The Y‐box‐binding protein (YB‐1) represents the most evolutionary conserved nucleic‐acid‐binding protein currently known. YB‐1 is a member of the cold‐shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB‐1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB‐1 and will then summarize the pleiotropic functions brought about via (...) DNA–RNA transaction and protein–protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB‐1. BioEssays 25:691–698, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

On April 5 2000, the Diet elected Yoshiro Mori as Japan's 55th prime minister. His predecessor, Keizo Obuchi, had suffered a stroke and became unable to carry out his official responsibility. Mori, who was the former Secretary General of the ruling Liberal Democratic Party (LDP), inherited the three party coalition between the LDP, the new Komei Party and the Conservative Party, and reappointed all of Obuchi's cabinet members. Yohei Kono was reposted as the Minister of Foreign Affairs; Hideo Usui as (...) Justice; Kiichi Miyazawa as Finance; Hirofumi Nakasone as Education, Science and Technology; Yuya Niwa as Health and Welfare; Tokuichiro Tanazawa as Agriculture, Forestry and Fisheries; Takeshi Fukaya as International Trade and Industry; Toshihiro Nikai as Transport; Eita Yashiro as Posts and Telecommunications; Takamori Makino as Labor; Masaaki Nakayama as Construction; Kosuke Hori as Home Affairs, Mikio Aoki as Chief Cabinet Secretary; Kunihiro Tsuzuki as Management and Coordination; Tsutomu Kawara as Defense; Taichi Sakaiya as Economic Planning; Kayoko Shimizu as environment; and Sadakazu Tanigaki as Financial Reconstruction. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Neither/Nor:Ruminating on the Metanoetic Pharmakon in Nietzsche and Other BuddhasTakeshi Morisato (bio)A Compliment to the Philosopher Chef and His table d'hôte intellectuelleIf a book title were comparable to the name of a restaurant, the table of contents would be their menu. Jason Wirth's Nietzsche and Other Buddhas (hereafter NOB) initially reminded me of a fusion restaurant with a strong "Asian" flavor, an ambiguous genre that we would see anywhere (...) in continental Europe. As one could easily imagine, this is not necessarily a compliment to the chef. By integrating various ingredients and different techniques from diverse culinary traditions, a fusion restaurant might claim to create a new dish or a unique course that transcends the conventional categories of our dietary practice. Like what Kant says about the uniqueness of nonsense, however, their end product could fail to be original or, what is worse, could even be offensive to those who are very familiar with any of the specific culinary traditions. If what comes after comparative philosophy results in this kind of "fusion philosophy," its success will have to feed on our ignorance of intellectual histories.1 Our feeding frenzy in this new, fashionable modus operandi may starve us to death of philosophy rather than liberate us from the hunger that has propelled us into a philosophical search in the first place. To borrow Wirth's use of the "felicitous analogy from Kierkegaard," it might as well be that "the last thing that we need is more food. Rather we need to lose something, to shed our gluttony. We need a medicinal poison to take away an unhealthy poison."2As you can see, I was initially skeptical about the soundness of a philosophical menu that mixes Zen, Schopenhauer, Hakuin, James, Pure Land, Shinran, Tanabe, Deleuze, Dōgen, and Nishida (in order of appearance) with an explosive spice or the deadly meat, Nietzsche. Could this be a process of ventriloquizing Nietzsche through Asian philosophical traditions? Or are we washing down the strong aftertaste of reading Nietzsche or Schopenhauer with Pure Land or Zen water? How could we stomach all of these thinkers and traditions in one setting without causing serious indigestion in our hearts-and-minds? To my surprise, Wirth's text gives a performative proof that they can indeed be read together and examined with the purpose of giving us food for thought. What makes NOB particularly successful in referring to different thinkers is its emphasis on "rumination." It [End Page 1070] self-reflectively questions what it is to read any text philosophically and what it means to integrate texts into one's process of thinking such that its creative insight points toward the nutrients that it has found in the process of digesting ideas from diverse intellectual traditions.This philosophical process of "rumination" is not merely an external comparison of ideas from different philosophical traditions. Nor is it an imposition of one tradition over another. Rather, by harmoniously fusing together various insights, the author's very process of understanding the cultural, linguistic, and historical milieu of his existence delves into fundamental issues concerning our human condition in the world today. NOB, in this sense, renders a final form of "comparative philosophy," where a thinker is liberated from conventional categories of philosophizing (especially in reference to the almost obsolete distinction between "East and West") and proves that what philosophers can stomach and integrate into their process of (self-)understanding should count as "philosophy." That is to say, depending on the capacity of the thinker to deal with a variety of intellectual resources, some intellectual traditions or a combination of ideas that are seemingly counterintuitive to most scholars in the field of philosophy could generate a tremendous force that accelerates the (re)new (ed) sense of philosophy.3 The "philosophy of food" in chapter 5 especially demonstrates this excellence, and we should anticipate a longer sequel that would mark Wirth's original contribution to the history of philosophy.Two Counterfeit NegativesA food critic, however, must entertain the possibility of some improvement, even when the dish is well prepared and its overall presentation is exquisite. I would like to draw our attention to two... (shrink)

A number of philosophers today endorse the view that material substances (e.g., cats, stones, atoms) can be analyzed as bundles of “particular properties” or “tropes”. Among several developments, the theory that Peter Simons proposed is seen as the most successful one. Simons’ theory seems to owe its high reputation to mainly two advantages which he claims for his theory: the capacity for avoiding infinite regress, and the explanatory adequacy for the phenomenon of change. In this paper, however, I try to (...) object to this high appraisal, by showing that the two alleged advantages in fact cannot be simultaneously secured by Simons’ position. To this aim, I proceed as follows: First, I present Simons’ theory and explain its alleged two advantages. Next, I take up Arda Denkel’s criticism and show that the explanatory adequacy will be lost unless Simons accepts a certain revision of his theory. Finally, I show that as a result of the revision needed, Simons’ position comes to lose the capacity for avoiding infinite regress in turn. (shrink)

本書は、2013年4月1日から2015年3月31日までの2年間、『みすず』誌に連載された「日記」を一書にしたものである。大学人としての仕事や作家として執筆に追われながら、政治学者として世の動向を分析し 、皇室の動きを観察し、鉄道旅行をする。日常から時代を解読する試み。.

私たちにとって歴史とは何か。改めて歴史意識を取り戻すため、橋川文三を今、とらえ、読むための入門書。.

1. Kō to shi no shisōshi -- 2. Kō to shi no shakai kagaku -- 3. Nihon ni okeru kō to shi -- 4. Ō-Bei ni okeru kō to shi -- 5. Kokka to ningen to kōkyōsei -- 6. Keizai kara mita kōshi mondai -- 7. Chūkan shūdan ga hiraku kōkyōsei -- 8. Kagaku gijutsu to kōkyōsei -- 9. chikyū kankyō to kōkyōsei -- 10. 21-seiki kōkyō tetsugaku no chihei -- 14. Rīdāshippu kara kangaeru kōkyōsei.

The purpose of this study is to investigate the relationship between a firm’s strategy and consumers’ decisions in the presence of the paradox of choice and sharing personal information. The paradox of choice implies that having too many choices does not necessarily ensure happiness and sometimes having less is more. A new model is constructed introducing a factor of information sharing into the model of a previous study that embedded the paradox of choice only (Kinjo and Ebina in AI Soc (...) 30(2):291–297, 2015). A key feature of the model is its disutility function. It is demonstrated that if the sign of the cross derivative of the function is positive (negative) at the optimum, there is a positive (negative) correlation between the degree of sharing personal information chosen by the consumers and the number of products offered by the firm in its recommendation systems. It is also numerically indicated that the profit function of the firm becomes convex or concave depending on the shape of the disutility function. These results suggest that firms should carefully investigate the shape of the disutility function, under the paradox of choice and sharing personal information. (shrink)

This book brings together the work of two significant figures in contemporary philosophy. By considering the work of Tanabe Hajime, the Japanese philosopher of the Kyoto School, and William Desmond, the contemporary Irish philosopher, Takeshi Morisato offers a clear presentation of contemporary comparative solutions to the problems of the philosophy of religion. Importantly, this is the first book-length English-language study of Tanabe Hajime's philosophy of religion that consults the original Japanese texts. Considering the examples of Christianity and Buddhism, Faith (...) and Reason in Continental and Japanese Philosophy focuses on finding the solution to the problem of philosophy of religion through comparative examinations of Tanabe's metanoetics and Desmond's metaxology. It aims to conclude that these contemporary thinkers -- while they draw their inspiration from the different religious traditions of Christianity and Mahayana Buddhism -- successfully reconfigure the relation of faith and reason. Faith and Reason in Continental and Japanese Philosophy marks an important intervention into comparative philosophy by bringing into dialogue these thinkers, both major figures within their respective traditions yet rarely discussed in tandem. (shrink)

The purpose of our study is to investigate the effects of the number of products, product attributes, and prices on consumer confusion, conduct a numerical analysis to check the robustness of the results, and present an example of the cell phone market in Japan. Following an ideal point model and embedding the number of products and product attributes, we clarify how these factors affect consumer confusion and purchase probability. We show that as the number of product attributes increases, the choice (...) probability of each product becomes equal, implying that consumer confusion occurs. This result is robust to the introduction of prices as strategic variables. (shrink)

Presentism is usually understood as the thesis that only the present exists whereas the rival theory of eternalism is usually understood as the thesis that past, present, and future things are all equally real. The significance of this debate has been threatened by the so-called triviality objection, which allegedly shows that the presentist thesis is either trivially true or obviously false: Presentism is trivially true if it is read as saying that everything that exists now is present, and it is (...) obviously false if read as saying that everything that has existed, exits or will exist is present. If eternalism is taken as the negation of presentism, it is also either trivially false or obviously true. In this paper, I try to respond to the triviality objection on behalf of presentism. In second section, I will examine how the argument proceeds. In third section, I will reflect on three possible ways to respond but will argue that none of them succeeds in giving a satisfactory solution. I will then try to clarify the core idea of presentism and to suggest that if we characterise presentism accurately, the problem will disappear. In fourth section, I will offer a plausible definition of presentism and will show how it can avoid the triviality objection and demonstrate why it is advantageous to accept the version of presentism I offer. (shrink)

This study compares Pairs of subjects with Single subjects in a task of discovering scientific laws with the aid of experiments. Subjects solved a molecular genetics task in a computer micro‐world (Dunbar, 1993). Pairs were more successful in discovery than Singles and participated more actively in explanatory activities (i.e., entertaining hypotheses and considering alternative ideas and justifications). Explanatory activities were effective for discovery only when the subjects also conducted crucial experiments. Explanatory activities were facilitated when paired subjects made requests of (...) each other for explanation and focused on them. The study extends from individual to collaborative discovery activities the importance to the discovery process of setting goals to find hypotheses and evidence (Dunbar, 1993) and to construct explanations of phenomena and processes encountered in examples (Chi, Bassok, Lewis, & Glaser, 1989). (shrink)

Shōwashi e no renketsu -- Higashi Ajia kara no me -- Tennō to iu jiba -- Watashi no kaikōki -- Jikokuhyō katate ni ekisoba o.

死後十余年を経ても、いまだに熱烈な支持層を誇る政治思想史の巨人・丸山眞男。半世紀にわたって師事した著者ならではの視点で、一代の碩学の真の姿や意外な側面を浮き彫りに。また折に触れ示された言葉の数々を初め て明らかにする。.

This introduction to Tanabe Hajime (1885-1962), the critical successor of the "father of contemporary Japanese philosophy" Nishida Kitaro (1870-1945), focuses on Hajime's central philosophical ideas and perspective on "self," "world," "knowledge," and the "purpose of philosophizing". Exploring his notable philosophical ideas including the logic of species, metanoetics, and philosophy of death, it addresses his life-long study of the history of Western philosophy. It sets out his belief that Western framework of thinking is incapable of giving sufficient answers to the philosophical (...) questions concerning the self and the world together and discusses the central ideas he developed while working in Eastern traditions such as Confucianism and Daoism. Featuring comprehensive further reading lists, discussion questions and teaching notes, this is an ideal introductory guide to Tanabe Hajime suitable for anyone interested in Japanese and World philosophy, as well as the development of the Kyoto School. (shrink)

According to the “truthmaker maximalism”, every true contingent proposition is made true by something in the world, called its truthmaker. Although at first sight the maximalism seems to be a natural position, it has serious difficulties, especially concerning negative truths. In view of this, many truthmaker theorists adopt some non-maximalist position. It is not clear, however, whether these non-maximalists are justified, since existing reasons to justify the non-maximalism are not good enough. In this paper, then, I shall propose a new (...) reason for the non-maximalism, which consists in the observation that the maximalism cannot acknowledge the widely accepted view that certain inferences involving logical constants are valid in the properly logical sense. (shrink)

宇宙はなぜ“果てない”のか、ヒトはなぜ“考える”のか、微生物はなぜ“小さい”のか―分野を横断し、時制を越境して、生きものの可能性をラディカルに照らす、生物学界の「風雲児」長沼毅の集大成。.

Kant's concept of sensuality, one of the revolutionary innovations of his philosophy, is anything but self-evident. It was however not recognized as a problem until it had been established how its specific aspects differ from the customary linguistic usage and the use of the term in the 18th century. The analysis of sources from the history of concepts which have hardly been considered up to now, the discussion of specific problems connected to Kant's language regulation and the examination of the (...) Latin source material show that there is a need for the revision of certain aspects. This applies not only to the history of the term sensuality but also to the lexicography which has been corrected and supplemented. In addition to the information for the history of aesthetics, this work makes an important contribution to determining the correct date of Kant's handwritten reflections. Kants Verstandnis von Sinnlichkeit, eine der umsturzenden Neuerungen seiner Philosophie, ist alles andere als selbstverstandlich. Als Problem erkennbar wird es jedoch erst dann, wenn herausgearbeitet wird, wie sich seine spezifischen Momente von dem im 18. Jahrhundert ublichen Sprach- und Begriffsgebrauch unterscheiden. Die Analyse von begriffsgeschichtlich bisher kaum berucksichtigten Quellen, die Erorterung der Sachprobleme, die mit der wohluberlegten Sprachregelung Kants verbunden sind, und die Untersuchung der lateinischen Vorlagen ergeben manchen Revisionsbedarf. Betroffen sind sowohl die Geschichte des Begriffs der 'Sinnlichkeit', als auch die Lexikographie, die korrigiert und erganzt wird. Neben Aufschlussen fur die Geschichte der deutschen Asthetik leistet die Arbeit einen wichtigen Beitrag zur richtigen Datierung von Kants handschriftlichen Reflexionen aus dem Nachlass. (shrink)