BackgroundSubjective cognitive decline, non-amnestic mild cognitive impairment, and amnestic mild cognitive impairment are regarded to be at high risk of converting to Alzheimer’s disease. Amplitude of low-frequency fluctuations can reflect functional deterioration while diffusion tensor imaging is capable of detecting white matter integrity. Our study aimed to investigate the structural and functional alterations to further reveal convergence and divergence among SCD, naMCI, and aMCI and how these contribute to cognitive deterioration.MethodsWe analyzed ALFF under slow-4 and slow-5 bands and white matter (...) fiber integrity among normal controls, SCD, naMCI, and aMCI groups. Correlation analyses were further utilized among paired DTI alteration, ALFF deterioration, and cognitive decline.ResultsFor ALFF calculation, ascended ALFF values were detected in the lingual gyrus and superior frontal gyrus within SCD and naMCI patients, respectively. Descended ALFF values were presented mainly in the LING, SFG, middle frontal gyrus, and precuneus in aMCI patients compared to CN, SCD, and naMCI groups. For DTI analyses, white matter alterations were detected within the uncinate fasciculus in aMCI patients and within the superior longitudinal fasciculus in naMCI patients. SCD patients presented alterations in both fasciculi. Correlation analyses revealed that the majority of these structural and functional alterations were associated with complicated cognitive decline. Besides, UF alterations were correlated with ALFF deterioration in the SFG within aMCI patients.ConclusionsSCD shares structurally and functionally deteriorative characteristics with aMCI and naMCI, and tends to convert to either of them. Furthermore, abnormalities in white matter fibers may be the structural basis of abnormal brain activation in preclinical AD stages. Combined together, it suggests that structural and functional integration may characterize the preclinical AD progression. (shrink)

本书内容包括:杨献珍哲学思想生成与发展的历史回溯,杨献珍的唯物论思想,杨献珍的认识论思想,杨献珍的辨证法思想等.

Critical edition of the portion of Tattvacintāmaṇi of Gaṅgésa, 13th cent., basic work on Hindu logic and epistemology of the neo-Nyaya school in Hindu philosophy.

本书收录了伦理学基础理论研究方面的诸多成果,对道德是什么,道德的评价标准是什么,道德的原则以及价值理性与科技理性的关系等基本问题进行了许多研究.

Basic work, with 15th century commentary, of the neo-Nyaya school in Indic philosophy; portion dealing with analogy (upamāna).

Portion of Tattvacintāmaṇi dealing with syllogism (avayava); includes commentaries and supercommentary.

Wen ji" fen wei "Wo de xue shu chuang xin zhi lu (dai zi xu)" he "Ming dai zhu ming zhe xue jia Wang Tingxiang yan jiu"(di 1-2 juan), "Zhongguo zhe xue Fan Chou shi yan jiu" (di 3-4 juan), "Zhongguo shi xue yu Dong Ya shi xue yan jiu", "Zhongguo guan li zhe xue yan jiu" (di 5-6 juan), "Zhonguo zhe xue ji qi xian dai quan shi lun ji" (di 10-12 juan) wu da ban kuai.

Portion of Pratyakṣakhaṇḍa of Tattvacintāmaṇi, compendium of Navya Nyāya philosophy by Gaṅgeśa, 13th century with Dīpikā commentary.

Sanskrit text, portion of Tattvacintāmaṇi dealing with syllogism (avayava) ; with commentary and supercommentary, of the Navya-Nyaya school in Indic philosophy.

Women entrepreneurs innovate, initiate, engage, and run business enterprises to contribute the domestic development. Women entrepreneurs think and start taking risks of operating enterprises and combine various factors involved in production to deal with the uncertain business environment. Entrepreneurship and technological innovation play a crucial role in developing the economy by creating job opportunities, improving skills, and executing new ideas. It has a significant impact on the income of the household. The study focused on investigating the role of women’s entrepreneurship (...) and innovation technologies in contributing to household income in the challenging situation of the pandemic COVID-19. The paper emphasized identifying the determinants of female entrepreneurial contribution toward household income. This study collected data from selected rural and urban areas of district Faisalabad through a self-administered questionnaire. Investigators interviewed female entrepreneurs and chose them through the snowball sampling technique from a population of purposively selected female-run businesses. Interviews were conducted with women entrepreneurs to gather relevant information for the survey investigation at their workplaces and home. The effects of various factors, including age, education, family size, income from other sources, time allocated to entrepreneurial activity, firm size, and location (rural/urban) were estimated empirically using an ordered logit model. The study findings exhibited a positive and significant role of respondents’ education, family size, time allocated to entrepreneurial activities, and firm size. The survey outcomes also indicated that the contribution of entrepreneurial income to household income in the rural areas is significantly higher than that in urban areas. This study signifies that regulations against gender discrimination in public and private institutions are helpful. Besides, encouraging an environment for entrepreneurial culture among women in the country would increase family income. The study’s findings and policy implications directly link to Sustainable Development Goal (SDGs) 5 of Gender Equality (GE) and SDG 8 related to decent work and economic growth. (shrink)

Selection of author's works on Svātantrika Madhyamika philosophy and logic.

Aujourd'hui la notion de nature est omniprésente : le mot se trouve au coeur des réflexions écologiques mais sert aussi d'argument publicitaire pour les produits les plus divers de l'industrie agroalimentaire à la cosmétique. Cependant, les usages actuels et multiformes de cette notion se trouvaient déjà dans les débats du siècle des Lumières. Alors que les fondements religieux de la société s'effritaient sous l'effet de la division du christianisme et de la révolution scientifique, la Nature cessait d'être l'oeuvre divine offerte (...) à la contemplation pour devenir l'objet de la science. Elle devint aussi le pivot d'un basculement culturel, social et politique lorsqu'on opposa à la religion révélée la religion naturelle, au droit divin le droit naturel. Si la dialectique entre la raison et la nature ouverte au XVIIIe siècle se poursuit, un retour sur ce thème des Lumières à nos jours éclaire l'actualité de ce début du XXIe siècle. Les articles réunis dans cet ouvrage s'intéressent successivement à l'idée de nature dans les sciences, les techniques, les arts, le droit et la politique ainsi qu'à l'héritage actuel de ces débats. (shrink)

" L'état social n'est avantageux aux hommes qu'autant qu'ils ont tous quelque chose et qu'aucun d'eux n'a rien de trop " écrit Rousseau. Une certaine redistribution des richesses est donc le préalable obligé d'une vie politique qui ne tourne pas à la domination des uns sur les autres. Le présent essai retrace la genèse de l'inégalité telle que Rousseau la conçoit et en analyse les conséquences. Rousseau ou la révolution impossible constitue ainsi une introduction à la lecture du Discours sur (...) l'origine de l'inégalité et du Contrat social. Mais, par delà l'éclairage apporté à des textes parfois difficiles, tous ceux qui ne se satisfont pas du cours pris par la vie politique dans les démocraties contemporaines devraient y trouver de quoi nourrir leur réflexion critique. (shrink)

This study investigates how board size and occupational background of directors differentially influence social performance in for-profit and non-profit organizations. Using data from California hospitals, we develop a quantitative measure of social performance and provide the following empirical evidence. First, board size is negatively (positively) associated with social performance in for-profit (non-profit) hospitals. Second, the presence of government officials on the board is negatively (positively) related to social performance in for-profit (non-profit) hospitals. Third, representation of physicians on the board is (...) positively associated with social performance in for-profit hospitals, whereas their presence is not significantly related to social performance in non-profit hospitals. Our findings highlight the different effects of governance mechanisms on social performance in for-profit and non-profit organizations. (shrink)

A quoi réent les machines? La question peut paraître étrange. C’est cependant une manière d’interroger nos propres rêveries autour des réalisations techniques, en faisant jouer aux machines le rôle de reflet de nos propres existences. A travers de nombreux artifices, dont les machines sont les plus élaborés, nous construisons notre monde, enchevêtrant raison et imaginaire et mêlant utile et gratuit. La machine et ses rêves nous renvoient alors une image éclairée de nous-mêmes. Ce jeu de miroir Ne pose-t-il pas la (...) question de savoir si, au bout de toute philosophique interrogation, nous ne serions pas plutôt des machines rêvant de devenir des humains. Ainsi, cette question ouvre une enquête sur l’imaginaire attaché aux machines, des premiers automates à l’ombre du cyborg, La définition rigoureuse de la machine, tentée en début d’ouvrage, se trouve, au fil des pages, débordée sur les frontières ténues entre raison technicienne et imaginaire. Ces rêveries de la machine ont finalement été prises au sérieux par les artistes, depuis Duchamp et Léger, jusqu’aux formes contemporaine de l’art numérique, en passant par Tinguely et Schöffer. S’intéresser aux rêves des machines, c’est prendre conscience qu’avec elles s’insinuent des parts d’ombre et de lumière. Car le songe ne va jamais sans risque. Humains nous sommes des êtres du désir, mais nous sommes aussi des êtres de l’artifice. C’est sur ce terrain-là que cet ouvrage entraîne notre réflexion, au-delà de l’opposition trop simple entre technologie naïve et technologie paralysante. (shrink)

Using Hofstede's culture theory (1980, 2001 Culture's Consequences: Comparing Values, Behaviours, Institutions, and Organizations Across Nation. Sage, NewYork), the current study incorporates the moral development (e.g. Thorne, 2000; Thorne and Magnan, 2000; Thorne et al., 2003) and multidimensional ethics scale (e.g. Cohen et al., 1993; Cohen et al., 1996b; Cohen et al., 2001; Flory et al., 1992) approaches to compare the ethical reasoning and decisions of Canadian and Mainland Chinese final year undergraduate accounting students. The results indicate that Canadian accounting (...) students' formulation of an intention to act on a particular ethical dilemma (deliberative reasoning) as measured by the moral development approach (Thorne, 2000) was higher than Mainland Chinese accounting students. The current study proposes that the five factors identified by the multidimensional ethics scale (MES), as being relevant to ethical decision making can be placed into the three levels of ethical reasoning identified by Kohlberg's (1958, The Development of Modes of Moral Thinking and Choice in the Years Ten to Sixteen. University of Chicago, Doctoral dissertation) theory of cognitive moral development. Canadian accounting students used post-conventional MES factors (moral equity, contractualism, and utilitarianism) more frequently and made more ethical audit decisions than Chinese accounting students. (shrink)

La 4e de couverture indique : "Le monde contemporain a plus que jamais besoin des éclairages de la sociologie : post-truth society, instabilité politique dans les pays démocratiques, montée des populismes... Mais cette discipline à vocation scientifique est prise en otage par ceux qui veulent en faire un « sport de combat » politique. Ce livre s'adresse donc à tous ceux qui s'intéressent aux faits sociaux et sont inquiets ou étonnés des dérives intellectuelles de certaines figures reconnues des sciences humaines (...) et sociales. Les sociologues ne sont pas immunisés contre les biais cognitifs qui peuvent nous égarer dans des récits idéologiques et outranciers : dans ce cas, toutes les conditions sont présentes pour que la sociologie « tourne » en une production plus militante que proprement scientifique. Il est donc temps pour eux de sortir de leur sommeil dogmatique et de s'astreindre aux règles qui régissent la cité des sciences. C'est ce que ce livre propose, en convoquant des données issues tout aussi bien de la sociologie que des sciences du cerveau dans le but de rendre accessibles aux non-spécialistes les enjeux fondamentaux que représente ce continent de la pensée.". (shrink)

Over the course of the past forty years, Ge;rard Genette’s work has profoundly influenced scholars of narratology, poetics, aesthetics, and literary and cultural criticism, and he continues to be one of France’s most influential theorists. The eighteen pieces in Essays in Aesthetics are of international interest because they are concerned either with universal aesthetic problems (the receiver’s relationship to an aesthetic object, abstract art, the role of repetition in aesthetics, genre theory, and the rapport between literature and music) or with (...) specific moments in the work of a well-known writer or artist (such as Stendhal, Proust, Manet, Pissarro, and Canaletto). Essays in Aesthetics contains a wealth of material related to the appreciation of beauty by one of the subtlest and most original minds working in aesthetics today. Genette knows the fine arts as well as he knows literature and as a result has innovative things to say to readers in that field as well as to philosophers and literary scholars. (shrink)

This book contributes to the developing dialogue between cognitive science and social sciences. It focuses on a central issue in both fields, i.e. the nature and the limitations of the rationality of beliefs and action. The development of cognitive science is one of the most important and fascinating intellectual advances of recent decades, and social scientists are paying increasing attention to the findings of this new branch of science that forces us to consider many classical issues related to epistemology and (...) philosophy of action in a new light. This book encourages scholars from different fields who are interested in the dialogue between cognitive science and social sciences, to develop and analyze new perspectives that allow us to elucidate the mystery of rationality. What is rationality? What are its limitations? What rationality assumptions must be used to study social and economic phenomena? The target audience primarily comprises researchers and experts in the field. Analysis of the concept of rationality is a leitmotiv in the history of the social sciences and has involved endless disputes. Since it is difficult to give a precise definition of this concept, and there is a lack of agreement about its meaning, it is possible to say that there is a ‘mystery of rationality’. What is it to be rational? Is rationality merely instrumental or does it also involve the endorsement of values, i.e. the choice of goals? Should we consider rationality to be a normative principle or a descriptive one? Can rationality be only Cartesian or can it also be argumentative? Is rationality a conscious skill or a partly tacit one? This book, which has been written by an outstanding collection of authors, including both philosophers and social scientists, tries to make a useful contribution to the debates on these problems and shed some light on the mystery of rationality. (shrink)

_Uses the concept of religiosity to challenge traditional views of Nietzsche and Zhuangzi as nihilistic and anti-religious._.

Based on signaling theory, we explore the impact of corporate fraud on firms’ innovation performance. First, we propose that corporate fraud harms firms’ innovation performance. This is because, as a negative signal, fraud makes it difficult for firms to obtain the policy, funding, and human resources needed for outstanding innovation performance. We further argue that the institutional aspects of the signaling environment (e.g., industrial competition, regional institutional development, and social trust) will influence core stakeholders’ reception and interpretation of fraud signals. (...) These factors, in turn, moderate the signaling effect of corporate fraud on firms’ innovation performance. Our views are supported by empirical and robustness tests using Chinese A‐share listed firms from 2010 to 2019. (shrink)

Supercommentary on the concept of pervasion (vyāpti) from a topic in Tattvacintāmaṇi, a basic neo-Nyaya work by Gaṅgeśa.

The explosion in sequencing technologies has provided us with an instrument to describe mammalian transcriptomes at unprecedented depths. This has revealed that alternative splicing is used extensively not only to generate protein diversity, but also as a means to regulate gene expression post‐transcriptionally. Intron retention (IR) is overwhelmingly perceived as an aberrant splicing event with little or no functional consequence. However, recent work has now shown that IR is used to regulate a specific differentiation event within the haematopoietic system by (...) coupling it to nonsense‐mediated mRNA decay (NMD). Here, we highlight how IR and, more broadly, alternative splicing coupled to NMD (AS‐NMD) can be used to regulate gene expression and how this is deregulated in disease. We suggest that the importance of AS‐NMD is not restricted to the haematopoietic system but that it plays a prominent role in other normal and aberrant biological settings. (shrink)

En associant philosophie et logique, cet ouvrage apporte un éclairage sur l'évolution de la logique de l'époque d'Aristote à nos jours. Il présente les différents formalismes des logiques non-standard en expliquant tout d'abord les besoins de ces logiques puis leurs descriptions syntaxiques et sémantiques. A l'aide d'exercices, il offre un panorama de ces logiques qui sont complexes à " utiliser " pour modéliser des connaissances permettant ainsi aux lecteurs d'appréhender ce domaine.

La question “qu'est-ce que l'homme, quelle est sa place dans le cosmos?” a occupé Scheler sa vie durant. Cette question, qu'il qualifie de métaphysique, possède chez lui non seulement une portée éthique mais est indissociable d'une critique de la civilisation. Elle se pose au regard d'une époque dans laquelle l'essence de l'homme est “devenue plus problématique que jamais”. Scheler en rend responsable le positivisme, le pragmatisme et l'évolutionnisme. C'est au cours de ce débat entre ces courants de pensée et les (...) sciences naturelles qu'il élabore son anthropologie philosophique, à laquelle il assigne la mission d'être une “métanthropologie”, c'est-à-dire de redonner sa place à une métaphysique qui prend l'homme pour centre. L'ouvrage rassemble des études originales, en français et en allemand, qui s'efforcent de dresser un bilan de la contribution philosophique de Max Scheler entre 1915 et 1925. (shrink)