Objective: Cognitive impairment is a common neurological complication in patients with end-stage renal disease undergoing maintenance hemodialysis. Brain network analysis based on graph theory is a promising tool for studying CI. Therefore, the purpose of this study was to analyze the changes of functional brain networks in patients on MHD with and without CI by using graph theory and further explore the underlying neuropathological mechanism of CI in these patients.Methods: A total of 39 patients on MHD and 25 healthy controls (...) matched for age, sex, and years of education were enrolled in the study. Resting-state functional magnetic resonance imaging and T1-weighted high-resolution anatomical data were obtained, and functional brain networks for each subject were constructed. The brain network parameters at the global and regional levels were calculated, and a one-way analysis of covariance was used to compare the differences across the three groups. The associations between the changed graph-theory parameters and cognitive function scores in patients on MHD were evaluated using Spearman correlation analysis.Results: Compared with HCs, the global parameters [sigma, gamma, and local efficiency ] in both patient groups decreased significantly. The clustering coefficient in patients with CI was significantly lower than that in the other two groups. The regional parameters were significantly lower in the right superior frontal gyrus, dorsolateral and gyrus rectus of patients with CI than those of patients without CI; however the nodal local efficiency in the left amygdala was significantly increased. The global Cp and regional parameters in the three brain regions were significantly correlated with the cognitive function scores.Conclusion: This study confirmed that the topology of the functional brain network was disrupted in patients on MHD with and without CI and the disruption of brain network was more severe in patients with CI. The abnormal brain network parameters are closely related to cognitive function in patients on MHD. (shrink)

Research showed that action real-time strategy gaming experience is related to cognitive and neural plasticity, including visual selective attention and working memory, executive control, and information processing. This study explored the relationship between ARSG experience and information transmission in the auditory channel. Using an auditory, two-choice, go/no-go task and lateralized readiness potential as the index to partial information transmission, this study examined information transmission patterns in ARSG experts and amateurs. Results showed that experts had a higher accuracy rate than amateurs. (...) More importantly, experts had a smaller stimulus-locked LRP component than amateurs on no-go trials, while the response-locked LRP component on go trials did not differ between groups. Thus, whereas amateurs used an asynchronous information transmission pattern, experts used a reduced asynchronous information transmission pattern or a synchronous pattern where most of processing occurred prior to response execution – an information transmission pattern that supports rapid, error-free performance. Thus, experts and amateurs may use different information transmission patterns in auditory processing. In addition, the information transmission pattern used by experts is typically observed only after long-term auditory training according to past research. This study supports the relationship between ARSG experience and the development of information processing patterns. (shrink)

In recent years, due to factors such as rising sea levels, several island nations such as Maldives, Tuvalu, Kiribati, and the Marshall Islands are in danger of disappearing completely. When the land of an island country disappeared, the human rights protection of Environmentally Displaced Persons in the migration process and the possible loss of their unique culture, language, and lifestyle have aroused great concern. We call such Environmentally Displaced Persons as EDPs. This study selects the EDPs’ data of 241 countries (...) or regions from 2008 to 2018, establishes an ARIMA model, and predicts the future population of EDPs. By combining the influencing factors of cultural loss, the risk assessment model of cultural loss is established to evaluate the possibility of cultural loss during the migration process of EDPs. We have established a Bayesian Network and a Fault Tree Model to demonstrate the improvement brought about by the implementation of policy recommendations from both qualitative and quantitative perspectives and use the method of fault tree analysis to illustrate the importance of policies from the degree of probability reduction after policy changes. Finally, based on the above model establishment and data analysis, corresponding countermeasures are proposed to protect EDPs’ human rights from being violated and their culture will not be lost. (shrink)

With the deepening of reform and opening-up, China’s economy has been further developed, but there is still a problem of uneven development. It is of great significance to completely construct China’s economic spatial correlation network, to clarify the role and status of each province in the whole network, and to study the influencing factors of the national spatial economic network. In this paper, we employ the network analysis method to analyze China’s economic development in the past 20 years. Based on (...) the modified gravity model, we construct China’s spatial economic network and explore the network structure from three aspects: the whole network structure feature, characteristics of individual provinces in the network, and block model analysis. The results show that China’s spatial economic network has strong internal cohesion, and the hierarchy of the network is becoming less and less obvious. However, the network density is low, and the overall network relationship still needs to be strengthened. The different levels in economic development illustrate the obvious economic unbalance among provinces. The block model analysis results demonstrated that coastal areas are more attractive to other provinces and are playing an important role in driving China’s economy. Finally, we employ Quadratic Assignment Procedure regression analysis to analyze the influential factors on spatial economic network. Numerical results show that the geographic proximity and the differences in six factors have significant impact on the spatial economic network. Moreover, the influence of these factors on the economic relation among provinces has been gradually strengthened in recent years. (shrink)

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

BackgroundLeft-behind children in China have aroused widespread concern in society and the academic field because they have a high risk of psychological problems. For left-behind children, depression is the most serious problem. Bullying victimization has been evidenced as one of the most common causes of children’s depression. However, less is known about its longitudinal association and the process for how bullying victimization influences depression among left-behind children. Thus, the presentation aims to explore the mechanisms underlying by considering the roles of (...) left-behind children’s negative thoughts and self-compassion.MethodsThe 3-wave longitudinal data were collected from a sample of 605 aged 8–11 from central China. We used the Olweus bully and victimization questionnaire, the children’s automatic thoughts scale, the depression scale, and the self-compassion scale.ResultsBullying victimization positively predicted the depression level of left-behind children. Negative thoughts and self-compassion mediate the relationship between bullying victimization and depression. In the mechanism of bullying victimization on depression exists gender differences among left-behind children.ConclusionThe present study suggested the association between bullying victimization and left-behind children’s depression and revealed the internal mechanism of negative thoughts and self-compassion. These findings provide a new perspective for left-behind children’s mental health education and intervention. (shrink)

ObjectiveThis study aimed to develop a diagnostic model of multi-kinematic parameters for patients with amnestic mild cognitive impairment (aMCI).MethodIn this cross-sectional study, 94 older adults were included (33 cognitively normal, CN; and 61 aMCI). We conducted neuropsychological battery tests, such as global cognition and cognitive domains, and collected gait parameters by an inertial-sensor gait analysis system. Multivariable regression models were used to identify the potential diagnostic variables for aMCI. Receiver operating characteristic (ROC) curves were applied to assess the diagnostic accuracy (...) of kinematic parameters in discriminating aMCI from healthy subjects.ResultsMultivariable regression showed that multi-kinematic parameters were the potential diagnostic variables for aMCI. The multi-kinematic parameter model, developed using Timed Up and Go (TUG) time, stride length, toe-off/heel stride angles, one-leg standing (OLS) time, and braking force, showed areas under ROC (AUC), 0.96 [95% confidence interval (CI), 0.905–0.857]; sensitivity, 0.90; and specificity, 0.91. In contrast, a single kinematic parameter’s sensitivity was 0.26–0.95 and specificity was 0.21–0.90. Notably, the separating capacity of multi-kinematic parameters was highly similar to Montreal Cognitive Assessment (MoCA; AUC: 0.96 vs. 0.95). Compared to cognitive domain tests, the separating ability was comparable to Auditory Verbal Learning Test (AVLT) and Boston Naming Test (BNT; AUC: 0.96 vs. 0.97; AUC: 0.96 vs. 0.94).ConclusionWe developed one diagnostic model of multi-kinematic parameters for patients with aMCI in Foshan. (shrink)

Current COVID-19 pandemic and previous SARS/MERS outbreaks have caused a series of major crises to global public health. We must integrate the large and exponentially growing amount of heterogeneous coronavirus data to better understand coronaviruses and associated disease mechanisms, in the interest of developing effective and safe vaccines and drugs. Ontologies have emerged to play an important role in standard knowledge and data representation, integration, sharing, and analysis. We have initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO). (...) As an Open Biomedical Ontology (OBO) library ontology, CIDO is an open source and interoperable with other existing OBO ontologies. In this article, the general architecture and the design patterns of the CIDO are introduced, CIDO representation of coronaviruses, phenotypes, anti-coronavirus drugs and medical devices (e.g. ventilators) are illustrated, and an application of CIDO implemented to identify repurposable drug candidates for effective and safe COVID-19 treatment is presented. (shrink)

Offers the first focused study of the shifei debates of the Warring States period in ancient China and challenges the imposition of Western conceptual categories onto these debates. In recent decades, a growing concern in studies in Chinese intellectual history is that Chinese classics have been forced into systems of classification prevalent in Western philosophy and thus imperceptibly transformed into examples that echo Western philosophy. Lin Ma and Jaap van Brakel offer a methodology to counter this approach, and illustrate their (...) method by carrying out a transcultural inquiry into the complexities involved in understanding shi and fei and their cognate phrases in the Warring States texts, the Zhuangzi in particular. The authors discuss important features of Zhuangzi’s stance with regard to language-meaning, knowledge-doubt, questioning, equalizing, and his well-known deconstruction of the discourse in ancient China on shifei. Ma and van Brakel suggest that shi and fei apply to both descriptive and prescriptive languages and do not presuppose any fact/value dichotomy, and thus cannot be translated as either true/false or right/wrong. Instead, shi and feican be grasped in terms of a pre-philosophical notion of fitting. Ma and van Brakel also highlight Zhuangzi’s idea of “walking-two-roads” as the most significant component of his stance. In addition, they argue that all of Zhuangzi’s positive recommendations are presented in a language whose meaning is not fixed and that every stance he is committed to remains subject to fundamental questioning as a way of life. (shrink)

Modern technology (Technik, la technique) has constituted the gears on which the wheels of the modern world keep turning. The later Heidegger devotes sustained reflection to this unprecedented phenomenon in human history. It is notable that, compared with other figures from twentieth-century continental philosophy, Heidegger has served as the most frequent reference point in current philosophy of technology (Technikphilosophie). This field of philosophy came into being after the so-called empirical turn of “Science and Technology Studies.” While relevant scholars focus mainly (...) on “Die Frage nach der Technik” of 1953, “Das Ge-stell” of 1949,1 and some other texts written in that period,2 the time span of Heidegger’s .. (shrink)

We argue that all general concepts are family resemblance concepts. These include concepts introduced by ostension, such as colour(s). Concepts of colour and of each of the specific colours are family resemblance concepts because similarities concerning an open‐ended range of colour or of appearance features crop up and disappear. After discussing the notion of “same colour” and Wittgenstein's use of the phrase “our colours”, we suggest family resemblance concepts in one tradition can often be extended to family resemblance concepts in (...) another tradition, illustrated by Wittgenstein's use of the words Spiel and “game”. (shrink)

ABSTRACTConsulting Heidegger's other texts composed during 1936–1942, this article employs a principle of charity and constructs a consistent discourse about an inceptual negativity Heidegger articulates through a confrontation with Hegel in GA 68. Heidegger deliberately differentiates his use of denial that bears Being-historical significance from Hegel's Negation that allegedly aims at synthesis or elevation as a dialectical movement. Being unsatisfied with his approach that remains entangled with metaphysics in the Contributions, Heidegger attempts to transform the question of the Nothing from (...) a subsidiary question to Beyng to an abyssal question. One needs to go under toward the Nothing in its concealed, conjoined, and most intimate relation to Beyng. The movement of going under is fundamentally significant for transitions that could occur from out of the history of Beyng. Never being the fullness of essence, the Nothing places a limit on Beyng, constantly thwarts its unfolding, and maint... (shrink)

Ben shu yi xing wei wu jia zhi er yuan lun wei yan jiu zhu xian, an zhao " ke guan gou cheng yao jian, pai chu ke guan wei fa de shi you, zhu guan gou cheng yao jian, pai chu zhu guan ze ren de shi you " si jie ceng fan zui lun ti xi de jia gou, cong ke guan yao jian, zhu guan yao jian, xiu zheng xing tai san ge wei du, lin xuan fan (...) zui lun ling yu de ruo gan zheng yi wen ti yi ci zhan kai tao lun. ben shu jian chi yi wen ti wei dao xiang, wei rao si fa shi jian ti chu de nan ti, shu li xue shuo de mai luo, kao cha li fa de tuo dang xing, dui ge zhong li lun he guan dian tiao fen lü xi, zhi li yu li lun, li fa yu si fa de liang xing hu dong he xie diao fa zhan, ti chu de fang an zai yi ding cheng du shang hui da le li lun he shi jian zhong de yi wen. (shrink)

In this article, I address the intricacies of Heidegger's existential notion of Mitsein, and expound a different way of understanding the relevant issue in light of a reinterpretation of Zhuangzi's fish story. I show that Heidegger's account of Mitsein is ultimately situated within the limit of Dasein's structural components. What is more problematic is his conception of the connection between Dasein and others as disengaged. Then I explicate a Zhuangzian idea of what I call Mitzutun, literally meaning doing something with. (...) I argue that the “with” of the Zhuangzian Mitzutun is lived out by human beings and non-human beings in the variegated forms of life. (shrink)

Why should interpretation of conceptual schemes and practices across traditions work at all? In this paper we present the following necessary conditions of possibility for interpretation in comparative and Chinese philosophy: the interpreter must presuppose that there are mutually recognizable human practices; the interpreter must presuppose that “the other” is, on the whole, sincere, consistent, and right; the interpreter must be committed to certain epistemic virtues. Some of these necessary conditions are consistent with the fact that interpretation is not thwarted (...) by the “danger” of relativism or of incommensurability. Some other conditions are suggestive of reorientations of methodologies of comparative and Chinese philosophy. (shrink)

In this article, we trace and elucidate Heidegger’s radical re-thinking on the relation between science and technology from about 1940 until 1976. A range of passages from the Gesamtausgabe seem to articulate a reversal of the primacy of science and technology in claiming that “Science is applied technology.” After delving into Heidegger’s reflection on the being of science and technology and their “coordination,” we show that such a claim is essentially grounded in Heidegger’s idea that “Science and technology are the (...) Same [das Selbe].” In addition, we argue that, although different ontic epochs can be distinguished in the evolvement of science and/or technology, for Heidegger there is only one unique ontological Epoch of modernity that encompasses various ontic epochs. Therefore, the change from an “epoch of objectivity” to an “epoch of orderability [Bestellbarkeit]” cannot be considered to be an ontological shift. Furthermore, it is not right to ascribe to Heidegger the view that the development of quantum physics signals the beginning of a new ontological Epoch. (shrink)

Recent years have witnessed a growth in the literature in Western languages devoted to Mou Zongsan 牟宗三.1 Among the New Confucians, Mou's writings are regarded as the most argumentative and the most systematic. He is also one who has engaged with Western philosophers such as Kant, Wittgenstein, Russell, Whitehead, Hegel, and Heidegger. This essay addresses a more primordial theme: how does Mou Zongsan compare with Heidegger when they come to the central issue of the self-transformation of traditions and the question (...) of cultural communication and integration? In relation to these concerns, they respectively formulate the notion of the self-reversal of moral reason (or of liangzhi 良知... (shrink)

Against the background that the top-level semantic framework of Chinese traditional culture is not comprehensive and unified, this study aims to preserve and disseminate cultural heritage information about Chinese traditional culture through the development of a domain ontology which is constructed from ancient books. A combination of top-down and bottom-up approaches was used to construct the ontology for Chinese traditional culture. An investigation of historians’ needs, and LDA topic clustering model were conducted, understanding the specific needs of historians, collecting the (...) topic, concepts and relationships. CIDOC CRM was reused to construct the basic framework of CTCO. Ontology structure and function were adopted to evaluate the effectiveness of CTCO. Evaluation results show that the ontology meets all the quality criteria of OntoMetrics, and the experts agreed on content representation. CTCO contributes to the organization of traditional Chinese culture and the construction of related databases. The study also forms a common path and puts forward proposals for the construction of domain ontology, which has great social relevance. (shrink)

In this paper, we discuss the development and piloting of a new methodology for illuminating the socio-material constitution of data objects and flows as data move between different sites of practice. The data journeys approach contributes to the development of critical, qualitative methodologies that can address the geographic and temporal scale of emerging knowledge infrastructures, and capture the ‘life of data’ from their initial generation through to re-use in different contexts. We discuss the theoretical development of the data journeys methodology (...) and the application of the approach on a project examining meteorological data on their journey from initial production through to being re-used in climate science and financial markets. We then discuss three key conceptual findings from this project about: the socio-material constitution of digital data objects, ‘friction’ in the movement of data through space and time and the mutability of digital data as a material property that contributes to driving the movement of data between different sites of practice. (shrink)

This paper proposes a constrained solution update strategy for multiobjective evolutionary algorithm based on decomposition, in which each agent aims to optimize one decomposed subproblem. Different from the existing approaches that assign one solution to each agent, our approach allocates the closest solutions to each agent and thus the number of solutions in an agent may be zero and no less than one. Regarding the agent with no solution, it will be assigned one solution in priority, once offspring are generated (...) closest to its subproblem. To keep the same population size, the agent with the largest number of solutions will remove one solution showing the worst convergence. This improves diversity for one agent, while the convergence of other agents is not lowered. On the agent with no less than one solution, offspring assigned to this agent are only allowed to update its original solutions. Thus, the convergence of this agent is enhanced, while the diversity of other agents will not be affected. After a period of evolution, our approach may gradually reach a stable status for solution assignment; i.e., each agent is only assigned with one solution. When compared to six competitive multiobjective evolutionary algorithms with different population selection or update strategies, the experiments validated the advantages of our approach on tackling two sets of test problems. (shrink)

Every scientific or intellectual movement is founded upon basic assumptions and hypotheses that shape its specifically formulated philosophy. This study seeks to explore and explicate the basic philosophical underpinnings of grey systems theory, as well as the paradigm governing its postulates. The study, more specifically, scrutinizes the underlying principles of GST from the perspective of postmodern philosophy. To accomplish this, the epistemology, ontology, human nature, and methodology of GST are substantially investigated in the light of postmodern philosophy. The study draws (...) on Burrell and Morgan’s framework to reveal the paradigm underlying the philosophy of GST. Results demonstrate that GST is an anti-realistic, anti-positivistic, and non-deterministic theory which is inherently pluralistic and ideographic. Based on the principles of GST, change is an indispensable dimension of human speculation about the world and systems, and knowledge is ceaselessly reproduced as new information is collected. As a result, knowledge, narratives, theories and scientific laws are dynamically changed. GST, then, is remarkably compatible with the foundations of postmodern thought and it could be regarded as a postmodern theory governed by a humanistic paradigm. (shrink)

This paper is to argue that conductive arguments could be understood from a rhetorical perspective. It contends that conductive arguments can be regarded as a particular mode of strategic maneuvering, rather than a new type of argument. Moreover, it demonstrates that the use of conductive arguments can be adequately analyzed and evaluated by adopting the theoretical tools developed in the extended Pragma-Dialectics.