Human cooperation is highly unusual. We live in large groups composed mostly of non-relatives. Evolutionists have proposed a number of explanations for this pattern, including cultural group selection and extensions of more general processes such as reciprocity, kin selection, and multi-level selection acting on genes. Evolutionary processes are consilient; they affect several different empirical domains, such as patterns of behavior and the proximal drivers of that behavior. In this target article, we sketch the evidence from five domains that bear on (...) the explanatory adequacy of cultural group selection and competing hypotheses to explain human cooperation. Does cultural transmission constitute an inheritance system that can evolve in a Darwinian fashion? Are the norms that underpin institutions among the cultural traits so transmitted? Do we observe sufficient variation at the level of groups of considerable size for group selection to be a plausible process? Do human groups compete, and do success and failure in competition depend upon cultural variation? Do we observe adaptations for cooperation in humans that most plausibly arose by cultural group selection? If the answer to one of these questions is “no,” then we must look to other hypotheses. We present evidence, including quantitative evidence, that the answer to all of the questions is “yes” and argue that we must take the cultural group selection hypothesis seriously. If culturally transmitted systems of rules (institutions) that limit individual deviance organize cooperation in human societies, then it is not clear that any extant alternative to cultural group selection can be a complete explanation. (shrink)

Does asking about trauma history create participant distress? If so, how does it compare with reactions to other personal questions? Do participants consider trauma questions important compared to other personal questions? Using 2 undergraduate samples (Ns = 240 and 277), the authors compared participants' reactions to trauma questions with their reactions to other possibly invasive questions through a self-report survey. Trauma questions caused relatively minimal distress and were perceived as having greater importance and greater cost-benefit ratings compared to other kinds (...) of psychological research in an undergraduate human subjects pool population. These findings suggest that at least some kinds of trauma research appear to pose minimal risk when compared to other minimal risk research topics, and that participants recognize the importance of research about trauma. (shrink)

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

Preparing the Next Generation of Oral Historians is an invaluable resource to educators seeking to bring history alive for students at all levels. Filled with insightful reflections on teaching oral history, it offers practical suggestions for educators seeking to create curricula, engage students, gather community support, and meet educational standards. By the close of the book, readers will be able to successfully incorporate oral history projects in their own classrooms.

The promotion of rights, autonomy and choice reacts against paternalism, an early twentieth-century response to intellectual disability that suppressed individual personhood through a combination of resource limitations and poor administration. These liberal individualist concepts reflect the contemporary zeitgeist of Anglophone nations, although the strength and certainty with which these concepts are expressed in ID policy when compared with policy for other vulnerable groups suggests that they also serve a secondary function. It has been argued that excessive certainty in ID evidences (...) a feared drop... (shrink)

We propose to expand the conversation around moral enhancement from direct brain-altering methods to include technological means of modifying the environments and media through which agents can achieve moral improvement. Virtual Reality (VR) based enhancement would not bypass a person’s agency, much less their capacity for reasoned reflection. It would allow agents to critically engage with moral insights occasioned by a technologically mediated intervention. Users would gain access to a vivid ‘experience machine’ that allows for embodied presence and immersion in (...) a virtual world that meaningfully replicates relevant aspects of real life. We explore how VR can train empathy and foster moral growth in complex ways that would be inaccessible even for traditional moral education. Virtual Reality Perspective Taking is a unique medium for making empathy more reflective. (shrink)

There is a need to rapidly assess the impact of new technology initiatives on the Counter Improvised Explosive Device battle in Iraq and Afghanistan. The immediate challenge is the need for rapid decisions, and a lack of engineering test data to support the assessment. The rapid assessment methodology exploits available information to build a probabilistic model that provides an explicit executable representation of the initiative’s likely impact. The model is used to provide a consistent, explicit, explanation to decision makers on (...) the likely impact of the initiative. Sensitivity analysis on the model provides analytic information to support development of informative test plans. (shrink)

In Moral Passages, Kathryn Pyne Addelson presents an original moral theory suited for contemporary life and its moral problems. Her basic principle is that knowledge and morality are generated in collective action, and she develops it through a critical examination of theories in philosophy, sociology and women's studies, most of which hide the collective nature and as a result hide the lives and knowledge of many people. At issue are the questions of what morality is, and how moral theories (...) (whether traditional or feminist) are implemented. Addelson takes up a large number of historical cases and contemporary social problems, including teen pregnancy, contraception and abortion, and gay rights. These cases allow her to see how the knowledge and lives of some people are declared deviant or immoral, while those of others appear to show the public consensus. One case she uses throughout the book is Margaret Sanger's early work on birth control with the anarcho-syndicalist movement--a revisionist history that reveals rather than hides the collective nature of morality and knowledge. Addelson shows how the usual individualist philosophies promote theories which hide the authority of the professionals who make them. A collectivist approach, she argues, must show the part professionals play in collective action. Her aim is to allow professional knowledge makers to be morally and intellectually responsible. Based on Addelson's twenty years of work in feminist philosophy and interactionist sociology as well as her long-standing involvement in women's community organization, Moral Passages investigates how morality and knowledge are collectively enacted in today's world. (shrink)

Background: Freezing of gait is a common symptom in Parkinson’s disease and can be difficult to treat with dopaminergic medications or with deep brain stimulation. Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation delivers current in various frequencies of bursts, while maintaining an intra-burst frequency identical to conventional DBS.Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG.Methods: Ten PD subjects with STN or GPi DBS (...) and complaints of FOG were recruited for this single center, single blinded within-subject crossover study. For each subject, we compared 4, 10, and 15 Hz BCDBS to conventional DBS during the PD medication-OFF state.Results: There were no serious adverse events with BCDBS. It was feasible and straightforward to program BCDBS in the clinic setting. The benefit was comparable to conventional DBS in measures of FOG, functional mobility and in PD motor symptoms. BCDBS had lower battery consumption when compared to conventional DBS.Conclusions: BCDBS was feasible, safe and well tolerated and it has potential to be a viable future DBS programming strategy. (shrink)

Contemporary educational goals place increasing emphasis on conferring recognition and building self-esteem for people deemed to be marginalised and vulnerable. Such goals coalesce with the language, symbols and practices of therapy inscribed within a broader 'therapeutic ethos'. The paper relates these trends to broader cultural demoralisation about people's potential for human agency and evaluates their effects on educational debates. A therapeutic ethos in education appears benign and empowering. Yet, the paper argues that it produces a diminished view of people and (...) low expectations about people's capacity for resilience and autonomy. One effect is to encourage an alignment between the values and activities of education and welfare. This both legitimises and extends institutional and government influence over people's psychological and emotional states. The paper explores these trends and evaluates their implications for educational ideas about human agency. (shrink)

_Why we cannot truly implement human rights unless we also recognize human responsibilities_ When we debate questions in international law, politics, and justice, we often use the language of rights—and far less often the language of responsibilities. Human rights scholars and activists talk about state responsibility for rights, but they do not articulate clear norms about other actors’ obligations. In this book, Kathryn Sikkink argues that we cannot truly implement human rights unless we also recognize and practice the corresponding (...) human responsibilities. Focusing on five areas—climate change, voting, digital privacy, freedom of speech, and sexual assault—and providing many examples of on‑the‑ground initiatives where people choose to embrace a close relationship between rights and responsibilities, Sikkink argues for the importance of responsibilities to any comprehensive understanding of political ethics and human rights. (shrink)

Instead he argues that there is an essence of comedy in the area of spirit rather than form, perspective rather than pattern. He draws upon the rich historical ensemble of types of comic figures, with a chapter devoted to each: the humorist, comedian, comic hero, rogue, trickster, clown, fool, underdog, and simpleton. He shows how each type incarnates a comic heroism in its own unique manner, offering a profound wisdom and philosophy of life.

In the process of conversion, one of the greatest challenges faced by Arab Muslims who choose to follow a Christian faith is determining how to relate to their birth communities, especially their immediate families. They continue to identify with their family and desire to function within its communal system and expectations, but also desire to be true to their new faith. For most converts in the Middle East, ceasing to adhere to the Islamic creed per se is not an act (...) of apostasy, but declaring that one has left Islam and chosen another faith is, and is seen as an act of rebellion by the community. The process of self-disclosure, or ‘coming out’, is complex, and many converts consider their decision about how to do this to be very important. There are various approaches converts may take, and various ways their families may respond, but one implicitly shared understanding between many converts and their families may be labelled ‘don’t ask, don’t tell’, whereby converts speak openly about their changed beliefs without explicitly declaring they have converted, and their families respond in kind, deliberately not asking if they have converted, in order to maintain a strong relationship with their loved ones. (shrink)

The paper identifies the phenomenal rise of increasingly invasive forms of elective cosmetic surgery targeted primarily at women and explores its significance in the context of contemporary biotechnology. A Foucauldian analysis of the significance of the normalization of technologized women's bodies is argued for. Three "Paradoxes of Choice" affecting women who "elect" cosmetic surgery are examined. Finally, two utopian feminist political responses are discussed: a Response of Refusal and a Response of Appropriation.

ALTHOUGH BIRTH CONTROL REMAINS A CONTROVERSIAL TOPIC AMONG Roman Catholics, it has all but disappeared in Protestant discussions of sexual ethics, owing to the seemingly more pressing issues of abortion and in vitro fertilization, as well as to the almost unanimous approval of contraceptive use among Protestant church bodies in the mid-1900s. This essay seeks to revive some past Reformed arguments pertinent to the subject, especially John Calvin's and Karl Barth's teachings on marriage and children, which both theologians view as (...) distinct goods. Marriage is seen as a covenant relationship, a good in and of itself, even apart from procreation; while children are a gift or "divine offer" from God that demands response. Reviving distinctively Christian descriptions of marriage and children is crucial to critiquing the utilitarian language that seeks to overshadow current conversations about marriage and children. (shrink)

For approximately two thousand years, human thinkers have been attempting to define a behaviour, referred to as art, that humans have been practicing for tens of thousands of years. Defining this term has proved to be so difficult that Munro (1949: 5) to claim that the arts “are too intangible and changing to be defined or classified.” In this paper a 12-property cluster theory proposed by Denis Dutton is critically evaluated not in light of how well it fits with current (...) thinking in aesthetics, but in light of its scientific strength and its usefulness for examining art across cultures. (shrink)

The Catholic Tradition requires the faithful to form and follow their conscience. This is the case even with the recognition that consciences can be malformed and one can make errors in practical judgments. Water Shaping Stone examines various aspects of this tradition regarding conscience by using, among other sources, twentieth-century magisterial documents, theologians' works, and Scripture. Kathryn Lilla Cox argues that while the Magisterium retains teaching authority, and a responsibility to help form consciences through its teaching, focusing only on (...) the Magisterium leads to incomplete formation. A more holistic vision of conscience formation means considering the formation of the moral agent to be a multifaceted process that draws on, for example, teaching, prayer, rituals, Scripture, practices, and virtues, along with relationships with the Triune God and communities of accountability. This vision of conscience formation retains the magisterial teaching authority while acknowledging discipleship as the theological basis for making and assessing practical judgments of conscience. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 61.1 (2000) 75-95 [Access article in PDF] "Not heretofore extant in print": Where the Mad Ranters Are Kathryn Gucer In 1654 Ephraim Pagitt published the fifth edition of Heresiography, subtitled "a Description of the Hereticks and Sectaries of these latter times." On the title page Pagitt promoted this latest edition of the catalog by stressing the "Additions" he had made. Among the (...) new targets of his anti-sectarian polemic were the Ranters, whom he introduced in a pithy character sketch as "an unclean beast much of the make with our Quaker." 1 But although Pagitt claimed to introduce the sect, Ranters had been around in print since Gerrard Winstanley attacked them in defense of his group, the Diggers, in 1649. 2 In fact writers had been attacking the sects generally--Anabaptists, Seekers, Brownists, Familists--in brief pamphlets like Winstanley's Vindication and in tome-like catalogs of sectarian "errours" since the outbreak of the Civil War. The anti-Ranter pamphlets were thus an incursion into an ongoing printed dialogue about the sects in general. Pagitt himself had been an interlocutor in this dialogue, having published four previous editions of his list. Why had he not marked the Ranters in 1649 and 1650 when Winstanley and others first noticed them?This essay will answer this question by arguing that the Ranters arose in dialogue across time, that they did not emerge spontaneously in Pagitt's 1654 text. When Pagitt introduced the sect in 1654, he was in fact responding to a heated discussion about the Ranters that had been developing for four years. He thus entered the debate a moment after "Ranters" and "ranting" had been defined by other pamphleteers. In this debate about the Ranters we can see the process by which pamphleteers invented a linguistic means of talking about religious diversity before it was an accepted feature of English society. At the same time that writers were exposing the Ranters' blasphemous excesses, they were also crafting a political identity for the group by attaching characteristic words and [End Page 75] behaviors to them in print. The printed controversy over the Ranters thus raises interesting questions about the relation between textual signification and actual politics. What were the processes by which pamphleteers invented new ways of talking about groups--sects and parties--in the period? What did labeling have to do with political identity?In fact the collective dialogue about the Ranters centered on a label that pamphleteers consistently attached to the group, their "madness." Although each writer identified the Ranters with a variety of creeds and practices, anti-Ranter pamphleteers all told their readers to view the group as an absence of reason. They claimed that Ranters were incapable of recognizing and conveying God's truth to their audience. Pagitt himself participated in the cooperative assault on Ranter madness. He consistently borrowed this language from his fellow interlocutors, branding the Ranters with terms such as "nonsensicall" and "absurd." Yet I argue that the label itself was largely a red herring. Writers shrewdly focused on Ranter unreason in order to persuade their readers not to use their own reason to consider the sectarian claims to authority. Moreover, writers shaped and reshaped what they meant by Ranter unreason in order to modulate its rhetorical effect on their readers. Thus it is not surprising that the precise construction of Ranter unreason shifted with the various responses these writers wanted to elicit from their readers. 3The explosion of anti-Ranter tracts, many of which had sensational titles showcasing the word "Ranters," indicated that the sect had particular rhetorical purchase on the public in the early 1650s: The Ranters Religion (11 October 1650), The Routing of the Ranters (19 November 1650), The Ranters Bible (9 December 1650), The Ranters Recantation And their Sermon (20 December 1650), The Joviall Crew, or the Devill turn'd RANTER (6 January 1651), Ranters of both Sexes, Male and Female (3 June 1651), RANTERS MONSTER (30 March 1652). 4 Although talk about Ranters was neither confined to print nor to... (shrink)

Innovative, data-driven methods provide more rigorous and systematic evidence for the description and explanation of diachronic semantic processes. The volume systematises, reviews, and promotes a range of empirical research techniques and theoretical perspectives that currently inform work across the discipline of historical semantics. In addition to emphasising the use of new technology, the potential of current theoretical models (e.g. within variationist, sociolinguistic or cognitive frameworks) is explored along the way.

Advances in the life sciences are occurring with extreme rapidity and accumulating a great deal of knowledge about life’s vital processes. While this knowledge is essential for fighting disease in a more effective way, it can also be misused either intentionally or inadvertently to develop novel and more effective biological weapons. For nearly a decade civil-academic society as well as States Parties to the Biological and Toxin Weapons Convention have recognised the importance of dual-use biosecurity education for life scientists as (...) a means to foster a culture of responsibility and prevent the potential misuse of advances in the life sciences for non-peaceful purposes. Nevertheless, the implementation of dual-use biosecurity education for life scientists has made little progress in institutions of higher learning. Professional societies and academic organizations have worked from the bottom-up in developing online dual-use biosecurity education modules that can be used for instruction. However, top-down help is needed from goverments if further progress is to be made in implementing biosecurity education for life scientists. (shrink)