ergebnis der Verwirklichung einer normativen Idee, die unabhängig von ihr existiert? Ist die Idee der Menschenrechte die Bedingung dafür, dass es die Praxis der Menschenrechte geben kann? Oder gibt es einen Vorrang der Praxis vor der Idee? In meinem Aufsatz argumentiere ich für zwei These: 1. These: Menschenrechte sind prinzipiell unabhängig von jeder (...) bestehenden rechtlichpolitischen Praxis und sind zugleich untrennbar an bestimmte rechtlich-politische Praktiken geknüpft. Darin besteht der konstitutive Widerspruch der Menschenrechte. 2. These: Aus diesem Widerspruch folgt nicht, dass wir aufhören sollten über Menschenrechte nachzudenken und eine Politik der Menschenrechte anzustreben. Der Widerspruch hat keine lähmende Wirkung, sondern ist theoretisch und praktisch produktiv. Um diese Thesen zu plausiblisieren, werde ich zunächst einige Grundzüge von Arendts Diskussion der Menschenrechte rekapitulieren (Abschnitt 2) und ihr Postulat eines den Menschenrechten vorgelagerten „Rechts, Rechte zu haben“ diskutieren (Abschnitt 3). Ausgehend von einer kritischen Diskussion der diskurstheoretischen Weiterentwicklung von Arendts These zu einem „Recht auf Rechtfertigung“ im diskurstheoretischen Konstruktivismus von Seyla Benhabib und Rainer Forst (Abschnitt 4) werde ich einen rechtfertigungstheoretischen Dekonstruktivismus vorstellen, der das Verhältnis von Praxis und Idee der Menschenrechte als produktiven Widerspruch fasst (Abschnitt 5). (shrink)

The second volume is devoted to issues of compositionality that arouse in the sciences of language, the investigation of the mind, and the modeling of representational brain functions. How could compositional languages evolve? How many sentences are needed to learn a compositional language? How does compositionality relate to the interpretation of texts, the generation of idioms and metaphors, and the understanding of aberrant expressions? What psychological mechanism underlies the combination of complex concepts? And finally, what neuronal structure can possibly realize (...) a compositional system of mental representations? (shrink)

Studies involving direct language imitation tasks have shown that pronunciation ability is related to musical competence and working memory capacities. However, this type of task may measure individual differences in many different linguistic dimensions, other than just phonetic ones. The present study uses an indirect imitation task by asking participants to a fake a foreign accent in order to specifically target individual differences in phonetic abilities. Its aim is to investigate whether musical expertise and working memory capacities relate to phonological (...) awareness (i.e., participants’ implicit knowledge about the phonological system of the target language and its structural properties at the segmental, suprasegmental and phonotactic levels) as measured on this task. To this end, French native listeners (N = 36) graded how well German native imitators (N = 25) faked a French accent while speaking in German. The imitators also performed a musicality test, a self-assessment of their singing abilities and working memory tasks. The results indicate that the ability to fake a French accent correlates with singing ability and musical perceptual abilities, but not with working memory capacities. This suggests that heightened musical abilities may lead to an increased phonological awareness probably by providing participants with highly efficient memorization strategies and highly accurate long-term phonetic representations of foreign sounds. Comparison with data of previous studies shows that working memory could be implicated in the pronunciation learning process which direct imitation tasks target, whereas musical expertise influences both storing of knowledge and later retrieval here assessed via an indirect imitation task. (shrink)

We present data from 122 nations showing that Baumard's argument on the ecological predictors of life history strategies and innovation is incomplete. Our analyses indicate that wealth, parasite stress, and cold climate impose orthogonal effects on life histories, innovation, and industrialization. Baumard also overlooks the historical exploitation of other nations which significantly enlarged the “pooled energy budget” available to England.

Japanese rank among the least likely to intervene to help a stranger in a non-emergency situation while Americans rank among the most likely. Across four studies, we demonstrate that Japanese are less likely to offer help to strangers because their decisions rely more heavily on the assessment of the needs of others. Accordingly, when there is uncertainty about the need for help, Japanese are less likely to intervene than Americans because without an understanding of the needs of recipient, the impact (...) of intervention may also be harmful. When the situation is unambiguous, Japanese and Americans are equally likely to help. This divergence in readiness to help strangers elaborates the understanding of why people in Japanese contexts are more likely than those in United States contexts to attend to the situation and to avoid uncertain situations. It also illuminates cultural differences in models of agency—implicit understandings of when and why a person should act to aid another. (shrink)

Zeit und Zeitlichkeit erscheinen für die Natur und die Existenz des Menschen grundlegend und fordern zugleich sein Denken wesentlich heraus. Das gilt in besonderer Weise für die Epoche des Mittelalters, in der sich Philosophen und Theologen, sowohl in Christentum als auch Islam, intensiv mit dem Thema auseinandergesetzt haben. Das daraus hervorgegangene, vielfältige und interessante Material ist oft als Gefüge aus naturphilosophischen, ethischen und religiösen Komponenten zu charakterisieren und eröffnet überraschende Einblicke - gerade in vergleichender Perspektive. Zu diesem Zweck wurden in (...) der vorliegenden Studie die zwei Denker al-Gazali ( 1111 Tus) und Meister Eckhart ( 1328 Avignon?) ausgewählt und gegenübergestellt. Nach der historischen bzw. ideengeschichtlichen Kontextualisierung beider werden im Detailzugriff auf die Texte die wichtigsten Punkte zu den jeweiligen Zeit- und Ewigkeitsvorstellungen herausgearbeitet und die Kategorien zu ihrer Gruppierung gebildet. Schliesslich werden im Vergleich die Gemeinsamkeiten und Unterschiede benannt. Die zwei Hauptthesen, denen die Arbeit dabei folgt, sind erstens die relative Ähnlichkeit der Referenzautoren, deren Zeitvorstellungen und spiritueller Ausrichtung. Und zweitens daran anknüpfend die Annahme, dass bei intellektueller und lebenspraktischer Vertiefung der Religion kulturelle und religionsspezifische Unterschiede in den Hinter- und universale Motive in den Vordergrund rücken."-- Back cover. (shrink)

Zusammenfassung Der Aufsatz beschäftigt sich mit den bei Strabon überlieferten moralischen Reformen des dakischen Herrschers Burebista, die dieser zusammen mit dem Priester Dekaineos/dekinais durchgeführt haben soll. Es wird dargelegt, dass die Reformen ein literarisches Konstrukt Strabons sind, die im Kontext des Dakerbilds des augusteischen Rom und der Selbstdarstellung des Augustus zu sehen sind, und dazu dienten, die Aufgabe ehemaliger Eroberungspläne des Augustus in Dakien zu relativieren.