What is the best way to analyse abstraction in scientific modelling? I propose to focus on abstracting as an epistemic activity, which is achieved in different ways and for different purposes depending on the actual circumstances of modelling and the features of the models in question. This is in contrast to a more conventional use of the term ‘abstract’ as an attribute of models, which I characterise as black-boxing the ways in which abstraction is performed and to which epistemological advantage. (...) I exemplify my claims through a detailed reconstruction of the practices involved in creating two types of models of the flowering plant Arabidopsisthaliana, currently the best-known model organism in plant biology. This leads me to distinguish between two types of abstraction processes: the ‘material abstracting’ required in the production of Arabidopsis specimens and the ‘intellectual abstracting’ characterising the elaboration of visual models of Arabidopsis genomics. Reflecting on the differences between these types of abstracting helps to pin down the epistemic skills and research commitments used by researchers to produce each model, thus clarifying how models are handled by researchers and with which epistemological implications. (shrink)

Sabina Alkire shows how Nobel Prize-winning economist Amartya Sen's capability approach can be coherently---and practically---put to work in poverty reduction activities so that the voices and values of the poor matter. This provides economists, philosophers, theologians, and development practitioners with a way forward that addresses both theoretical and practical challenges.

Community databases have become crucial to the collection, ordering and retrieval of data gathered on model organisms, as well as to the ways in which these data are interpreted and used across a range of research contexts. This paper analyses the impact of community databases on research practices in model organism biology by focusing on the history and current use of four community databases: FlyBase, Mouse Genome Informatics, WormBase and The Arabidopsis Information Resource. We discuss the standards used by the (...) curators of these databases for what counts as reliable evidence, acceptable terminology, appropriate experimental set-ups and adequate materials (e.g., specimens). On the one hand, these choices are informed by the collaborative research ethos characterising most model organism communities. On the other hand, the deployment of these standards in databases reinforces this ethos and gives it concrete and precise instantiations by shaping the skills, practices, values and background knowledge required of the database users. We conclude that the increasing reliance on community databases as vehicles to circulate data is having a major impact on how researchers conduct and communicate their research, which affects how they understand the biology of model organisms and its relation to the biology of other species. (shrink)

This article considers the temporal dimension of data processing and use and the ways in which it affects the production and interpretation of knowledge claims. I start by distinguishing the time at which data collection, dissemination, and analysis occur from the time in which the phenomena for which data serve as evidence operate. Building on the analysis of two examples of data reuse from modeling and experimental practices in biology, I then argue that Dt affects how researchers select and interpret (...) data as evidence and identify and understand phenomena. (shrink)

Bogen and Woodward characterized data as embedded in the context in which they are produced (‘local’) and claims about phenomena as retaining their significance beyond that context (‘nonlocal’). This view does not fit sciences such as biology, which successfully disseminate data via packaging processes that include appropriate labels, vehicles, and human interventions. These processes enhance the evidential scope of data and ensure that claims about phenomena are understood in the same way across research communities. I conclude that the degree of (...) locality of both data and claims about phenomena varies depending on the packaging used to make them travel and on the research setting in which they are used. †To contact the author, please write to: ESRC Centre for Genomics in Society, University of Exeter, Byrne House, St. Germans Road, EX4 4PJ Exeter, United Kingdom; e‐mail: [email protected]. (shrink)

Arabidopsis is currently the most popular and well-researched model organism in plant biology. This paper documents this plant's rise to scientific fame by focusing on two interrelated aspects of Arabidopsis research. One is the extent to which the material features of the plant have constrained research directions and enabled scientific achievements. The other is the crucial role played by the international community of Arabidopsis researchers in making it possible to grow, distribute and use plant specimen that embody these material features. (...) I argue that at least part of the explosive development of this research community is due to its successful standardisation and to the subsequent use of Arabidopsis specimen as material models of plants. I conclude that model organisms have a double identity as both samples of nature and artifacts representing nature. It is the resulting ambivalence in their representational value that makes them attractive research tools for biologists. (shrink)

This paper discusses what it means and what it takes to integrate data in order to acquire new knowledge about biological entities and processes. Maureen O’Malley and Orkun Soyer have pointed to the scientific work involved in data integration as important and distinct from the work required by other forms of integration, such as methodological and explanatory integration, which have been more successful in captivating the attention of philosophers of science. Here I explore what data integration involves in more detail (...) and with a focus on the role of data-sharing tools, like online databases, in facilitating this process; and I point to the philosophical implications of focusing on data as a unit of analysis. I then analyse three cases of data integration in the field of plant science, each of which highlights a different mode of integration: inter-level integration, which involves data documenting different features of the same species, aims to acquire an interdisciplinary understanding of organisms as complex wholes and is exemplified by research on Arabidopsis thaliana; cross-species integration, which involves data acquired on different species, aims to understand plant biology in all its different manifestations and is exemplified by research on Miscanthus giganteus; and translational integration, which involves data acquired from sources within as well as outside academia, aims at the provision of interventions to improve human health and is exemplified by research on Phytophtora ramorum. Recognising the differences between these efforts sheds light on the dynamics and diverse outcomes of data dissemination and integrative research; and the relations between the social and institutional roles of science, the development of data-sharing infrastructures and the production of scientific knowledge. (shrink)

The collection and dissemination of data on human and nonhuman organisms has become a central feature of 21st-century biology and has been endorsed by funding agencies in the United States and Europe as crucial to translating biological research into therapeutic and agricultural innovation. Large molecular data sets, often referred to as “big data,” are increasingly incorporated into digital databases, many of which are freely accessible online. These data have come to be seen as resources that play a key role in (...) mediating global market exchange, thus achieving a prominent social and economic status well beyond science itself. At the same time, calls to make all such data publicly and freely available have garnered strength and visibility, most prominently in the form of the Open Data movement. I discuss these developments by considering the conditions under which data journey across the communities and institutions implicated in globalized biology and biomedicine, and what this indicates about how Internet-based communication and the use of online databases affect scientific research and its role within contemporary society. (shrink)

An influential strand in philosophy of science claims that scientific paradigms can be understood as relativized a priori frameworks. Here, Kant’s constitutive a priori principles are no longer held to establish conditions of possibility for knowledge which are unchanging and universally true, but are restricted only to a given scientific domain. Yet it is unclear how exactly a relativized a priori can be construed as both stable and dynamical, establishing foundations for current scientific claims while simultaneously making intelligible the transition (...) to a subsequent framework. In this article, I show that important resources for this problem have been overlooked in Kant’s theory of reflective judgement in the third Critique. I argue that Kant accorded the task of formulating new scientific laws to reflective judgement, which is charged with forming new ‘universals’ that guide the experience of nature. I show that this is the very task attributed to the relativized a priori: the constitution of a given conceptual framework, not of the conditions for object-reference as such. I conclude that Kant’s considered conception of science encompasses the operations of both reflective and determining judgement. Relativizations of the a priori should follow Kant’s lead. (shrink)

This article focuses onsarcasm, for which the definitions have often been loose and confusing, integrating it into the concept ofirony. My approach is based on a large corpus of examples taken from two contemporary television-series, which help identify the wide range of linguistic processes at the core of sarcastic utterances. I present a quantitative and descriptive analysis of the main processes found in two American television-series:House M.D.andThe Big Bang Theory. The results show the intricate meanings created in sarcasm through various (...) linguistic mechanisms, such as repetition, explicitation, metonymy, metaphor, shift of focus, reasoning, and rhetorical questions. This more holistic analysis, including a broad corpus of instances and a more detailed analysis of the examples, aims to fill the unexplored gaps in more classical analyses, emphasizing the complexities and implications that can be drawn in interaction. (shrink)

This multilevel meta-analysis examines whether emotional intelligence can be enhanced through training and identifies training effects’ determinants. We identified 24 studies containing 28 samples aiming at increasing individual-level EI among healthy adults. The results revealed a significant moderate standardized mean change between pre- and post-measurement for the main effect of EI training, and a stable pre- to follow-up effect. Additionally, the type of EI model, dimensions of the four branch model, length, and type of publication turned out to be significant (...) moderators. The results suggest that EI trainings should be considered effective interventions. (shrink)

I argue that Open Science as currently conceptualized and implemented does not take sufficient account of epistemic diversity within research. I use three case studies to exemplify how Open Science threatens to privilege some forms of inquiry over others, thus exasperating divides within and across systems of practice, and overlooking important sources and forms of epistemic diversity. Building on insights from pluralist philosophy, I then identify four aspects of diverse research practices that should serve as reference points for debates around (...) Open Science: (1) specificity to local conditions, (2) entrenchment within repertoires, (3) permeability to newcomers, and (4) demarcation strategies. (shrink)

Sabina Lovibond invites her readers to see how the "practical reason view of ethics" can survive challenges from within philosophy and from the antirationalist postmodern critique of reason. She elaborates and defends a modern practical-reason view of ethics by focusing on virtue or ideal states of character that involve sensitivity to the objective reasons circumstances bring into play. At the heart of her argument is the Aristotelian idea of the formation of character through upbringing; these ancient ideas can be (...) made contemporary if one understands them in a naturalized way. She then explores the implications that arise from the naturalization of the classical view, weaving into her theory ideas of Jacques Derrida and J. L. Austin. The book also discusses two modes of resistance to an existing ethical culture--one committed to the critical employment of shared norms of rationality, the other aspiring to a more radical attitude, grounded in hostility to the "universal." Lovibond tries to determine what may be correct in this second, admittedly paradoxical, tendency. This is a timely and valuable effort to connect the most advanced forms of thinking in the analytic tradition and in the Continental tradition, and to extend our understanding of the intimacies and resistances between these two prominent strands of contemporary philosophy. (shrink)

Increases in international travel and migratory flows have enabled infectious diseases to emerge and spread more rapidly than ever before. Hence, it is increasingly easy for local infectious diseases to become global infectious diseases (GIDs). National governments must be able to react quickly and effectively to GIDs, whether naturally occurring or intentionally instigated by bioterrorism. According to the World Health Organisation, global partnerships are necessary to gather the most up-to-date information and to mobilize resources to tackle GIDs when necessary. Communicable (...) disease control also depends upon national public health laws and policies. The containment of an infectious disease typically involves detection, notification, quarantine and isolation of actual or suspected cases; the protection and monitoring of those not infected; and possibly even treatment. Some measures are clearly contentious and raise conflicts between individual and societal interests. In Europe national policies against infectious diseases are very heterogeneous. Some countries have a more communitarian approach to public health ethics, in which the interests of individual and society are more closely intertwined and interdependent, while others take a more liberal approach and give priority to individual freedoms in communicable disease control. This paper provides an overview of the different policies around communicable disease control that exist across a select number of countries across Europe. It then proposes ethical arguments to be considered in the making of public health laws, mostly concerning their effectiveness for public health protection. (shrink)

Derrida desde las Indias -- Antropología y deconstrucción -- El silencio de los dátiles -- Bordes de la plegaria -- Golosa.

Sin tantear recorridos lineales, la mayor parte de los siguientes renglones, entresacados de aquellos parajes por los que merodearían los lectores de Emmanuel Lévinas más propensos a las responsabilidades del sueño lúcido, modifican unas páginas de Teleón, obra no del todo en marcha entregada a las excursiones que la escritura de León de Greiff estimula a través de regiones y climas no siempre incluidos en los informes de la crítica literaria o en los plegables temáticos de los debates ideológicos. A (...) distinción de los textos del lituano y demás autores mencionados, ningún dispositivo referencial acompaña las citas inherentes a las composiciones del antioqueño, no propiamente con la intención de dar a entender que su procedencia debería resultar descontada a las generaciones sumidas en todos los hechos y en los hechos del Todo que, a juicio de algún televidente muy dueño y señor de su cabeza, refutarían las exigencias éticas de Lévinas, si acaso con el propósito de sugerir la urgencia de subvertir los criterios de vigilancia universitaria acogiendo el asomo del otro, ningún duplicado, ningún paredros gnóstico, sino el otro expirante e inspirante, el poeta en persona, quien por ventura los devolvería al sarcófago vacío de la “momia fiambre” que nunca quiso llegar a ser. (shrink)

This article explores the philosophical underpinnings and implications of the idea of the public in the US state processes of knowledge production and control. In it we take up questions of public and counterpublic political philosophical knowledge production and mediation in relation to an expanding state. Specifically, we examine the political philosophies of racialized counterpublics since the 1960s, considering the particular knowledge production genre of the political prison letter. We suggest that the philosophical principles of the dominant public in the (...) US have a proclivity to merge with state mechanisms of domination and to thwart counterpublics and their modes of political knowledge production. (shrink)

Scientific knowledge production is currently affected by the dissemination of data on an unprecedented scale. Technologies for the automated production and sharing of vast amounts of data have changed the way in which data are handled and interpreted in several scientific domains, most notably molecular biology and biomedicine. In these fields, the activity of data gathering has become increasingly technology-driven, with machines such as next generation genome sequencers and mass spectrometers generating billions of data points within hours, and with little (...) need for human supervision. Given the relative ease and low costs with which datasets can be produced (that is, once a laboratory has been able to afford .. (shrink)

Scientific classification has long been recognized as involving a specific style of reasoning and doing research, and as occasionally affecting the development of scientific theories. However, the role played by classificatory activities in generating theories has not been closely investigated within the philosophy of science. I argue that classificatory systems can themselves become a form of theory, which I call classificatory theory, when they come to formalize and express the scientific significance of the elements being classified. This is particularly evident (...) in some of the classification practices used in contemporary experimental biology, such as bio-ontologies used to classify genomic data and typologies used to classify “normal” stages of development in developmental biology. In this paper, I explore some characteristics of classificatory theories and ways in which they differ from other types of scientific theories and other components of scientific epistemology, such as models and background assumptions. (shrink)

Knowledge-making practices in biology are being strongly affected by the availability of data on an unprecedented scale, the insistence on systemic approaches and growing reliance on bioinformatics and digital infrastructures. What role does theory play within data-intensive science, and what does that tell us about scientific theories in general? To answer these questions, I focus on Open Biomedical Ontologies, digital classification tools that have become crucial to sharing results across research contexts in the biological and biomedical sciences, and argue that (...) they constitute an example of classificatory theory. This form of theorizing emerges from classification practices in conjunction with experimental know-how and expresses the knowledge underpinning the analysis and interpretation of data disseminated online. (shrink)

This Editorial introduces the thematic series on 'Toward a New Psychiatry: Philosophical and Ethical Issues in Classification, Diagnosis and Care' http://www.biomedcentral.com/series/newpsychiatry.

This groundbreaking, open access volume analyses and compares data practices across several fields through the analysis of specific cases of data journeys. It brings together leading scholars in the philosophy, history and social studies of science to achieve two goals: tracking the travel of data across different spaces, times and domains of research practice; and documenting how such journeys affect the use of data as evidence and the knowledge being produced. The volume captures the opportunities, challenges and concerns involved in (...) making data move from the sites in which they are originally produced to sites where they can be integrated with other data, analysed and re-used for a variety of purposes. The in-depth study of data journeys provides the necessary ground to examine disciplinary, geographical and historical differences and similarities in data management, processing and interpretation, thus identifying the key conditions of possibility for the widespread data sharing associated with Big and Open Data. The chapters are ordered in sections that broadly correspond to different stages of the journeys of data, from their generation to the legitimisation of their use for specific purposes. Additionally, the preface to the volume provides a variety of alternative “roadmaps” aimed to serve the different interests and entry points of readers; and the introduction provides a substantive overview of what data journeys can teach about the methods and epistemology of research. (shrink)

In the Groundwork and all three Critiques, Kant expresses the hope of eventually unifying theoretical and practical reason in one system, with a principle common to both. But he never clarifies what this principle is, leaving scholars to advance different possibilities. I advance a new response to this problem: I claim that Kant begins to refer to what he calls the ‘autonomy of ideas of reason’ in his final decade, enabling a new approach to finally bridging the theoretical and the (...) practical. This concept of autonomy, however, is no longer equivalent to the moral autonomy attributed to the self-legislating will, nor does it refer to the spontaneity of theoretical reason. Instead, it corresponds to the autonomy ascribed to reflective judgment in representing both theoretical and practical ideas of reason. Thus, this conception furnishes a principle, the principle of purposiveness, which I propose as the unifying principle Kant had been seeking. (shrink)

This paper proposes an account of scientific data that makes sense of recent debates on data-driven and ‘big data’ research, while also building on the history of data production and use particularly within biology. In this view, ‘data’ is a relational category applied to research outputs that are taken, at specific moments of inquiry, to provide evidence for knowledge claims of interest to the researchers involved. They do not have truth-value in and of themselves, nor can they be seen as (...) straightforward representations of given phenomena. Rather, they are fungible objects defined by their portability and prospective usefulness as evidence. (shrink)

How should actions to redress absolute human deprivation be framed? Current international coordinated actions on absolute poverty are framed by human rights or by goals such as the Millennium Development Goals. But appropriate, effective and sustained responses to needs require localized participation in the definition of those rights/goals/needs and in measures taken to redress them. Human rights or the MDGs do not seem necessarily to require such processes. For this reason some argue that no universal framework can describe economic, social, (...) or cultural rights. Yet to address absolute poverty purely from the local perspective still requires the identification and prioritization of capabilities or needs, and often requires actions by greater-than-local institutions, so in practical terms a framework is not rejected without cost. This paper argues that the identification and prioritisation of rights or MDGs can and should be done at an international level, but that they might be framed as capabilities, and that far greater attention need be given to the iterative specification of these rights, and to the ongoing protection of certain agency freedoms. The paper explores how Wiggins’ account of need can fruitfully inform the specification of needs claims. It also draws significantly on Sen’s work to identify the intrinsic importance of process and opportunity freedoms, and to identify how these can relate to universal priorities. (shrink)

While increasing attention has been paid in recent years to the relation between Foucault’s conception of critique and Kant’s, much controversy remains over whether Foucault’s most sustained early engagement with Kant, his dissertation on Kant’s Anthropology, should be read as a wholesale rejection of Kant’s views or as the source of Foucault’s late return to ethics and critique. In this paper, I propose a new reading of the dissertation, considering it alongside 1950s-era archival materials of which I advance the first (...) scholarly appraisal. I argue that Foucault manifests a fundamental ambivalence to Kantian anthropology, rejecting it in theoretical terms while embracing its practical (‘pragmatic’) conception of the subject. Furthermore, I take these texts to collectively evidence Foucault’s attempt to situate himself within the anthropological-critical tradition rather than extricating himself from it. If we interpret Foucault to reject this tradition’s appeal to an essentialized, theoretical conception of subjectivity, what remains of anthropology is its inherent practical reflexivity in structure. Thus, I situate Foucault’s conception of ethics as one’s relation to oneself in continuity with this tradition. (shrink)

In response to broad transformations brought about by the digitalization, globalization, and commodification of research processes, the Open Science [OS] movement aims to foster the wide dissemination, scrutiny and re-use of research components for the good of science and society. This Element examines the role played by OS principles and practices within contemporary research and how this relates to the epistemology of science. After reviewing some of the concerns that have prompted calls for more openness, I highlight how the interpretation (...) of openness as the sharing of resources, so often encountered in OS initiatives and policies, may have the unwanted effect of constraining epistemic diversity and worsening epistemic injustice, resulting in unreliable and unethical scientific knowledge. By contrast, I propose to frame openness as the effort to establish judicious connections among systems of practice, predicated on a process-oriented view of research as a tool for effective and responsible agency. (shrink)

Dispositional mindfulness and emotion regulation are two psychological constructs closely interrelated, and both appear to improve with the long-term practice of mindfulness meditation. These constructs appear to be related to subcortical, prefrontal, and posterior brain areas involved in emotional processing, cognitive control, self-awareness, and mind wandering. However, no studies have yet discerned the neural basis of dispositional mindfulness that are minimally associated with emotion regulation. In the present study, we use a novel brain structural network analysis approach to study the (...) relationship between structural networks and dispositional mindfulness, measured with two different and widely used instruments [Mindfulness Attention Awareness Scale and Five Facet Mindfulness Questionnaire ], taking into account the effect of emotion regulation difficulties. We observed a number of different brain regions associated with the different scales and dimensions. The total score of FFMQ and MAAS overlap with the bilateral parahippocampal and fusiform gyri. Additionally, MAAS scores were related to the bilateral hippocampus and the FFMQ total score to the right insula and bilateral amygdala. These results indicate that, depending on the instrument used, the characteristics measured could differ and could also involve different brain systems. However, it seems that brain areas related to emotional reactivity and semantic processing are generally related to Dispositional or trait mindfulness, regardless of the instrument used. (shrink)

Is Big Data science a whole new way of doing research? And what difference does data quantity make to knowledge production strategies and their outputs? I argue that the novelty of Big Data science does not lie in the sheer quantity of data involved, but rather in the prominence and status acquired by data as commodity and recognised output, both within and outside of the scientific community and the methods, infrastructures, technologies, skills and knowledge developed to handle data. These developments (...) generate the impression that data-intensive research is a new mode of doing science, with its own epistemology and norms. To assess this claim, one needs to consider the ways in which data are actually disseminated and used to generate knowledge. Accordingly, this article reviews the development of sophisticated ways to disseminate, integrate and re-use data acquired on model organisms over the last three decades of work in experimental biology. I focus on online databases as prominent infrastructures set up to organise and interpret such data and examine the wealth and diversity of expertise, resources and conceptual scaffolding that such databases draw upon. This illuminates some of the conditions under which Big Data needs to be curated to support processes of discovery across biological subfields, which in turn highlights the difficulties caused by the lack of adequate curation for the vast majority of data in the life sciences. In closing, I reflect on the difference that data quantity is making to contemporary biology, the methodological and epistemic challenges of identifying and analysing data given these developments, and the opportunities and worries associated with Big Data discourse and methods. (shrink)

Open Science policies encourage researchers to disclose a wide range of outputs from their work, thus codifying openness as a specific set of research practices and guidelines that can be interpreted and applied consistently across disciplines and geographical settings. In this paper, we argue that this “one-size-fits-all” view of openness sidesteps key questions about the forms, implications, and goals of openness for research practice. We propose instead to interpret openness as a dynamic and highly situated mode of valuing the research (...) process and its outputs, which encompasses economic as well as scientific, cultural, political, ethical, and social considerations. This interpretation creates a critical space for moving beyond the economic definitions of value embedded in the contemporary biosciences landscape and Open Science policies, and examining the diversity of interests and commitments that affect research practices in the life sciences. To illustrate these claims, we use three case studies that highlight the challenges surrounding decisions about how––and how best––to make things open. These cases, drawn from ethnographic engagement with Open Science debates and semistructured interviews carried out with UK-based biologists and bioinformaticians between 2013 and 2014, show how the enactment of openness reveals judgments about what constitutes a legitimate intellectual contribution, for whom, and with what implications. (shrink)

International Studies in the Philosophy of Science, Volume 25, Issue 4, Page 420-422, December 2011.

This article explores the concept of ‘gendering’, as applied to various traditional fields of enquiry and to ethics in particular. It starts from the idea of a form of criticism that challenges the masculine bias of our inherited models of human nature. But it then argues that if we are to correct this kind of bias and to win back due respect for characteristics hitherto devalued as ‘feminine’, we shall need some criterion of when these characteristics actually deserve respect and (...) when, instead, they should be seen as artefacts of a hostile sexual power structure. Because such a criterion cannot be provided without some degree of engagement in pre-existing patterns of ethical reasoning, the process of ‘gendering’ – however radical – turns out to be one that operates on ethics from a position not wholly external but at least partially internal to it. And this is unsurprising in that feminism depends for its motivation on an egalitarian, and hence irredeemably ethical, impulse. (shrink)