In eukaryotes, small amounts of nitrite confer cytoprotection against ischemia/reperfusion‐related tissue damage in vivo, possibly via reduction to nitric oxide (NO) and inhibition of mitochondrial function. Several hemeproteins are involved in this protective mechanism, starting with deoxyhemoglobin, which is capable of reducing nitrite. In facultative aerobic bacteria, such as Pseudomonas aeruginosa, nitrite is reduced to NO by specialized heme‐containing enzymes called cd1 nitrite reductases. The details of their catalytic mechanism are summarized below, together with a hypothesis on the biological role (...) of the unusual d1‐heme, which, in the reduced state, shows unique properties (very high affinity for nitrite and exceptionally fast dissociation of NO). Our results support the idea that the nitrite‐based reactions of contemporary eukaryotes are a vestige of earlier bacterial biochemical pathways. The evidence that nitrite reductase activities of enzymes with different cellular roles and biochemical features still exist today highlights the importance of nitrite in cellular homeostasis. (shrink)

Recent investigations have revealed 1) that the isochores of the human genome group into two super‐families characterized by two different long‐range 3D structures, and 2) that these structures, essentially based on the distribution and topology of short sequences, mold primary chromatin domains (and define nucleosome binding). More specifically, GC‐poor, gene‐poor isochores are low‐heterogeneity sequences with oligo‐A spikes that mold the lamina‐associated domains (LADs), whereas GC‐rich, gene‐rich isochores are characterized by single or multiple GC peaks that mold the topologically associating domains (...) (TADs). The formation of these “primary TADs” may be followed by extrusion under the action of cohesin and CTCF. Finally, the genomic code, which is responsible for the pervasive encoding and molding of primary chromatin domains (LADs and primary TADs, namely the “gene spaces”/“spatial compartments”) resolves the longstanding problems of “non‐coding DNA,” “junk DNA,” and “selfish DNA” leading to a new vision of the genome as shaped by DNA sequences. (shrink)

T.S. Eliot, who went up to Oxford from America to write his doctoral dissertation, not only appreciated Bradley for his philosophical views, but perhaps even more for his prose, to the extent that he used to refer to the British philosopher as the ‘master of style’. The poet would have been surprised, and perhaps disappointed, to hear that such elegant writings are no longer available to the general public, confined as they are to antiquarian booksellers or philosophy libraries — and (...) sometimes not even to the latter. Indeed, it appears that what Eliot regarded as masterpieces of English prose have since turned into inaccessible and neglected texts. (shrink)

1. La trasformazione dei principi di legittimazione degli ordinamenti giuridici contemporanei -- 2. I mutamenti nel sistema giuridico -- 3. Analisi del linguaggio giuridico, legistica e legimatica -- 4. I diritti difficili nel sistema giuridico.

Roscoe Pound, in the introduction, gives a panorama of the various schools of legal philosophy, & places natural law in its proper perspective relative to ...

The three-yearly conference of Italian Society for Logic and Philosophy of Science (SILFS) has taken place in Bergamo, the 15th, 16th and 17th December 2010. The charming venue has been the former convent of Sant’Agostino, nowadays University of Bergamo. The conference program has been structured distinguishing plenary and parallel sessions: the first ones were 40 minutes long and designed for international guests: S. Abramsky from the Wolfson College of Oxford, A. Hagar from Indiana University, P. Janich from Philipps Universitaet of (...) Marburg and S. Okasha from University of Bristol. The complete program of the conference can be downloaded here: . We followed all the plenary sessions, and the first part of our report concerns them. There is just the exception of professor S. Psillos’ talk, which was indeed programmed, but didn’t take place due to greek unrest of the last December. The second part of our report concers the parallel sessions, that were 20 minutes long and designed for concurrent talks split between subject areas. We will keep this division into areas in our report and we chose four talks per area. However, it must be said that we had not watch the parallel sessions completely, since their being simoultaneous. This means that our review of the conference will be perspective, both because of subjective standpoint and because of the mentioned limitation. Still we hope we can offer a quite complete picture of the three-days conference, as we hope this overview may be considered as a general review of it. Just a few words must be still said to introduce to our review. The structure of each review will consists in a presentation of the talk’s author(s) (which we faithfully copy hereinafter) followed by a brief remark by us. Since many compliments could be surely done to the SILFS’ organization and to the University of Bergamo, an overall effect seems hard to be drawn, because of some arising perplexities. Although these are just our shared impressions about the conference, we think they must be remembered. One could note outward that the conference have had three official languages: English, French and Italian. Apparently, this is something that has not been justified since French has been useless and Italian has often prevented the comprehension by foreigner attendance. Many defections have taken place, something that could be said about the conformity with the program (in spite of the high number of speeches). Of course these defections have been caused by different reasons, but they become an indication of lack of professionalism as the number grows. Coming to an estimation of the inner issues, first we are seriously puzzled about the selection criterion (if any) which the SILFS has chosen the invited speakers with. One can notice that excellent talks have been put together to shallow speech without substantial scientific commitment. One has to keep in mind that who is just worthless, much lowers the general level. The topics have been various, although many were historical reconstruction and the "historiographic" approach in the study of Philosophy of Science seems therefore prevailing. Those talks whose subject was Logic and its applications, have been the highest-quality ones, by the fact that they were close to contemporary researches. More specifically, we would like to quote those concerning Quantum Computation and Logic of Quantum Mechanics. Talks of Philosophy of Biology and Cognitive Science were first-rate works, too, having showed high proficiency, though even specialistic topics were often technically handled, to the detriment of laymen (as us). (shrink)

"Contents: " "Man Without Letters." Newton, the Enigma. Paolo Toscanelli and His Friends. Alessandro Volta. Galileo Today. Necessity, Contingency, and Natural Law. Prologue to Parmenides. Galileo and Oppenheimer. The Role of Art in the Scientific Renaissance. The Italian Novel Today--A Note on Realism. The Seventeenth-Century Legacy: Our Mirror of Being. Philolaos in Limbo, Or: What Happened to the Pythagoreans? Paralipomena of the Future. Vico and Descartes. Eudodux and Plato: A Study in Chronology. "Scientific Rationalism." Einstein (pour le decennal de sa (...) mort). Les Grandes Doctrines Cosmologiques. De Bruno a Leibnitz. Postface a Galilee; Les Suites de l'Affaire. La Storia da Riscrivere. Fato Antico--Fato Moderno. Salvemini. Il Rovescio della Medaglia. (shrink)

Semblanza de G. Tagliacozzo a través de las distintas voces que, desde su infancia hasta su muerte, lo llamaron en su vida: las primeras vocaciones de grandeza , las voces de la academia , la voz de América , la impelente voz de Vico , la voz de los caminos que la naturaleza recorre .Semblance of G. Tagliacozzo through the voices that he followed from his younger age to his death: the first calls for greatness , the voices of academy (...) , the voice of America , the impelling voice of Vico , and the voice of the ways that nature runs. (shrink)

Giorgio Levi Della Vida (1886-1967) was not only an eminent Islamologist, belonging to that tradition of Italian Oriental studies that stretches from Ignazio Guidi to Leone Caetani, Carlo Alfonso Nallino and Francesco Gabrieli - he was also a man with solid roots in his own time. He taught in Naples and Rome, then for the ten years 1939-1948 at the University of Pennsylvania. He was one of the few university teachers who, when the oath of loyalty to the Italian (...) fascist regime was introduced, in October 1931, opted not to accept that act of submission. (shrink)

This book offers the first comprehensive analysis of the origin and development of the concept of physical continuity in ancient thought before Aristotle, combining a thorough study of Presocratic philosophy with Aristotle's perspective. The concept of continuity plays a fundamental role in Aristotle's philosophy, particularly in his physics; however, nowhere in his corpus does he present his theory of continuity. In this book, readers gain a solid foundation for understanding Aristotle's theory of the continuum through an in-depth exploration of Presocratic (...) views on being and continuity. The book's innovative approach critically analyzes Aristotle's engagement with his predecessors, including the work of Anaximander, the Pythagoreans, Eleatic philosophy, and the Atomists. By addressing this gap in existing literature, this volume not only enriches the discourse on Presocratic thought, but also establishes a clearer understanding of Aristotle's contributions to the concept of continuity. This book is suitable for students and scholars of ancient philosophy and the philosophy of science, particularly those working on Presocratic philosophy and Aristotle's thought more broadly. (shrink)