The pituitary hormone prolactin (PRL) is best known for its role in the regulation of lactation. Recent evidence furthermore indicates PRL is required for normal reproduction in rodents. Here, we report on the insertion of two transposon-like DNA sequences in the human prolactin gene, which together function as an alternative promoter directing extrapituitary PRL expression. Indeed, the transposable elements contain transcription factor binding sites that have been shown to mediate PRL transcription in human uterine decidualised endometrial cells and lymphocytes. We (...) hypothesize that the transposon insertion event has resulted in divergent (pituitary versus extrapituitary) expression of prolactin in primates, and in differential actions of pituitary versus extrapituitary prolactin in lactation versus pregnancy respectively. Importantly, the TE insertion might provide a context for some of the conflicting results obtained in studies of PRL function in mice and man. (shrink)

We sometimes strive to achieve difficult goals when our evidence suggests that success is unlikely – not just because it will require strength of will, but because we are targets of prejudice and discrimination or because success will require unusual ability. Optimism about one’s prospects can be useful for persevering in these cases. That said, excessive optimism can be dangerous; when our evidence is unfavourable, we should be at most agnostic about whether we will succeed. This paper explores the nature (...) and rational significance of agnostic practical commitments. Most importantly, the rationality of striving against the odds can depend on investing in a plan for failure: a plan B. I aim to make headway on an account of what backup plans are, how they are related to primary plans, and whether the standard norms of plan rationality apply to our agnostic commitments. (shrink)

The present paper focuses on essentialism about natural kinds as a case study in order to illustrate this more general point. Saul Kripke and Hilary Putnam famously argued that natural kinds have essences, which are discovered by science, and which determine the extensions of our natural kind terms and concepts. This line of thought has been enormously influential in philosophy, and is often taken to have been established beyond doubt. The argument for the conclusion, however, makes critical use of intuitions, (...) and I note that the intuitions are of the sort had by preschool children, and that they are traceable to a deep-seated cognitive outlook, which is often called “psychological essentialism.” Further, if we did not have such a cognitive outlook or implicit belief set—a belief set which is in fact in place by at least age 4—then we would not have the relevant philosophical intuitions. In light of this, I consider the question of whether natural kinds actually have scientifically discovered or discoverable essences, and whether these putative essences could determine the extensions of our terms and concepts as Kripke, Putnam, and many others have supposed. In fact, a number of philosophers of biology and chemistry have argued that biological and chemical kinds do not have such essences, yet these arguments—particularly in the case of chemistry—have not been assimilated by philosophers more generally. The reason for this poor assimilation is, I suggest, that the Kripke/Putnam view is just so intuitive. But this fact, I argue, is due to a deep-seated cognitive bias, rather than to any special insight into the nature of reality. (shrink)

I use the psychological phenomenon of ‘attribute framing’ as a case study for exploring philosophical conceptions of semantics and the semantics-pragmatics divide. Attribute frames are pairs of sentences that use contradictory expressions to predicate the same property of an individual or object. Despite their equivalence, pairs of attribute frames have been observed to induce systematic variability in hearers’ responses. One explanation of such framing effects appeals to the distinct ‘reference point information’ conveyed by alternative frames. Although this information is taken (...) to be pragmatic, a live debate in the philosophy of language concerns the extent to which pragmatic information can really be held apart from semantics. Therefore, in this article I examine whether – and how – reference point information might be thought to intrude on the semantics of an attribute frame. I describe two ways in which the information might be considered broadly semantic, due to its being directly communicated or conventional. However, I argue that the framing data in fact support a narrower conception of semantics, and a semantics-pragmatics distinction that separates standing sentence meaning from enriched communicated meaning. (shrink)

A compelling argument for the morality of limitations on procreation in lessening the harmful environmental effects of unchecked populationWe live in a world where a burgeoning global population has started to have a major and destructive environmental impact. The results, including climate change and the struggle for limited resources, appear to be inevitable aspects of a difficult future. Mandatory population control might be a possible last resort to combat this problem, but is also a potentially immoral and undesirable violation of (...) human rights. Since so many view procreation as an essential component of the right to personal happiness and autonomy, the dominant view remains that the government does not have the right to impose these restrictions on its own citizens, for the sake of future people who have yet to exist.Sarah Conly is first to make the contentious argument that not only is it wrong to have more than one child in the face of such concerns, we do not even retain the right to do so. In One Child, Conly argues that autonomy and personal rights are not unlimited, especially if one's body may cause harm to anyone, and that the government has a moral obligation to protect both current and future citizens. Conly gives readers a thought-provoking and accessible exposure to the problem of population growth and develops a credible view of what our moral obligations really are, to generations present and future. (shrink)

The present article explores the views of al-Jāḥiẓ, Abū Bakr al-Rāzī, and Fakhr al-Dīn al-Rāzī - three pre-modern thinkers of the Islamic world outside the Peripatetic tradition - on the question o...

In Memory: A Self-Referential Account, Fernández offers a functionalist account of the metaphysics of memory, which is portrayed as presenting significant advantages over causal and narrative theories of memory. In this paper, I present a series of challenges for Fernández’s functionalism. There are issues with both the particulars of the account and the use of functionalism more generally. First, in characterizing the mnemonic role of episodic remembering, Fernández fails to make clear how the mental image type that plays this role (...) should be identified. Second, I argue that a functionalist approach, which appeals to the overall structure of the memory system and tendencies of mental state types, is ill-suited to the metaphysical question about episodic remembering that is of interest to the causal and narrative theorists with which Fernandez engages. Fernández’s self-referential account of memory has many other virtues, but functionalism is a poor fit for episodic remembering. (shrink)

: Contextualism in epistemology has been proposed both as a way to avoid skepticism and as an explanation for the variability found in our use of "knows." When we turn to contextualism to perform these two functions, we should ensure that the version we endorse is well suited for these tasks. I compare two versions of epistemic contextualism: attributor contextualism and methodological contextualism. I argue that methodological contextualism is superior both in its response to skepticism and in its mechanism for (...) changing contexts. However, methodological contextualism still faces two challenges: explaining why we are solidly committed to some contexts, and explaining why knowledge within a context is valuable. I propose virtue contextualism as a useful extension of methodological contextualism, focusing on the way that our virtues depend on our social roles. My proposed virtue contextualism retains the benefits of methodological contextualism while explaining both our commitment to particular contexts and the value of knowledge held within those contexts. (shrink)

Over the past decade land has again moved to the centre of resource conflicts, agrarian struggles, and competing visions over the future of food and farming. This renewed interest in land necessitates asking the seemingly simple, but pertinent, question ‘whatisland?’ To reach a more profound understanding of the uniqueness of land, and what distinguishes land from other resources, this symposium suggests the notion of ‘land imaginaries’ as a crucial lens in the study of current land transformations. Political-economy, and the particular (...) economic, financial, or political interests of various actors involved in land projects do not directly result in, or translate into, outcomes, such as dispossession and enclosure, increased commodification, financialization, and assetization, or mobilization and resistance. All these processes are informed by different imaginaries of land—the underlying understandings, views, and visions of what land is, can, and should be—and associated visions, hopes, and dreams regarding land. Drawing on a variety of case studies from across the world, crossing Global North/South and East/West, and including contemporary and historical instances of land transformation, this symposium addresses the multifaceted ways in which implicit, explicit, and emergent understandings of land shape current land transformations. (shrink)

It is sometimes claimed that if moral realism is true, then rational and informed individuals would not disagree about morality. According to this line of thought, the moral realist is committed to an extremely substantive convergence thesis, one that might very well turn out to be false. Although this idea has been accepted by prominent moral realists as well as by antirealists, I argue that we have no reason to think that it is true, and that the only convergence claims (...) to which the realist is committed are trivial ones. (shrink)

line-by-line notes are invariably informative and helpful, as well thought-provoking.' John M. Cooper, Stuart Professor of Philosophy, Princeton UniversityIn a new English translation by Christopher Rowe, this great classic of moral philosophy is accompanied here by an extended introduction and detailed lin-by-line commentary by Sarah Broadie. Assuming no knowledge of Greek, her scholarly and instructive approach will prove invaluable for students reading the text for the first time. This thorough treatment of Aristotle's text will be an indispensable resource for (...) students, teachers, and scholars alike. (shrink)

What is the best model of epistemic agency for virtue epistemology? Insofar as the intellectual and moral virtues are similar, it is desirable to develop models of agency that are similar across the two realms. Unlike Aristotle, the Stoics present a model of the virtues on which the moral and intellectual virtues are unified. The Stoics’ materialism and determinism also help to explain how we can be responsible for our beliefs even when we cannot believe otherwise. In this paper I (...) show how a neo-Stoic model of epistemic agency can address common objections to treating epistemic and moral agency similarly and allow a robust explanatory role for character in determining our actions and beliefs. The picture of epistemic responsibility that flows from this model also explains why we often deserve credit for our knowledge, while demonstrating that the truth of our beliefs is not something for which we are epistemically responsible. (shrink)

Plato's Sun-Like Good is a revolutionary discussion of the Republic's philosopher-rulers, their dialectic, and their relation to the form of the good. With detailed arguments Sarah Broadie explains how, if we think of the form of the good as 'interrogative', we can re-conceive those central reference-points of Platonism in down-to-earth terms without loss to our sense of Plato's philosophical greatness. The book's main aims are: first, to show how for Plato the form of the good is of practical value (...) in a way that we can understand; secondly, to make sense of the connection he draws between dialectic and the form of the good; and thirdly, to make sense of the relationship between the form of the good and other forms while respecting the contours of the sun-good analogy and remaining faithful to the text of the Republic itself. (shrink)

Drawing on data from 100 qualitative interviews with the recently unemployed, this study examines how participants made decisions about attempting to return to work and identifies how class and gender shape these decisions. Middle-class men were most likely to take time to attempt to return to work, middle-class women were most likely to begin a deliberate job search, working-class men were most likely to report an urgent search, and working-class women were most likely to have diverted searches. Financial resources, gendered (...) labor force attachments, and family responsibilities shaped decision making. Ultimately, those in the middle-class appear doubly advantaged—both in their financial capabilities and in their ability to respond to the crisis with greater gender flexibility. (shrink)

In his recent book, Frame It Again: New Tools for Rational Decision-Making, J. L. Bermúdez argues that it can be rational to evaluate the same thing differently when it is described using alternati...

Despite multiple axes of variation in defining wellbeing, the paper argues for the dominance of a ‘components approach’ in current research and practice. This approach builds on a well-established tradition within the social sciences of attending to categories whether for their identification, their value or their meanings and political resonance. The paper critiques the components approach and explores how to move beyond it towards conceptually integrating the various categories and dimensions through a relational and situated account of wellbeing. Drawing on (...) more fluid social sciences, wellbeing is framed as an effect, dependent on the mobilisation of resources from everyday encounters with complex assemblages of people, things and places. Through such a framing, wellbeing can be conceived of as stable and amenable to change, as individual and collective and as subjective and objective. Policy interventions then need to attend to the relationalities of particular social and spatial contexts. (shrink)

The issue which I wish to address in this paper is the widespread tendency in Anglophone philosophy to insist on a separation between the history of philosophy and the history of ideas or intellectual history. This separation reflects an anxiety on the part of philosophers lest the special character of philosophy will be dissolved into something else in the hands of historians. And it is borne of a fundamental tension between those who think of philosophy's past as a source of (...) ideas and arguments of interest to the present, and those who hold that the philosophy of the past should be studied on its own terms, in relation to its immediate context, without reference to the present. The challenge, then, is to re-historicise the history of philosophy, and to keep the philosophers onside. (shrink)

If we adopt a virtue approach to epistemology, what form should the intellectual virtues take? In this paper, I argue that the proper structure of the intellectual virtues should be one that follows the tradition of internalism in epistemology. I begin by giving a general characterization of virtue epistemology and then define internalism within that framework. Arguing for internalism, I first consider the thought experiment of the new evil demon and show how externalist accounts of intellectual virtue, though constructed to (...) accommodate our intuitions in such cases, cannot fully do so. I further argue that only adopting an internalist structure of the virtues will provide intellectual virtues that appropriately mirror the structure of the classical moral virtues. Finally, I argue that only an internalist structure of the virtues can explain why the intellectual virtues are valuable in themselves. (shrink)

Volume 20, Issue 9, September 2020, Page 39-41.

A number of sociologists have identified the emergence of a ‘new paradigm’ of health, based on the principle that the National Health Service should seek to prevent ill-health rather than simply treat the sick. The sociology of health promotion that has emerged over the past 15 years has contributed to debates about risk, lifestyle and consumerism, but the gendered nature of what some refer to as the ‘new morality of health’, and in particular its urging of feminine attributes, has largely (...) been neglected. This article provides a critical examination of the ‘new paradigm’ of health and its relationship to femininity. I suggest that femininity involves a certain attitude to the body that we also find in current health policy, and cultural representations of health more generally: that the body is essentially uncontrollable (yet something we should seek to control, as a matter of virtue), that it is a good in and of itself, and that it is synonymous with the self. (shrink)

Ralph Cudworth’s theory of mind was the most fully developed philosophical psychology among the Cambridge Platonists. Like his seventeenth-century contemporaries, Cudworth discussed mental powers in terms of soul rather than mind and considered the function of the soul to be not merely intellectual, but vital and moral. Cudworth conceived the soul as a single self-determining unit which combined many powers. He developed this against a philosophical agenda set by Descartes and Hobbes. But he turned to ancient philosophy, especially the philosophy (...) of Plotinus, to develop a psychology which is distinguished by the attention he gives to both conscious and unconscious states, and to the powers which enable it to reflect on itself, to co-ordinate its activities and direct them to good ends. I argue that in so doing, Cudworth sought to elaborate a theory of mind which accounted for observable experience of mental operations. My paper outlines the complexities of Cudworth’s taxonomy of mental powers, focusing on three key powers which Cudworth developed through his reading of Plotinus: energy, self-power, and sympathy. (shrink)

The multiplicity of deubiquitinating enzymes (DUBs) encoded by vertebrate genomes is partly attributable to whole genome duplication events that occurred early in chordate evolution. By surveying the literature for the largest family of DUBs (the ubiquitin-specific proteases), extensive functional redundancy for duplicated genes has been confirmed as opposed to singletons. Dramatically conflicting results have been reported for loss of function studies conducted through RNA interference as opposed to inactivating mutations, but the contradictory findings can be reconciled by a recently proposed (...) compensatory mechanism involving nonsense-mediated RNA degradation. Duplicated genes are often inactivated to become pseudogenes, and it is proposed that such is the fate of the USP15 gene of zebrafish, a commonly used model system. As it is reviewed here, these observations have implications not only for the interpretation of model system phenotypes but also for therapeutic interventions designed to target DUBs. (shrink)

Named one of the Ten Best Books of 2016 by the New York Times, a spirited account of a major intellectual movement of the twentieth century and the revolutionary thinkers who came to shape it, by the best-selling author of How to Live Sarah Bakewell. Paris, 1933: three contemporaries meet over apricot cocktails at the Bec-de-Gaz bar on the rue Montparnasse. They are the young Jean-Paul Sartre, Simone de Beauvoir, and longtime friend Raymond Aron, a fellow philosopher who raves (...) to them about a new conceptual framework from Berlin called Phenomenology. "You see," he says, "if you are a phenomenologist you can talk about this cocktail and make philosophy out of it!" It was this simple phrase that would ignite a movement, inspiring Sartre to integrate Phenomenology into his own French, humanistic sensibility, thereby creating an entirely new philosophical approach inspired by themes of radical freedom, authentic being, and political activism. This movement would sweep through the jazz clubs and cafés of the Left Bank before making its way across the world as Existentialism. Featuring not only philosophers, but also playwrights, anthropologists, convicts, and revolutionaries, At the Existentialist Café follows the existentialists' story, from the first rebellious spark through the Second World War, to its role in postwar liberation movements such as anti-colonialism, feminism, and gay rights. Interweaving biography and philosophy, it is the epic account of passionate encounters--fights, love affairs, mentorships, rebellions, and long partnerships--and a vital investigation into what the existentialists have to offer us today, at a moment when we are once again confronting the major questions of freedom, global responsibility, and human authenticity in a fractious and technology-driven world. (shrink)

An interpretation is offered of the Aristotelian concept of “practical truth” in the wake of Anscombe’s very interesting exegesis. Her own interpretation is considered and its merits noted, but a question is raised as to its plausibility as an account of what Aristotle himself intended in speaking of “truth that is practical”.

Aliénés: Une histoire sociale de la folie au xixe siècle dresse l’histoire – ou devrait-on dire les histoires – des aliénés du xixe siècle dans leurs dimensions les plus fines. Si l’histoire de l’asile se donne à voir à travers les trajectoires des aliénés, l’ambition de l’auteur est davantage de faire une histoire “des malades” que des maladies et des institutions. Anatole Le Bras analyse les façons dont l’asile façonne et travaille les corps, interfère avec les classes sociales, les genres...

This paper investigates the structure of English restrictive relative clauses. It provides support for the view that restrictive relative clauses are structurally ambiguous between two structures: the head-internal, raising structure and the matching structure, which has both an internal and an external head. We present a new test from extraposition facts that distinguishes between the raising and matching structures for relative clauses. Furthermore, this paper presents an account of the semantics of raising relative clauses which is intended to complete the (...) picture of the semantics of relative clauses. In particular, we argue that raising relative clauses are not islands for Quantifier Raising (QR) and that in these clauses there is successive cyclic movement through a CP-adjoined position. (shrink)

Our paper contributes to emerging management research on the effects of societal inequality. It aims to study the relationship between societal-level inequality and perceived unequal HR practices within organizations based on relationships which we term “relation-based inequality” (RBI). We further examine the moderating effect of country corruption on the RBI-employee commitment link. Thus, whereas previous research has looked at single countries, there is still much to know about societal effects of inequality and corruption on employee perceptions and attitudes at work (...) across countries. By surveying 691employees from five countries and using country-level indicators we take a first step in this direction, and establish that inequality (income, health and education) is linked to higher levels of relation-based HR practices. We also show that the effect of RBI is different for continuance, affective and normative commitment, and contingent on country corruption levels. (shrink)

This chapter demonstrates how early modern male and female thinkers alike were concerned not only with ethical, religious, and political liberty, but also with the liberty to philosophize, or libertas philosophandi. It is argued that while men’s interests in this latter kind of liberty tended to lie with the liberty to philosophize differently from their predecessors, women were more concerned with the liberty to philosophize at all. For them, the idea that women should be free to think was foundational. This (...) chapter shows how some women thinkers of the period, such as Damaris Cudworth Masham (1658–1708) and Mary Astell (1666–1731), followed through on the general trend of thinking about liberty in terms of freedom of the mind, to thinking about liberty for women in wider ethical and political terms. To support this point, the chapter explores their views on education, female rationality, and moral philosophy. (shrink)

A quest for information concerning one of the missing room interiors of Wray Castle, a Gothic villa near Windermere in Cumbria, built for a Liverpool surgeon in the 1840s, curiously led the National Trust to the wonderfully contrasting neo-classical Manchester Central Library, designed by E. Vincent Harris and completed in 1934. A trawl through the records revealed a keen donor but a reluctant architect. Sixteenth-and seventeenth-century carved oak panels from the library of Wray Castle were removed and donated for use (...) in the new Central Library by the Lord Mayor of Manchester, Sir Robert Noton Barclay, before he gave the castle to the National Trust. Archive material held at Manchester shows that Harris was reluctant to accept the panels, stating his reasons firmly, but that he was prevailed upon to do so and finally incorporated them some years later. (shrink)

Summary 1. Ecologists and conservation biologists consider many issues when designing a field study, such as the expected value of the data, the interests of the study species, the welfare of individual organisms and the cost of the project. These different issues or values often conflict; however, neither animal ethics nor environmental ethics provides practical guidance on how to assess trade-offs between them. -/- 2. We developed a decision framework for considering trade-offs between values in ecological research, drawing on the (...) field of ecological ethics. We used a case study of the population genetics of three frog species, in which a researcher must choose between four methods of sampling DNA from the study animals. We measured species welfare as the reduction in population growth rate following sampling, and assessed individual welfare using two different definitions: (i) the level of suffering experienced by an animal, and (ii) the level of suffering combined with loss of future life. -/- 3. Tipping the tails of tadpoles ranked as the best sampling method for species welfare, while collecting whole tadpoles and buccal swabbing of adult frogs ranked best for the first and second definitions of individual welfare, respectively. Toe clipping of adult frogs ranked as the worst sampling method for species welfare and the first definition of individual welfare, and equal worst for the second definition of individual welfare. -/- 4. When considering species and individual welfare simultaneously, toe clipping was clearly inferior to the other sampling methods, but no single sampling method was clearly superior to the other three. Buccal swabbing, collecting tadpoles and tail tipping were all preferred options, depending on the definition of individual welfare and the level of precision with which we assessed species welfare. -/- 5.Synthesis and applications. The decision framework we present can be used by ecologists to assess ethical and other trade-offs when planning field studies. A formal decision analysis makes transparent how a researcher might negotiate competing ethical, financial and practical objectives. Defining the components of the decision in this way can help avoid errors associated with human judgement and linguistic uncertainty. (shrink)

Identifying links between human personality and attributed robot personality is a relatively new area of human–robot interaction. In this paper we report on an exploratory study that investigates human and robot personality traits as part of a human–robot interaction trial. The trials took place in a simulated living-room scenario involving 28 participants and a human-sized robot of mechanical appearance. Participants interacted with the robot in two task scenarios relevant to a ‘robot in the home’ context. It was found that participants’ (...) evaluations of their own personality traits are related to their evaluations of the robot’s personality traits. The statistical analysis of questionnaire data yields several statistically significant results: Participants do not tend to assign their personality traits to match the robots’, For individual personality traits, participants rated themselves as having stronger personality characteristics compared to the robot, Specific significant correlations were found between participants’ and robot personality traits, and Significant group differences for participant gender, age and technological background are highlighted. The results are discussed in light of developing personalized robot companions. (shrink)

Merker, Williford, and Rudrauf make several arguments against the integrated information theory of consciousness; whereas some have merit, their conclusion that the theory should be discarded is premature. Coming years promise advances in the empirical study of consciousness, and only after theories are independently tested with shared data can they be ruled in or out. We propose future research directions.

The study of emotional intelligence and its relationship with the dark triad has emerged as a popular research area. However, the complex nature of the dark triad and EI, including multiple me...

This chapter contains sections titled: Introduction A. The Formula of Autonomy – Initial Statements B. The Formula of Autonomy, the Formula of Universal Law, and the Formula of Humanity C. The Kingdom of Ends D. Price and Dignity E. Critical Remarks and Worries F. The Formula's Larger Implications References.

In March 2020, the World Health Organization declared the disease caused by SARS-CoV-2 coronavirus “pandemic.” To reduce the risk of contamination, many countries have ordered a lockdown characterized by social distancing and restrictive isolation measures. While the lockdown has proven to be quite effective in terms of physical health, little is known about its impact on couple satisfaction in a dyadic perspective. The current research was a 4-waves longitudinal study with the objective to examine the trajectory of couple satisfaction during (...) the lockdown with a dyadic perspective, including the presence of children at home, the number of hours spent together, and the duration of the relationship as time-invariant predictors and the partner’s couple satisfaction trajectory as a time-varying covariate. Results showed positive intraindividual changes in couple satisfaction during the lockdown, especially an increase in partners’ effectiveness for resolving couple conflicts and a decrease in partners’ aggressiveness. Partners had also perceived the influence of the lockdown as more and more positive over time on couple and family functioning. Finally, the couple satisfaction of both partners changed in tandem during the lockdown: The perception of the couple relationship seems to similarly evolve between partners. (shrink)