Aliénés: Une histoire sociale de la folie au xixe siècle dresse l’histoire – ou devrait-on dire les histoires – des aliénés du xixe siècle dans leurs dimensions les plus fines. Si l’histoire de l’asile se donne à voir à travers les trajectoires des aliénés, l’ambition de l’auteur est davantage de faire une histoire “des malades” que des maladies et des institutions. Anatole Le Bras analyse les façons dont l’asile façonne et travaille les corps, interfère avec les classes sociales, les genres...

The domain of professional ethics -- Virtue, ethics, and professional life -- Virtues, vices, and situations -- Professional wisdom -- Care -- Respectfulness -- Trustworthiness -- Justice -- Courage -- Integrity.

On the face of it, some of our knowledge is of moral facts (for example, that this promise should not be broken in these circumstances), and some of it is of non-moral facts (for example, that the kettle has just boiled). But, some argue, there is reason to believe that we do not, after all, know any moral facts. For example, according to J. L. Mackie, if we had moral knowledge (‘‘if we were aware of [objective values]’’), ‘‘it would have (...) to be by some special faculty of moral perception or intuition, utterly different from our ordinary ways of knowing everything else’’(1977,p.38).But wehavenosuchspecialfaculty.So,wehavenomoralknowledge. Following Mackie, let us distinguish two questions: Q1: Assuming that we have moral knowledge, how do we have it? Q2: Do we in fact have any moral knowledge? In response to the first question, I argue that if we have moral knowledge, we have some of it in the same way we have knowledge of our immediate environment: by perception. Many people think that this answer leads to moral skepticism, because they think that we obviously cannot have moral knowledge by perception. But I will argue that this is incorrect. The plan for the paper is as follows. In Sections 2–4, I work up to my answer to Q1 by considering rivals. In Section 5, I explain what marks my answer to Q1 as a distinctive view, and defend it. In Section 6, I briefly discuss how this answer to Q1 affects what we say in response to Q2. (shrink)

I begin by proposing and explicating a plausible articulation of the view that morality is overriding. I then argue that it would be desirable for this thesis to be sustained. However, the prospects for its vindication will depend crucially on which moral theory we adopt. I examine some schematic moral theories in order to bring out which are friendly and which unfriendly to moral overridingness. In light of the reasons to hope that the overridingness thesis can be sustained, theories apparently (...) incompatible with it – I argue that consequentialism is one – have a count against them. (shrink)

This study provides an additional partial test of the Hunt-Vitell theory [1986, Journal of Macro-marketing, 8, 5-16; 1993, 'The General Theory of Marketing Ethics: A Retrospective and Revision', in N. C. Smith and J. A. Quelch (eds.), Ethics in Marketing (Irwin Inc., Homewood), pp. 775-784], within the consumer ethics context. Using structural equation modeling, the relationships among an individual's personal values (conceptualized by the typology of Schwartz [1992, 'Universals in the Content and Structure of Values: Theoretical Advances and Empirical Tests (...) in 20 Countries', in M. P. Zanna (ed.), Advances in Experimental Social Psychology (Vol. 25, Academic Press, Orlando), pp. 1--65] ethical ideology and ethical beliefs are investigated. The validity of the model is assessed in a two-step procedure. First, a measurement model of constructs is tested for key validity dimensions. Next, the hypothesized causal relationships are examined in several path models, comparing no mediation, partial and complete mediation of ethical ideology. The empirical results indicate that individual differences in value priorities (resultant conservation and resultant self-enhancement) directly and indirectly (through idealism) influence the judgment of ethically questionable consumer practices. These findings may significantly contribute to the theoretical understanding of ethical decision-making. (shrink)

What justifies state-sponsored supports for individual welfare within a Kantian political system, as well as the purpose and extent of such supports and the form they may take, are vexed questions. This Element characterizes and assesses main contenders by examining the competing interpretations of Kant's larger political theory that found their social welfare claims. It then develops and defends an alternative based in civic respect. This emphasizes the perspective and institutional commitments that Kant's model of citizenship entails and what is (...) required to respect each as both a person and a participant in joint governance. (shrink)

My chief aim is to explain how someone can act freely against her own best judgment. But I also have a second aim: to defend a conception of practical rationality according to which someone cannot do something freely if she believes it would be better to do something else. These aims may appear incompatible. But I argue that practical reason has the capacity to undermine itself in such a way that it produces reasons for behaving irrationally. Weakness of will is (...) possible because it is possible to conclude that one has sufficient reason to reject the verdicts of one's own reason. (shrink)

John Harris has previously proposed that there is a moral duty to participate in scientific research. This concept has recently been challenged by Iain Brassington, who asserts that the principles cited by Harris in support of the duty to research fail to establish its existence. In this paper we address these criticisms and provide new arguments for the existence of a moral obligation to research participation. This obligation, we argue, arises from two separate but related principles. The principle of fairness (...) obliges us to support the social institutions which sustain us, of which research is one; while the principle of beneficence, or the duty of rescue, imposes upon us a duty to prevent harm to others, including by supporting potentially beneficial, even life-saving research. We argue that both these lines of argument support the duty to research, and explore further aspects of this duty, such as to whom it is owed and how it might be discharged. (shrink)

Kitcher urges us to think of mathematics as an idealized science of human operations, rather than a theory describing abstract mathematical objects. I argue that Kitcher's invocation of idealization cannot save mathematical truth and avoid platonism. Nevertheless, what is left of Kitcher's view is worth holding onto. I propose that Kitcher's account should be fictionalized, making use of Walton's and Currie's make-believe theory of fiction, and argue that the resulting ideal-agent fictionalism has advantages over mathematical-object fictionalism.

Named one of the Ten Best Books of 2016 by the New York Times, a spirited account of a major intellectual movement of the twentieth century and the revolutionary thinkers who came to shape it, by the best-selling author of How to Live Sarah Bakewell. Paris, 1933: three contemporaries meet over apricot cocktails at the Bec-de-Gaz bar on the rue Montparnasse. They are the young Jean-Paul Sartre, Simone de Beauvoir, and longtime friend Raymond Aron, a fellow philosopher who raves (...) to them about a new conceptual framework from Berlin called Phenomenology. "You see," he says, "if you are a phenomenologist you can talk about this cocktail and make philosophy out of it!" It was this simple phrase that would ignite a movement, inspiring Sartre to integrate Phenomenology into his own French, humanistic sensibility, thereby creating an entirely new philosophical approach inspired by themes of radical freedom, authentic being, and political activism. This movement would sweep through the jazz clubs and cafés of the Left Bank before making its way across the world as Existentialism. Featuring not only philosophers, but also playwrights, anthropologists, convicts, and revolutionaries, At the Existentialist Café follows the existentialists' story, from the first rebellious spark through the Second World War, to its role in postwar liberation movements such as anti-colonialism, feminism, and gay rights. Interweaving biography and philosophy, it is the epic account of passionate encounters--fights, love affairs, mentorships, rebellions, and long partnerships--and a vital investigation into what the existentialists have to offer us today, at a moment when we are once again confronting the major questions of freedom, global responsibility, and human authenticity in a fractious and technology-driven world. (shrink)

Throw: Harry throws a stone at Dick, hitting him. Intuitively, there is a moral difference between the first and the second case of each of these pairs.1 In the second case, the agent’s behavior is morally worse than his behavior in the first case. But in each pair, the agent’s behavior has the same outcome: in No Check and Shoot, the outcome is that a child dies, and Jim saves $40; in No Catch and Throw, the outcome is that Dick (...) is hit by a stone. Let us call these pairs of cases “the paradigm pairs.” The paradigm pairs, and others like them, provide evidence that common sense morality is not consequentialist: common sense morality does not judge the moral worth of actions just in terms of their consequences. But it has proved extremely difficult to provide an account of a morally relevant difference between the members of pairs like the ones above. One hypothesis about the difference that has received a lot of attention in the literature is that in the first kind of case the agent allows the outcome to occur, while in the second the agent makes the.. (shrink)

In the last 50 years, multiauthored publications have become more prevalent, given the increasing number of collaborative, interdisciplinary, multicenter research studies. The determination of authorship credit and order is a difficult process, especially for graduate students, whose disadvantaged power position in research settings increases their vulnerability to exploitation. The American Psychological Association has published ethical standards for determining authorship credit, but the power difference inherent in the student-faculty relationship may complicate this ethical dilemma. The authors reviewed a number of previously (...) recommended strategies and proposed that determining authorship credit is most effectively facilitated through professional development. (shrink)

Jansen and Wall suggest a new way of defending hard paternalism in clinical research. They argue that non-therapeutic research exposing people to more than minimal risk should be banned on egalitarian grounds: in preventing poor decision-makers from making bad decisions, we will promote equality of welfare. We argue that their proposal is flawed for four reasons.First, the idea of poor decision-makers is much more problematic than Jansen and Wall allow. Second, pace Jansen and Wall, it may be practicable for regulators (...) to uncover the values that a potential research participant holds when agreeing to enter a research project, so their claim that we must ban such research projects for all if we are to ban them for poor decision-makers looks to be unmotivated. Third, there seem to be cases where the liberty to enter the sort of research project Jansen and Wall discuss is morally weighty, and arguably should outweigh concerns of egalitarian distribution. Fourth, banning certain types of research, which seem on the face of it to offer an unfavourable risk-benefit ratio, would have unwelcome consequences for all clinical research, which Jansen and Wall do not recognize. (shrink)

Henri Bergson's philosophy, which Sartre studied as a student, had a profound but largely neglected influence on his thinking. In this paper I focus on the new light that recognition of this influence throws on Sartre's central argument about the relationship between negation and nothingness in his Being and Nothingness. Sartre's argument is in part a response to Bergson's dismissive, eliminativist account of nothingness in Creative Evolution (1907): the objections to the concept of nothingness with which Sartre engages are precisely (...) those raised by Bergson. Even if Sartre's account of nothingness in its entirety is found to be flawed, I argue that the points he makes specifically against Bergson are powerful. My discussion concludes with a brief examination of the wider philosophical background to Sartre's and Bergson's discussion of nothingness: here I point to some important aspects of Sartre's early philosophy, including some features of his conception of nothingness, that may testify to Bergson's positive influence on his thought. (shrink)

Several accounts of the nature of fiction have been proposed that draw on speech act theory. I argue that speech act theory is insufficient for this task. Martinich’s, Searle’s and Currie’s accounts are considered and rejected. However dependent fiction may be on the intentional structure of communication, focus on this structure diverts attention from works themselves in an unhelpful way. The weakness inherent in speech act theory is that it does not have the resources to capture the most interesting processes (...) of interpretation in our engagement with fictions, those by which we construct their content and those through which they achieve their intended effects. (shrink)

The story of Anna is a brief description of a faithful prophetess which is consciously paired with the previous and more developed narrative of Simeon. Hannah’s story is significant to the Lukan Gospel and yet her voice, which men and women visiting the temple heard repeatedly, is not articulated by Luke. She has been the topic of much research, in as much as three verses in their context can provide, while no one has sought to let Hannah speak for herself. (...) This article aims to do this by exploring her story within the Lukan narrative, considering prophetesses in the Old Testament, and echoing the dynamics of the Jewish story of Judith with which she is intertextually paired. (shrink)

This article discusses the nature of interprofessional ethics and some of the ethical issues and challenges that arise when practitioners from different professions work closely together in the fields of health and social care. The article draws on materials from a conference on this theme, covering issues of confidentiality and information sharing in practice and research with vulnerable people; challenges for teaching and learning about ethics in interprofessional settings; the potential of virtue ethics and an ethic of care for understanding (...) and handling ethical issues in interprofessional practice; and the extent to which interprofessional working may be about surveillance and control. It concludes that the need to understand and handle ethical issues in interprofessional working is contributing to the revitalisation of professional ethics as a dynamic field of study. (shrink)

Ethics in participatory research -- Partnership, collaboration and power -- Blurring the boundaries between researcher and researched, academic and activist -- Community rights, conflict and democratic representation -- Co-ownership, dissemination and impact -- Anonymity, privacy, and confidentiality -- Institutional ethical review processes -- Social action for social change.

In his commentary on the first Aphorism of Hippocrates Maimonides lists the seven parts of medicine. Scholars have studied the relation of this text to the work of al-Fārābī. In particular, they have focused on the Iḥṣāʼ al-ʼulῡm, which in its present form does not contain a discussion of medicine, and on al-Fārābīʼs Risāla fi al-ţibb. The article examines the medieval Hebrew versions of the Iḥṣāʼ al-ʽūlum. On the basis of these versions, it is argued that there existed a version (...) of the Ihşāʼ al-ʽulūm which did contain a section on medicine; that the Risala fi al-ţibb could have originated in such a fuller version of the Ihsa' al-'ulum; and that Maimonides's ultimate source for his classification of medicine was probably the Iḥṣāʼ al-ʽulūm. An appendix to the paper examines Maimonides's references to Galen and to Abū Bakr al- Rāzī. These references show Maimonides's perception of al-Fārābīʼs view of physicians who claim to be philosophers. Dans son commentaire sur le premier aphorisme d'Hippocrate, Maïmonide décrit les sept parties de la médecine. Dans le passé, les chercheurs ont étudié le rapport de ce texte avec l'œuvre d'al-Fārābī, surtout le Iḥṣāʼ al-ʼulῡm et la Risāla fi al-ţibb. L'article examine les traductions hébraïques médiévales du Iḥṣāʼ al-ʽulūm. Ces traductions suggèrent l'existence d'une version, aujourd'hui disparue, du Iḥṣāʼ al-ʼulῡm, contenant une section sur la médecine. II est possible que la Risāla fi al-ţibb trouve son origine dans cette version, et il semble que la taxonomie de la médecine offerte par Maïmonide est issue, en dernière analyse, du Iḥṣāʼ al-ʼulῡm. Un appendice examine les références faites par Maïmonide à Galien et à Abū Bakr al-Rāzī, et prend note de ce que Maïmonide croyait être l'opinion d'al- Fār¯bī sur les médecins qui se prennent pour des philosophes. (shrink)

We investigated spectral resting-state EEG in persons with chronic stroke-induced aphasia to determine its reliability, sensitivity, and relationship to functional behaviors. Resting-state EEG has not yet been characterized in this population and was selected given the demonstrated potential of resting-state investigations using other neuroimaging techniques to guide clinical decision-making. Controls and persons with chronic stroke-induced aphasia completed two EEG recording sessions, separated by approximately 1 month, as well as behavioral assessments of language, sensorimotor, and cognitive domains. Power in the classic (...) frequency bands was examined via spectral analysis of resting-state EEG data. Results suggest that power in the theta, alpha, and beta bands is reliable for use as a repeated measure. Significantly greater theta and lower beta power was observed in persons with aphasia than controls. Finally, in PWAs theta power negatively correlated with performance on a discourse informativeness measure, while alpha and beta power positively correlated with performance on the same measure. This indicates that spectral rsEEG slowing observed in PWAs in the chronic stage is pathological and suggests a possible avenue for directly altering brain activation to improve behavioral function. Taken together, these results suggest that spectral resting-state EEG holds promise for sensitive measurement of functioning and change in persons with chronic aphasia. Future studies investigating the utility of these measures as biomarkers of frank or latent aphasic deficits and treatment response in chronic stroke-induced aphasia are warranted. (shrink)

The benefits of belonging for academic performance and persistence have been examined primarily in terms of subjective perceptions of social belonging, but feeling ability belonging, or fit with one’s peers intellectually, is likely also important for academic success. This may particularly be the case in male-dominated fields, where inherent genius and natural talent are viewed as prerequisites for success. We tested the hypothesis that social and ability belonging each explain intentions to persist in physical science, technology, engineering, and math (pSTEM). (...) We further explore whether women experience lower social and ability belonging than men on average in pSTEM and whether belonging more strongly relates to intentions to persist for women. At three time points throughout a semester, we assessed undergraduate pSTEM majors enrolled in a foundational calculus or physics course. Women reported lower pSTEM ability belonging and self-efficacy than men but higher identification with pSTEM. End-of-semester social belonging, ability belonging, and identification predicted intentions to persist in pSTEM, with a stronger relationship between social belonging and intentions to persist in pSTEM for women than men. These findings held after controlling for prior and current academic performance, as well as two conventional psychological predictors of academic success. (shrink)

The multiplicity of deubiquitinating enzymes (DUBs) encoded by vertebrate genomes is partly attributable to whole genome duplication events that occurred early in chordate evolution. By surveying the literature for the largest family of DUBs (the ubiquitin-specific proteases), extensive functional redundancy for duplicated genes has been confirmed as opposed to singletons. Dramatically conflicting results have been reported for loss of function studies conducted through RNA interference as opposed to inactivating mutations, but the contradictory findings can be reconciled by a recently proposed (...) compensatory mechanism involving nonsense-mediated RNA degradation. Duplicated genes are often inactivated to become pseudogenes, and it is proposed that such is the fate of the USP15 gene of zebrafish, a commonly used model system. As it is reviewed here, these observations have implications not only for the interpretation of model system phenotypes but also for therapeutic interventions designed to target DUBs. (shrink)

This essay traces the development of Levinas’s conception of Judaism from 1928 to1947 with an aim to reveal how Levinas’s postwar conceptions of Jewish election and anti-historicism derive from his early treatments of the Heideggerian themes of Geworfenheit (thrownness) and historicality. In the process, I show how the similarities that Levinas perceived between Heidegger and Rosenzweig allowed him to recast Heideggerian categories in Jewish terms. Finally the essay considers the potential political implications and tensions that follow from Levinas’s concern after (...) World War II to maintain Rosenzweig’s contention that Judaism stands outside of History. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Human Liberty and Human Nature in the Works of Faustus Socinus and His ReadersSarah MortimerI.Few issues were more hotly contested by early modern theologians than the extent of human liberty and its implications for both religion and society. In the Protestant world, the sixteenth century saw increasingly strident statements of mankind's bondage to sin and the importance of God's eternal decree of predestination, but the concept of human moral (...) responsibility still had its defenders. One influential proponent of human liberty was Faustus Socinus (1539–1604), the Italian scholar known most commonly today for his denial of the trinity. Yet the central theme of his theology was his insistence that Christian virtues must be carried out voluntarily; it was from this principle that his more heterodox ideas flowed. He made a sharp distinction between natural and voluntary action, and argued that the practice of Christianity must be an act of human will, not one to which men were drawn by nature. Separating Christianity from the natural order, Socinus argued that eternal life awaited those who chose to follow the law of Christ rather than the natural law. His argument challenged the Protestant commitment to the unity of natural and divine law and it opened up conceptual space for voluntary action outside the natural law. In this article, I shall sketch the Socinian position on human liberty and Christianity, and suggest how and why the Italian's ideas were developed by Protestants in the early seventeenth century. His readers included the eminent Dutch scholar Hugo [End Page 191] Grotius (1583–1645), and the exchange between Grotius and the Socinians reveals the concern on both sides to explain the relationship between human liberty, Christianity, and natural law.Socinus' life, like his theology, began within the reform movement in Italy and ended among the marginalised anti-trinitarians in Poland. Born of a long line of Italian jurists, he shared both his family's legal interests and their critical approach to the Catholic Church. In his youth he had been a courtier in Florence but his increasingly critical attitude towards Catholicism—and the death of his patron Grand-Duke Cosimo I—resulted in his departure from Italy in 1574. After a period in Basel he found a home among the Polish Anabaptists at Rakow, a young and precarious community which he helped to sustain through his advice and through the tracts which he penned on their behalf.1 During these years, he was also able to develop his own interpretation of Christianity, and to explain it in numerous works issuing from the community's press. Although his ideas generated a lively debate from the start, both in Poland and Germany, it was only after his death that they began to be absorbed into the mainstream of European intellectual discussions. Socinus' theological ideas had their attractions for some Protestant readers, but they became entangled with more political questions and their implications for civil life began to cause serious alarm. For this reason my focus will be upon the responses of Dutch and German readers, particularly Hugo Grotius and Johan Crell (1590–1633), both of whom addressed the civil as well as the theological aspects of Socinus' legacy. First, however, I shall draw out the salient points from Socinus' rich and complex theology, paying particular attention to his understanding of human liberty. Unlike his orthodox Protestant contemporaries, Socinus believed that liberty was the precondition for virtue.Socinus shared with the broader Christian humanist tradition the belief that Christ demanded works as well as faith from his followers. Christians must follow the pattern of ethical living laid down by their master; like Erasmus before him, and like the Italian exiles he met in Basel, Socinus saw Christianity as a religion of action.2 For this reason, he was determined to protect the liberty and capacity of each individual to act virtuously, and therefore to defend what he understood as human free will. It was, he felt, [End Page 192] a pressing task, for these qualities were being undermined by his contemporaries and particularly by those on the Protestant side. Most Protestants followed Luther's belief, expressed most forcefully in De Servo Arbitrio (1525... (shrink)

Miscellaneous Sarah Adams, Think, FirstView Article.

Nuclear speckles are eukaryotic nuclear bodies enriched in splicing factors. Their exact purpose has been a matter of debate. The different proposed roles of nuclear speckles are reviewed and an additional layer of function is put forward, suggesting that by accumulating splicing factors within them, nuclear speckles can buffer the nucleoplasmic levels of splicing factors available for splicing and thereby modulate splicing rates. These findings build on the already established model that nuclear speckles function as a storage/recycling site for splicing (...) factors. Many studies have demonstrated proximity between nuclear speckles and sites of active transcription, suggesting that this juxtaposition can enhance the rates of gene expression. It is found that nuclear speckle disassembly increases splicing factor availability in the nucleoplasm, leading to an increase in splicing rates and faster release of nascent transcripts from the gene after transcription. Altogether, this era in which genomic and imaging approaches are applied to study nuclear organization has expanded the outlook on the possible roles of nuclear speckles. (shrink)

Abstract We act so as to make things better than they would have been but for the action; we are horrified by an uncontrollable catastrophe because it made things so much worse than they would have been without it. Such attitudes are reasonable only if it is reasonable to make the associated counterfactual conditional judgments. But making such judgments cannot be reasonable if one holds both (1) that this world is absolutely and uniquely actual (?absolute actualism?), and (2) that everything (...) is settled (?ES?). Determinism (strictly understood) figures as the most obvious example of ES theory, but ES can occur in an indeterministic form too: both forms are considered. (shrink)