Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This is one of the most important books on quantum mechanics to have appeared in recent years. It offers a dramatically new interpretation that resolves puzzles and paradoxes associated with the measurement problem and the behavior of coupled systems. A crucial feature of this interpretation is that a quantum mechanical measurement can be certain to have a particular outcome even when the observed system fails to have the property corresponding to that outcome just prior to the measurement interaction.

In his new introduction, "Note on a Missing Text," Richard Wolin uses the absence from this edition of an interview with Jacques Derrida as a springboard for ...

It is sometimes argued that while human gestures are produced ostensively and intentionally, great ape gestures are produced only intentionally. If true, this would make the psychological mechanisms underlying the different species’ communication fundamentally different, and ascriptions of meaning to chimpanzee gestures would be inappropriate. While the existence of different underlying mechanisms cannot be ruled out, in fact claims about difference are driven less by empirical data than by contested assumptions about the nature of ostensive communication. On some accounts, there (...) are no reasons to doubt that great ape gestural communication is ostensive. If these accounts are correct, attributions of meaning to chimpanzee gestures would be justified. (shrink)

Early in the first volume of his Ideen zu einer reinen Phiinomeno logie und phiinomenologischen Philosophie, Edmund Husserl stated concisely the significance and scope of the problem with which this present study is concerned. When we reflect on how it is that consciousness, which is itself absolute in relation to the world, can yet take on the character of transcendence, how it can become mundanized, We see straightaway that it can do that only by means of a certain participation in (...) transcendence in the first, originary sense, which is manifestly the transcendence of material Nature. Only by means of the experiential relation to the animate organism does consciousness become really human and animal (tierischen), and only thereby does it achieve a place in the space and in the time of Nature. l Consciousness can become "worldly" only by being embodied within the world as part of it. In so far as the world is material Nature, consciousness must partake of the transcendence of material Nature. That is to say, its transcendence is manifestly an embodiment in a material, corporeal body. Consciousness, thus, takes on the characteristic of being "here and now" (ecceity) by means of experiential (or, more accurately, its intentive) relation to that corporeal being which embodies it. Accordingly, that there is a world for consciousness is a conse quence in the first instance of its embodiment by 2 that corporeal body which is for it its own animate organism. (shrink)

This analysis of Frege's views on language and metaphysics in On Sense and Reference, arguably one of the most important philosophical essays of the past hundred years, provides a thorough introduction to the function/argument analysis and applies Frege's technique to the central notions of predication, identity, existence and truth. Of particular interest is the analysis of the Paradox of Identity and a discussion of three solutions: the little-known Begriffsschrift solution, the sense/reference solution, and Russell's 'On Denoting' solution. Russell's views wend (...) their way through the work, serving as a foil to Frege. Appendices give the proofs of the first 68 propositions of Begriffsschrift in modern notation. This book will be of interest to students and professionals in philosophy and linguistics. (shrink)

He describes this most private work of Heidegger's philosophy as "a dissonant symphony that imperfectly weaves together its moments into a vast fugue, under the ...

The concept of self-control is incorporated in a theory of individual intertemporal choice by modeling the individual as an organization. The individual at a point in time is assumed to be both a farsighted planner and a myopic doer. The resulting conflict is seen to be fundamentally similar to the agency conflict between the owners and managers of a firm. Both individuals and firms use the same techniques to mitigate the problems which the conflicts create. This paper stresses the implications (...) of this agency model and discusses as applications the effect of pensions on saving, saving and the timing of income flows, and individual discount rates. (shrink)

This work focuses upon decisions to withhold or withdraw life-supporting treatment from incompetent patients. It offers a critical examination of the latest developments with a view to developing a new framework for resolving disputes in the clinic that is not only theoretically robust but also practically relevant.

Bioethics and feminist scholarship has explored various justice implications of nonmedical sex selection and family balancing. However, prospective users’ viewpoints have been absent from the debate over the socially acceptable bounds of nonmedical sex selection. This qualitative study provides a set of empirically grounded perspectives on the moral values that underpin prospective users’ conceptualizations of justice in the context of a family balancing program in the United States. The results indicate that couples pursuing family balancing understand justice primarily in individualist (...) and familial terms rather than in terms of social justice for women and girls or for children resulting from sex selection. Study participants indicated that an individual’s desire for gender balance in their family is ethically complex and may not be inherently sexist, immoral, or socially consequential, particularly given the social context in which they live. Our findings suggest that the social conditions that contribute to prospective users’ desires for gender balance in their families may direct them away from recognizing or engaging broader social justice concerns relating to sexism and stratified reproduction. (shrink)

The essays in this collection examine developments in three fundamental biological disciplines--embryology, evolutionary biology, and genetics--in conflict with each other for much of the twentieth century. They consider key methodological problems and the difficulty of overcoming them. Richard Burian interweaves historical appreciation of the settings within which scientists work, substantial knowledge of the biological problems at stake and the methodological and philosophical issues faced in integrating biological knowledge drawn from disparate sources.

Through constructive arguments covering the principal topics and controversies in epistemology, ethics, and aesthetics, Autonomy and Normativity demonstrates how truth, right and beauty can retain universal validity without succumbing to the mistaken Enlightenment strategy of seeking foundations for rational autonomy. Presenting a compact, yet comprehensive statement of a powerful and provocative alternative to the reigning orthodoxies of current philosophical debate, Richard Winfield employs Hegelian techniques and presents a radical and systematic critique of the work of mainstream thinkers including: Kant, (...) Rawls, Husserl and Habermas. This book offers an invaluable resource for students of both analytic and continental philosophical traditions, and related areas of law, social theory and aesthetics. (shrink)

A notable achievement of T.M. Scanlon's What We Owe to Each Other is its sustained critique of welfarist consequentialism. Consequentialism is the doctrine that one morally ought always to do an act, of the alternatives, that brings about a state of affairs that is no less good than any other one could bring about. Welfarism is the view that what makes a state of affairs better or worse is some increasing function of the welfare for persons realized in it. I (...) shall argue that Scanlon’s critique, though containing much of interest, fails on its own terms. (shrink)

For many years, the aims of education have been informed by liberalism, with an emphasis on autonomy. The aim has been to mentally equip students to be autonomous individuals, able to live self-directed lives. In this volume, international philosophers of education explore and question diverse strains of the liberal tradition, discussing not only autonomy but other key issues such as: social justice; national identity; curriculum; critical thinking; and social practices. The contributors write from a variety of standpoints, offering many interpretations (...) of what liberalism might mean in educational terms. The result is a collection of research, which is intended to stimulate debate. (shrink)

It is widely assumed that selection history accounts of function can support a fully reductive naturalization of functional properties. I argue that this assumption is false. A problem with the alternative causal role account of function in this context is that it invokes the teleological notion of a goal in analysing real function. The selection history account, if it is to have reductive status, must not do the same. But attention to certain cases of selection history in biology, specifically those (...) involving meiotic drive, shows that selection historical explanations are available in the case of items without any plausible function. Making contributions to goals, here fitness, must be introduced as an additional constraint in the analysis, either explicitly, or implicitly by appeal to individual functions or the selection-of/selection-for distinction. (shrink)

Lennan, Richard Review of: From north to south: Southern scholars engage With Edward Schillebeeckx, edited by Helen F. Bergin, OP, Adelaide: ATF Theology, 2013, pp. 163, epub, $31; hardback, $50; paperback, $37.95; pdf, $19.95.

One way to think about capitalism-versus-socialism is to examine the extent to which capitalist economic institutions are compatible with the fulfillment of socialist ideals. The late G. A. Cohen has urged that the two are strongly incompatible. He imagines how it would make sense for friends to organize a camping trip, distills the socialist moral principles that he sees fulfilled in the camping trip model, and observes that these principles conflict with a capitalist organization of the economy. He adds that (...) these principles are ethically attractive, so if it is feasible to organize the economy on the camping trip model, we ought to do so. This essay argues to the contrary that for all that has been said, capitalist economic arrangements might be in the set of institutional arrangements that overall would best fulfill the camping trip principles, and anyway, the principles themselves ought to be rejected, so the question whether or not a capitalist set-up might satisfy these principles should not interest us. The grounds for rejecting the camping trip principles support a form of welfarist consequentialism that denies that equality of distribution of any sort is per se ethically desirable and also denies that liberal freedoms to live as one chooses are per se morally desirable. Equality and freedom should rather be regarded as in the light of possible means (or hindrances) to advancing good for people, fairly distributed. (shrink)

The objection to R-S accounts that was raised by the possibility of external agents requires the acceptance of two premises, viz., that all R-S accounts allow for puppeteers and that puppeteers necessarily make us unfree. The Metaphilosophical reply shows that to the extent that puppeteers are more problematic than determinism per se, pup-peteers may be explicitly excluded since they violate our paradigm of free will. The Metaphilosophical reply also suggests that we should not expect our mature R-S account to supply (...) logically necessary and sufficient conditions for free will, but rather give us answers that agree with our intuitions regarding paradigms of free and unfree decisions. The Irrelevancy reply completed our reply to incompatibilists who continue to object that determinism per se destroys the R-S program. It may be debated whether my autonomy variable account is a satisfactory way to spell out the Irrelevancy reply, but I think that this type of approach suggests the way to vindicating the R-S view from an important type of objection. (shrink)

During the 1840s and the 1850s botanist Joseph Hooker developed distinct notions about the proper characteristics of a professional man of science. While he never articulated these ideas publicly as a coherent agenda, he did share his opinions openly in letters to family and colleagues; this private communication gives essential insight into his and his X-Club colleagues' public activities. The core aspiration of Hooker's professionalization was to consolidate men of science into a dutiful and centralized community dedicated to national well-being. (...) The nation in turn owed the scientific community for its ministration. When the government bestowed funds and status on men of science it was rewarding science -- not purchasing it. His proposed reforms were piecemeal, immediate, and above all practical. He harbored no taste for vast millenarian transformation, and rested his conception of scientific professionalism upon a respectable High Victorian foundation of patronage and pillars of duty, reciprocity, intimacy, and inequality. The process of professionalization he envisioned was as much shrewd compromise between existing interests as a vindication of principle. His power and prestige from the mid-1850s onward gave him considerable ability to carry out his reform program, although his general success did occasion some undesired consequences for the status of natural-history pursuits. (shrink)

The primary theme of this paper is the normative case against ownership of one's genetic information along with the source of that information (usually human tissues samples). The argument presented here against such “upstream” property rights is based primarily on utilitarian grounds. This issue has new salience thanks to the Human Genome Project and “bio-prospecting” initiatives based on the aggregation of genetic information, such as the one being managed by deCODE Genetics in Iceland. The rationale for ownership is twofold: ownership (...) will protect the basic human rights of privacy and autonomy and it will enable the data subjects to share in the tangible benefits of the genetic research. Proponents of this viewpoint often cite the principle of genetic exceptionalism, which asserts that genetic information needs a higher level of protection than other kinds of personal information such as financial data. We argue, however, that the recognition of such ownership rights would lead to inefficiency along with the disutility of genetic discoveries. Biomedical research will be hampered if property rights in genes and genetic material are too extensive. We contend that other mechanisms such as informed consent and strict confidentiality rules can accomplish the same result as a property right without the liabilities of an exclusive entitlement. (shrink)

SUMMARYAmong the elements of the modern scientific ethos, as identified by R.K. Merton and others, is the commitment of individual effort to a long-term inquiry that may not bring substantial results in a lifetime. The challenge this presents was encapsulated in the aphorism of the ancient Greek physician, Hippocrates of Kos: vita brevis, ars longa. This article explores how this complaint was answered in the early modern period by Francis Bacon’s call for the inauguration of the sciences over several generations, (...) thereby imagining a succession of lives added together over time. However, Bacon also explored another response to Hippocrates: the devotion of a ‘whole life’, whether brief or long, to science. The endorsement of long-term inquiry in combination with intensive lifetime involvement was embraced by some leading Fellows of the Royal Society, such as Robert Boyle and Robert Hooke. The problem for individuals, however, was to find satisfaction in science despite concerns, in some fields, that current observations and experiments would not yield material able to be extended by future investigations. (shrink)

Technology is developing fast - so fast that it threatens to overwhelm the very species whose genius lies in its technological cunning: us. From the metaverse to genetic engineering and mood-altering pharmaceuticals, to cybersex and cyberwar and the widespread automation of work, new technologies are rewriting the terms of our existence, not in a neutral spirit of 'progress' but in line with the priorities of power and profit, and in ways that often work against the grain of our fundamental being.In (...) this timely, provocative book, Richard King argues that we need to evolve a more critical attitude to new technologies if we are to avoid a world in which humans are no different in kind from algorithmic machines. The stakes could not be higher. As science, technology and capitalism fuse into a single system, and activists and entrepreneurs talk of a 'post-human' future in which individuals will transform themselves using powerful computers and biotechnologies, we are entering unchartered territory - a territory marked with the mapmaker's warning, Here Be Dragons... Here Be Monsters. (shrink)

Since the publication of the original edition in 1947, Richard McKeon's _Introduction to Aristotle _has become the standard text for a variety of courses in philosophy and the humanities. For this revised and enlarged edition, Professor McKeon has completely rewritten his General Introduction and his introductions to the particular works. He has also expanded the collection to include material from _On the Parts of Animals_ and the _Rhetoric_. Aristotle's contribution to Western civilization is enormous. Our language, our distinctions, our (...) ways of thinking, all are profoundly affected by his work. Since an understanding of Aristotle is indispensable for the understanding of our own culture, the ready availability of his work is crucial. This collection, for students and general readers alike, provides in one volume _Posterior Analytics_, _De Anima_, _Nicomachean Ethics_, and _Poetics_, complete and unabridged, together with generous selections from _Physics, On the Parts of Animals, Metaphysics, Politics, _and_ Rhetoric_. These works, together with Professor McKeon's revised introductions, provide a convenient and thorough exposure to the works of Aristotle and to the structural interrelations in the Aristotelian system of thought. (shrink)

This article explores the ways in which Janelle Monáe’s audiovisual performances leverage black female flesh to trouble historically constituted imaginings of ‘the human’. Tracking Monáe’s audiovisual aesthetics across ‘Many moons’ and Dirty Computer, I interrogate acoustic and imagistic resonances that recall the repeating horrors of bondage, and which also constitute performative ‘fabulations’ whereby freedoms that are engendered specifically by and within black female flesh might be imagined. Monáe ‘enfleshes’ the cyborg to critique cyberfeminist and posthumanist theories that advocate for material (...) dissolution as a framework for liberation, as well as to trouble black women’s historical relationships to the category ‘human’. Rather than understand Dirty Computer as a (re)turn to the human Monáe, I contend that the project extends the artist’s longstanding critical engagement with the black female cyborg and black sonic cyberfeminist liberatory potentialities. (shrink)

In the fifth of our articles on , Richard Norman explains why he believes we can be good without God.

Addicts may simply deny that they are addicted; or they may use self-signalling to try to provide evidence that giving up is not worthwhile. I provide an account that shows how easy it is to provide apparent evidence either that the addiction is so bad that it cannot be escaped; or that there is no real addiction, and hence nothing to escape. I suggest that the most effective way of avoiding this is to avoid self-signalling altogether.

Burke is an important exception to Nietzsche's claim that philosophical aesthetics ignores physiology and the role of practical interest. Grounded on the powerful interest of survival, Burke's theory of the sublime also offers a physiological explanation of our feelings of sublimity that explicitly defines certain conditions of our nerves as the ‘efficient cause’ of such feelings. While his general account of sublimity is widely appreciated, its somatic dimension has been dismissed as hopelessly misguided. In examining Burke's views in relation to (...) contemporary somaesthetics, cognitive psychology, and physiology, this paper shows that though Burke's somatic arguments can be criticized as overly simplistic and mechanistic, his recognition of the crucial bodily dimensions of aesthetic experience should be taken more seriously. In refining Burke's insight that bodily factors can help explain our aesthetic reactions, somaesthetics further urges that improved somatic understanding and performance can provide valuable means for enhancing our aesthetic response. (shrink)

This is not an obituary, there’ll be time enough for them. It is not a tribute, not a considered assessment of a brilliant life, not a eulogy. It..