Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This paper describes theories and computer systems illustrating two innovative models of computer support for integrating working and learning. TheVdde system illustrates thedesign critiquing model helping individual professionals in analyzing current work situations, applying existing knowledge to these situations, and articulating new knowledge. The SmartMedia system illustrates thedomain construction model helping communities of practice to collaboratively evolve new ways of working.

Herders Metakritik aus dem Jahr 1799 ist ein Generalangriff auf Kants Kritik der reinen Vernunft und den beginnenden Kantianismus an der Universitat Jena, zu dem Herder offensichtlich auch die Philosophie Fichtes rechnet. Bei den Zeitgenossen war dieses Werk Herders Ruf als Philosoph nicht eben zutraglich. Die Nachwelt aber kann Herders auf Hamann gestutzte, sprachanalytisch verfahrende Kritik auch einer kritisch bereinigten Metaphysik als Vorbereitung des linguistic turn der Philosophie des 20. Jahrhunderts ganz neu schatzen und interessiert sich fur den Ansatz eines (...) holistischen, lebensphilosophischen Naturalismus und seine unausgeschopften Potentiale. - Die in diesem Band versammelten Beitrage versuchen, die schwierigen Lehrstucke dieses Werks transparent zu machen, und werfen ein Licht auf den Entstehungs- und Wirkungskontext dieser so lange vernachlassigten Schrift. - Mit Beitragen von Andreas Arndt, Manfred Baum, Oswald Bayer, Martin Bondeli, Markus Buntfuss, Marion Heinz, Petra Lohmann, Angelica Nuzzo, Violetta Stolz, Pierluigi Valenza, Rainer Wisbert und Gunter Zoller. (shrink)

Modeled on THE NEW NIETZSCHE, this collection revitalizes the thought of Spinoza. These essays establish Spinoza's rightful role in the development and direction of contemporary continental philosophy. The volume should interest not only the growing group of scholars attracted to Spinoza's ideas on ethics, politics, and subjectivity, but also theorists in a variety of fields.

Mental state reasoning or theory-of-mind has been the subject of a rich body of imaging research. Although such investigations routinely tap a common set of regions, the precise function of each area remains a contentious matter. With the help of functional magnetic resonance imaging (fMRI), we sought to determine which areas are involved when processing mental state or intentional metarepresentations by focusing on the relational aspect of such representations. Using non-intentional relational representations such as spatial relations between persons and between (...) objects as a contrast, the results ascertained the involvement of the precuneus, the temporal poles, and the medial prefrontal cortex in the processing of intentional representations. In contrast, the anterior superior temporal sulcus and the left temporo-parietal junction were implicated when processing representations that refer to the presence of persons in relational contexts in general. The right temporo-parietal junction, however, was specifically activated for persons entering spatial relations. The level of representational complexity, a previously unexplored factor, was also found to modulate the neural response in some brain regions, such as the medial prefrontal cortex and the right temporo-parietal junction. These findings highlight the need to take into account the critical roles played by an extensive network of neural regions during mental state reasoning. (shrink)

In very general terms, an agent is a being with the capacity to act, and 'agency' denotes the exercise or manifestation of this capacity. The philosophy of action provides us with a standard conception and a standard theory of action. The former construes action in terms of intentionality, the latter explains the intentionality of action in terms of causation by the agent’s mental states and events. From this, we obtain a standard conception and a standard theory of agency. There are (...) alternative conceptions of agency, and it has been argued that the standard theory fails to capture agency. Further, it seems that genuine agency can be exhibited by beings that are not capable of intentional action, and it has been argued that agency can and should be explained without reference to causally efficacious mental states and events. Debates about the nature of agency have flourished over the past few decades in philosophy and in other areas of research. In philosophy, the nature of agency is an important issue in the philosophy of mind, the philosophy of psychology, the debates on free will and moral responsibility, in ethics, meta-ethics, and in the debates on the nature of reasons and practical rationality. For the most part, this entry focuses on conceptual and metaphysical questions concerning the nature of agency. In the final sections, it provides an overview of empirically informed accounts of the sense of agency and of various empirical challenges to the commonsense assumption that our reasons and our conscious intentions make a real difference to how we act. (shrink)

The ArgumentContemporary natural sciences succeed remarkably well in ensuring a relatively continuous transmission of their cognitively relevant traditions and in creating a widely shared background consensus among their practitioners – hermeneutical ends seemingly achieved without hermeneutical awareness or explicitly acquired hermeneutical skills.It is a historically specific – emerging only in the nineteenth century – cultural organization of the Author-Text-Reader relation which endows them with such an ease of hermeneutical achievements: an institutionally fixed form of textual and intertextual practices, normatively posited (...) ways of adequate reception and criticism, etc. The same organization also explains a number of their often-discussed epistemic and cultural characteristics: their depersonalized objectivity, the social closure of their discourse and their reduced cultural significance, the shallow historical depth of their activated traditions, etc.The cognitive structure and the social function of contemporary natural sciences are intimately interwoven with a set of sui generis cultural relations that are partially fixed in the textual characteristics of their literary objectivations. A comparative hermeneutical analysis of natural sciences as a specifically constituted and institutionalized cultural genre or discourse-type brings into relief those contingent cultural conditions and relations to which some of their fundamental epistemological characteristics are bound, or at least with which they are historically closely associated. (shrink)

Assertions are speech acts by means of which we express beliefs. As such they are at the heart of our linguistic and social practices. Recent research has focused extensively on the question whether the speech act of assertion is governed by norms, and if so, under what conditions it is acceptable to make an assertion. Standard theories propose, for instance, that one should only assert that p if one knows that p (the knowledge account), or that one should only assert (...) that p if p is true (the truth account). In a series of four experiments, this question is addressed empirically. Contrary to previous findings, knowledge turns out to be a poor predictor of assertability, and the norm of assertion is not factive either. The studies here presented provide empirical evidence in favour of the view that a speaker is warranted to assert that p only if her belief that p is justified. (shrink)

Robustness is often presented as a guideline for distinguishing the true or real from mere appearances or artifacts. Most of recent discussions of robustness have focused on the kind of derivational robustness analysis introduced by Levins, while the related but distinct idea of robustness as multiple accessibility, defended by Wimsatt, has received less attention. In this paper, I argue that the latter kind of robustness, when properly understood, can provide justification for ontological commitments. The idea is that we are justified (...) in believing that things studied by science are real insofar as we have robust evidence for them. I develop and analyze this idea in detail, and based on concrete examples show that it plays an important role in science. Finally, I demonstrate how robustness can be used to clarify the debate on scientific realism and to formulate new arguments. (shrink)

The two main domains of high culture - the arts and the sciences - seem to be completely different, simply unrelated. Is there any sense then in talking about culture in the singular as a unity? A positive answer to this question presupposes that there is a single conceptual scheme, in terms of which it is possible to articulate both the underlying similarities and the basic differences between these domains. This article argues that - at least in respect of ‘classical’ (...) modernity - there is such a framework: the normatively conceived Author-Work-Recipient relation. It allows the disclosure of the paradoxical unity of culture: its two main realms are constituted as polar opposites and thus as strictly complementary. Through such an organization, culture could fulfil an affirmative, compensatory role. At the same time however, it also allowed culture to acquire the character of social critique, a function realized through the antagonistically opposed projects of Enlightenment and Romanticism - projects whose illusions are now evident. (shrink)

From the late seventeenth century on the idea of culture underwent a gradual transformation. Originally this concept referred essentially to the “refined” way of life of the ruling social elite. Popular culture, on the other hand, refers to the usually collective practices of groups of rural and urban workers taking the form of performance. They were not only excluded from refined culture, but it was regarded as completely unsuitable for them, potentially creating dangerous social aspirations. It is with the great (...) social transformation from feudal to bourgeois society that the idea of refined culture was replaced by that of “high culture” encompassing both the arts and the sciences: works claiming universal human significance. This “high culture” for a considerable time coexisted with the remnants of popular culture. It has been only due to the great technical advances that its true opposite, “mass culture” emerged, at the turn to twentieth century, claiming an empirical universality: being understandable and truly interesting to everyone. In economic respect, there is a competitive relation between high and mass culture. However, it is argued that there can be no cultural competition between them. For they posit differing and potentially co-existing receptive attitudes. The characterisation of this difference and the discussion of the seeming exceptions to the so-articulated conceptual scheme occupies the concluding part of this essay. (shrink)

The relationship between psychological states and the brain remains an unresolved issue in philosophy of psychology. One appealing solution that has been influential both in science and in philosophy is Dennett’s concept of the intentional stance, according to which beliefs and desires are real and objective phenomena, but not necessarily states of the brain. A fundamental shortcoming of this approach is that it does not seem to leave any causal role for beliefs and desires in influencing behavior. In this paper, (...) I show that intentional states ascribed from the intentional stance should be seen as real causes, develop this to an independently plausible ontological position, and present a response to the latest interventionist causal exclusion worries. (shrink)

In this paper I develop a philosophical account of actual mathematical infinity that does not demand ontologically or epistemologically problematic assumptions. The account is based on a simple metaphor in which we think of indefinitely continuing processes as defining objects. It is shown that such a metaphor is valid in terms of mathematical practice, as well as in line with empirical data on arithmetical cognition.

Although Kant is often considered the founding father of the controversial principle ‘Ought Implies Can’ (OIC), it is not at all clear how Kant himself understands and defends this principle. This essay provides a substained interpretation of Kant's views on OIC. I argue that Kant endorses two versions of OIC: a version that is concerned with our physical capacities, and a version that posits a link between moral obligation and a volitional power of choice. I show that although there are (...) important senses in which Kant's conception of OIC differs from the way in which OIC is discussed in recent philosophy, his account raises important issues for contemporary theory: for instance, it highlights the extent to which acceptance or rejection of OIC reflects convictions about the sources of normativity. (shrink)

In this paper I study the development of arithmetical cognition with the focus on metaphorical thinking. In an approach developing on Lakoff and Núñez, I propose one particular conceptual metaphor, the Process → Object Metaphor, as a key element in understanding the development of mathematical thinking.

Is the assessment of a view of life only a matter of personal preference? I argue that there is more than personal preference. I defend the position that a view of life must be useful for the ascription of meaning and therefore needs to fulfil the requirements of the process of ascribing meaning. In this article I analyse this process and its requirements and deduce from them a set of criteria by which views of life can be assessed.

This article explores whether perspective taking has an impact on the ascription of epistemic states. To do so, a new method is introduced which incites participants to imagine themselves in the position of the protagonist of a short vignette and to judge from her perspective. In a series of experiments, perspective proves to have a significant impact on belief ascriptions, but not on knowledge ascriptions. For belief, perspective is further found to moderate the epistemic side-effect effect significantly. It is hypothesized (...) that the surprising findings are driven by the special epistemic authority we enjoy in assessing our own belief states, which does not extend to the assessment of our own knowledge states. (shrink)

The first reference on rationality that integrates accounts from psychology and philosophy, covering descriptive and normative theories from both disciplines. Both analytic philosophy and cognitive psychology have made dramatic advances in understanding rationality, but there has been little interaction between the disciplines. This volume offers the first integrated overview of the state of the art in the psychology and philosophy of rationality. Written by leading experts from both disciplines, The Handbook of Rationality covers the main normative and descriptive theories of (...) rationality—how people ought to think, how they actually think, and why we often deviate from what we can call rational. It also offers insights from other fields such as artificial intelligence, economics, the social sciences, and cognitive neuroscience. The Handbook proposes a novel classification system for researchers in human rationality, and it creates new connections between rationality research in philosophy, psychology, and other disciplines. Following the basic distinction between theoretical and practical rationality, the book first considers the theoretical side, including normative and descriptive theories of logical, probabilistic, causal, and defeasible reasoning. It then turns to the practical side, discussing topics such as decision making, bounded rationality, game theory, deontic and legal reasoning, and the relation between rationality and morality. Finally, it covers topics that arise in both theoretical and practical rationality, including visual and spatial thinking, scientific rationality, how children learn to reason rationally, and the connection between intelligence and rationality. (shrink)

This paper is about two topics: 1. systems of explicit mathematics with universes and a non-constructive quantification operator $\mu$; 2. iterated fixed point theories with ordinals. We give a proof-theoretic treatment of both families of theories; in particular, ordinal theories are used to get upper bounds for explicit theories with finitely many universes.

The problematics of alienation have played a rather significant role in the discussions\nabout the sense and relevance of Marxism which have taken place in\nthe last twenty years. &dquo;Back to Marx&dquo; was at least one of the main slogans of\nthat ideological/intellectual movement, which evolved both in the East and\nWest from the mid-fifties and which is sometimes referred to as the trend of\n&dquo;humanist&dquo; Marxism. The idea of a &dquo;Marx-Renaissance&dquo; was undoubtedly\ndirected first of all against the completely petrified framework of institutionalized\nMarxism, turned into (...) a &dquo;religion of state&dquo; legitimating the domination\nof a bureaucratic apparatus over the population of East European societies.\nThe &dquo;rediscovery&dquo; and &dquo;rehabilitation&dquo; of the young Marx, the emphasis on\nthe continuity of his thought, meant not only a reintroduction of a number\nof categories, problems and ideas, which were thought fruitful in their critical\ninsight into contemporary conditions and which the impoverished and distorted\nversion of Marxism in official communist ideology (deliberately) failed\nto take into account: it also meant a global challenge to the appropriation of\nthe Marxian tradition by an apologetic ideology, which disguised its positivistic\ncontent through the form of an old-fashioned, dogmatic metaphysics; it\nwas an attempt to recover the critical/emancipatory meaning of this tradition\nwithin the realities of the twentieth century. It was in this context that the\nnotion of &dquo;alienation&dquo; again reappeared -- as a concept through which one\ncould articulate an attitude which was critical simultaneously of Western\ncapitalist and so-called &dquo;socialist&dquo; Eastern societies. Within the framework of\nEast European realities even the rather abstract character of this notion found\nin young Marx, was well suited to the theoretical vagueness and the practical\nlimitations of this new-found leftist criticism of home-societies. (shrink)

The dynamic differentiation of various social spheres in modernity has not been matched by any similarly dynamic development of new forms of trust which would help to maintain the connection between the impersonal/ systemic forms and the personal ones. Instead, we face today an increasing gap between the forms of trust related to the proliferating ‘abstract systems’ and the personal forms of trust. It is, above all, in this context that the topic of friendship became reintroduced into theoretical debates in (...) search for a model of human relationships which might bridge this gap. It is argued that such transformation of friendship into a ‘radical utopia’ is only the latest phase in the long series of historical transformations it has undergone in the context of changing social articulation of the relation between privacy and publicness. (shrink)

If we think of recognition as the practical relation consciously enacted by concerned individual subjects as social actors, which allows them to fulfil their intersubjectively valid social roles, this by no means exhausts the significance that recognition is accorded by Hegel. In fact the problem of recognition is central to the understanding and evaluation of Hegel’s metaphysical system. Thus a close scrutiny of the presentation of self-consciousness in Phenomenology of Spirit and the interpretative difficulties it poses leads on to the (...) question of the subject and Hegel’s distinction between finite, accidental individuals and the true subject in his system: the concept of Spirit, understood not as a separate entity but as a system of relations, objectified in the historical forms of the Absolute Spirit. But what is the price of Hegel’s metaphysics of subjectivity? Hegelian recognition signifies the recognition by individuals of recognition in its truth, that is, the self-recognition by finite individuals that they participate in Spirit as the true universal subject to the degree that they recognize their shared world of actions as the world of their own making. Modernity is therefore defined for Hegel as the recognition and realization of ‘conscious freedom’, whose telos lies in the actualization of universal reciprocal recognition that brings the unfreedom of history to an end. The idea of freedom and the thesis of the ‘end of history’ remain, however, the preserve of the thinking few. Hegelian recognition and with it Hegel’s whole metaphysical system founders on the rock of finitude, on the unfreedom of finite human beings. (shrink)

In this paper the role of incomprehensibility in the conceptualization of the DSM-IV definition of delusion is discussed. According to the analysis, the conceptual dependence of DSM-IV definition of delusion on incomprehensibility is manifested in several ways and infested with ambiguity. Definition of bizarre delusions is contradictory and gives room for two incompatible readings. Also the definition of delusion manifests internal inconsistencies and its tendency to account for delusions in terms of misinterpretation is bound to miss the content of the (...) traditional comprehension of delusionality. It is suggested that the ambiguities in defining delusions has to do with the question whether psychiatric practice is better accounted for in terms of the grammar of incorrectness or of incomprehensibility. (shrink)

Name der Zeitschrift: Jahrbuch für Wissenschaft und Ethik Jahrgang: 20 Heft: 1 Seiten: 73-112.

Mentalization-based family therapy and family rehabilitation represent a rich variety of approaches for assisting families with difficult interaction patterns. On the other hand, adventure therapy methods have been successfully used with families to offer them empowering experiences of succeeding together against difficult odds and to improve communication between family members. Further, the health promoting qualities of spending time outdoors are now well established and recognized. The Nordic approach to mentalization-based family rehabilitation combines adventure, outdoor, and systemic therapy. We provide three (...) examples of nature-based family rehabilitation practices that are delivered as brief, multi-family psychological interventions taking place in nearby nature and aiming to support sustainable, systemic change. The current contribution is a description of clinical practice, not a systematic review or a formal evaluation. We propose that recontextualizing mentalization-based family rehabilitation to the outdoors can not only provide added health benefits, but also strengthen intra-familial attuned interaction and emotional connectedness. The outdoor adventure provides the families with embodied, multisensory experiences of verbal and, especially, non-verbal interaction that can be usefully examined through the lens of theory of mentalization. The concreteness of adventure experiences is particularly beneficial for families that have difficulties in verbal communication and/or utilizing executive functions, perhaps due to neuropsychiatric traits, intellectual disabilities, or learning difficulties. Furthermore, outdoor adventure can support the participants’ connectedness to nature. (shrink)

Hans G. Ulrich's book, Wie Geschöpfe leben, engages eclectically but vigorously with moral and theological aspects of the Bible's teaching on ethics. This article employs three questions as an entrée to understanding his encounter with Scripture: it asks about his implicit biblical canon, his approach and presuppositions in hermeneutics, and finally about his major critical conversation partners. Supplementing Ulrich's strong sense of the Bible's importance for theological ethics, a strongly Lutheran reading of notions like `law' and `commandment' here goes hand (...) in hand with a concentration on Matthew, Romans and the Psalms; this in turn is matched by a characteristically unstated (but implicitly Protestant) Rule of Faith. There is a broad engagement with contemporary philosophers and theologians, but little attention is paid either to patristic and medieval voices or for that matter to biblical scholars, even those who have in recent years attempted to recover the connection between Scripture and Theology. (shrink)

Perceptual dialectology is concerned with subjective, non-specialist, naive perspectives of German and the role they play in day-to-day social interaction. What do non-specialists in linguistics think about dialects and their speakers? What cognitive maps do they have of these dialects? What attitudes do they have towards the dialects and their speakers? Do non-specialists in linguistics associate particular features with the dialects or perceive them in a special way? The book contains the latest research findings on this subject.".

In this highly original book, Markus Gabriel presents 'Neo-Existentialism', an anti-naturalist view that holds that human mindedness consists in an open-ended proliferation of mentalistic vocabularies. Challenged by Charles Taylor, Andrea Kern and Jocelyn Benoist, Gabriel deftly refutes naturalism's metaphysical claim to epistemic exclusiveness.

Pioneering molecular work on chelicerate visual system development in the horseshoe crabLimulus polyphemussurprised with the possibility that this process may not depend on the deeply conserved retinal determination function ofPax6transcription factors. Genomic, transcriptomic, and developmental studies in spiders now reveal that the arthropodPax6homologseyelessandtwin of eyelessact as ancestral determinants of the ocular head segment in chelicerates, which clarifies deep gene regulatory and structural homologies and recommends more unified terminologies in the comparison of arthropod visual systems. Following this phylotypic stage, chelicerate visual (...) system development differs fundamentally from other arthropods during the compartmentalization of the ocular segment in that eye and optic neuropil primordia originate independently from each other. Comparative analyses of this phase identified further gene regulatory homologies but also major differences, most notably the possibly compensatory replacement ofPax6byPax2in lateral eye specification. Also see the video abstract here:https://youtu.be/Hdfr3z5kEXU. (shrink)

Luca M. Possati, Jean Grondin, Paul Ricoeur ; Aurore Dumont, François Dosse et Catherine Goldenstein, Paul Ricoeur: penser la mémoire ; Paul-Gabriel Sandu, Gert-Jan van der Heiden, The Truth of Language. Heidegger, Ricoeur and Derrida on Disclosure and Displacement ; Paul Marinescu, Marc-Antoine Vallée, Gadamer et Ricoeur. La conception herméneutiquedu langage ; Witold Płotka, Saulius Geniusas, Th e Origins of the Horizon in Husserl’s Phenomenology ; Delia Popa, Annabelle Dufourcq, La dimension imaginaire du réel dans la philosophie de Husserl ; (...) Maria GyemantDenis Seron, Ce que voir veut dire. Essai sur la perception ; Christian Ferencz-Flatz, Hans Friesen, Christian Lotz, Jakob Meier, Markus Wolf, Ding und Verdinglichung. Technik- und Sozialphilosophie nach Heidegger und der Kritischen Th eorie ; Bogdan MincăLarisa Cercel, John Stanley, Unterwegs zu einer hermeneutischen Übersetzungswissenschaft. Radegundis Stolze zu ihrem 60. Geburtstag ; Denisa Butnaru Johann Michel, Sociologie du soi. Essai d’herméneutique appliquée ; Ovidiu Stanciu, Jan Patočka, Aristote, ses devanciers, ses successeurs. Trad. fr. Erika Abrams ; Mădălina Diaconu, Emmanuel Alloa, Das durchscheinende Bild. Konturen einer medialen, Phänomenologie. (shrink)

Hegel's Philosophy of Right represents a unique theory type in the history of political philosophy. It is a normative theory that departs in its construction from an empirical facticity without reducing norms to facts. It unifies teleological and deontic considerations. It is a theory of the normatively requisite institutional structures able to realize the demands of a historically particular form of individuality, and simultaneously it presents the phenomenology of modern subjectivity committed to the ultimate value of true freedom. In this (...) way it aims to transform into genuine self-knowledge the illusory social-political self-image of its addressees. The paper discusses the connection between this phenomenological method and Hegel's conception of freedom - his critique of unconditional, abstract normativity, his solution to the problem of collision between equally valid norms and the possible relevance of his methodological principles to contemporary political philosophy. (shrink)

Bertolt Brecht is internationally known as one of the most influential dramatists, directors, and theater theorists of the twentieth century and also, within German culture, as one of its most innovative modern poets and prose stylists. Whereas Brecht’s contributions to a Marxist aesthetics of drama, theater, poetry, and prose are widely acknowledged, he is less well known as a major thinker on ethical issues, mostly because of his materialist orientation, which conflicts with ethical traditions rooted in metaphysics. Against these traditions, (...) Brecht envisioned an “ethics for the satisfaction of needs”1 and claimed that “material needs as ethical, ethical ones as material, this is not grasped.”2 This.. (shrink)

Adorno’s extended conception of ‘culture industry’ renders the usual criticism of his views as ‘elitist’ meaningless. The same expansion creates, however, logical strains and contradictions in his analysis of the character and function of the culture industry: a strain in its ‘psychosocial’ and ‘status compulsion’ interpretation. In his late work Adorno attempts to solve this contradiction, but at a heavy price, by creating a conceptual barrier between pleasure and happiness.

We propose a multi-step evaluation schema designed to help procurement agencies and others to examine the ethical dimensions of autonomous systems to be applied in the security sector, including autonomous weapons systems.