In international human rights law ‘jurisdiction’ is the centre of the debate on extraterritorial obligations. The purpose of the present paper is to a) analyse how facts and principles contribute t...

A critical, philosophical engagement of the psychological structures that propagate the continued oppression of women. In this book, the Italian feminist thinker Lea Melandri argues that systemic violence against women has deep psychoanalytic roots. Drawing inspiration from the work of Freud and the psychiatrist and psychoanalyst Elvio Fachinelli, along with feminist practices of consciousness-raising, Melandri demonstrates how male dominance and female subservience are established by society through a binary and oppositional understanding of sex and gender. This understanding—and the oppression and (...) violence against women that results—is inscribed in the psyches of both men and women, and is replicated anew from generation to generation. Melandri analyzes women in media, politics, philosophy, and literature to show how this plays out, and calls for awareness of these deep psychic structures and expectations formed within the dynamics of society and primary family relations. Lea Melandri is one of Italy’s best-known feminist thinkers and activists. She is the author of many books and continues to write and advocate for women’s rights. In 2012, she was awarded by the city of Milan the Ambrogino d’oro, one of the city’s highest honors. Antonio Calcagno is Professor of Philosophy at King’s University College at Western University, Canada. He the editor of Contemporary Italian Political Philosophy and the coeditor (with Inna Viriasova) of Roberto Esposito: Biopolitics and Philosophy, both also published by SUNY Press. (shrink)

The marine ecosystem is governed by a multitude of environmental cycles, all of which are linked to the periodical recurrence of the sun or the moon. In accordance with these cycles, marine species exhibit a variety of biological rhythms, ranging from circadian and circatidal rhythms to circalunar and seasonal rhythms. However, our current molecular understanding of biological rhythms and clocks is largely restricted to solar‐controlled circadian and seasonal rhythms in land model species. Here, we discuss the first molecular data emerging (...) for circalunar and circatidal rhythms and present selected species suitable for further molecular analyses. We argue that a re‐focus on marine species will be crucial to understand the principles, interactions and evolution of rhythms that govern a broad range of eukaryotes, including ourselves. (shrink)

This dissertation abstract and the reflection commentary present the work done by Dr. Lea Stadtler. Comprising four articles, the dissertation explores the challenge of designing successful public–private partnerships for development and contributes to the discourse on partnerships and business engagement in society. Article I adopts the company perspective and develops a conceptual framework for interest alignment in PPPs for development. Based on a theoretical analysis, Article II examines the role that different structures play in handling common design challenges. Articles III (...) and IV are empirical: The former analyzes how partners cope with tensions occurring on the PPP’s boundaries, while Article IV explores the roles of broker organizations, which increasingly facilitate the partnering process of PPPs for development. This extended dissertation abstract introduces the dissertation’s research focus and summarizes each article’s research question, methods, and main findings. The reflection commentary in the appendix discusses the author’s views of her dissertation journey as a junior scholar and the research process. (shrink)

Plasminogen activator inhibitor‐1 (PAI‐1) is a physiological inhibitor of urokinase (uPA), a serine protease known to promote cell migration and invasion. Intuitively, increased levels of PAI‐1 should be beneficial in downregulating uPA activity, particularly in cancer. By contrast, in vivo, increased levels of PAI‐1 are associated with a poor prognosis in breast cancer. This phenomenon is termed the “PAI‐1 paradox”. Many factors are responsible for the upregulation of PAI‐1 in the tumor microenvironment. We hypothesize that there is a breast cancer (...) predisposition to a more aggressive stage when PAI‐1 is upregulated as a consequence of Metabolic Syndrome (MetS). MetS exerts a detrimental effect on the breast tumor microenvironment that supports cancer invasion. People with MetS have an increased risk of coronary heart disease, stroke, peripheral vascular disease and hyperinsulinemia. Recently, MetS has also been identified as a risk factor for breast cancer. We hypothesize the existence of the “PAI‐1 cycle”. Sustained by MetS, adipocytokines alter PAI‐1 expression to promote angiogenesis, tumor‐cell migration and procoagulant microparticle formation from endothelial cells, which generates thrombin and further propagates PAI‐1 synthesis. All of these factors culminate in a chemotherapy‐resistant breast tumor microenvironment. The PAI‐1 cycle may partly explain the PAI‐1 paradox. In this hypothesis paper, we will discuss further how MetS upregulates PAI‐1 and how an increased level of PAI‐1 can be linked to a poor prognosis. BioEssays 29:1029–1038, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Suppose that the following describes an intelligible scenario. A subject is wired up to another's body in such a way that she has bodily experiences ‘as from the inside’ caused by states and events in the other body, that are subjectively indistinguishable from ordinary somatosensory perception of her own body. The supposed intelligibility of such so-called crossed wire cases constitutes a significant challenge to the claim that our somatosensory judgements are immune to error through misidentification relative to uses of the (...) first person pronoun. After all, the subject in this case is liable to commit precisely the sort of error ruled out by such a claim. In this paper I argue that the proponent of this challenge must establish at least two things: that the subject is committing an error of misidentification, and that her judgement shares its epistemic grounds with our ordinary somatosensory judgements. Neither condition, I argue, can be reached from the stipulations permitted into the starting descriptions of the cases. (shrink)

This article explores the justification of states' territorial rights. It starts by introducing three questions that all current theories of territorial rights attempt to answer: how to justify the right to settle, the right to exclude, and the right to settle and exclude with reference to a particular territory. It proposes a ‘permissive’ theory of territorial rights, arguing that the citizens of each state are entitled to the particular territory they collectively occupy, if and only if they are also politically (...) committed to the establishment of a global political authority realizing just reciprocal relations. The article is developed by introducing some key features of the permissive theory and by explaining how such an account addresses the questions of settlement, exclusion and particularity in ways that significantly improve on existing rival accounts (most prominently: acquisition theories, legitimacy-based theories and nationalist theories). (shrink)

Whilst Rahimzadeh et al. (2023) apply a critical lens to the pedagogical use of LLM bioethics assistants, we outline here further reason for skepticism. Two features of LLM chatbots are of signific...

Why are people interested in money? Specifically, what could be the biological basis for the extraordinary incentive and reinforcing power of money, which seems to be unique to the human species? We identify two ways in which a commodity which is of no biological significance in itself can become a strong motivator. The first is if it is used as a tool, and by a metaphorical extension this is often applied to money: it is used instrumentally, in order to obtain (...) biologically relevant incentives. Second, substances can be strong motivators because they imitate the action of natural incentives but do not produce the fitness gains for which those incentives are instinctively sought. The classic examples of this process are psychoactive drugs, but we argue that the drug concept can also be extended metaphorically to provide an account of money motivation. From a review of theoretical and empirical literature about money, we conclude that (i) there are a number of phenomena that cannot be accounted for by a pure Tool Theory of money motivation; (ii) supplementing Tool Theory with a Drug Theory enables the anomalous phenomena to be explained; and (iii) the human instincts that, according to a Drug Theory, money parasitizes include trading (derived from reciprocal altruism) and object play. (Published Online April 5 2006) Key Words: economic behaviour; evolutionary psychology; giving; incentive; money; motivation; play; reciprocal altruism. (shrink)

Global Justice and Avant-Garde Political Agency offers a fresh, nuanced example of political theory in an activist mode. Setting the debate on global justice in the context of recent methodological disputes on the relationship between ideal and nonideal theorizing, Ypi's dialectical account shows how principles and agency really can interact.

In this article, we shed light on the emergence, diffusion, and use of socio-technological future visions. The artificial intelligence future vision of the German federal government is examined and juxtaposed with the respective news media coverage of the German media. By means of a content analysis of frames, it is demonstrated how the German government strategically uses its AI future vision to uphold the status quo. The German media largely adapt the government´s frames and do not integrate alternative future narratives (...) into the public debate. These findings are substantiated in the framing of AI futures in policy documents of the German government and articles of four different German newspapers. It is shown how the German past is mirrored in the German AI future envisioned by the government, safeguarding the present power constellation that is marked by a close unity of politics and industry. The German media partly expose the government´s frames and call for future visions that include fundamentally different political designs less influenced by the power structures of the past and present. (shrink)

Passer à l'acte. Arrêter d'attendre. Se lancer sans filet. Dans la psychanalyse, la criminologie ou le langage courant, le passage à l'acte désigne un acte impulsif autant qu'irrationnel. Et si c'était le contraire? Et s'il y avait dans le passage à l'acte un véritable élan de pensée et de création? Et si le passage à l'acte était avant tout une manière d'accorder une puissance propre à l'étincelle de l'instant, à l'intensité de l'appel d'air? Dans cet essai, on suivra la trajectoire (...) transgressive d'une meurtrière dans un roman de Marguerite Duras, ou encore la ligne de fuite d'un philosophe braqueur de banques. Au plus près des œuvres de Chantal Akerman, Pierre Michon ou Francis Ponge et des idées de Michel Foucault, Jacques Lacan ou Gilles Deleuze, Léa Bismuth propose une réflexion inédite sur le rôle que jouent les crises, les bifurcations brusques, les explosions qu'il est devenu impossible de contenir dans des existences que nous croyons maîtriser. Et si l'art de passer à l'acte était avant tout l'art des commencements aventureux? Et si l'art de passer à l'acte était l'art de vivre la vie elle-même? (shrink)

En este trabajo se pide suponer que algo está mal con el colonialismo, con lo cual se hace una revisión de las principales posturas que intentan justificarlo, para mostrar que no resuelven correctamente ciertos cuestionamientos.

Scholarship on Plato's Timaeus has paid relatively little attention to Tim. 77a–81, a seemingly disjointed passage on topics including plants, respiration, blood circulation, and musical sounds. Despite this comparative neglect, commentators both ancient and modern have levelled a number of serious charges against Timaeus' remarks in the passage, questioning the coherence and explanatory power of what they take to be a theory of respiration. In this paper, I argue that the project of 77a–81e is not to sketch theories of respiration, (...) circulation, and digestion, but to explain how the human body is maintained in light of and despite constant environmental depletion. Further, I argue that in order to understand this account of “the replenishing system,” we need to understand Timaeus' striking analogy of the fish trap or nassa. Commentators have generally focused directly on the workings of the bodily construction that Timaeus likens to a fish trap, but without considering how we should understand the analogy qua analogy. I develop a functional reading of the analogy that yields a coherent account of the replenishing system on which previous criticisms of Timaeus' remarks on respiration do not arise. Aside from lending greater unity to the passage, both internally and within its immediate context in the dialogue, this account of the replenishing system contributes to our understanding of Timaeus' reason-and-necessity explanatory framework as applied to the human body and has noteworthy implications for specific explanatory principles, in particular like-to-like motion and circular thrust. (shrink)

Many challenges to economic and social well-being require close collaboration between business, government, and civil-society actors. In this context, the involvement of multiple companies rather than a single company may enhance such cross-sector social partnerships’ outcomes. However, extant literature cautions about the tensions arising from companies’ competitive interests and the detrimental effects on the CSSP’s social outcome. Similarly, studies analyzing simultaneous collaboration and competition suggest shielding off competitive elements from the collaboration. Based on insights into two multi-company CSSPs, we conversely (...) find that government and NGO partnership managers deliberately leveraged competition through the CSSP design. They used similar segmentation mechanisms to enhance CSSP contributions, but differed in the way they integrated collaborative and competitive elements, leading to sustained corporate commitment in one CSSP and unmet promises in the other. These insights expose the paradoxical nature of coopetition at the interface of social and economic goals, and advance current research by indicating competition’s positive effects and the respective partnership design implications. On this basis, our study helps reveal and better understand sustainability-related tensions and opportunities at the inter-organizational level. (shrink)

This book focuses on a question issued from The Architectonic of Pure Reason, one of the most important sections of Kant's first Critique: what is the human being? It suggests that the answer to this question is tied to a particular account of the unity of reason - one that stresses its purposive character.

Historisch-pedagogische studie over de plaats van de jeugd in het grotere geheel van de volwassenen wereld.

heories of embodied cognition (e.g., Perceptual Symbol Systems Theory; Barsalou, 1999, 2009) suggest that modality specific simulations underlie the representation of concepts. Supporting evidence comes from modality switch costs: participants are slower to verify a property in one modality (e.g., auditory, BLENDER-loud) after verifying a property in a different modality (e.g., gustatory, CRANBERRIES-tart) compared to the same modality (e.g., LEAVES-rustling, Pecher et al., 2003). Similarly, modality switching costs lead to a modulation of the N400 effect in event-related potentials (ERPs; Collins (...) et al., 2011; Hald et al., 2011). This effect of modality switching has also been shown to interact with the veracity of the sentence (Hald et al., 2011). The current ERP study further explores the role of modality match/mismatch on the processing of veracity as well as negation (sentences containing “not”). Our results indicate a modulation in the ERP based on modality and veracity, plus an interaction. The evidence supports the idea that modality specific simula- tions occur during language processing, and furthermore suggest that these simulations alter the processing of negation. (shrink)

L’intérêt public est au cœur de la sémantique politique : le syntagme est omniprésent dans les pratiques discursives du droit et de l’administration publics ainsi que dans les discours rhétoriques et polémiques des acteurs du débat public. Pourtant, s’il constitue un élément de langage fondamental, son contenu a rarement été défini : ce sont les usages à travers le temps qui peuvent en indiquer le sens, mais ce sens, pour n’avoir pas été explicitement posé, demeure nécessairement incertain et peut varier (...) selon les contextes, les énonciateurs et les destinataires à qui il est adressé.La difficulté sémantique tient à l’apposition quasiment oxymorique du terme d’« intérêt » – qui, logiquement, devrait être relatif à chaque individu – et de celui de « public » uni, uniforme et homogène. Sur quel fondement comment peut-on dégager un contenu objectif à l’expression? Peut-il être suffisamment précis et solide pour être le fondement de la légitimité politique, peut-il être le critère pour déterminer si la réalisation d’une politique publique est justifiée ou pas? L’imprécision sémantique empêche-t-elle d’établir l’existence d’un concept politique d’intérêt commun? C’est donc le statut épistémologique de l’intérêt public qu’il convient de questionner in fine : il nous faut déterminer de quel type d’objet épistémologique il s’agit pour saisir à quelles fins il est manipulé dans les pratiques discursives. Il s’agira dans cet article de développer la thèse selon laquelle l’intérêt public n’est pas un concept scientifique à proprement parler, ni une catégorie, ni même une expérience politique pure, il est éventuellement un concept au sens politique du terme, à comprendre comme une structure langagière, une fiction régulatrice toujours en cours de formation, historiquement élaborée en réponse à une anthropologie rationnelle. Pour cela, on mettra en évidence, dans un premier moment, l’absence de définition du prétendu concept d’intérêt public. Dans un second temps, nous expliquerons sa persistance paradoxale non seulement dans les discours politiques mais aussi dans les discours théoriques en revenant sur les étapes les plus importantes de la généalogie du concept. Finalement, nous pourrons développer les difficultés que suppose la qualification épistémologique de la notion « d’intérêt public » et proposer une interprétation de son statut. (shrink)

This book explores the relationship between the security state and the dominant economic interests, pointing to the ever-increasing reliance on a quantitative understanding of the natural and social worlds, which has vitiated the traditional values that constrained the exercise of power by both the market and the intrusive apparatus of the state.

Confirmatory bias, defined as the tendency to misinterpret new pieces of evidence as confirming previously held hypotheses, can lead to implacable, even incorrect decision making. It is one of the biases, along with anchoring, framing, and other judgment heuristic errors, that may lead to non-optimal behavior. This paper tests for the existence of confirmatory bias behavior in a uniquely economic setting (tax policy) and in a context relatively lacking in ambiguity. It also tests whether the confirmatory bias phenomenon can be (...) prevalent enough to affect aggregate outcomes, a characteristic important in economic models in particular. The results indicate not only that confirmatory bias exists, but that the confirmatory bias effect may be stronger for evidence relating to losses than for comparable evidence relating to gains. (shrink)

O pensamento freudiano certamente conta entre as próprias condições de possibilidade do feminismo. A tese da bissexualidade originária do ser humano é fundamental nesse sentido porque ela serve de ponto de partida para a ideia de que a sexuação resulta de um processo, resulta de um tornar-se. Não estando dada de uma vez por todas, como se se tratasse de algo natural, ela pode ser entendida tanto no seu fator disruptivo relativamente a uma série de constrições tradicional e ideologicamente vinculadas (...) ao organismo biológico, quanto nas possibilidades históricas que carrega consigo naquilo que concerne à própria construção do humano. Mas, por outro lado, não podemos negligenciar o fato de que as últimas considerações de Freud sobre a sexualidade feminina apresentam teses inapelavelmente inaceitáveis. Entre elas, lembremos que Freud situa as mulheres na contracorrente da civilização ao sustentar que nós seríamos menos capazes de sublimação e que possuiríamos um Supereu mais fraco. O objetivo do artigo é mostrar em detalhe como Freud tece suas teses a respeito da inferioridade feminina, sem diminuir o tom dessas teses, sem escamoteá-las e, ao mesmo tempo, tentando mostrar como elas produzem suas próprias armadilhas, ou seja, tentando destacar os momentos em que a argumentação de Freud simplesmente não se sustenta, ficando refém de modo não marginal de alguns preconceitos próprios. (shrink)

Partnerships can play an important role in addressing environmental concerns and fostering environmental improvement. In this context, we argue that a more elaborate understanding is needed of how partners intend to reach beyond the partnership boundaries and target stakeholders at the firm, industry, supply-chain, or societal levels. As environmental improvement is intertwined with the process of change, we build on the theory of planned change to explain how the focus on selected partnership mechanisms may help partners anticipate and overcome barriers (...) when targeting environmental improvement at these different levels. We test our framework, using a sample of 566 environmental partnerships formed in the USA, and provide rich insights into how partners intend to reach beyond the partnership boundaries. From a practical perspective, these insights may inform corporate managers’ decision to configure environmental partnerships in terms of the target group and suitable partnership mechanism. From a theory perspective, the study helps develop a more systematic understanding of what partners intend to do and when partnerships may provide benefits in addressing level-specific change barriers. These insights provide a first step in positioning partnerships in the broader context of environmental change and encourage future research to move from the intentions to the actual outcomes. (shrink)