Cofactor squelching is the term used to describe competition between transcription factors (TFs) for a limited amount of cofactors in a cell with the functional consequence that TFs in a given cell interfere with the activity of each other. Since cofactor squelching was proposed based primarily on reporter assays some 30 years ago, it has remained controversial, and the idea that it could be a physiologically relevant mechanism for transcriptional repression has not received much support. However, recent genome‐wide studies have (...) demonstrated that signal‐dependent TFs are very often absent from the enhancers that are acutely repressed by those signals, which is consistent with an indirect mechanism of repression such as squelching. Here we review these recent studies in the light of the classical studies of cofactor squelching, and we discuss how TF cooperativity in so‐called hotspots and super‐enhancers may sensitize these to cofactor squelching. (shrink)

Interdisciplinary research needs innovation. As an action-oriented intervention, this Manifesto begins from the authors’ experiences as social scientists working within interdisciplinary science and technology collaborations in agriculture and food. We draw from these experiences to: 1) explain what social scientists contribute to interdisciplinary agri-food tech collaborations; (2) describe barriers to substantive and meaningful collaboration; and (3) propose ways to overcome these barriers. We encourage funding bodies to develop mechanisms that ensure funded projects respect the integrity of social science expertise and (...) incorporate its insights. We also call for the integration of social scientific questions and methods in interdisciplinary projects from the outset, and for a genuine curiosity on the part of STEM and social science researchers alike about the knowledge and skills each of us has to offer. We contend that cultivating such integration and curiosity within interdisciplinary collaborations will make them more enriching for all researchers involved, and more likely to generate socially beneficial outcomes. (shrink)

While many theories exist to explain the complexity of environmental behaviour, the role of individuals’ relationship with nature has not yet been fully clarified. This paper attempts to operationalise human-nature relationships. It expands upon a scale assessed by an iterative process of mixed methods in the US and Europe. This scale is then used to assess individuals’ relationship with nature, and whether such relationships correlate with environmental behaviour. The value scale of Schwartz's Theory of Basic Values is used to validate (...) the results. The results verify that people hold multiple human-nature relationships, confirm strong correlations between human-nature relationships and values, and reveal that individuals’ behaviour is connected to the relationship they have with nature. (shrink)

Contemporary organizations often reciprocate to society for using resources and for affecting stakeholders by engaging in corporate social responsibility. It has been shown that CSR has a positive impact on employee attitudes. However, not all employees may react equally strongly to CSR practices. Based on socio-emotional selectivity theory, we contend that the effect of CSR on employee satisfaction will be more pronounced for older than for younger employees, because CSR practices address those emotional needs and goals that are prioritized when (...) people’s future time perspective decreases. In one multi-source field study and one experimental study, we demonstrate that CSR indeed has a stronger positive effect on employee satisfaction for older relative to younger employees. Accordingly, engaging in CSR can be an attractive tool for organizations that aim to keep their aging workforce satisfied with their job. (shrink)

Experiences of discrimination such as everyday racism can negatively affect the mental and physical health of children and adolescents with an immigrant background and impair their integration process in the host societies. Although experiences of racism are part of the everyday life of many minors affected by the process of “Othering” (e.g., those with an immigrant background), an overview of empirical findings is missing for this age group worldwide. A systematic review was conducted to identify and analyze international research on (...) the impact of discrimination on the developmental outcomes and integration of immigrant children and adolescents. Three scientific databases were systematically searched up to June 11, 2021. A total ofk= 4,769 identified publications were reviewed based on inclusion and exclusion criteria in terms of the PICOS format by independent reviewers. Thirty-four primary studies published between 1998 and 2021 met all inclusion criteria. The samples examined were mainly migrant youth (k= 30), with onlyk= 2 studies assessing refugee youth andk= 1 study assessing both migrant and refugee youth. The majority of included studies assessed perceived discrimination, with onlyk= 1 study directly assessing experiences of racism. The association between discrimination or racism and developmental outcomes was assessed by the included studies within the three main topics of (a) mental and physical health-related outcomes (k= 30, e.g., self-esteem, depressive symptoms), (b) school-related outcomes (k= 6, e.g., academic achievement), and (c) other developmental outcomes (k= 13, e.g., misconduct or delinquency). Data collection procedures were implemented, and findings on minors’ developmental outcomes and integration process who experience discrimination and racism were summarized and discussed. The current review suggests experienced (racial) discrimination as a negative predictor of children and adolescents’ (mental) health-related outcomes, while no clear results could be found for the association between discrimination and school-related outcomes. A need for more empirical research focusing on the path and (possibly) indirect link between discrimination and children and adolescents’ school-related outcomes as well as resulting school recommendations and the chosen career path was derived.Systematic Review Registration[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=260291], identifier [CRD42021260291]. (shrink)

This paper is a discussion of Gabriel, Hülser and Schlotter’s 2009 article on a possible causal relation between Stoic logic and Frege. The paper provides detailed argument for why Rudolf Hirzel should not be taken as the qualified middleman in philosophical discussion with whom Frege learned what he ‘borrowed’ without acknowledgement from Stoic logic. Additionally, this paper offers some modest findings about some aspects of Frege's and Hirzel's lives and work habits, which may help us understand a little better Frege's (...) connection to Hirzel and to Stoic logic as well as Frege’s failure to acknowledge the Stoics. This paper is a purely historical offshoot of my essay ‘Frege plagiarized the Stoics’. Zero direct insights into either Frege’s or Stoic philosophy are offered. OPEN ACCESS. Choose 'without proxy' below. (shrink)

The ability to learn sequential contingencies of actions for predicting future outcomes is indispensable for flexible behavior in many daily decision-making contexts. It remains open whether such ability may be enhanced by transcranial direct current stimulation. The present study combined tDCS with functional near-infrared spectroscopy to investigate potential tDCS-induced effects on sequential decision-making and the neural mechanisms underlying such modulations. Offline tDCS and sham stimulation were applied over the left and right dorsolateral prefrontal cortex in young male adults in a (...) double-blind between-subject design using a three-state Markov decision task. The results showed an enhanced dlPFC hemodynamic response during the acquisition of sequential state transitions that is consistent with the findings from a previous functional magnetic resonance imaging study; a tDCS-induced increase of the hemodynamic response in the dlPFC, but without accompanying performance-enhancing effects at the behavioral level; and a greater tDCS-induced upregulation of hemodynamic responses in the delayed reward condition that seems to be associated with faster decision speed. Taken together, these findings provide empirical evidence for fNIRS as a suitable method for investigating hemodynamic correlates of sequential decision-making as well as functional brain correlates underlying tDCS-induced modulation. Future research with larger sample sizes for carrying out subgroup analysis is necessary in order to decipher interindividual differences in tDCS-induced effects on sequential decision-making process at the behavioral and brain levels. (shrink)

This book presents a study of human intelligence beginning with a semantic theory and leading into a critique of music.

We analyzed the association between the analog and the digital home learning environment in toddlers’ and preschoolers’ homes, and whether both aspects are associated with children’s social and academic competencies. Here, we used data of the national representative sample of Growing up in Germany II, which includes 4,914 children aged 0–5 years. The HLE was assessed via parental survey that included items on the analog HLE and items on the digital HLE. Children’s socio-emotional, practical life skills, and academic competencies were (...) assessed via standardized parental ratings. Our results indicate that there are two dimensions of the HLE, an analog and a digital, that are slightly positively associated, especially in the toddler age group. For toddlers, only analog HLE activities were associated with better socio-emotional outcomes and practical life skills. However, interaction effects indicate that toddlers with less frequent analog HLE activities showed better socio-emotional skills in households with more frequent digital activities. For preschoolers, digital HLE activities were associated with weaker socio-emotional skills but higher academic skills, although the analog HLE shows higher effect sizes for the academic outcomes. Our study points out that analog and digital HLE activities seem to be partly associated, but not interchangeable. Further, they seem to be important variables that can explain individual differences in young children’s socio-emotional, practical life, and academic competencies. However, digital media usage at home may also have negative effects on children’s social–emotional competencies. This association needs to be investigated further. (shrink)

The ‘Dialectical school’ denotes a group of early Hellenistic philosophers that were loosely connected by philosophizing in the — Socratic — tradition of Eubulides of Megara and by their interest in logical paradoxes, propositional logic and dialectical expertise. . Its two best known members, Diodorus Cronus and Philo the Logician, made groundbreaking contributions to the development of theories of conditionals and modal logic. Philo introduced a version of material implication; Diodorus devised a forerunner of strict implication. Each developed a system (...) of modal notions that satisfies the basic logical requirements laid down by modern standard modal theories. In antiquity, Diodorus Cronus was famous for his so called Master Argument, which aims to prove that only the actual is possible. (shrink)

Number processing abilities are important for academic and personal development. The course of initial specialization of ventral occipito-temporal cortex sensitivity to visual number processing is crucial for the acquisition of numeric and arithmetic skills. We examined the visual N1, the electrophysiological correlate of vOTC activation across five time points in kindergarten, middle and end of first grade, second grade, and fifth grade. A combination of cross-sectional and longitudinal EEG data of a total of 62 children at varying familial risk for (...) dyslexia were available to form groups of 23, 22, 27, 27, and 42 participants for each of the five time points. The children performed a target detection task which included visual presentation of single digits, false fonts, and letters to derive measures for coarse and fine digit sensitive processing across development. The N1 amplitude analyses indicated coarse and fine sensitivity characterized by a stronger N1 to digits than false fonts across all five time points, and stronger N1 to digits than letters at all but the second time point. In addition, lower arithmetic skills were associated with stronger coarse N1 digit sensitivity over the left hemisphere in second grade, possibly reflecting allocation of more attentional resources or stronger reliance on the verbal system in children with poorer arithmetic skills. To summarize, our results show persistent visual N1 sensitivity to digits that is already present early on in pre-school and remains stable until fifth grade. This pattern of digit sensitivity development clearly differs from the relatively sharp rise and fall of the visual N1 sensitivity to words or letters between kindergarten and middle of elementary school and suggests unique developmental trajectories for visual processing of written characters that are relevant to numeracy and literacy. (shrink)

Die Sprachlichkeit des Glaubens ist von Anfang an zentrales Thema protestantischer Theologie. Der Glaube, als Vertrauen auf das biblisch bezeugte und lebendig gepredigte Evangelium, lebt in der Sprache, weil er aus dem Horen kommt: Er vollzieht sich im Modus des Verstehens. Seit jeher sind daher theologische Hermeneutik und Homiletik Orte, an denen die Sprachlichkeit des Glaubens reflektiert wird. Diese Reflexion setzen die Beitrage des vorliegenden Bandes in je unterschiedlicher Facherperspektive fort.

This book offers a new account of what it is to act for a normative reason. The first part of the book examines the problems of causal accounts of acting for reasons and suggests to solve them by a dispositional approach. The author argues for a dispositional account which unites epistemic, volitional, and executional dispositions in a complex normative competence. This ‘Normative Competence Account’ allows for more and less reflective ways of acting for normative reasons. The second part of the (...) book clarifies the relation between the normative reason that an agent acts for and his or her motivating reasons. It refutes the widely held ‘identity view’ that acting for a normative reason requires the normative reason to be identical with a motivating reason. The author describes how normative reasons are related to motivating reasons by a relation of correspondence, and proposes a new understanding of how normative reasons explain those actions that are performed for them. Determined by Reasons engages with current debates from a wide range of different philosophical areas, including action theory, metaethics, moral psychology, epistemology, and ontology, to develop a new account of acting for normative reasons. (shrink)

This study investigated the effect of stroking vs. simple human presence on later reactions of dairy cows to routine veterinary handling. While in two groups of cows the experimenter stroked the ventral part of the neck or the withers for three consecutive weeks, the third group was exposed to close visual presence. After the treatment period the cows were subjected to rectal palpation. The three groups differed significantly in stepping during rectal palpation, which occurred less often in Neck- and Withers-animals (...) than in control animals. Heart rate increase was significantly higher in the control group than in the two stroking groups. Previous stroking led to fewer stress reactions during the rectal palpation, possibly due to a combined effect of improved relationship towards and thus perception of humans and lasting anti-stress effects of tactile stimulation. Keywords: cattle; tactile stimulation; human–animal relationship; animal welfare. (shrink)

When a fragmented line-drawing of an object moves relative to a background of randomly oriented lines, the previously hidden object can be segregated from the background and consequently enters awareness. In this shape-from-motion paradigm, the percept of the object briefly persists after the motion stops, demonstrating the maintenance of a bound percept in awareness. This study investigated how the manipulation of object features that are crucial to recognition influences both the binding process and the maintenance of objects in awareness. Overall, (...) we found that objects that took longer to recognize were nonetheless maintained in awareness for longer. We argue that this effect is mediated by additional elaborative processing that is required to bind these less recognizable forms, which generates stronger and more robust representations. These representations are then more easily maintained in awareness, suggesting an important role of elaborative mechanisms for conscious representations. (shrink)

Patients’ experience of symptoms does not follow the body–mind divide that characterizes the classification of disease in the health care system. Therefore, understanding patients in their entirety rather than in parts demands a different theoretical approach. Attempts have been made to formulate such approaches but many of these, such as the biopsychosocial model, are still basically dualistic or methodologically reductionist. In primary care, patients often present with diffuse symptoms, making primary care the ideal environment for understanding patients’ undifferentiated symptoms and (...) disease patterns which could readily fit both bodily and mental categories. In this article we discuss theoretical models that have attempted to overcome this challenge: The psychosomatic approach could be called holistic in the sense of taking an anti-dualistic stance. Primary care theorists have formulated integrative views but these have not gained a foothold in primary care medicine. McWhinney introduced a new metaphor, ‘the body–mind’, and Rudebeck advocated cultivating ‘bodily empathy’. These views have much in common with both phenomenological thinking and mentalization, a psychological concept for understanding others. In the process of understanding patients there is a need for the physician to enter an intersubjectivity that aims at understanding the patient’s experiences and sensations without initially jumping to diagnostic conclusions or into a division into mental and physical phenomena. Mentalization theory could form the basis of an approach to a more comprehensive understanding of patients. The success of such an approach is, however, dependent upon structural and organizational conditions that do not counteract it. (shrink)

The paper presents a new theory of higher-order vagueness. This theory is an improvement on current theories of vagueness in that it (i) describes the kind of borderline cases relevant to the Sorites paradox, (ii) retains the ‘robustness’ of vague predicates, (iii) introduces a notion of higher-order vagueness that is compositional, but (iv) avoids the paradoxes of higher-order vagueness. The theory’s central building-blocks: Borderlinehood is defined as radical unclarity. Unclarity is defined by means of competent, rational, informed speakers (‘CRISPs’) whose (...) competence, etc., is indexed to the scope of the unclarity operator. The unclarity is radical since it eliminates clear cases of unclarity and, that is, clear borderline cases. This radical unclarity leads to a (bivalence-compatible, non-intuitionist) absolute agnosticism about the semantic status of all borderline cases. The corresponding modal system would be a non-normal variation on S4M. (shrink)

In their paper ‘Why Frege did not plagiarize the Stoics’ (Gabriel et al. 2024), G. Gabriel, K. Hülser and D. Rami provide an extended set of arguments to show that Frege didn’t, and couldn’t have, plagiarize(d) the Stoics via Prantl’s long chapter on Stoic logic (Prantl 1855) or at all, thus attempting to counter Bobzien’s 2021 ‘Frege plagiarized the Stoics’. The present short essay is Part II of a four-part refutation of Gabriel et al. 2024: The authors repeatedly ‒ and (...) wrongly ‒ claim that there is a tradition of Stoic logic (and Stoic logical terminology) transmitted continuously from antiquity to the 19th century that was generally known in the 18th and 19th centuries. In this second part of the refutation, it is shown that, and why, the authors are entirely mistaken on every one of these points. (shrink)

Chapter Introduction. Syntactic focus theory and the phenomenon of secondary predication The primary goal of this monograph is to examine the interaction of ...

Since assisted reproductive technologies (ART) are becoming increasingly important in wildlife conservation breeding programs, we need to discuss their implications to ensure their responsible use regarding the environment, the animals, and the people involved. In this article, we seek to contribute to the ongoing ethical and philosophical debate on ART in conservation by discussing the current attempt to save the northern white rhino (Ceratotherium simum cottoni, NWR) from extinction. Only two female NWRs are known to the world, both unable to (...) carry a pregnancy, and the last chance to avoid sure extinction relies on pushing the boundaries of contemporary science through the use of advanced ART and stem cell-associated techniques. The attempt to save the NWR constitutes a valuable testbed for assessing the use of ART in conservation and an occasion for identifying possible critical issues. It touches upon several ethically relevant points—that we identify and organize in an Ethical Matrix—such as the need to guarantee animal welfare, and it provides the opportunity to discuss some significant questions related to conservation. For instance, how far is it legitimate to go in trying to save a taxon? Is using sophisticated technologies to remedy anthropogenic harm a part of the problem rather than the solution? (shrink)

Through advances in production and treatment technologies, transparent glass has become an increasingly versatile material and a global hallmark of modern architecture. In the shape of invisible barriers, it defines spaces while simultaneously shaping their lighting, noise, and climate conditions. Despite these unique architectural qualities, little is known regarding the human experience with glass barriers. Is a material that has been described as being simultaneously there and not there from an architectural perspective, actually there and/or not there from perceptual, behavioral, (...) and social points of view? In this article, we review systematic observations and experimental studies that explore the impact of transparent barriers on human cognition and action. In doing so, the importance of empirical and multidisciplinary approaches to inform the use of glass in contemporary architecture is highlighted and key questions for future inquiry are identified. (shrink)

Biodiversity is the key indicator of a healthy planet and healthy society. Losses of biodiversity have now become widespread and current rates are potentially catastrophic for species and habitat integrity. Biodiversity, Sustainability and Human Communities advocates both the preservation of the best remaining habitats and the enhancement of new biodiverse habitats to ensure that they cope with human impact, climate change and alien species invasion. The authors argue that these aims can be achieved by a mix of strict protection, inclusive (...) involvement of people inside and adjacent to reserves, and by combining livelihoods and social well-being in all future biodiversity management. Case studies from regions around the world, including Europe, the United States, Latin America and Africa are examined and discussed, and the contributors include political scientists, economists and ecologists. (shrink)

Are epistemic reasons normative in the same sense as, for instance, moral reasons? In this paper I examine and defend the claim that epistemic reasons are normative only relative to an epistemic standard. Unlike moral reasons they are not substantially normative, because they fail to make an independent contribution to obligations or permissions simpliciter. After presenting what I take to be the main argument for this view, I illustrate that the argument has often been defended by examples which controversially presuppose (...) strong epistemic obligations or pragmatic reasons for belief. Opponents of the argument often deny the existence of obligations and reasons of these kinds. I therefore examine whether the argument can withstand that line of critique by employing new examples. (shrink)

Der Kolner Dominikaner Gerhard von Sterngassen verfasste im ersten Viertel des 14. Jahrhunderts einen Laster- und Tugendtraktat, der unter zwei metaphorischen Titeln "Medela languentis animae" bzw. "Pratum animarum" in zwei unterschiedlich umfangreichen Redaktionen uberliefert ist. Trotz der wiederholten Erwahnung des Werkes im Zusammenhang der Deutschen Thomistenschule bzw. der Rheinischen Dominikanerschule fehlte bislang eine umfassende Untersuchung und Edition. Den zentralen Inhalt des Buches von Susanne Kaup bilden die text- und quellenkritische Edition sowie die theologische Interpretation der Lehre von den Gluckseligkeiten (...) (beatitudines) der Bergpredigt einer Thematik, deren mittelalterliche Rezeptionsgeschichte bisher wenig Aufmerksamkeit erfuhr und die die haufig in der Forschung diskutierte philosophische Lehre vom Gluck aus theologischer Perspektive erganzt. In der Zitation von Autoren der Patristik bis hin zu Thomas von Aquin werden systematische Texte und narrative Exempla der Wustenvatertheologie miteinander verbunden. Gerhard von Sterngassen verfasste ein theologisch-spirituelles, heils-padagogisches Werk fur die Privatfrommigkeit; durch die umfangreiche Benutzung des Thomas von Aquin leistete er einen wichtigen Beitrag zur Breitenwirkung dieses Gedankengutes. Die Dissertation wurde im Juni 2010 mit dem Promotionsforderpreis der Munchener Universitatsgesellschaft ausgezeichnet.". (shrink)