Background: Genomic analysis may reveal both primary and secondary findings with direct relevance to the health of probands’ biological relatives. Researchers question their obligations to return findings not only to participants but also to family members. Given the social value of privacy protection, should researchers offer a proband’s results to family members, including after the proband’s death? Methods: Preferences were elicited using interviews and a survey. Respondents included probands from two pancreatic cancer research resources, plus biological and nonbiological family members. (...) Hypothetical scenarios based on actual research findings from the two cancer research resources were presented; participants were asked return of results preferences and justifications. Interview transcripts were coded and analyzed; survey data were analyzed descriptively. Results: Fifty-one individuals (17 probands, 21 biological relatives, 13 spouses/partners) were interviewed. Subsequently, a mailed survey was returned by 464 probands, 1,040 biological family members, and 399 spouses/partners. This analysis highlights the interviews, augmented by survey findings. Probands and family members attribute great predictive power and lifesaving potential to genomic information. A majority hold that a proband’s genomic results relevant to family members’ health ought to be offered. While informants endorse each individual’s choice whether to learn results, most express a strong moral responsibility to know and to share, particularly with the younger generation. Most have few concerns about sharing genetic information within the family; rather, their concerns focus on the health consequences of not sharing. Conclusions: Although additional studies in diverse populations are needed, policies governing return of genomic results should consider how families understand genomic data, how they value confidentiality within the family, and whether they endorse an ethics of sharing. A focus on respect for individual privacy—without attention to how the broad social and cultural context shapes preferences within families—cannot be the sole foundation of policy. (shrink)

We clarify options for conceptualizing equity, or what we refer to as justice, in resource allocation. We do this by systematically differentiating, expounding, and then illustrating eight different substantive principles of justice. In doing this, we compare different meanings that can be attributed to “need” and “the capacity to benefit”. Our comparison is sharpened by two analytical tools. First, quantification helps to clarify the divergent consequences of allocations commended by competing principles. Second, a diagrammatic approach developed by economists Culyer and (...) Wagstaff offers a visual and conceptual aid. Of the eight principles we illustrate, only two treat as relevant both a person’s initial health state and a person’s CTB per resource unit expended: allocate resources so as to most closely equalize final health states and allocate resources so as to equally restore health states to population norms. These allocative principles ought to be preferred to the alternatives if one deems relevant both a person’s initial health state and a person’s CTB per resource unit expended. Finally, we examine some possibilities for conceptualizing benefits as relative to how badly off someone is, extending Parfit’s thought on Prioritarianism. Questions arise as to how much intervention effects accruing to the worse off count for more and how this changes with improving health. We explicate some recent efforts to answer these questions, including in Dutch and British government circles. These efforts can be viewed as efforts to operationalize need as an allocative principle. Each effort seeks to maximize in the aggregate quanta of effect that are differentially valued in favor of the worst off. In this respect, each effort constitutes one type of Prioritarianism, which Parfit failed to differentiate from other types. (shrink)

ABSTRACTThis study aimed to investigate the association of locus of control with reading and mathematics achievement of high school students with disabilities using data from the Special Educ...

Lower plasma levels of high-density lipoproteins in adolescents with type 2 diabetes have been associated with a higher pulse wave velocity, a marker of arterial stiffness. Evidence suggests that HDL proteins or particle subspecies are altered in T2D and these may drive these relationships. In this work, we set out to reveal any specific proteins and subspecies that are related to arterial stiffness in youth with T2D from proteomics data. Plasma and PWV measurements were previously acquired from lean and T2D (...) adolescents. Each plasma sample was separated into 18 fractions and evaluated by mass spectrometry. Then, we applied a validated network-based computational approach to reveal HDL subspecies associated with PWV. Among 68 detected phospholipid-associated proteins, we found that seven were negatively correlated with PWV, indicating that they may be atheroprotective. Conversely, nine proteins show positive correlation with PWV, suggesting that they may be related to arterial stiffness. Intriguingly, our results demonstrate that apoA-I and histidine-rich glycoprotein may reverse their protective roles and become antagonistic in the setting of T2D. Furthermore, we revealed two arterial stiffness-associated HDL subspecies, each of which contains multiple PWV-related proteins. Correlation and disease association analyses suggest that these HDL subspecies might link T2D to its cardiovascular-related complications. (shrink)

ABSTRACT This essay is a critical study of Jason Brennan's Against Democracy. We make three main points. First, we argue that Brennan's proposal of a right to competent government only works if one considers the absence of government a viable proposition, something most of his opponents are not prepared to do. Second, we suggest that Brennan's account of competent decision-making is blind to forms of oligarchic power that work against the very ideals of justice and epistemic virtue that competence (...) is meant to safeguard. Third, we muster empirical evidence to argue that, in the real world, democracy is not just about making decisions and selecting policies, in which case Brennan's argument misses its mark. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Torah and Law in “Paradise Lost,”Gordon TeskeyTorah and Law in “Paradise Lost,” by Jason P. Rosenblatt; Princeton: Princeton University Press, 1994, $39.50.The epic project that includes the poems Paradise Lost and Paradise Regained marks the last occasion in Europe when the most ambitious literary form sought stability in theology rather than in philosophy. The philosophical poem, a minor form before the Enlightenment, became after Milton the (...) general idea of what a great long poem should be. One thinks of Faust, naturally enough, where the triumph of philosophy over theology is enacted, of Coleridge’s youthful plans for a philosophical epic, and of Wordsworth’s qualified achievement of it in The Prelude. Hegel said that art, having been supplanted by philosophy as the discourse of truth, must be for us a thing of the past. A less striking but perhaps more accurate statement would be that the art that once sought stability in the knowledge of God now seeks it in the impersonal knowledge of truth. The Milton who, before Paradise Lost, composed for his own use a theological treatise in which every point made is anchored in scripture, belongs to an earlier age. Yet there are in him clear indications of what is to come. No poet before Milton is so preoccupied with metaphysical questions, with the ultimate nature of being and the causative principles governing creation.It is the theological Milton with which Jason P. Rosenblatt is concerned in this fine study of Paradise Lost, a study that is more controversial than is suggested by its title or by its eirenic scholarly tone. The book is an attack on what its author regards as the Pauline bias of Milton studies in the tradition of A. S. P. Woodhouse and Arthur Barker. It is a bias, persisting even in Miltonists who are unconcerned with theological questions, against Hebraism in general and the “Old Law” in particular, the system of law referred to as Torah. Expressed in positive terms, Rosenblatt’s aim is to show how Milton’s prose tracts of 1643–1645 (the tracts on divorce) are “the principal doctrinal matrix of the middle books of Paradise Lost” (p. ix), that is, of the books in which human beings are shown in the state of innocence, giving us a utopian model [End Page 546] of what we should strive for in our own lives. But the Hebraic ethos of Eden gives way in the later books of the epic, after the Fall, to a Pauline perspective where the Law is an evil that stands in the way of our freedom. Whereas Pauline theology condemns the Hebrew Law as a law of bondage, Torah, like the Tao, is a means to live freely in accord with the law of one’s nature. Such law is felt not as a restraint but as a path. Rosenblatt suggests that Paradise Lost is not the unified, orthodox Christian vision Woodhouse claimed it to be but a work that undergoes radical ideological change after the Fall, reenacting the historical change brought about by Christianity itself.In the 1640s Milton embarked on an arduous program of Hebraic studies, spurred on by his desire to recuperate the one Mosaic law Christ explicitly overturned: that permitting divorce for causes other than fornication, a word that, as Milton’s Satan says of another, bears no single sense. After the exaggerated assessments, earlier this century, of Milton’s Hebrew erudition an over-correction set in, asserting that because Milton resorted to secondary sources, reference works, and translations his Hebrew learning was shallow. But Milton never pretended to be a Hebrew or an Aramaic scholar. He knew the languages and used them to learn more, as he used and acknowledged the work of great scholars like Selden; and for an amateur his attainments were truly remarkable. Miltonists will value this book for its balanced, expert reassessment of the poet’s Hebrew learning. And it will be especially appreciated by Miltonists for the new insight it brings to the importance of the divorce tracts of the 1640s for the representation of human innocence in Paradise Lost.For most readers the book will be of interest as... (shrink)

Puts Schelling in conversation with twentieth-century continental philosophy.

This textbook offers a dynamic new approach to logic with emphasis on the development of skills. The reader learns to use practical guidelines and helpful hints in dealing with statements, questions and their presuppositions, single and multiple arguments, and dialogues as they occur in ordinary language.Symbolic logic is presented in a clear and measured fashion with an eye to ordinary language applications. The reader is introduced to natural deduction through the use of proof constructions based on a core set of (...) simple rules.This text also presents a fresh approach to traditional logic though set theory. Carroll diagrams are used in place of Venn diagrams in order to help develop a more intuitive understanding of syllogisms. (shrink)

The purpose of this book is expressed in its title. It is an essay, an attempt to explore the ways in which the medieval outlook on the world was changing and giving place to the fourteenth century to new consessions that were ultimately to bring its supersession. It is not a survey, still less a textbook, but rather a delineation of what seem to me to have been the areas of fundamental change. It is, therefore, one individual's interpretation, much though (...) it owes to others. (shrink)

Some feminists and animal advocates defend what I call the Linked Oppressions Thesis, according to which the oppression of women and the oppression of animals are linked causally, materially, normatively, and/or conceptually. Alasdair Cochrane offers objections to several versions of the Linked Oppressions Thesis and concludes that the Thesis should be rejected in all its forms. In this paper I defend the Thesis against Cochrane's objections as well as objections leveled by Beth Dixon, and argue that the failure of these (...) objections illuminates the idea of linked oppressions as well as misunderstandings of the Linked Oppressions Thesis, and may provide guidance to philosophers theorizing animal rights from a feminist perspective. (shrink)

Politics, Philosophy & Economics, Volume 21, Issue 4, Page 415-436, November 2022. Recent debates over ideal theory have reinvigorated interest in the question of anarchy. Would a perfectly just society need—or even permit—a state? Ideal anarchists such as Jason Brennan, G.A. Cohen, Christopher Freiman, and Jacob Levy argue that strict compliance with justice obviates the need for a state. Ideal statists such as David Estlund, Gregory Kavka, and John Rawls think that coercive political institutions serve indispensable functions even in (...) ideal conditions. This paper defends ideal anarchism. Our argument begins by describing a camping trip inspired by Cohen that illustrates why an anarchist form of cooperation is more intrinsically desirable than the statist alternative. After detailing Rawls's ideal theory and Estlund's “nonconcessive” moral theory, we argue—contrary to Rawls, Estlund, and Kavka—that large-scale societies without moral imperfection do not need a state. (shrink)

Prey-catching behavior (PCB) in frogs and toads has been the focus of intense neuroethological research from the mid-twentieth century to the present and epitomizes some major themes in science and philosophy during this period. It reflects the movement from simple reflexology to more complex views of instinctive behavior, but it also displays a neural reductionism that denies subjectivity and individual agency The present article engages contemporary PCB research but provides a philosophically more promising picture of it based on Whitehead's nonreductionist (...) "philosophy of organism," which proposes that the flow of events from stimulus to response in organisms of all kinds is mediated by "the intervening touch of mentality " This approach resolves some basic mind-body and mind-nature issues that have long bedeviled modern philosophy and presents an image of a postmodern frog for a constructively postmodern science. (shrink)

I begin by examining how genetics drivesschizophrenia research, and raise both familiar andrelatively novel criticisms of the evidence putativelysupporting the genetic basis of schizophrenia. Inparticular, I call attention to a set of concernsabout the effects of placentation on concordance ratesof schizophrenia in monozygotic twins, which furtherweakens the case for schizophrenia''s so-called stronggenetic component. I then underscore two criticalpoints. First, I emphasize the importance of takingseriously considerations about the complexity of bothontogenesis and the development of hereditarydiseases. The recognition of developmentalconstraints and (...) supports is crucial, for attention todevelopment exposes the naivete of too many models ofgene action in the aetiology of disease. Secondly, Iattend to those schizophreniologists who ignoremethodological criticisms and thus presume a geneticbasis for schizophrenia, and then seek the schizophrenic genotype lacking an adequatephenotype. In response I attempt to demonstrate thenecessity of a sustained effort at characterizing thephenotype of schizophrenia as an enabling conditionfor the whole enterprise of psychiatric genetics – andfor psychiatry itself. Without the organism-levelphenotype, research at the level of genes will remainunproductive – assuming of course that research at thegenetic level is appropriate at all. (shrink)

In a critical discussion, interlocutors can strategically maneuver by shading their expressed degree of standpoint commitment for rhetorical effect. When is such strategic shading reasonable, and when does it cross the line and risk fallacious derailment of the discussion? Analysis of President George W. Bush’s 2002–2003 prewar commentary on Iraq provides an occasion to explore this question and revisit Douglas Ehninger’s distinction between argumentation as coercive correction and argumentation as a person-risking enterprise. Points of overlap between Ehninger’s account and pragma-dialectical (...) argumentation theory suggest avenues for harmonization of rhetorical and dialectical perspectives on argumentation. Out of this conceptual convergence comes theoretical resources for understanding strategic maneuvering, by accounting for ways that discussants exploit gaps between their externalized and actual discussion attitude. As such higher-order strategic maneuvering played a major role in the 2003 Iraq prewar discourse failure, perspicacious understanding of this particular argumentative maneuver carries practical, as well as theoretical import. (shrink)

We agree with Emily Walsh (2020) that the current preferences of patients with dementia should sometimes supersede those patients’ advance directives. We also agree that consensus clinical ethics guidance does a poor job of explaining the moral value of such patients’ preferences. Furthermore, Walsh correctly notes that clinicians are often averse to treating patients with dementia over their objections, and that this aversion reflects clinical wisdom that can inform revisions to clinical ethics guidance. But Walsh’s account of the moral value (...) of the preferences of patients with dementia suffers from three major problems: (1) it does not engage the actual practices of clinical ethics; (2) it provides an inadequate account of why these patients’ preferences matter; and (3) it offers a poor explanation of clinicians’ intuitions in these cases. Her arguments engage a philosophical debate that is largely irrelevant to clinical practice and she therefore leaves pressing real-world clinical ethics questions unaddressed. After underscoring some of Walsh’s main points, we will discuss each of these shortcomings. (shrink)

I argue that the simple foreknowledge view, according to which God knows at some time t 1 what an agent S will do at t 2 , is incompatible with human free will. I criticize two arguments in favor of the thesis that the simple foreknowledge view is consistent with human freedom, and conclude that, even if divine foreknowledge does not causally compel human action, foreknowledge is nevertheless relevantly similar to other cases in which human freedom is undermined. These cases (...) include those in which certain human actions are logically, rather than causally, foreclosed. (shrink)

Today the ethical and normative concerns of everyday citizens are all too often sidelined from the study of political and social issues, driven out by an effort to create a more "scientific" study. This book offers a way for social scientists and political theorists to reintegrate the empirical and the normative, proposing a way out of the scientism that clouds our age. In Alasdair MacIntyre, Charles Taylor, and the Demise of Naturalism: Reunifying Political Theory and Social Science, Jason Blakely (...) argues that the resources for overcoming this divide are found in the respective intellectual developments of Charles Taylor and Alasdair MacIntyre. Blakely examines their often parallel intellectual journeys, which led them to critically engage the British New Left, analytic philosophy, phenomenology, continental hermeneutics, and modern social science. Although MacIntyre and Taylor are not sui generis, Blakely claims they each present a new, revived humanism, one that insists on the creative agency of the human person against reductive, instrumental, technocratic, and scientistic ways of thinking. The recovery of certain key themes in these philosophers' works generates a new political philosophy with which to face certain unprecedented problems of our age. Taylor's and MacIntyre's philosophies give social scientists working in all disciplines (from economics and sociology to political science and psychology) an alternative theoretical framework for conducting research. "This book does an excellent job in identifying a real problem in mainstream political theory--its overly normative character and its separation from social science. It contains many original contributions to the field. I particularly liked the way in which the problems of naturalism are presented as institutional, cultural, and political as well as philosophical. The historical background to these problems is also interesting and sheds fresh light on the issues." --Nicholas Smith, Macquarie University. (shrink)

David Hume was a great philosopher of religion and of common life. In this essay, I interpret him as making extreme religious skepticism one part of his overall rhetorical form. In all his religious writings, however, Hume always takes a step back from Pyrrhonian style results to a position that is more compatible with common life. The great twentieth-century religious studies scholar, Ninian Smart, offers seven dimensions of religion which show the extent to which it is thoroughly entwined with the (...) practices and beliefs of ordinary human life, and this connection to ordinary life makes Smart’s divisions a nice match for Hume and his philosophy of common life. I elucidate the ways in which Hume’s philosophy contributes to our understanding of religion in terms of Smart’s dimensions, and in each case, I argue that Hume treats religion not from the perspective of a hostile enemy, but as a student of religion who grounds it in common life and seeks to correct it from that vantage point. (shrink)

This squib investigates the nature and syntactic placement of the restriction of quantificational determiners under the copy theory of movement and presents a brief argument from the interaction of antecedent-contained deletion (ACD) and Principle C that while relative clauses in ACD must be deleted from their base positions, complements and adjuncts in NP need not be, and hence must not be.

Calls for incorporating social science into patient care typically have accounted for neither the logistic constraints of medical training nor the methodological fallacies of utilizing aggregate “social facts” in clinical practice. By elucidating the different epistemic approaches of artistic and scientific practices, this paper illustrates an integrative artistic pedagogy that allows clinical practitioners to generate social scientific insights from actual patient encounters. Although there is no shortage of calls to bring social science into medicine, the more fundamental processes of thinking (...) by which art and science proceed have not been addressed to this end. As such, the art of medical practice is conceptualized as an innate gift, and thus little is done to cultivate it. Yet doing so is more important than ever because uncertainty in diagnosing and treating chronic illnesses, the most significant contemporary mortality risks, suggests a re-expanding role for clinical judgment. (shrink)

Calls for the “translation” of research from bench to bedside are increasingly demanding. What is translation, and why does it matter? We sketch the recent history of outcome-oriented translational research in the United States, with a particular focus on the Roadmap Initiative of the National Institutes of Health. Our main example of contemporary translational research is stem cell research, which has superseded genomics as the translational object of choice. We explore the nature of and obstacles to translational research and assess (...) the ethical and biomedical challenges of embracing a translational ethos. (shrink)

The emergence of Bildwissenschaft as a new interdisciplinary formation that is intended to encompass all images calls for an analysis of the grounds on which the claim to universality can be upheld. I argue that whereas the lifting of scope restrictions imposes only a weak universality requirement, the identification of features that belong to the entire class of entities that are categorized as images imposes a strong universality requirement. Reflection on this issue brings into focus the distinctive character of Bildwissenschaft (...) and the features that distinguish it not only from other related disciplines such as art history and visual studies, but also from recent work in the philosophy of the image. (shrink)

The book brings together thirteen essays presented to medical and psychiatric societies, mainly during the 1970's and 1980's. In these essays, Gadamer justifies the reasons for a philosophical interest in health and medicine, and a corresponding need for health practitioners to enter into a dialogue with philosophy.

The article focuses on the theme of Christian identity presented by both Faustus and Augustine. It highlights how Faustus emphasises ethical and moral issues as the hallmarks of Christian identity, whereas, according to him, Nicene Christians gave more importance to dogmatic issues and neglected ethical elements. Some texts from the Contra Faustum are quoted to support the differences between the two Christian identities, both the Manichaean and the Catholic or Nicene Christian.

In Volume Three of Capital in a striking but somewhat uncharacteristic formula, Marx argues that the labor relation is the “hidden basis” of the entire social edifice including the state and politics. As an attempt to clarify and develop this insight I examine the dual nature of labor as abstract and concrete labor, arguing that the two sides of labor correspond not just to two sides of the commodity, but to different ethics and alienations of labor, and ultimately to different (...) philosophical anthropologies. (shrink)

This essay is focused upon the question raised by the economic historian Andrei Znamenski: was National Socialism really socialist? I lay out his answer—that indeed it was—and explore it. I introduce the notion of neo-socialism as a way to characterize the Nazi regime, and fascist regimes more generally. I explore the key role played in the development of this ideology a number of thinkers called by Jeffrey Herf “reactionary modernists”: Ferdinand Tonnies; Werner Sombart; Hans Freyer; Martin Heidegger; Ernst Junger; Carl (...) Schmitt; and (to a lesser degree) Oswald Spengler. I conclude the essay by explaining the role of the uniquely virulent Nazi anti-Semitism—as well as the changes of the breakout of the war in 1939—played in the decision to exterminate the Jews. (shrink)

In 1927, Winthrop Bell inaugurated the teaching of phenomenology in the English-speaking world, with his course “Husserl and the Phenomenological Movement” at Harvard University. The seminar shows ways to introduce phenomenology to students who have a philosophical background, but who do not yet know phenomenology. Additionally, it reveals phenomenology’s relations to pragmatism, analytic philosophy, and the broader continental tradition. Bell, as the first Anglophone student who wrote his dissertation with Husserl, enjoyed a privileged access to his phenomenological teachers, with whom (...) he studied between 1911-1914, during the time of Husserl’s publication of the Ideen and Scheler’s publication of his Formalism in Ethics. Bell, relying not only on Husserl’s and Scheler’s books but on his own detailed notes from his studies with these founding figures, shows students the germination of the movement, and its most fundamental ideas: its understanding of the a priori and its relation to induction, the nature of intentionality, the relation of idealism and empiricism, along with studies of attention, fulfillment, and meaning. Given phenomenology’s important influences on the North American curriculum, attention to Bell’s seminar can show us how this influence begin, and why phenomenology has become and remained such an important influence in English and in North American philosophy. (shrink)

American Catholic Philosophical Association President James Marsh is calling for a “Philosophy after Catonsville.” This paper begins by examining Catonsvilleas specifically American, Catholic, and philosophical. “Wildness” is then presented as it has emerged recently as a category in environmental philosophy andis shown to necessitate a social ecology for Catonsville. Finally, Marsh’s problematic relationship to ecology will be presented and resolved by discussing the necessary entailment of social ecology by his trilogy of Post-Cartesian Meditations, Critique, Action, and Liberation, and Process, Praxis, (...) and Transcendence. By the end of this paper, wildness will have established a crucial connection between Catonsville, Marsh’s “greened” critical theory, and social ecology as a necessary condition for the possibility of a “Philosophy after Catonsville.”. (shrink)