New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

"He completed the assignment in two phases: The photographs made during the first phase capture the natural ruggedness of the terrain and establish its relationship to the developed neighboring enclaves. Those made during the second phase not only record the actual construction process but also reveal Deal's personal perspective on the qualities of light and the creation of form. Represented in this book as a selection from the resulting portfolio, Topos, a Greek word meaning place, site, position, and occasion - (...) Deal's artistic legacy to the Gerry Center."--BOOK JACKET. (shrink)

There has recently been an explosion of interest in rational and moral choice under evaluative uncertainty—uncertainty about values or reasons. However, the dominant views on such choice have at least three major problems: they are overly demanding, they are incompatible with supererogation, and they cannot be applied to agents with credence in indeterminate evaluative theories. The authors propose a unified view that solves all these problems. According to this view, permissible options maximize expected utility relative to permissible preferences, and different (...) kinds of permissibility for options correspond to different kinds of permissibility for preferences. Thus, rationally permissible options maximize expected utility relative to rationally permissible preferences, and morally permissible options maximize expected utility relative to morally permissible preferences. The authors argue that this view has more plausible implications than its rivals not only under evaluative uncertainty but also under ordinary uncertainty. (shrink)

Is there any number of people you should save from paralysis rather than saving one person from death? Is there any number of people you should save from a headache rather than saving one person from death? Many people answer ‘yes’ and ‘no’, respectively. They therefore accept a partially aggregative moral view. Patrick Tomlin has recently argued that the most promising partially aggregative views in the literature have implausible implications in certain cases in which there are additions or subtractions to (...) the groups of people that we can save. Several philosophers have begun responding to this argument by developing partially aggregative views that avoid the relevant implications. In this paper, I extend Tomlin’s argument to create a dilemma that no partially aggregative view can avoid. I conclude that we should accept a fully aggregative moral view. (shrink)

Externalism with regard to mental content says that in order to have certain types of intentional mental states (e.g. beliefs), it is necessary to be related to the environment in the right way.

This is a paper about the methodology of normative ethics. I claim that much work in normative ethics can be interpreted as modelling, the form of inquiry familiar from science, involving idealised representations. I begin with the anti-theory debate in ethics, and note that the debate utilises the vocabulary of scientific theories without recognising the role models play in science. I characterise modelling, and show that work with these characteristics is common in ethics. This establishes the plausibility of my interpretation. (...) Taking methodological inspiration from modelling in science gives us new tools for managing idealisations, and a new perspective on pluralism. I demonstrate why this interpretation is a fruitful way of interpreting ethics, by looking at three case studies. First, I return to the anti-theory debate and argue that modelling opens up a new middle ground. Second, I argue that a modelling lens offers a new way of understanding impossibility theorems in population ethics, and their bearing on ethics as a whole. Finally, I show how viewing our work as modelling can be deployed in debates within ethics, using the debate over prioritarianism as an example. I close with further methodological suggestions for those who choose to see themselves as modellers. I discuss the role of counterexamples, our responses to moral disagreement, and the training of new ethicists. (shrink)

The problem of self-determination in the dying process confronts a dilemma regarding clients’ desire to know and not to know. Ambivalence and guilt make “free choice” problematic in choosing the way to die. Telling dying clients the “whole truth” about their condition is an art or skill. The question of a meaningful death raises questions that philosophical analysis can help clarify.

This essay follows the movements of the word “scene” across post-war French thought. The word appears at pivotal moments in the period: it is at the centre of Laplanche and Pontalis’ develo...

Can virtue be taught by the many? Socrates insists that the perfection of our souls is of supreme importance, he defines virtue as that which will make our souls good if it comes to be present, and he claims that, if we do not already possess virtue, then we should seek some teacher of it. We shall assume that he is basically right: that if our ultimate aim is to live well, if this requires us to know how to do (...) so, and if we are unsure whether we already possess this know-how, then we should in the first instance seek some teacher in good living. 1 Who should it be? Not the many, according to Socrates.2 As a general rule, and especially on matters of virtue, he asserts that we should be guided by the one with expert knowledge rather than the many, who lack such knowledge. Unlike other interlocutors in other dialogues, Alcibiades disagrees. Having suggested that he has learnt justice from people in general, he meets Socrates' stock assertion that '[w]hen you give the credit to "people in general", you're falling back on teachers who are no good', and he responds with the thought that the many can teach lots of different things. If we aim to live well, this issue is of vital importance. Together with the Great Speech in the Protagoras, the ensuing discussion in the Alcibiades is the most extensive treatment in the Socratic dialogues of the competence of the general public to teach virtue. Accordingly, we shall approach the issue of whether the general public can teach virtue by examining Socrates' arguments, in particular, that the Greek public did not teach Alcibiades justice. (shrink)

This paper examines Pedro Tabensky's claims that rational human life has a single unifying purpose, and that there is an analogy between the skill of living and that of painting. It examines his arguments for the first claim, in particular the relation between ratio nality and different ways in which a life might be unified. For, in addition to the narrative or artistic unification which Tabensky favours, there is also (for example) the possibility of unifying one's life through the adoption (...) of a so-called monolithic end, such as pleasure (assuming that pleasure is monolithic). The paper also investigates the implications of each of these modes of unification for how we should understand the skill of living. According to the narrative or artistic model, living will indeed be like painting; however, according to the mono lithic-end model, living may be more like business management; and other models may make other analogies salient. All this will make a difference to our attitudes to events within our lives, for example, whether the inevitable disturbances within our lives are to be integrated or, rather, eliminated. S. Afr. J. Philos. Vol.23(4) 2004: 353-364. (shrink)

THIS ESSAY MAKES AN ETHICAL CASE FOR UNBOUNDED BUT NOT UNLIMited economic growth. The preliminary case for such growth is its correlation with significant reductions in global poverty and the wealth that is created by economic growth. The essay then seeks to show that opposition to growth often rests on controversial assumptions about the nature of markets and productivity. I challenge these assumptions by presenting two important developments in economic theory: new growth theory, especially as related to the work of (...) economist Paul Romer, and evolutionary economics, a trajectory that has evolved into "complexity economics." An ethic of "creative abundance" is presented as a framework from within which to evaluate the prescriptive claims of the essay. (shrink)

Few fates seem worse than living without cause for hope. Yet what is it to have a cause for hope? And how is it related to having hope? Although these questions have received relatively little philosophical attention, I argue that Kant advances a rationalist account of hope that addresses them. My central thesis has two parts. First, hope is a rational attitude for Kant; certain rational conditions are needed to differentiate hope from other desiderative attitudes (such as mere wishing or (...) fantasizing). Second, these rational conditions involve causal inferences made by the hoping agent. To hope, an agent must make certain inferences about the cause of her desire and the cause of her belief that the object of her desire is possible. In short, to hope requires an agent to take herself to have a cause for hope. (shrink)

According to weak utilitarianism, at least when other things are equal, you should maximize the sum of well-being. This view has considerable explanatory power, but it also has two implications that seem to me implausible. First, it implies that, other things equal, it is wrong to harm yourself, or even to deny yourself benefits. Second, it implies that, other things equal, given the opportunity to create new happy people, it is wrong not to. These implications can be avoided by accepting (...) a complaints-based alternative to weak utilitarianism. However, complaints-based views face two decisive problems, originally noticed by Jacob Ross. I here develop a view that avoids these problems while retaining the advantages of complaints-based views. (shrink)

Judgments concerning animals have arisen across a variety of established practice areas. There is, however, no publicly available repository of judgments concerning the emerging practice area of animal protection law. This has hindered the identification of individual animal protection law judgments and comprehension of the scale of animal protection law made by courts. Thus, we detail the creation of an initial animal protection law repository using natural language processing and machine learning techniques. This involved domain expert classification of 500 judgments (...) according to whether or not they were concerned with animal protection law. 400 of these judgments were used to train various models, each of which was used to predict the classification of the remaining 100 judgments. The predictions of each model were superior to a baseline measure intended to mimic current searching practice, with the best performing model being a support vector machine (SVM) approach that classified judgments according to term frequency—inverse document frequency (TF-IDF) values. Investigation of this model consisted of considering its most influential features and conducting an error analysis of all incorrectly predicted judgments. This showed the features indicative of animal protection law judgments to include terms such as ‘welfare’, ‘hunt’ and ‘cull’, and that incorrectly predicted judgments were often deemed marginal decisions by the domain expert. The TF-IDF SVM was then used to classify non-labelled judgments, resulting in an initial animal protection law repository. Inspection of this repository suggested that there were 175 animal protection judgments between January 2000 and December 2020 from the Privy Council, House of Lords, Supreme Court and upper England and Wales courts. (shrink)

The aim of this paper is to begin developing a version of Gualtiero Piccinini’s mechanistic account of computation that does not need to appeal to any notion of proper (or teleological) functions. The motivation for doing so is a general concern about the role played by proper functions in Piccinini’s account, which will be evaluated in the first part of the paper. I will then propose a potential alternative approach, where computing mechanisms are understood in terms of Carl Craver’s perspectival (...) account of mechanistic functions. According to this approach, the mechanistic function of ‘performing a computation’ can only be attributed relative to an explanatory perspective, but such attributions are nonetheless constrained by the underlying physical structure of the system in question, thus avoiding unlimited pancomputationalism. If successful, this approach would carry with it fewer controversial assumptions than Piccinini’s original account, which requires a robust understanding of proper functions. Insofar as there are outstanding concerns about the status of proper functions, this approach would therefore be more generally acceptable. (shrink)

There are many cases in which, by making some great sacrifice, you could bring about either a good outcome or a very good outcome. In some of these cases, it seems wrong for you to bring about the good outcome, since you could bring about the very good outcome with no additional sacrifice. It also seems permissible for you not to make the sacrifice, and bring about neither outcome. But together, these claims seem to imply that you ought to bring (...) about neither outcome rather than the good outcome. And that seems very counterintuitive. In this paper, I develop this problem, propose a solution, and then draw out some implications both for how we should understand supererogation and for how we should approach charitable giving. (shrink)

By pairing translations of _Gorgias_ and _Rhetoric_, along with an outstanding introductory essay, Joe Sachs demonstrates Aristotles response to Plato. If in the _Gorgias_ Plato probes the question of what is problematic in rhetoric, in _Rhetoric_, Aristotle continues the thread by looking at what makes rhetoric useful. By juxtaposing the two texts, an interesting "conversation" is illuminated—one which students of philosophy and rhetoric will find key in their analytical pursuits. Focus Philosophical Library translations are close to and are non-interpretative of (...) the original text, with the notes and a glossary intending to provide the reader with some sense of the terms and the concepts as they were understood by Aristotle and Plato’s immediate audience. (shrink)

Is there any number of people you should save from paralysis rather than saving one person from death? Is there any number of people you should save from a migraine rather than saving one person from death? Many people answer ‘yes’ and ‘no’, respectively. The aim of partially aggregative moral views is to capture and justify combinations of intuitions like these. These views contrast with fully aggregative moral views, which imply that the answer to both questions is ‘yes’, and with (...) non-aggregative moral views, which imply that the answer to both questions is ‘no’. In this paper, I review the most natural and influential ways of developing partially aggregative views and explain the main problems they face. (shrink)

Is there any number of people you should save from paralysis rather than saving one person from death? Is there any number of people you should save from a migraine rather than saving one person from death? Many people answer “yes” and “no,” respectively. The aim of partially aggregative moral views is to capture and justify combinations of intuitions like these. In this article, I develop a risk-based reductio argument that shows that there can be no adequate partially aggregative view. (...) I then argue that the only plausible response to this reductio is to accept a fully aggregative view. (shrink)

The answer is surprising, and what we're about to learn will wake us up to a reality most of us never knew existed.The reason we're so oblivious is because we've all been operating at human speed, relying on our own physical power and our five senses. But there is something extremely important we've all been missing. It holds the key to everything good--the key to life, success, happiness, peace of mind, and understanding beyond our wildest imagination. It's perhaps the best-kept (...) secret in the history of mankind and it packs a staggering, invigorating message that can change your life for the better--improving understanding, eliminating anxiety, and helping to extend your living years indefinitely. All we have to do is open our eyes and ears.We're all inundated with this secret at all times. It's present in our favorite songs and movies, the stories we tell our children, and even in every commercial campaign! The secret is broadcast in famous news stories including the coronavirus pandemic, the sinking of the Titanic, or the collapse of the World Trade Center on 9/11. It's in ordinary life activities such as breathing, sleeping, waking up, traveling, sex, and getting married and changing one's name.Now, bestselling author and award-winning journalist Joe Kovacs reveals the solution--cracking the divine code that shifts our minds from operating at slow, human speed and making the jump to the incredibly quick "God speed."Hundreds of ancient mysteries and prophecies are instantly unsealed as the master key that unlocks the mystery of everything is now in your hands. (shrink)

The Environmental Gaze: Reading Sartre through Guido van Helten's No Exit Murals offers an environmental reading of Sartre's theory of the gaze. Challenging the common association of his work with Western anthropocentrism, Balay argues that the Sartrean gaze involves an inter-human-natural mode of perception: the environmental gaze.

Qu'y a-t-il de plus paradoxal et de plus profondément décevant que de ne plus pouvoir parler ouvertement aujourd'hui de la beauté sans être soupçonné de naïveté, tant elle a été elle-même frappée de mutisme voire d'interdiction par toutes les "déconstructions" de la métaphysique, toutes les "ruptures" des "avant-gardes artistiques", toutes les industries du divertissement de masse et toutes les formes de nihilisme qui en résultent? La beauté ne continue-t-elle pas, pourtant, de faire l'objet d'une irréductible expérience qui, modestement mais résolument, (...) féconde toujours l'existence humaine, dans sa dimension proprement esthétique, certes, mais aussi dans les domaines éthique (comme en amour et en amitié) et socio-politique (dans le partage du sensible nécessaire à tout sens commun)? C'est à redonner la parole et droit de cité à cette expérience de la beauté que nous espérons ici contribuer, en dialogue avec les Anciens et les Modernes, en nous instruisant à la fois des principes de la philosophie et des révélations de la littérature et des autres arts, comme de la vie la plus quotidienne. (shrink)

Journal of International Political Theory, Ahead of Print.

This paper argues that G.R.G. Mure’s use of ‘commensurate universal’ to translate ‘katholou’ is mistaken in An. Post. A24, and that throughout this chapter whenever the word ‘katholou’ appears it is to be translated ‘universal’ simpliciter. Establishing this requires a short commentary on Aristotle’s use of the word ‘katholou’, which apparently he coined, and used none too carefully.

In The Stigma of Genius: Einstein, Consciousness and Critical Education, we muse over ways in which to be, to become, to recognize uniqueness and different paths to genius. Understanding that there is no prescribed procedure, but only multiple actions, means, measures in which to recognize or teach to genius, we look at Einstein's life and knowledges to connect our pedagogies and students. Today's schools often exemplify an inability to stimulate and encourage students to find passion, goals, and reasons to be (...) educated. Our public school students are often not succeeding, many are failing and are discouraged. Teachers are exhausted, overworked, lacking respect and administrative support in districts controlled by local and national politics. Using Einstein as an example, but also a metaphor for educators, The Stigma of Genius is straight talk about the needs for schools/teachers/administrators/students to become critically and contextually aware. We argue for an education which is conscious of students' needs, and the nuances within each school and each classroom. Discussing cognition, classes, urban education, and diversity, we have attempted to circle back to Einstein and understand ways to support and encourage today's geniuses. (shrink)

This book presents a system of spiritual psychology, integrating astrology and the chakras, including detailed case studies for each chakra.

The philosophy of the Presocratics still governs scholarly discussion today. This important volume grapples with a host of philosophical issues and philological and historical problems inherent in interpreting Presocratic philosophers.

In his recent book, A Frightening Love: Recasting the Problem of Evil, Andrew Gleeson challenges a certain conception of justification assumed in mainstream analytic philosophy and argues that analytic philosophy is ill-suited to deal with the most pressing, existential, form of the problem of evil. In this article I examine some aspects of that challenge.

The distinction between explanation and understanding was foundational to Jaspers’ ‘phenomenological’ approach to psychiatry. It makes sense that those now calling for a phenomenological approach to psychiatry would look to Jaspers for inspiration, and that in doing so, they would take up this distinction. However, I argue that it is and was a mistake to use the distinction in work on psychiatry: adhering to the distinction now would undermine, rather than support, the goals of those advocating a phenomenological approach to (...) psychiatry; furthermore, if the distinction had been adhered to, then contemporary psychiatry and its patients would be worse off. (shrink)

This chapter contains sections titled: Introduction Domesticated Democracy The Principle of Consensus as a Feature of Democracy Conclusion.

This chapter examines modal modelling in climate science. It considers two related topics. The first is the use of climate models to attribute extreme weather events to climate change. The second is the interpretation and use of collections of climate models. Each topic is the subject of a current debate within climate science and philosophy of science, and each has an important modal component. The debates are similar in that each involves a contrast between probabilistic and non-probabilistic methods. In each (...) case, the chapter examines the kind of modal claims scientists make and how they are justified. As climate change is an important practical problem, each debate has a link to policy decisions, and so the chapter ends with a discussion of how modal modelling, and the possibilities it identifies, can support decision-making. (shrink)

ABSTRACT Shagrir and Sprevak explore the apparent necessity of representation for the individuation of digits in computational systems.1 1 I will first offer a response to Sprevak’s argument that does not mention Shagrir’s original formulation, which was more complex. I then extend my initial response to cover Shagrir’s argument, thus demonstrating that it is possible to individuate digits in non-representational computing mechanisms. I also consider the implications that the non-representational individuation of digits would have for the broader theory of computing (...) mechanisms. 1 The Received View: No Computation without Representation 2 Computing Mechanisms and Functional Individuation 3 Against Computational Externalism 4 Implications for the Mechanistic Account. (shrink)

This collection assembles Church's referee reports, Fitch's 1963 paper, and nineteen new papers on the knowability paradox.

Content note: This paper discusses rape throughout.Abstract. In this paper, I consider arguments in favor of jury trials. While I find these generally persuasive, I argue that there can be cases where juries are not fit for purpose. In those cases, I argue that they should be replaced by judge-only trials. In doing so, I propose a framework for determining whether a type of case is unsuitable for jury trials. Partly in response to low conviction rates, there have been recent (...) suggestions that rape trials should be conducted without juries. I suggest that there is strong evidence that these offences qualify under the criteria I have described. As a result, I argue that judge-only trials should be adopted for trying rape cases. (shrink)