New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Ethical care is beginning to be recognised as care that accounts for the views of those at the receiving end of care. However, in the context of palliative and supportive district nursing care, the patients’ and their carers’ views are seldom heard. This qualitative research study explores these views. Data were collected through semi-structured interviews with 26 patients with palliative and supportive care needs receiving district nursing care, and 13 of their carers. Participants were recruited via community nurses and hospices (...) between September 2010 and October 2011. Post-structural discourse analysis is used to examine how discourses operate on a moral level. One discourse, ‘busyness’, is argued to preclude a moral form of nursing care. The discourse of friendship is presented to contrast this. Discussion explores Gallagher’s ‘slow ethics’ and challenges the currently accepted ways of measuring to improve quality of care concluding that quality cannot be measured. (shrink)

This paper is a clarification and partial justification of a novel approach to the interpretation of Gramsci. My approach aims to avoid reductionism, intellectualism, and one-sidedness, as well as the traditional practice of conflating his political thought with his active political life. I focus on the political theory of the Prison Notebooks and compare it with that of Gaetano Mosca. I regard Mosca as a classic exponent of democratic elitism, according to which elitism and democracy are not opposed to each (...) other but are rather mutually interdependent. Placing Gramsci in the same tradition, my documentation involves four key points. First, the Notebooks contain an explicit discussion of Mosca's ideas such that when Gramsci objects to a theoretical concept or principle, he often presupposes a common methodological orientation, and when he objects to a particular method or approach, he often presupposes a common theoretical view. Second, Gramsci accepts and gives as much importance to Mosca's fundamental principle that in all societies organized elites rule over the popular masses. Third, Gramsci accepts Mosca's distinctive theory of democracy defined as a relationship betwen elites and masses such that the elites are open to the influx of members from the masses. Finally, there is an emblematic practical political convergence btween the two: in 1925, both opposed a Fascist bill against Freemasonry. Although their rhetoric was different, their speeches exhibit astonishing substantive, conceptual and logical similarties. (shrink)

C'est bien à la question de savoir s'il est légitime de parler d'une connaissance philosophique, que Gilles-Gaston Granger a voulu répondre, et répondre par l'affirmative, en publiant son dernier livre intitulé Pour la connaissance philosophique. À en juger pourtant par les réactions agaçées que provoque souvent cette enquête constamment réouverte sur la nature de la philosophie, il se pourrait bien que nombre de philosophes trouvent un peu excessif de consacrer encore un ouvrage de près de trois cents pages à justifier (...) la portée cognitive d'une discipline qui, au cours de sa longue histoire, a produit autant d'œuvres dont le moins qu'on puisse dire est qu'elles ont hautement contribué à enrichir le bagage culturel de l'humanité. Qui, parmi ceux qui vouent l'essentiel de leur vie à l'enseignement de la philosophie, accepterait de se voir refuser le droit de prétendre transmettre une connaissance authentique? Pourtant, je voudrais soutenir ici que, compte tenu de son contexte, non seulement l'intervention de Granger n'était pas superflue mais qu'elle n'aura pas été suffisante pour établir de façon convaincante qu'il existe telle chose qu'une connaissance proprement philosophique. (shrink)

De profonds déséquilibres environnementaux et sociaux caractérisent en négatif le bilan de la culture humaine en ce début de XXe siècle. La transformation radicale des sociétés sur des bases de justice sociale apparaît comme la condition pour que le genre humain poursuive son processus de libération et soit enfin fidèle à la démarche éthique qui le singularise. Pourtant, les révolutions du siècle passé, qui ont tenté de construire un nouveau monde, ont toutes échoué. La plupart d'entre elles ont étouffé la (...) liberté et bafoué les principes humanistes. De fait, les adversaires de l'exploitation de l'homme par l'homme sont actuellement affaiblis et désorientés. Ils ont bien du mal à s'opposer aux offensives des classes dirigeantes qui partout dans le monde appliquent des politiques libérales antisociales. Comment galvaniser les résistances? Est-il possible de refonder l'idéal émancipateur? Quelles devraient être les caractéristiques essentielles d'une société véritablement émancipatrice? Quel cheminement peut nous y conduire? (shrink)

Children and adults from a remote Zafimaniry village in eastern Madagascar were probed for their intuitive understanding of the biological inheritance of bodily features. They were told a story about a baby adopted at birth, and were asked whether, when grown, he would be more likely to resemble his birth parents or his adoptive parents in bodily traits, beliefs, preferences, temperaments, and skills. In spite of the fact that the Zafimaniry, like other Southeast Asian and Malagasy peoples, profess explicit beliefs (...) concerning the fixation of individuals' properties that are at variance with Western folkbiology, Zafimaniry adults responded as do American adults on the task. Zafimaniry children, however, did not repond as did the adults, nor did they respond as did the majority of American children. Rather, they responded in the manner most consistent with what would be predicted, for children as well as for adults, from the ethnographic literature. That is, they tended to judge that an adopted boy would resemble his adoptive rather than his birth parents on virtually all traits, including bodily traits. The implications of these findings for current debates within cognitive science and anthropology are discussed. (shrink)

The ArgumentThe relation between alchemy and early chemistry is still open to debate. How did what is now often dismissed as a pseudo-science contribute to the emerging science of chemistry, a subject that by the late eighteenth century, was often held up as a model for other sciences? Alchemy may have bequeathed to chemistry some processes and apparatus; more fundamental, however, was a transformation in mentality. It was in the seventeenth century that much of this transformation took place.A study that (...) was deeply anthropomorphic, making constant use of allegories and symbolism, and with a language rejoicing in mystery and concealment, gradually became depersonalized, much more objective, and more open. Poetic descriptions, a moral dimension, and a hierarchical view of matter all disappeared. Practical considerations required a concern for greater purity of materials, necessary for the successful replication of experiments. A study of the series of seventeenth-century French textbooks of chemistry from Beguin to Lemery reveals a growing desire for practical results and plain speaking. Robert Boyle was particularly influential in urging the necessity of plain language. The creation of a suitable language to denote and differentiate among different chemical species was a crucial step in the development of early chemistry, thus preparing the way for the systematic names introduced in the following century and the full organization of the science on rational lines. (shrink)