In eukaryotes, small amounts of nitrite confer cytoprotection against ischemia/reperfusion‐related tissue damage in vivo, possibly via reduction to nitric oxide (NO) and inhibition of mitochondrial function. Several hemeproteins are involved in this protective mechanism, starting with deoxyhemoglobin, which is capable of reducing nitrite. In facultative aerobic bacteria, such as Pseudomonas aeruginosa, nitrite is reduced to NO by specialized heme‐containing enzymes called cd1 nitrite reductases. The details of their catalytic mechanism are summarized below, together with a hypothesis on the biological role (...) of the unusual d1‐heme, which, in the reduced state, shows unique properties (very high affinity for nitrite and exceptionally fast dissociation of NO). Our results support the idea that the nitrite‐based reactions of contemporary eukaryotes are a vestige of earlier bacterial biochemical pathways. The evidence that nitrite reductase activities of enzymes with different cellular roles and biochemical features still exist today highlights the importance of nitrite in cellular homeostasis. (shrink)

Sex robots are already a reality: in this provocative text, Maurizio Balistreri explores the fascinating world of future sex, exploring the ethical questions raised by the existence of a sex robot industry.

The Italian philosopher Maurizio Lazzarato reveals the underpinnings of contemporary subjectivity in the aesthetics and politics of mass media. This book discloses the conceptual groundwork of Lazzarato's thought as a whole for a time when his writings have become increasingly influential.

There is a growing body of scholarship that is addressing the ethics, in particular, the bioethics of space travel and colonisation. Naturally, a variety of perspectives concerning the ethical issues and moral permissibility of different technological strategies for confronting the rigours of space travel and colonisation have emerged in the debate. Approaches ranging from genetically enhancing human astronauts to modifying the environments of planets to make them hospitable have been proposed as methods. This paper takes a look at a critique (...) of human bioenhancement proposed by Mirko Garasic who argues that the bioenhancement of human astronauts is not only functional but necessary and thus morally permissible. However, he further claims that the bioethical arguments proposed for the context of space do not apply to the context of Earth. This paper forwards three arguments for how Garasic’s views are philosophically dubious: (1) when he examines our responsibility towards future generations he refers to a moral principle (which we will call the principle of mere survival) which, besides being vague, is not morally acceptable; (2) the idea that human bioenhancement is not natural is not only debatable but morally irrelevant; and (3) it is not true that the situations that may arise in space travel cannot occur on Earth. We conclude that not only is the (bio)enhancement of humans on Earth permissible but perhaps even necessary in certain circumstances. (shrink)

Biopower agregates no longer families distributed on land but mobile individuals. How can power count forces and take energy from them, if they differ from each other, if they are free? Power comes from beneath, from strategic relations between subjects.

Nationalism and patriotism are two of the most powerful forces shaping world history. In this paperback edition of a highly successful, wide-ranging study, Maurizio Viroli shows exactly why patriotism is a political virtue and nationalism a political vice.

Mirko Garasic (2021) argued that space travel and, by extension, the colonization of other planets could morally justify using technologies and interventions capable of profoundly modifying the characteristics of astronauts and future Martian generations. According to Garasic, however, the fact that space interventions such as human (bio)enhancement or reproductive technologies such as artificial wombs may be morally justified does not mean that they are morally acceptable technologies to be used on Earth as well. Garasic’s thesis is that we should resist (...) the temptation to establish or reinforce a continuity between the ethical standards that apply to space travel and those that apply on Earth because what applies in space (or on other planets) does not necessarily apply to our planet. Garasic argues that in space, genetic enhancement interventions are morally acceptable, as they are essential for survival. On Earth, however, we can survive even without any form of (bio)enhancement. In a previous article (2022), we presented several arguments against Garasic’s thesis regarding the exceptional morality of what is morally acceptable in space. In this article, we examine and reply to Garasic (2022), showing that he fails to defend his thesis from the objections we previously advanced. Garasic’s mistakes are: (1) assuming nature (and consequently what is “natural”) as a normative point of reference which allows establishing what is moral and what is not moral; (2) defending the choices concerning reproduction as an insufficiently demanding and therefore unsatisfactory moral principle (according to Garasic we should not bring into the world people who can have a quality of life or a condition of well-being superior to mere survival); and finally (3) of not explaining clearly what it means to defend a principle of moral exceptionalism for space travel (Garasic does not explain whether this position applies to any behavior, for which what on Earth is a virtue, in space is a vice or is not a general principle, but he makes this case only for enhancement and reproductive technologies). Through our analysis, we not only refute Garasic’s position but also show that any attempt to address space travel issues as “special” moral issues faces several difficulties and, ultimately, is doomed to failure. (shrink)

Starting from a historical-juridical study of A. M. de Aldama on the origin and evolution of the reference to the teaching of Christian doctrine to pueri contained in the formula of final vows of all priests in the Society of Jesus, the author investigates the meaning of this ministry and its importance today. In an analytic section, the article traces the historical development of the ministry of education in Christian doctrine to pueri and rudes in the experience of Ignatius and (...) his first companions and in the foundational texts. The theme is treated above all in the light of some questions brought up by the historical data of the past and present. In conclusion the author seeks to reply synthetically to the questions, by showing some essential elements in the significance of the ministry of teaching Christian doctrine to children for an apostle in today's world. (shrink)

Our understanding of body–world relations is caught in a curious contradiction. On one side, it is well established that many concepts that describe interaction with the outer world – ‘plasticity’ or ‘metabolism’- or external influences on the body - ‘environment’ or ‘milieu’ – appeared with the rise of modern science. On the other side, although premodern science lacked a unifying term for it, an anxious attentiveness to the power of ‘environmental factors’ in shaping physical and moral traits held sway in (...) nearly all medical systems before and alongside modern Europe. In this article, I build on a new historiography on the policing of bodies and environments in medieval times and at the urban scale to problematize Foucault’s claim about biopolitics as a modern phenomenon born in the European eighteenth-century. I look in particular at the collective usage of ancient medicine and manipulation of the milieu based on humoralist notions of corporeal permeability (Hippocrates, Galen, Ibn Sīnā) in the Islamicate and Latin Christendom between the 12th and the 15th century. This longer history has implications also for a richer genealogy of contemporary tropes of plasticity, permeability and environmental determinism beyond usual genealogies that take as a starting point the making of the modern body and EuroAmerican biomedicine. (shrink)

This text explores the intricate relationship between personal autonomy and public health objectives, particularly accentuated during the recent pandemic. Emphasising the challenge of balancing individual autonomy with broader public health imperatives, the discussion delves into state interventions that may restrict individual freedom and the potential moral justifications behind such actions. Public health interventions, encompassing various policies from data collection to preventive legislation, are examined in light of their impact on individual freedom. Drawing on Holland’s analysis, the text illustrates how these (...) policies may limit individual autonomy while serving the interests and welfare of society. It argues that, in a liberal society, restrictions on citizen choices are justified not only for individual health but also to safeguard collective interests. The recent COVID-19 response, including measures like lockdowns and vaccine passports, exemplifies this evolving balance. The text contends that, as the state places more emphasis on public health over personal autonomy, interventions like genome editing might cease to be considered mere options, potentially leading to mandatory genetic modifications for those desiring children. This shift raises ethical questions about protecting individual autonomy in a diverse society. The text highlights the absence of compelling justifications against restricting individuals from making autonomous decisions about their children’s genetic makeup or imposing legal obligations for genome editing. (shrink)

The debtor-creditor relation, which is at the heart of this book, sharpens mechanisms of exploitation and domination indiscriminately, since, in it, there is no distinction between workers and the unemployed, consumers and producers, working and non-working populations, between retirees and welfare recipients. They are all "debtors," guilty and responsible in the eyes of capital, which has become the Great, the Universal, Creditor.--from The Making of the Indebted Man Debt -- both public debt and private debt Has become a major concern (...) of economic and political leaders. In The Making of the Indebted Man, Maurizio Lazzarato shows that, far from being a threat to the capitalist economy, debt lies at the very core of the neoliberal project. Through a reading of Karl Marx's lesser-known youthful writings on John Mill, and a rereading of writings by Friedrich Nietzsche, Gilles Deleuze, Felix Guattari, and Michel Foucault, Lazzarato demonstrates that debt is above all a political construction, and that the creditor/debtor relation is the fundamental social relation of Western societies.Debt cannot be reduced to a simple economic mechanism, for it is also a technique of "public safety" through which individual and collective subjectivities are governed and controlled. Its aim is to minimize the uncertainty of the time and behavior of the governed. We are forever sinking further into debt to the State, to private insurance, and, on a more general level, to corporations. To insure that we honor our debts, we are at once encouraged and compelled to become the "entrepreneurs" of our lives, of our "human capital." In this way, our entire material, psychological, and affective horizon is upended and reconfigured. How do we extricate ourselves from this impossible situation? How do we escape the neoliberal condition of the indebted man? Lazzarato argues that we will have to recognize that there is no simple technical, economic, or financial solution. We must instead radically challenge the fundamental social relation structuring capitalism: the system of debt. (shrink)

Sex robots are already a reality: in this provocative text, Maurizio Balistreri explores the fascinating world of future sex, exploring the ethical questions raised by the existence of a sex robot industry.

The contradictions between food poverty affecting a large section of the global population and the everyday wastage of food, particularly in high income countries, have raised significant academic and public attention. All actors in the food chain have a role to play in food waste prevention and reduction, including farmers, food manufacturers and processors, caterers and retailers and ultimately consumers. Food surplus redistribution is considered by many as a partial solution to food waste reduction and food poverty mitigation, while others (...) criticize charitable initiatives as inadequate responses, that inhibit governments from responsibly protecting the citizens right to food. This paper frames food assistance as “hybrid systems”, situating at the intersection of territorial food, public welfare and third sector voluntary systems. Based on available literature and reflections on previous research examining food banks in Italy, we develop a system dynamics conceptual mapping. The aim is to model a set of relations and dynamic mechanisms associated with variables relevant to food waste generation, food recovery for social purposes and food poverty alleviation. The analysis of feedback interactions highlights the vulnerabilities of food assistance systems that occur when addressing food poverty by reducing food surplus. In summary, as the awareness on food poverty and food surplus arises, incentives to food recovery and redistribution strengthen the role of food assistance actors, increasing their exposure to drivers of change, such as retailers’ standards for food surplus prevention. This paper contributes to the current academic debate on charitable food assistance, with insights for policy makers and other systems’ actors. (shrink)

The article investigates the influence that the theological debates on divine grace have exercised on the evolution of Dante’s reflection on the relationship between nobility of the soul and natural predisposition, from the Vita nuova to the Commedia. If in his youthful work, commenting the sonnet Negli occhi porta la mia donna amore, Dante had attributed to Beatrice the ability to «induce Love in potentiality where he is not» (Vn. 12, 6) - an ability that Augustine’s doctrine of grace had (...) reserved to God -, in Le dolci rime d’amor and, above all, in the IV book of the Convivio, Dante affirms, with Guinizelli, the essential correlation between a «gentle heart» and love, that is to say the necessity of a natural predisposition for the purpose of possessing nobility, i. e. the divine «grace» (Cv. IV XX 7). Finally, in the Commedia, the poet returns to freeing God’s gift from any preventive natural disposition, as demonstrated not only by the repeated references to the twins Jacob and Esau, destined to opposite fates by virtue of the «grace» with which God «at his own pleasure endows each creature differently» (Pd. XXXII, vv. 65-6), but also by the XXX canto of Purgatorio, where Dante no longer appears uncertain whether to attribute his genius to a «good star» or to «a better thing» (If. XXVI, vv. 21-24), but clearly affirms its dependence on the «largess of celestial graces» (v. 112). (shrink)

The theme of human extinction is increasingly at the center of the current debate on moral philosophy and bioethics. We look at space missions and station construction projects capable of accommodating a large population and at the colonization of other planets with great hope. However, solutions are not excluded either, which for now certainly appear to be much more original. One of the most original projects involves launching a spacecraft containing cryopreserved human embryos, which, once they arrive at destination on (...) another planet, must be thawed and birthed by intelligent machines through artificial wombs (ectogenesis). In this paper, I do not intend to analyze whether the embryo space colonization project is indeed feasible. Instead, I will focus on examining the primary moral questions raised by the embryo space colonization project to determine whether, at least prima facie, it can be deemed morally acceptable. I will begin by discussing the objection advanced by Konrad Szocik (2021), according to which any embryo space colonization project is doomed to failure because it cannot offer the hoped-for solution to the problem of the extinction of the human species (second paragraph). In the third paragraph, then, I will ask whether embryo space colonization is able to ensure the people it brings into the world an adequate or at least the morally appropriate quality of life. Finally, in the fourth and last paragraph, I will examine the question of the morality of human reproduction that passes through the guidance and choice of intelligent machines. I will argue that to evaluate the morality of this project we should consider not only the interests and quality of life of the first people who could be born but also the interests of all possible subsequent generations. (shrink)

An analysis of how capitalism today produces subjectivity like any other “good,” and what would allow us to escape its hold. “Capital is a semiotic operator”: this assertion by Félix Guattari is at the heart of Maurizio Lazzarato's Signs and Machines, which asks us to leave behind the logocentrism that still informs so many critical theories. Lazzarato calls instead for a new theory capable of explaining how signs function in the economy, in power apparatuses, and in the production of (...) subjectivity. Moving beyond the dualism of signifier and signified, Signs and Machines shows how signs act as “sign-operators” that enter directly into material flows and into the functioning of machines. Money, the stock market, price differentials, algorithms, and scientific equations and formulas constitute semiotic “motors” that make capitalism's social and technical machines run, bypassing representation and consciousness to produce social subjections and semiotic enslavements. Lazzarato contrasts Deleuze and Guattari's complex semiotics with the political theories of Jacques Rancière, Antonio Negri and Michael Hardt, Paolo Virno, and Judith Butler, for whom language and the public space it opens still play a fundamental role. Lazzarato asks: What are the conditions necessary for political and existential rupture at a time when the production of subjectivity represents the primary and perhaps most important work of capitalism? What are the specific tools required to undo the industrial mass production of subjectivity undertaken by business and the state? What types of organization must we construct for a process of subjectivation that would allow us to escape the hold of social subjection and machinic enslavement? In addressing these questions, Signs and Machines takes on a task that is today more urgent than ever. (shrink)

Cooperazione e competizione sembrano comporre un dualismo di difficile coesistenza. Tuttavia, l'intreccio tra il pensiero gruppoanalitico e il microcredito modello Grameen pare riesca a superare questa prospettiva. In questo articolo proponiamo una discussione focalizzata sulla cooperazione e sulla competizione intese come due bisogni; due diversi modi di stare nelle relazioni umane. Il gruppo č il protagonista principale di questo dibattito inteso nella sua identitÀ di generatore di beni relazionali teoricamente infiniti. Altro punto centrale in questa discussione č il significato relazionale (...) della parola oikos nomos, l'espressione greca da cui deriva la parola ‘economia'. Questo ci porta all'idea di un sistema di condivisione che nasce dalla famiglia per estendersi alla comunitÀ e alla societÀ piů vasta. (shrink)