Keratins are a family of intermediate filaments that serve various crucial roles in skin physiology. For mammalian skin to function properly, and to produce epidermal and hair keratins that are optimally adapted for their environment, it is critical that keratin gene and protein expression are stringently controlled. Given that the skin is not only targeted by multiple hormones, but also constitutes a veritable peripheral endocrine organ, it is not surprizing that intracutaneous keratin expression is underlined by tight endocrine controls. These (...) controls encompass thyroid hormones, steroid hormones such as glucocorticoids (GCs), retinoic acid (RA) and vitamin D, and several neuroendocrine mediators. Here, we review why a better understanding of the endocrine controls of keratin expression is not only required for an improved insight into normal human skin and hair function, but may also open new therapeutic avenues in a wide range of skin and hair diseases. (shrink)

Human skin produces numerous neurohormones and neuropeptides. Recent evidence has shown that the neuroendocrine regulation of human skin biology also extends to keratins, the major structural components of epithelial cells. For example, thyrotropin‐releasing hormone, thyrotropin, opioids, prolactin, and cannabinoid receptor 1‐ligands profoundly modulate human keratin gene and protein expression in human epidermis and/or hair follicle epithelium in situ. Since selected keratins are now understood to exert important regulatory functions beyond mechanical stability, we argue that neuroendocrine pathways of keratin regulation are (...) important for maintaining skin and hair follicle homeostasis. This invites innovative neuroendocrine therapeutic interventions for skin disorders characterized by abnormal keratin expression, ranging from psoriasis to genodermatoses, and for promoting skin wound healing and hair growth. This strategy can be probed in simple, but instructive and readily available human skin and hair follicle organ culture assays as ideal models for exploring this new neuroendocrine frontier in translational epithelial biology. (shrink)

Currently, the dominant enforcement paradigm is based on the idea that states deal with 'bad people' - or those pursuing their own self-interests - with laws that exact a price for misbehavior through sanctions and punishment. At the same time, by contrast, behavioral ethics posits that 'good people' are guided by cognitive processes and biases that enable them to bend the laws within the confines of their conscience. In this illuminating book, Yuval Feldman analyzes these paradigms and provides a (...) broad theoretical and empirical comparison of traditional and non-traditional enforcement mechanisms to advance our understanding of how states can better deal with misdeeds committed by normative citizens blinded by cognitive biases regarding their own ethicality. By bridging the gap between new findings of behavioral ethics and traditional methods used to modify behavior, Feldman proposes a 'law of good people' that should be read by scholars and policymakers around the world. (shrink)

Dolev's ambitious project is to show that the traditional debate in the philosophy of time between the so-called ‘tensed’ and ‘tenseless’ theorists is not a sustainable one. The key to the negative portion argument is that both the tensed and tenseless view of time can be understood only from within their respective ontological frameworks. Moreover, that there is only really an appearance of understanding within these frameworks, since neither framework furnishes us with the wherewithal to genuinely understand temporal language. Moving (...) past these frameworks is the goal Dolev sets us. The positive aspect of the text tries to teach us how to transcend this merely ontological dispute and engage in phenomenological considerations of time itself. The conclusion to the positive project is that we cannot postulate an adequate metaphysical system of time, though we can understand what time is if we treat it as the time of our experiences in everyday life.The prospect that we might be able to move past the existing debate into fresh philosophical terrain is exciting. But I am not quite persuaded by the arguments that are intended to motivate the move to pastures new. First, on occasion Dolev seems to slightly …. (shrink)

In this paper I argue that physics is, always was, and probably always will be voiceless with respect to tense and passage, and that, therefore, if, as I believe, tense and passage are the essence of time, physics’ contribution to our understanding of time can only be limited. The argument, in a nutshell, is that if "physics has no possibility of expression for the Now", to quote Einstein, then it cannot add anything to the study of tense and passage, and (...) specifically, cannot add anything to the debate between deniers and affirmers of the existence or reality of tense and passage. Since relativity theory did not equip physics with a new language with which to speak of tense and passage, I draw the further conclusion that relativity theory has not generated the revolution to our conception of time that is attributed to it. In the last section I discuss the motivations behind the continued but misguided attempts to integrate tense into a relativistic setting, and assess the manners in which relativity theory has nevertheless enhanced, albeit indirectly, our understanding of tense and passage. (shrink)

What intelligent person has never pondered the meaning of life? For Yuval Lurie, this is more than a puzzling philosophical question; it is a journey, and in this book he takes readers on a search that ranges from ancient quests for the purpose of life to the ruminations of postmodern thinkers on meaning. He shows that the question about the meaning of life expresses philosophical puzzlement regarding life in general as well as personal concern about one’s own life in (...) particular. Lurie traces the emergence of this question as a modern philosophical quandary, riddled with shifts and turns that have arisen over the years in response to it. _Tracking the Meaning of Life _is written as a critical philosophical investigation stretching over several traditions, such as analytic philosophy, phenomenology, and existentialism. It maps out a journey that explores pivotal responses to this question, drawing especially on the thought of Tolstoy, Wittgenstein, Sartre, and Camus and exploring in depth the insights these thinkers offer regarding their own difficulties concerning the meaning of life. In the book’s four sections, Lurie discusses Tolstoy’s challenge to experience the religious and transcendental meaning of life by choosing a simple, hardworking existence; Wittgenstein’s focus on ethics and discovering the sense of the world, his conclusion that the question of the meaning of life makes no sense, and his turning to experience the mystical aspect of the world; Sartre’s positing of freedom as the basis of human life, stipulating a personal answer to the question of the meaning of life; and Camus’ view of the absurdity of life, unalleviated by any personal meaning. Guided by these views, Lurie imparts new insight to ideas that underlie our concern with life’s meaning, such as the difference between attitudes toward life and beliefs and opinions about life, the meaning of words versus the meaning of events, shared meanings versus personal meanings, and the link between ethics and personal identity. _Tracking the Meaning of Life_ is no mere dry philosophical study but a journey that dramatically illustrates the poignancy of the quest for meaning, showing that along the way it gradually becomes more obvious how personal meaning may be found in the pulsations of everyday life. The book offers stimulating reading not only for scholars in philosophy but also for general readers who wish to see how their personal concerns are echoed in modern philosophical thought. More than a description of a journey, it is a map to anxieties and puzzlements we all face, pointing to ideas that can guide readers on their own search for meaning. (shrink)

The paper examines the effects of intersecting social divisions on constructions of multi‐layered citizenships and the politics of belonging in contemporary Britain. It starts with conceptual clarifications of the notions of citizenship, belonging and intersectionality and then turns to examine contemporary politics of belonging in contemporary Britain, focusing on the current debate on the ‘death of multiculturalism’ and on ‘social cohesion’. It illustrates how the use of civic and democratic values as signifiers of belonging can end up as exclusionary, rather (...) than inclusionary in that discourse. (shrink)

Spinoza is commonly perceived as the great metaphysician of coherence. The Euclidean manner in which he presented his philosophy in the _Ethics _has led readers to assume they are facing a strict and consistent philosophical system that necessarily follows from itself. As opposed to the prevailing understanding of Spinoza and his work, _The Role of Contradictions in Spinoza's Philosophy_ explores an array of profound and pervasive contradictions in Spinoza’s system and argues they are deliberate and constitutive of his philosophical thinking (...) and the notion of God at its heart. Relying on a meticulous and careful reading of the _Theological-Political Treatise_ and the _Ethics_, this book reconstructs Spinoza's philosophy of contradictions as a key to the ascending three degrees of knowledge leading to the _Amor intellectualis Dei_. Offering an exciting and clearly-argued interpretation of Spinoza’s philosophy, this book will interest students and scholars of modern philosophy and philosophy of religion, as well as Jewish studies. Yuval Jobani is Assistant Professor at the Department of Hebrew Culture Studies and the School of Education at Tel-Aviv University. (shrink)

Mahloket [dispute] has been part of the human experience since time immemorial. Upon departure from the Garden of Eden the first mahloket arose between Cain and Abel - a conflict that ultimately led to bloodshed. Ever since, the phenomenon of mahloket has been a fact of life¿ The state of mahloket nowadays is lamentable. Debates on the internet are aggressive, even violent, seemingly governed solely by the law of the jungle. A terrible litany of personal attacks, lies, distortions, slander, invasion (...) of privacy, and an overall lack of civility abound¿ We are facing a critical threat to humanity in general, and to the State of Israel, the Jewish nation, and the Torah in particular.After years of exploring the topic of mahloket - recognizing its importance, its benefits, and its destructive potential - Rabbi Yuval Cherlow presents LeShem Shamayim, an ambitious and groundbreaking work on the ethics of public discourse. Drawing upon both the culture of debate embodied by generations of Jewish Sages and upon principles of postmodernism, Rabbi Cherlow has written a comprehensive code of ethics for conducting fair, productive discourse. (shrink)

Dreams are a remarkable experiment in psychology and neuroscience, conducted every night in every sleeping person. They show that the human brain, disconnected from the environment, can generate an entire world of conscious experiences by itself. Content analysis and developmental studies have promoted understanding of dream phenomenology. In parallel, brain lesion studies, functional imaging and neurophysiology have advanced current knowledge of the neural basis of dreaming. It is now possible to start integrating these two strands of research to address fundamental (...) questions that dreams pose for cognitive neuroscience: how conscious experiences in sleep relate to underlying brain activity; why the dreamer is largely disconnected from the environment; and whether dreaming is more closely related to mental imagery or to perception. (shrink)

1. Nicholas Robbins argues that, like many other thinkers, Hobbes adopted the monster genre narrative. The commonwealth is interpreted as representing humanity, which is frequently threatened not o...

In this paper I claim that as bitter as the eternalist/presentist rivalry is, as far as both camps are concerned, a third position—which I defend—is more disturbing. The reason is that what eternalists and presentists agree on is more fundamental than what they disagree about. They agree that time carves, to use Orilia’s term, “ontological inventories.” This in a way answers the “fundamental question”—what is time? They disagree about the contents of the inventories, but that, I suggest, is a secondary (...) issue. Thus, an argument against what they agree about would be more detrimental to their joint project—analyzing tense in ontological terms—than the internal disagreement they are engaged in. I develop this thesis by responding to Orilia’s paper “Two Metaphysical Perspectives on the Duration of the Present”. I criticize the specialized use Orilia makes of the notion of an “ontological inventory” in the context of the metaphysics of time, but also Quine’s approach to ontology, on which Orilia’s account relies. The gist of my criticism is that it is question begging to rely on the notion of an “ontological inventory” for giving content to the presentism/eternalism debate, and for arguing that there can’t be an alternative. (shrink)

We present and defend a view labeled “practiceism” which provides a solution to the incompatibility problems. The classic incompatibility problem is inconsistency of:1. Someone who intentionally violates the rules of a game is not playing the game.2. In many cases, players intentionally violate the rules as part of playing the game.The problem has a normative counterpart:1’. In normal cases, it is wrong for a player to intentionally violate the rules of the game.2’. In many normal cases, it is not wrong (...) for a player to intentionally violate the rules of the game.According to both formalism and informalism, the rules of the game include the formal rules of the game. Both traditional positions avoid the incompatibility problems by rejecting 1 and 1'. Practiceism rejects 2 and 2’: it maintains that the rules are the rules manifested in playing the game, not the formal rules.Practiceism presents two theses: (... (shrink)

The scandal to philosophy and human reason, wrote Kant, is that we must take the existence of material objects on mere faith . In contrast, the skeptical paradox that has scandalized recent philosophy is not formulated in terms of faith, but rather in terms of justification, warrant, and entitlement. I argue that most contemporary approaches to the paradox (both dogmatist/liberal and default/conservative) do not address the traditional problem that scandalized Kant, and that the status of having a warrant (or justification) (...) that is derived from entitlement is irrelevant to whether we take our beliefs on mere faith. For, one can have the sort of warrant that most contemporary anti-skeptics posit while still taking one’s belief on mere faith. An alternative approach to the traditional problem is sketched, one that still makes use of contemporary insights about “entitlement.”. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Understand All, Forgive Nothing:The Self-Indictment of Humbert HumbertYuval EylonFor me a work of fiction exists only insofar as it affords me what I shall bluntly call aesthetic bliss, that is a sense of being somehow, somewhere, connected with other states of being where art (curiosity, tenderness, kindness, ecstasy) is the norm.—Vladimir Nabokov, "On a Book Entitled Lolita"Pride is the tendency to overestimate oneself, or underestimate others. In either case, (...) a proud person overestimates his own qualities. Since such a person is inclined to view others as inferior and his own actions as admirable, a proud person is disposed to underestimate the suffering he inflicts on others, or worse—to try and justify it. Curiosity about others, tenderness, and kindness, rarely accompanies pride. Thus, it often conflicts with a charitable view of others, and begets cruelty and callousness. Pride is often accompanied by the desire to be admired by others. This desire gives rise to vanity, or vainglory: a vice that seems destined to give rise to further vices. Aquinas clearly expresses this view in the Summa Theologia:1... the vices which by their very nature are such as to be directed to the end of a certain capital vice, are called its daughters. Now the end of vainglory is the manifestation of one's own excellence, as stated above (A1, 4). To this end a man may tend in two ways. On one way directly, [End Page 158] either by words, and this is boasting, or by deeds, and then if they be true and call for astonishment, it is love of novelties which men are wont to wonder at most; but if they be false, it is hypocrisy. On another way a man strives to make known his excellence by showing that he is not inferior to another, and this in four ways. First, as regards the intellect, and thus we have "obstinacy," by which a man is too much attached to his own opinion, being unwilling to believe one that is better. Secondly, as regards the will, and then we have "discord," whereby a man is unwilling to give up his own will, and agree with others. Thirdly, as regards "speech," and then we have "contention," whereby a man quarrels noisily with another. Fourthly as regards deeds, and this is "disobedience," whereby a man refuses to carry out the command of his superiors.However, whereas pride is an attitude that a person has towards himself, vanity involves a relation with others which pride does not: it emanates from the need to manifest one's excellence to others and gain their approval. Thus, since the proud person does not engage with the opinions of others, his view of himself remains secure. Vanity, on the hand, can prove to be a blessing in disguise: the attempt to gain approval could lead to self-awareness.The pride of Humbert Humbert, the main character and narrator in Nabokov's Lolita, is the pride of an aesthete: intellectually superior, and determined to pursue his appetites. But Humbert is not only proud.2 He is also vain. Vanity leads him to seek the approval of others, and underlines his artistic aspirations. He undertakes the writing of a manuscript, designed to be a masterpiece that vindicates his actions. In his manuscript, Humbert tries to elicit the reader's sympathy, in the conviction that sympathetic identification would lead to acceptance. However, while he successfully challenges and threatens the reader's moral outlook, writing the manuscript has an unintended effect: it shatters Humbert's own convictions and leads to moral transformation. The reason for this transformation is that he recognizes the aesthetic faults of his work, and traces these faults to his own moral faults.The claim that aesthetic considerations can play an important role in moral thinking cannot be taken for granted. First, the threat of an empty aestheticism must be addressed, because it seems that aesthetic considerations and the pursuit of aesthetic ideals compete with moral considerations, rather than complete them. As Humbert illustrates, aesthetic pursuit motivates acts of cruelty and callousness, and aesthetic ideals are often devoid of any moral significance. Second, if aesthetic [End Page 159] considerations... (shrink)

Dolev's ambitious project is to show that the traditional debate in the philosophy of time between the so-called ‘tensed’ and ‘tenseless’ theorists is not a sustainable one. The key to the negative portion argument is that both the tensed and tenseless view of time can be understood only from within their respective ontological frameworks. Moreover, that there is only really an appearance of understanding within these frameworks, since neither framework furnishes us with the wherewithal to genuinely understand temporal language. Moving (...) past these frameworks is the goal Dolev sets us. The positive aspect of the text tries to teach us how to transcend this merely ontological dispute and engage in phenomenological considerations of time itself. The conclusion to the positive project is that we cannot postulate an adequate metaphysical system of time, though we can understand what time is if we treat it as the time of our experiences in everyday life .The prospect that we might be able to move past the existing debate into fresh philosophical terrain is exciting. But I am not quite persuaded by the arguments that are intended to motivate the move to pastures new. First, on occasion Dolev seems to slightly …. (shrink)

This article explores various analytical issues involved in conceptualizing the interrelationships of gender, class, race and ethnicity and other social divisions. It compares the debate on these issues that took place in Britain in the 1980s and around the 2001 UN World Conference Against Racism. It examines issues such as the relative helpfulness of additive or mutually constitutive models of intersectional social divisions; the different analytical levels at which social divisions need to be studied, their ontological base and their relations (...) to each other. The final section of the article attempts critically to assess a specific intersectional methodological approach for engaging in aid and human rights work in the South. (shrink)

In this paper, I argue that context sensitivity is crucial for a proper exegesis of Wittgenstein's remark that one can say of the standard metre rod neither that it is one metre long nor that it is not one metre long. I discuss cases in which we can meaningfully assert that the rod in question is one metre long and explain why these cases do not conflict with Wittgenstein's insight. I analyse Pollock's recent defence of Wittgenstein's remark, as well as (...) Kripke's objections to it, and show that, while their commentaries are helpful, blindness to context renders them unsatisfactory. (shrink)

Universities in the USA have become bastions of secularity in a distinctly religious society. As such, they are subjected to a variety of robust and rigorous religious critiques. In this paper I do not seek to engage in the debate between the supporters of the secular university and its opponents. Furthermore, I do not claim to summarize the history of the critique of the secular university, nor to present an exhaustive map of its current articulations. My purpose is rather more (...) limited and modest, namely, to locate some of the key arguments of the current religious criticism of the secular university and put them in a wider philosophical context. Exploring the philosophical infrastructure of this criticism enables not only a more comprehensive and profound understanding of it, but also urges us to rethink the purpose and essence of the university as an institution that both reflects and forms our society and culture. The article is structured as follows; first section puts the religious criticism of the secular university in the context of the latest wave of criticism levelled at contemporary universities. Second section explores the argument according to which the secularization of the university led to the loss of the ideal of education for excellence in the wide, classical sense of the term. Third section examines the theoretical foundations of the call to reintegrate religion in contemporary universities, while fourth section explores the various practical consequences of this demand. (shrink)

Around the world, many liberal democracies are facing in recent years serious challenges and threats emanating inter alia from the rise of political populism. Such challenges and threats are feeding an almost existential discourse about the crisis of democracy, and recent legal and political developments in Israel aimed at weakening the power of the Supreme Court and other rule of law institutions have also been described in such terms. This Article primarily intends to explore the relevance of the discourse surrounding (...) the decline of liberal democracy, and its possible relevance for Israeli democracy, by examining the principal similarities and differences between specific legislative and administrative measures recently taken or contemplated in Israel and in two Central European states: Poland and Hungary. We focus on three sets of illiberal measures adopted or contemplated in Hungary, Poland, and Israel: (i) measures directed at limiting the power of the judiciary; (ii) measures intended to restrict the operation of civil society organizations; and (iii) measures directed at curbing dissent to governmental policies and at influencing the discourse in the media and academia. Although Israeli democratic institutions still retain much of their independence and vitality, we nonetheless find some degree of similarity between measures taken or contemplated by Hungary, Poland, and Israel, despite the many differences between their legal systems, historical contexts, political cultures, and the distinct stages of backsliding they seem to experience. (shrink)

In “The Blessing of Departure—Exchange of Populated Territories The Lieberman Plan as anExercise in Demographic Transformation,” Prof. Timothy Waters offers a strong endorsement of the right of ethnic majorities within a state to redefine their state's boundaries in ways consistent with the majority's right to self-determination and to opt out of a political union with minority groups, regardless of the latter's' political preferences. Applied to the Israeli context, Waters concludes that parts of the Lieberman Plan—a plan advocating the redrawing of (...) Israel borders, inter alia, in ways which exclude some areas populated by Israeli citizens belonging to the Arab-Palestinian minority —does not run afoul of international law . This short response challenges two points that are central to Waters’s analysis. First, that the right to self-determination of peoples—in particular, the right to external self-determination —is subject to temporal or contextual limitations. The right is fully applicable only in exceptional and formative moments in the life of a nation—e.g., during the formation of a new polity or the collapse of an existing political arrangement , and when states systematically fail to respect the basic interest of some of the groups that comprise its populace—i.e., in response to extraordinary situations of groups exclusion or oppression. Second, even if Waters is correct and an ongoing right to self-determination—including, a right to secede from existing states—is available to ethnic groups comprising diverse national societies, the invocation of such a right must necessarily be limited by other positive rules of international law designed to protect group and individual interests. Specifically, Waters’s concept of self-determination as a right of a preliminary nature, that overrides other human rights , is debatable. (shrink)

Strategic fouls are intentional violations of the rules ‘in which the violator expects to be detected and penalized but expects some benefit to his or her competitive effectiveness’ (Fraleigh...

Wittgenstein on the Human Spirit provides a new understanding of Wittgenstein’s discourse as an insightful philosophy of culture, pursued through self-reflection. It offers an edifying perspective on the conceptual underpinnings of culture as a shared expressive spiritual form of life. The ideas investigated in it are highly relevant for discussions in philosophy, aesthetics, anthropology, and cultural studies. The book embraces three studies: The Spirit of Jews, The Spirits of Culture and Civilization, and The Common Spirit of Human Beings. The first (...) discusses Wittgenstein's remarks about Jews, focusing on their place within his philosophical thinking, self-reflection, and European discourse about culture and Jews. It shows how overcoming the anti-Semitic attitude implicit in them set off the major change in his philosophy. The second discusses Wittgenstein’s reflections on the “deterioration of culture” in the modern period, showing how they are related to his remarks about following rules. The third discusses Wittgenstein’s insights regarding the symbolic nature of myth, magic and religion. It suggests that modern human beings and those of ancient cultures possess a common expressive spiritual nature. This enables us to understand expressive practices in other cultures without interpretation. Nonetheless religious belief during the modern period is problematic. (shrink)

For millennia, war was viewed as a supreme test. In the period 1750-1850 war became much more than a test: it became a secular revelation. This new understanding of war as revelation completely transformed Western war culture, revolutionizing politics, the personal experience of war, the status of common soldiers, and the tenets of military theory.

The paper argues that Rawls's account of the obligation to keep promises entails that inasmuch as we are obliged to keep promises, we are also obliged to carry out threats. On the basis of the principle of fairness, Rawls claimed that a social practice creates a moral obligation if it is just, and one has benefited from it or entered it voluntarily. A practice of threats meets Rawls's first principle of justice. We may reasonably assume that immoral threats, just like (...) immoral promises, are not socially obliging. Threats meet Rawls's second principle of justice mainly because weaker parties benefit from drawing red lines, backed by credible threats. Finally, threats create social benefits: they contribute to social cooperation and collaboration. The argument entails that we must either accept the counterintuitive claim that threats are morally binding, or reject Rawls's account of the obligation to keep promises. (shrink)

The article discusses some of the major issues which need to be examined in a gendered reading of citizenship. However, its basic claim is that a comparative study of citizenship should consider the issue of women's citizenship not only by contrast to that of men, but also in relation to women's affiliation to dominant or subordinate groups, their ethnicity, origin and urban or rural residence. It should also take into consideration global and transnational positionings of these citizenships. The article challenges (...) the gender-blind and Westocentric character of many of the most hegemonic theorizations of citizenship, focusing in particular on the questions of membership in ‘the community’, group rights and social difference and the ways binaries of public/private and active/passive have been constructed to differentiate between different kinds of citizenships. The article argues that in order to be able to analyse adequately people's citizenship, especially in this era of ethnicization on the one hand and globalization on the other hand, and with the rapid pace at which relationships between states and their civil societies are changing, citizenship should best be analysed as a multi-tiered construct which applies, at the same time to people's membership in sub-, cross- and supra-national collectivities as well as in states. (shrink)

In this paper I discuss an unconventional form of presentism which, I claim, captures better than all other versions of the doctrine the fundamental notion underpinning it, namely, the notion that 'only what is present is real'. My proposal is to take this maxim as stating, not the rather uncontroversial view that past things are not real now, but the more radical idea that they never were. This rendition of presentism is, I argue, the only one that is neither trivial (...) nor absurd. I examine this proposal by considering it against a sceptical hypothesis that bears similarities to it, viz., the hypothesis that the world was created five minutes ago. On this hypothesis, the past, all but five minutes of it, is unreal, in precisely the sense in which the presentism I discuss claims it is. I show that, assuming semantic externalism, this sceptical hypothesis cannot be sustained, but that a somewhat weaker hypothesis, the Creationist hypothesis that the world is 5,768 years old, cannot be refuted. Together, these conclusions enable a demarcation of those presentist intuitions that language and thought tolerate and those they do not. (shrink)