Over the past half-century, modelling has come to play an increasingly important role in cancer research. These representational tools frame perceptions of malignant disease, guide public health responses, and help determine which interventions are necessary. But what makes a cancer model a model? What authority do they have? What stories do they tell? And how do they shape our understanding of disease and bodies? To shed light on these questions, this article explores the long history of cancer modelling in sub-Saharan (...) Africa: a place where malignant disease has often been imagined as different, and where experimentation and improvisation in cancer research and treatment has been rife. Drawing on archival and ethnographic sources, we examine modelling strategies that health professionals have used to generate information about cancer in Africa from the mid 20th century to the present day. Focusing on three different case studies – anatomical models of Burkitt's lymphoma patients, diagnostic models for Kaposi sarcoma, and statistical models of the African smoking and lung cancer epidemic – we meditate on the multiplicity of models and modelling by identifying the epistemic strands that hold these representations together, as well as what sets them apart. In addition to contributing to discussions of how cancer research has taken shape beyond the Anglo-American realm, our article helps expand and complicate our understandings of what a disease model is. (shrink)

3500 word interview with Tom Cochrane discussing his philosophical background, the nature of aesthetic value, the benefits of art, and aestheticism.

Cet article fait valoir que la recherche sur le développement international devrait être soumise à la surveillance des comités d’éthique de la recherche dans les pays où les données seront collectées. Cela inclut les personnes ayant un statut qui leur permet de se soustraire des lignes directrices ou des politiques d’éthique, telles que les personnes engagées par des organisations non gouvernementales. L’argument repose sur une compréhension de la justice sociale qui reconnaît que ne pas rechercher l’approbation éthique au niveau local (...) peut être un affront au mouvement de décolonisation et peut entraîner des dommages directs importants pour les participants. La supervision éthique au niveau local favorise une meilleure prise en compte des législations locales, des règlements, des priorités et du contexte. Par exemple, un comité d’éthique de la recherche local est souvent mieux placé qu’un comité étranger pour évaluer si un projet proposé comporte des risques spécifiques au contexte donné. En outre, le fait de soumettre un projet à un comité d’éthique de la recherche local permet de reconnaître la légitimité des autorités locales, prenant ainsi position contre l’histoire de la perte de pouvoir en lien avec la colonisation. La supervision locale permet d’accroître la responsabilité des chercheurs travaillant à l’étranger : si l’autorité locale et l’adaptation au contexte spécifique doivent être respectées, il doit y avoir des mécanismes pour s’assurer que la recherche qui ne satisfait pas à ces exigences ne peut avoir lieu. Les objections fondées sur la capacité limitée de supervision dans certains pays et sur les préoccupations liées à la politisation du processus d’évaluation sont abordées. Enfin, les rôles et les responsabilités des différentes parties prenantes dans la mise en œuvre d’une plus grande supervision éthique au niveau local sont définis. (shrink)

All states must make decisions about how to regulate the treatment of animals. In this book, Alasdair Cochrane argues that this must go further. In order to ensure that their interests are taken seriously, it is imperative that we represent them throughout the political process - not only rights to protection, but also to democratic membership.

"Racism" and "white privilege" have outlived their usefulness as concepts and judgments. Neither term explains what's going on in America today. Two factors now necessitate a conceptual shift.First, the unexpected election of Donald Trump as the forty-fifth President of the United States. Mainstream news reporters, political pundits, and social media commentators now have to discover and explore what they overlooked during their coverage of the 2016 presidential campaign: the needs, issues, interests, and narratives of white middle-class and working-class Americans.1Second, Hillary (...) Clinton's categorization of Trump supporters as "the basket of deplorables"; "racist, sexist, homophobic, xenophobic, Islamaphobic";... (shrink)

The concept of dignity is pervasive in bioethics. However, some bioethicists have argued that it is useless on three grounds: that it is indeterminate; that it is reactionary; and that it is redundant. In response, a number of defences of dignity have recently emerged. All of these defences claim that when dignity is suitably clarified, it can be of great use in helping us tackle bioethical controversies. This paper rejects such defences of dignity. It outlines the four most plausible conceptions (...) of dignity: dignity as virtuous behaviour; dignity as inherent moral worth; Kantian dignity; and dignity as species integrity. It argues that while each conception is coherent, each is also fundamentally flawed. As such, the paper argues for a bioethics without dignity: an 'undignified bioethics.'. (shrink)

The advent of new antiretroviral medicines means that the effects of HIV can now be curbed, but only one in twenty infected people have so far benefited. For those living in developing countries, the new treatments are practically unattainable. Governments, UNAIDS and pharmaceutical companies recognise this only too well and have rethought established assumption in order to try and overcome the challenges posed by cost, inadequate health services and unreliable local supply of medicines.

This book examines the dialogue between Roman Stoic ethics and the work of Martin Luther, John Calvin, and Jonathan Edwards. Elizabeth Agnew Cochran illuminates key theological convictions that provide a foundation for constructing a contemporary Protestant virtue ethic consistent with a number of theological beliefs characteristic of the historical Reformed tradition. Building on this conversation, this book develops the claims that faith holds a unique value among possible moral goods; virtue has a unity that coincides with a soteriology that conceives (...) justification as radically transforming a Christian from a sinner to one who is righteous before God; and moral responsibility is realized through a dispositional consent to God's loving providence. (shrink)

The author comments on the article “The neurobiology of addition: Implications for voluntary control of behavior,‘ by S. E. Hyman. The author agrees with Hyman that debate persists whether addiction is a brain disease or a moral condition. The author suggests that even if we understand the neurobiology of addiction, it will make sense to seek accountability from the addict and to modify his behavior. He also suggests that no facts about neurobiology will change these moral requirements. Accession Number: 24077917; (...) Authors: Cochrane, Thomas I. 1; Email Address: [email protected]; Affiliations: 1: Harvard Medical School; Subject: EDITORIALS; Subject: ADDICTIONS; Subject: NEUROBIOLOGY; Subject: BEHAVIOR; Subject: HYMAN, S. E.; Number of Pages: 2p. (shrink)

Educational Roots of Political Crisis in Egypt explores Egypt's political, economic, social, and cultural leadership from the remarkable civilization of the past to the unique socialistic/capitalistic educational conglomerate of today.

It is an important feature of creatures like us that our various motivations compete for control over our behaviour, including mental behaviour such as imagining and attending. In large part, this competition is adjudicated by the stimulation of affect — the intrinsically pleasant or unpleasant aspects of experience. In this paper I argue that the motivation-affect system controls a sub-type of attention called 'alerting attention' to bring various goals and stimuli to consciousness and thereby prioritize those contents for action. This (...) view allows me to flesh out the global workspace theory of consciousness, as well as some of the phenomenal characteristics of conscious experience. (shrink)

In this book, Tom Cochrane develops a new control theory of the emotions and related affective states. Grounded in the basic principle of negative feedback control, his original account outlines a new fundamental kind of mental content called 'valent representation'. Upon this foundation, Cochrane constructs new models for emotions, pains and pleasures, moods, expressive behaviours, evaluative reasoning, personality traits and long-term character commitments. These various states are presented as increasingly sophisticated layers of regulative control, which together underpin the (...) architecture of the mind as a whole. Clearly structured and containing numerous diagrams and examples to illustrate the discussion, this study draws on the latest research from fields including philosophy, psychology and neuroscience, and will appeal to readers interested in the philosophy and cognitive science of emotion. (shrink)

I argue for the possibility of an extremely intimate connection between the emotional content of the music and the emotional state of the person who produces that music. Under certain specified conditions, the music may not just influence, but also partially constitute the musician’s emotional state.

There is now widespread agreement that many non-human animals are sentient, and that this fact has important moral and political implications. This book is devoted to sketching what this 'sentientist politics' might look like.

The ArgumentThe purpose of this essay is revisionist on two counts: first, that the American colonies and early United States republic kept pace with Great Britain in reaching a relatively advanced stage of industrialization by the early nineteenth century and second, that the Middle Atlantic States shared equally with New England the innovative role in creating America's industrial revolution. In both cases the industrial leaders achieved their preeminence by different routes. By concentrating on the importance of the sources of machine (...) power as the defining characteristic of industrialism, scholars have overlooked alternative paths to industrial change. In Britain steam power and the textile industry were the foundations of an industrial revolution. But in American colonies the use of water power and the growth of industries such as woodworking and building led to an equally revolutionary change in the production of machine-made products. Benign geography in colonial America provided abundant wood and water power and an excellent transportation system based on navigable rivers and a hospitable coastline. But the crucial factors were cultural: the compelling urge to do things with less human work, the open reception to new immigration, a younger and more venturesome population, a favorable legal and fiscal environment for enterpreneurs. In the American context the tendency of scholars to emphasize the leadership of New England was largely a result of the greater local availability of manufacturing records. But recent research has demonstrated that Philadelphia, the largest port of entry in the eighteenth century, was quite naturally a center of innovation in construction materials, woodworking machinery and shipbuilding to meet the needs of the expanding agricultural hinterland and the coastal trade. In sum, the values of an expanding, youthful, skilled population replenished by fresh and venturesome sources from abroad helped shape cultural values that were particularly favorable in the geographic environment of North America for alternative paths of rapid industrial growth. (shrink)

Drawing on the work of Jonathan Edwards, this essay explores two dimensions of Reformed thought central to considering the emotions’ moral significance. First, Reformed theology’s singular understanding of virtue and holiness as love to God and neighbor gives rise to a distinctive account of the emotions’ place in the moral life. Certain emotions are to be embraced insofar as they have the capacity to be sanctified and thereby made compatible with growth in love to God. Second, Reformed theology historically links (...) the emotions with the will, which is subject to moral necessity. Contemporary Reformed reflection on the emotions must therefore grapple with questions about moral agency and accountability that arise from this account of necessity. (shrink)

The known facts of quantum physics and biology strongly suggest the following hypotheses: atoms and the fundamental particles have a rudimentary degree of consciousness, volition, or self-activity; the basic features of quantum mechanics are a result of this fact; the quantum mechanical wave properties of matter are actually the conscious properties of matter; and living organisms are a direct result of these properties of matter. These hypotheses are tested by using them to make detailed predictions of new facts, and then (...) by showing that the predictions can be verified. The hypotheses are used to predict successfully that the quantum wave properties of matter are strongly predominant in proteins, to explain the presence and relative abundance of carbon, hydrogen, nitrogen, oxygen, phosphorus, and sulfur in proteins, and to explain diffraction phenomena, the behavior of helium II, the exclusion principle, and causality and determinism in modern science, thus closely relating physics and biology. (shrink)

This paper examines the proposal that the indigenous cosmovision of buen vivir (good living)—the “organizing principle” of Ecuador's 2008 and Bolivia's 2009 constitutional reforms—constitutes an appropriate basis for responding to climate change. Advocates of this approach blame climate change on a “civilizational crisis” that is fundamentally a crisis of modern Enlightenment reason. Certain Latin American feminists and indigenous women, however, question the implications, for women, of any proposed “civilizational shift” seeking to reverse the human separation from nonhuman nature wrought via (...) Enlightenment's “disenchantment of nature.” The paper argues that, in order to adequately address both the climate crisis and feminist concerns about buen vivir, a different critique of Enlightenment modernity is necessary—one drawing on Adorno's philosophy of negative dialectics and on Adorno and Horkheimer's nonidentitarian dialectical understanding of Enlightenment. Conceiving Enlightenment as composed of nonsublatable moments of domination and liberation, Adorno and Horkheimer call for a rational critique of reason and for affinity rather than identity with nonhuman nature. The paper ends with a brief discussion of how feminist critiques of buen vivir and approaches to climate justice can be furthered via an engagement with an environmental feminist philosophy informed by a negative dialectical approach to Enlightenment. (shrink)

This paper examines the causal basis of our ability to attribute emotions to music, developing and synthesizing the existing arousal, resemblance and persona theories of musical expressivity to do so. The principal claim is that music hijacks the simulation mechanism of the brain, a mechanism which has evolved to detect one's own and other people's emotions.

During an illness requiring brief use of life-sustaining therapy, patients and surrogates sometimes feel that LST must be withdrawn before it becomes unnecessary to avoid later being stuck living in a debilitated condition that the patient considers worse than death. This fear depends on the belief that the patient can legitimately refuse only artificial LST, so that if such therapies are no longer required, he or she will have missed the ‘opportunity to die.’ This fear of being stuck with life (...) can lead to premature decisions to terminate LST and is unfounded because adequate ethical and moral justification exists for refusal of not just artificial LST, but also for refusal of natural LST, including oral hydration and nutrition. (shrink)

ABSTRACTThis paper explores the international implications of liberal theories which extend justice to sentient animals. In particular, it asks whether they imply that coercive military intervention in a state by external agents to prevent, halt or minimise violations of basic animal rights can be justified. In so doing, it employs Simon Caney's theory of humanitarian intervention and applies it to non-human animals. It argues that while humane intervention can be justified in principle using Caney's assumptions, justifying any particular intervention on (...) behalf of animals is much more difficult – and in present circumstances impossible. If these claims are correct, a number of important conclusions follow. First, all states lack legitimacy because of the horrors that they inflict upon animals. As a result of this, all states are prima facie liable to intervention by external agents. To remedy this situation, all states have the responsibility to massively transform their relationsh... (shrink)

The author proposes a dimensional model of our emotion concepts that is intended to be largely independent of one’s theory of emotions and applicable to the different ways in which emotions are measured. He outlines some conditions for selecting the dimensions based on these motivations and general conceptual grounds. Given these conditions he then advances an 8-dimensional model that is shown to effectively differentiate emotion labels both within and across cultures, as well as more obscure expressive language. The 8 dimensions (...) are: (1) attracted—repulsed, (2) powerful—weak, (3) free—constrained, (4) certain—uncertain, (5) generalized—focused, (6) future directed—past directed, (7) enduring—sudden, (8) socially connected—disconnected. (shrink)

The rapid pace of technological development often outstrips the ability of legislators and regulators to establish proper guardrails on emerging technologies. A solution is for those who develop, deploy, and use these technologies to develop themselves as moral agents—i.e., as agents capable of steering the course of emerging technologies in a direction that will benefit humanity. However, there is a dearth of literature discussing how to foster moral agency in computer science courses, and little if any research on the effectiveness (...) of such courses in computer science. This paper addresses this gap by providing an overview of an undergraduate course on technology ethics. It then shares and discusses a subset of data collected from a mixed-methods study using a pre-post design that sought to examine the course’s effectiveness in developing students’ moral, intellectual, and civic virtues, as well as related dispositions. (shrink)

This paper elaborates the hypothesis that the unique demography and sociology of Ashkenazim in medieval Europe selected for intelligence. Ashkenazi literacy, economic specialization, and closure to inward gene flow led to a social environment in which there was high fitness payoff to intelligence, specifically verbal and mathematical intelligence but not spatial ability. As with any regime of strong directional selection on a quantitative trait, genetic variants that were otherwise fitness reducing rose in frequency. In particular we propose that the well-known (...) clusters of Ashkenazi genetic diseases, the sphingolipid cluster and the DNA repair cluster in particular, increase intelligence in heterozygotes. Other Ashkenazi disorders are known to increase intelligence. Although these disorders have been attributed to a bottleneck in Ashkenazi history and consequent genetic drift, there is no evidence of any bottleneck. Gene frequencies at a large number of autosomal loci show that if there was a bottleneck then subsequent gene flow from Europeans must have been very large, obliterating the effects of any bottleneck. The clustering of the disorders in only a few pathways and the presence at elevated frequency of more than one deleterious allele at many of them could not have been produced by drift. Instead these are signatures of strong and recent natural selection. (shrink)

Alasdair Cochrane introduces an entirely new theory of animal rights grounded in their interests as sentient beings. He then applies this theory to different and underexplored policy areas, such as genetic engineering, pet-keeping, indigenous hunting, and religious slaughter. In contrast to other proponents of animal rights, Cochrane claims that because most sentient animals are not autonomous agents, they have no intrinsic interest in liberty. As such, he argues that our obligations to animals lie in ending practices that cause (...) their suffering and death and do not require the liberation of animals. Cochrane's "interest-based rights approach" weighs the interests of animals to determine which is sufficient to impose strict duties on humans. In so doing, Cochrane acknowledges that sentient animals have a clear and discernable right not to be made to suffer and not to be killed, but he argues that they do not have a prima facie right to liberty. Because most animals possess no interest in leading freely chosen lives, humans have no moral obligation to liberate them. Moving beyond theory to the practical aspects of applied ethics, this pragmatic volume provides much-needed perspective on the realities and responsibilities of the human-animal relationship. (shrink)

Vittorio Gregotti—the architect of Barcelona’s Olympic Stadium, Milan’s Arcimboldi Opera Theater, and Lisbon’s Centro Cultural de Belém, among many other noted constructions—is not only a designer of international repute but an acclaimed theorist and critic. _Architecture, Means and Ends _is his practical and imaginative reflection on the role of the technical aspects of architectural design, both as part of the larger process of innovation and in relation to the mythic opposition between vision and construction. Interweaving the seemingly irreconcilable concerns of (...) aesthetics, meaning, and construction, _Architecture_, _Means and Ends _reflects Gregotti’s overarching claim that buildings always have a symbolic, cultural content. In this book, he argues that by making symbolic expression a primary objective in the design of a project, the designer will produce a practical aesthetic as well as an ethical solution. _Architecture_, _Means and Ends _embraces that philosophy and will appeal to those, like Gregotti, working at the intersections of the history of design, art criticism, and architectural theory. (shrink)

The rise of computer-assisted journalism coincides with increasing public concerns about individual privacy, especially in the realm of information stored in electronic databases. This article contends that journalists (a) need to be more receptive to privacy concerns, and (b) need to reassure the public they will be sensitive in dealing with private information contained in electronic databases. The author calls for creation of a Code of Information Practices that could guide journalists in making decisions about usingprivate information in electronicformat. Such (...) a code might help persuade the public to be more receptive to journalists' arguments over the need for access to records and information. (shrink)

This article aims to open a discussion on better ethical assurance for non-university research actors drawing on democratic norms. It derives from the author’s experience of a gap in ethical assurance for social science and humanities (SSH) research that takes place outside academia, for example within international organisations, public bodies, non-governmental organisations (NGOs) and by private entities. Many of these actors commission, conduct or sub-contract research activities involving human participants on a regular basis, an activity that often increases during times (...) of crisis where researchers in both the public and private sphere scramble to generate the new knowledge necessary to respond and prevent further harms. The ethical assurance frameworks for such research, while growing, remain limited. Discussion of research conducted by actors outside of university settings and their ethical assurance frameworks are both subjects under-interrogated within the literature. This paper seeks to open that discussion by presenting this broad non-university research context through the frame of research in crisis settings, where the ethical requirements of ‘do no harm’ and the ‘dual imperative’ possess an even heavier significance in research ethics. Furthermore, the global and diverse nature of crisis settings often gives rise to conversations concerning the positioning of the research actor and the need to empower the research participant. This paper presents an early vision of the non-university research actor and ethical assurance process based on the democratic norms of equality and inclusivity. (shrink)

During an illness requiring brief use of life-sustaining therapy, patients and surrogates sometimes feel that LST must be withdrawn before it becomes unnecessary to avoid later being stuck living in a debilitated condition that the patient considers worse than death. This fear depends on the belief that the patient can legitimately refuse only artificial LST, so that if such therapies are no longer required, he or she will have missed the ‘opportunity to die.’ This fear of being stuck with life (...) can lead to premature decisions to terminate LST and is unfounded because adequate ethical and moral justification exists for refusal of not just artificial LST, but also for refusal of natural LST, including oral hydration and nutrition. (shrink)

This paper develops a mechanistic account of basic mental agency by identifying similarities between two of its major exemplars: endogenous attention and imagination. Five key similarities are identified: i) that both capacities are driven by currently prioritised goals that are either person-level or apt to become person-level. ii) that both deliver their outputs to the working memory iii) that both range across all and only conceptual contents; iv) that both proceed under the guidance of norms and/or habits; and v) that (...) both directly activate rather than inhibit content. These five features are consolidated by proposing that basic mental agency is essentially the power to call for conceptual content and hold it within our working memories. (shrink)

The fear of death resists philosophical attempts at reconciliation. Building on theories of emotion, I argue that we can understand our fear as triggered by a de se mode of thinking about death which comes into conflict with our will to live. The discursive mode of philosophy may help us to avoid the de se mode of thinking about death, but it does not satisfactorily address the problem. I focus instead on the voluntary diminishment of one’s will to live. I (...) argue that we can encourage a natural tendency for the will to live to decline as we approach death. I then consider two objections: Is not the will to live too fundamental for us to control? And even if we can control it, would not a declining will to live result in a general despair that it is better to resist? I argue that both of these objections can be overcome. (shrink)

Many societies have norms of equity – that those who make symmetric social contributions deserve symmetric rewards. Despite this, there are widespread patterns of social inequity, especially along gender and racial lines. It is often the case that members of certain social groups receive greater rewards per contribution than others. In this article, we draw on evolutionary game theory to show that the emergence of this sort of convention is far from surprising. In simple cultural evolutionary models, inequity is much (...) more likely to emerge than equity, despite the presence of stable, equitable outcomes that groups might instead learn. As we outline, social groups provide a way to break symmetry between actors in determining both contribution and reward in joint projects. (shrink)