AimResting state functional magnetic resonance imaging was used to analyze changes in functional connectivity within various brain networks and functional network connectivity among various brain regions in patients with high myopia.Methodsrs-fMRI was used to scan 82 patients with HM and 59 healthy control volunteers matched for age, sex, and education level. Fourteen resting state networks were extracted, of which 11 were positive. Then, the FCs and FNCs of RSNs in HM patients were examined by independent component analysis.ResultsCompared with the HC (...) group, FC in visual network 1, dorsal attention network, auditory network 2, visual network 3, and sensorimotor network significantly increased in the HM group. FC in default mode network 1 significantly decreased. Furthermore, some brain regions in default mode network 2, default mode network 3, auditory network 1, executive control network, and significance network increased while others decreased. FNC analysis also showed that the network connection between the default mode network and cerebellar network was enhanced in the HM group.ConclusionCompared with HCs, HM patients showed neural activity dysfunction within and between specific brain networks, particularly in the DMN and CER. Thus, HM patients may have deficits in visual, cognitive, and motor balance functions. (shrink)

本书内容包括：启蒙早期的欧洲大陆与英国、转写与翻译说明、英文转写与中文译稿、洛克现存书信简介、洛克书信中关于中国的部分、洛克早期未刊作品与中国、洛克藏书概述、洛克的中国藏书等。.

Eighth-century Chinese Buddhism produced a localization of the first offshoot of Zen - Rural Yang case, pioneer Zen Weishan Ling Yu Huai Hai Baizhang its division that whether he went to visit the furnace flames and enlightenment, he had replied: "No fire ", but refused to Baizhang, deep furnace ashes, took out some of the many remnants of charcoal did not eliminate, to show him:" What is this? "In doing so, Ling Yu becomes aware that this is caused (...) by koan study after reflection. Spiritual perception of that hidden in the depths of the usual waiting time is ripe was only was only excavated. Everyone has the perception by nature, and cause the season to see. Zen appeals to one's direct experienee, it is the light of enlightment, it is the way to the true nature, it is the language of your pure mind. All sentient beings have two ways to enter the Zen: one is reason, another one is conduct. Sometime Our ​​pure nature is overwrapped by the superfluous objects, if we abandon the desire, crave nothing but wisdom, give up selfness, jealous, hatred, we may keep close to the reality-the spirit of pure One. There is neither self nor other, The Buddha and Our mind are one essence. The sentient being is the same with the Buddha, Where is the Buddha nature? It is your pure mind. (shrink)

该书分“修辞理论探索”、“双关新论”、“修辞文化论”、“语体风格论”、“修辞学史研究”、“争鸣与质疑”等七部分,收入相关论文34篇。.

生き物はどこから来て、どこへ行くのか。人々の世界認識を変えた生物学史上の金字塔、ダーウィン進化論。ダーウィン進化論を取り巻く六人の学者たち、ラマルク、キュヴィエ、ハクスリー、スペンサー、ヘッケル、ドブ ジャンスキー、それぞれの栄光と挫折のドラマ。.

「人の心」を学ぶ。揺れ動き、変わりゆく宣長の思想を、積み重ねられた言葉のなかに探す。.

希望学は終わらない。凄惨で過酷な現実は、希望の母でもある。過去や現在の悲惨な事実に正面から向き合うことなく、未来の希望を語ることはできない。それは、全4巻を通じた希望学全体のメッセージである。.

Research in the field of Chinese as a foreign language education has been increasing in the past decades. However, the number of studies on CFL teacher identity is limited. To bridge the gap, this study employed a qualitative method to explore Chinese CFL teachers’ identity formation and reformation in Australian contexts. A Chinese-Australian language program was studied to examine the challenges, struggles and developments of Chinese CFL teachers who came to Australia to pursue professional growth. Five Master’s theses and three (...) interview participants were included to paint a picture of how Chinese CFL teachers interact internally and externally with a new environment. Guided by Mead’s theory of self and other, we found that Chinese CFL teachers’ identity formation and reformation in Australian classrooms are deeply influenced by their self-identification and their integration with others in the community. Cultural connectedness is a key for organizational attitudes in the relationship of self and other. Chinese CFL teachers were found lacking the wholeness of self in Australian contexts, which led to obstacles in teacher identity construction. Insufficient communication between self and other resulted in their positioning crisis. (shrink)

国内外40ヶ所以上で上映、3000人を動員している映画『哲学への権利』、ついに書籍化。特典映像を加えた映画DVD付。.

偶然を「運命」として生きる生き方とは何か。九鬼周造が哲学的思索の果てにたどりついた世界観を明らかにする。.

本書は、「経験と存在」の関わりあるいは「経験と世界」の関わりという、哲学においてたえず問い直されかつ捉え返されつづけてきた問題について、カント哲学を手がかりにしながら考察したものである。.

Ren nao huo dong di ben zhi (Yi ge shou gong yi ren di miao shu)--Lun luo ji shu jian--Yi ge she hui zhu yi zhe zai ren shi lun ling yu zhong di man you--Zhe xue di cheng guo.

啓蒙思想の系譜を繙き、理性の力を問い直す。古代ギリシアから、ホッブズ、カント、フランクフルト学派を経て最新の議論まで。啓蒙を巡る問題意識の変遷を追う論考集。.

For almost 700 years shoguns ruled Japan. These "gentleman warriors" developed a dedicated system of honor and strict guidlelines of behavior that Taira Shigesuke first brought together in his 16th century book—Bushido Shoshinshu. Present to a modern audience in clear, easy-to-read English, this new translation captures the majesty of the higher principles as well as the usefulness of the daily advice. From principles such as "a samurai should keep foremost in his mind the fact that he must die" to rules (...) regarding duty, personal obligation and even money management, this book sets out the guidelines that defined Japan's "way of the warrior." Honor and obligation are emphasised above all to the reader, who is taught that a samurai is expected to be indifferenet to pain, unquestioningly loyal, and an expert in his training. (shrink)

ObjectiveAnti-epidemic work against coronavirus disease has become routine work in China. Our study was intended to investigate the emotional and psychological state of healthcare workers and look for the association between sociodemographic factors/profession-related condition and emotional state.MethodsA cross-sectional survey was conducted online among healthcare workers from various backgrounds. Symptoms of anxiety and depression were assessed by the Chinese versions of the seven-item Generalized Anxiety Disorder and the nine-item Patient Health Questionnaire, respectively. Supplementary questions were recorded to describe the participants’ information (...) about workplace violence, profession, and attitude related to the COVID pandemic. Wherever suitable, independent t-test, and one-way ANOVA were performed to detect group differences of GAD-7 and PHQ-9 total scores after grouping by sociodemographic variables, respectively, such as age, gender, marital status, educational level, after-tax income, department category, job title, experience of workplace violence, and anti-epidemic participation. Multiple linear regression analyses were utilized in order to look for the potential associated factors of GAD-7 and PHQ-9 total scores.ResultsA total of 2,139 questionnaires with valid response were completed. Approximately 86.44% of participants had minimal symptoms of anxiety, 11.08% mild, 1.59% moderate, and 0.89% severe. Meanwhile, 81.34% had minimal symptoms of depression, 14.07% mild, 2.90% moderate, 1.17% moderately severe, and 0.51% severe. Student’s t-test showed that participants with female gender, with experience of workplace violence scored higher on both GAD-7 and PHQ-9, and participants with experience of anti-epidemic front-line work during pandemic scored lower on both GAD-7 and PHQ-9. ANOVA showed that participants aging from 31 to 40, with higher educational level, with middle level of annual after-tax income, with department of internal medicine or surgery, or with middle level of job title scored higher on both GAD-7 and PHQ-9. Regression analyses showed that female gender, high job title, and the experience of workplace violence positively were associated with anxiety or depression. Doctoral education, department, job enthusiasm, and professional self-identity were negatively associated with anxiety or depression. Additionally, psychological support was negatively associated with depression.ConclusionAs the epidemic prevention and control against COVID-19 become normalized in China, emotional state of healthcare workers deserves extensive attention. Our study revealed that gender, educational level, department category, job title, the experience of workplace violence, job enthusiasm, and professional self-identity are the most important influencing factors of physician’s anxiety and depression. Self-tailored psychological intervention should be based on the predisposing factors above to mentally prepare healthcare workers for this long-lasting battle against COVID-19. (shrink)

Ben shu tong guo dui Kang Youwei zhi "qun" yu"du" guan nian de kao cha, lai ba wo Kang Youwei dui ge ren, guo jia nai zhi tian xia zhi xu de shen ke si kao. Zhu yao nei rong you: yi, Jin dai"qun-du" guan nian de chu xian ji qi zou xiang, er, Kang Youwei "qun-du" guan nian chan sheng de si xiang bei jing, san, "Du ren" yu Kang Youwei dui xian dai xing ge ti sheng cun zhi (...) ling hui, si, "Qun" yu guo jia wei xin, wu, "qun-du" guan lian yu chong tu: min quan yu guo jia guan nian zhi jian de zhang li, liu, Shi jie fan wei zhi "du" yu "qun" : guo jia yu "da tong"deng. (shrink)

Ben shu gong you ba jiang zu cheng, fen bie shi sheng ren bi ke xue er zhi, Wang Yangming de xin xue ti xi, shi gong yu bing xue, wen xue si xiang yu shi wen chuang zuo, jiao yu si xiang yu shi jian, Yangming hou xue, Yangming xue zai jin xian dai de ying xiang, Yangming wen hua yu Guizhou lü you. Mei ge lun ti lun shu ji zhong, shen du shi zhong, xu shu xing yu (...) yan tong su liu chang, gu shi xing qiang, hen shi he da zhong du zhe yue du. wei qi fa du zhe si kao, zeng qiang yue du xiao guo, zai mei yi jiang zhi hou shi liang she zhi le yi xie ming ci jie shi, jian da tao lun ti. ling pei he xiang guan wen zi, she zhi le yi xie tu pian, bei ke he Yangming shu fa zuo pin deng, ju you ji jia de guan shang xing. (shrink)

Closed-loop transcutaneous auricular vagal nerve stimulation was officially proposed in 2020. This work firstly reviewed two existing CL-taVNS forms: motor-activated auricular vagus nerve stimulation and respiratory-gated auricular vagal afferent nerve stimulation, and then proposed three future CL-taVNS systems: electroencephalography -gated CL-taVNS, electrocardiography -gated CL-taVNS, and subcutaneous humoral signals -gated CL-taVNS. We also highlighted the mechanisms, targets, technical issues, and patterns of CL-taVNS. By reviewing, proposing, and highlighting, this work might draw a preliminary blueprint for the development of CL-taVNS.

When it comes to books on samurai philosphy, Hagakure is iconic to contemporary readers. But Budōshoshinshū, which was also written by a respected samurai during the Edo period, was equally influential at the time. Both works address the warrior's role in times of peace and emphasize the importance of living selflessly. Written by Daidōji Yūzan (1639-1730), a Confucian scholoar who descended from a long line of prominent warriors, Budōshoshinshū comprises 56 pithy instructive essays for young samurai on how to live (...) morally, with professional integrity and a higher purpose; to carry on the true chivalrous tradition of bushido. Budōshoshinshū is imbued with classic Confucian philosophy, centered on living one's life with sincerity and loyalty. (shrink)

The Code of the Samurai is a four-hundred-year-old explication of the rules and expectations embodied in Bushido, the Japanese way of the warrior. Bushido has played a major role in shaping the behavior of modern Japanese government, corporations, society.

Immerse yourself in the world of the Samurai with this classic text. Code of the Samurai is the 350-year-old summary of the rules and expectations embodied in Bushido-the ancient Japanese "Way of the Warrior." Written by Taira Shigesuke, a Samurai and prominent teacher of military techniques, it was published posthumously in 1834. This influential book was intended as a training manual for young Samurai, outlining personal and professional standards. This accessible and enjoyable translation is by Thomas Cleary, the foremost translator (...) of Asian martial classics, accompanied by the powerful line drawings of master illustrator Oscar Ratti. A new foreword by Alexander Bennett, a leading expert on Samurai history, explains the lasting importance of this classic work and its place within the canon of Japanese literature. (shrink)

One who is a Samurai must before all things keep constantly in mind, by day and by night ... the fact that he is going to die.

AimPatients with high myopia reportedly exhibit changes in functional brain activity, but the mechanism underlying such changes is unclear. This study was conducted to observe differences in dynamic spontaneous brain activity between patients with HM and healthy controls via dynamic regional homogeneity analysis.MethodsResting-state functional magnetic resonance imaging scans were performed on 82 patients with HM and 59 HCs who were closely matched for age, sex, and weight. The dReHo approach was used to assess local dynamic activity in the human brain. (...) The association between mean dReHo signal values and clinical symptoms in distinct brain areas in patients with HM was determined via correlation analysis.ResultsIn the left fusiform gyrus, right inferior temporal gyrus, right Rolandic operculum, right postcentral gyrus, and right precentral gyrus, dReHo values were significantly greater in patients with HM than in HCs.ConclusionPatients with HM have distinct functional changes in various brain regions that mainly include the L-FG, R-ITG, R-ROL, R-PoCG, and R-PreCG. These findings constitute important evidence for the roles of brain networks in the pathophysiological mechanisms of HM and may aid in the diagnosis of HM. (shrink)

BackgroundThe Life Extension Medical Decision law enacted on February 4, 2018 in South Korea was the first to consider the suspension of futile life-sustaining treatment, and its enactment caused a big controversy in Korean society. However, no study has evaluated whether the actual implementation of life-sustaining treatment has decreased after the enforcement of this law. This study aimed to compare the provision of patient consent before and after the enforcement of this law among cancer patients who visited a tertiary university (...) hospital's emergency room to understand the effects of this law on the clinical care of cancer patients.MethodsThis retrospective single cohort study included advanced cancer patients aged over 19 years who visited the emergency room of a tertiary university hospital. The two study periods were as follows: from February 2017 to January 2018 (before) and from May 2018 to April 2019 (after). The primary outcome was the length of hospital stay. The consent rates to perform cardiopulmonary resuscitation (CPR), intubation, continuous renal replacement therapy (CRRT), and intensive care unit (ICU) admission were the secondary outcomes.ResultsThe length of hospital stay decreased after the law was enforced from 4 to 2 days (p = 0.001). The rates of direct transfers to secondary hospitals and nursing hospitals increased from 8.2 to 21.2% (p = 0.001) and from 1.0 to 9.7%, respectively (p < 0.001). The consent rate for admission to the ICU decreased from 6.7 to 2.3% (p = 0.032). For CPR and CRRT, the consent rates decreased from 1.0 to 0.0% and from 13.9 to 8.8%, respectively, but the differences were not significant (p = 0.226 and p = 0.109, respectively).ConclusionAfter the enforcement of the Life Extension Medical Decision law, the length of stay in the tertiary university hospital decreased in patients who established their life-sustaining treatment plans in the emergency room. Moreover, the rate of consent for ICU admission decreased. (shrink)

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)