IntroductionDeep brain stimulation is an effective treatment for advanced Parkinson’s disease with the targeting bilateral subthalamic nucleus or globus pallidus internus. So far, detailed studies on the efficacy of unilateral STN-DBS for motor symptoms have been reported, but few studies have been conducted on unilateral GPi-DBS.Materials and MethodsSeventeen patients with Parkinson’s disease who underwent unilateral GPi-DBS were selected. We conducted comparison analyses between scores obtained 6–42 months pre- and postoperatively using the following measurement tools: the Movement Disorder Society Unified Parkinson’s (...) Disease Rating Scale part III, the Hoehn and Yahr stage, the presence/absence of dyskinesia, Mini-Mental State Examination, Frontal Assessment Battery, Geriatric Depression Scale, levodopa equivalent dose, and cerebral blood flow by single photon emission computed tomography. Patient backgrounds were compared between four cohorts with favorable and unfavorable postoperative outcome.ResultsSignificant improvement was observed postoperatively in the following: total MDS-UPDRS Part III scores during the off period, contralateral scores, ipsilateral scores, and axial scores. Similarly, the Hoehn and Yahr stages during the off period, and GDS also showed significant decrease. In contrast, LED, MMSE, and FAB remained unchanged while the number of patients who scored positive for dyskinesia decreased by 40%. Abnormal cerebral blood flow preoperatively seen in the cerebral cortex had normalized in the total score-based good responder cohort. In the ipsilateral score-based good responder cohort, cerebral blood flow increased in the contralateral frontal lobe including in the premotor cortex, contralateral to the DBS. Compared to the poor responders, postoperative good responders demonstrated significantly higher preoperative MMSE scores.DiscussionUnilateral GPi-DBS therapy was effective in improving contralateral, ipsilateral, and axial motor symptoms of patients with advanced PD; in particular, it was found to be especially beneficial in PwPD whose cognitive function was unimpaired; the treatment efficacy rivaled that of bilateral counterparts up till at least 6 months postoperatively. Finally, normalization of preoperative abnormalities in cerebral blood flow and increased cerebral blood flow in the contralateral frontal lobe indicated the beneficial potential of this therapy on ipsilateral motor symptoms. (shrink)

Background: Freezing of gait is a common symptom in Parkinson’s disease and can be difficult to treat with dopaminergic medications or with deep brain stimulation. Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation delivers current in various frequencies of bursts, while maintaining an intra-burst frequency identical to conventional DBS.Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG.Methods: Ten PD subjects with STN or GPi DBS (...) and complaints of FOG were recruited for this single center, single blinded within-subject crossover study. For each subject, we compared 4, 10, and 15 Hz BCDBS to conventional DBS during the PD medication-OFF state.Results: There were no serious adverse events with BCDBS. It was feasible and straightforward to program BCDBS in the clinic setting. The benefit was comparable to conventional DBS in measures of FOG, functional mobility and in PD motor symptoms. BCDBS had lower battery consumption when compared to conventional DBS.Conclusions: BCDBS was feasible, safe and well tolerated and it has potential to be a viable future DBS programming strategy. (shrink)

In this paper we define the notion of -linearity for and discuss interpretability (and noninterpretability) of -linear orders in structures and theories.

We discuss the possibility of applying the compactness theorem to the study of finite structures. Given a class of finite structures, it is important to determine whether it can be expressed by a particular category of sentences. We are interested in this type of problem, and use nonstandard method for showing the non‐expressibility of certain classes of finite graphs by an existential monadic second order sentence.

ABSTRACTAnother individual’s gaze automatically shifts an observer’s attention to a location. This reflexive response occurs even when the gaze is presented subliminally over a short period. Another’s gaze also increases the preference level for items in the gaze direction; however, it was previously unclear if this effect occurs when the gaze is presented subliminally. This study showed that the preference levels for nonsense figures looked at by a subliminal gaze were significantly greater than those for items that were subliminally looked (...) away from. Targets that were looked at by a subliminal gaze were detected faster ; however, the participants were unable to detect the gaze direction. These results indicate that another individual’s gaze automatically increases the preference levels for items in the gaze direction without conscious awareness. (shrink)

In any nonstandard model of Peano arithmetic, the standard part is not first-order definable. But we show that in some model the standard part is definable as the unique solution of a formula , where P is a unary predicate variable.

We say that a subset A of M is implicitly definable in M if there exists a sentence $\phi$ in the language $\mathcal{L} \cup \{P\}$ such that A is the unique set with $ \models \phi$. We consider implicit definability of subfields of a given field. Among others, we prove the following: $\overline{\mathbb{Q}}$ is not implicitly $\emptyset$-definable in any of its elementary extension $K \succ \overline{\mathbb{Q}}$. $\mathbb{Q}$ is implicitly $\emptyset$-definable in any field K with tr.deg $_{\mathbb{Q}}K < \omega$. In a (...) field extension $\mathbb{Q} < K$ with K algebraically closed, $\mathbb{Q}$ is implicitly definable in K if and only if tr.deg $_{\mathbb{Q}}$ is finite. (shrink)

「意識のクオリア」も五感も、すべては錯覚だった。「心は脳が作り上げた幻想である」ことを述べた著者が、自己意識や五感が錯覚であることに的を絞って説明。.

Many functional glycoproteins are expressed on the lymphocyte cell surface. Some of them carry O-linked oligosaccharides (O-glycans), which are conjugated through serine or threonine residues. During various biological processes, including T-cell activation, a tetrasaccharide on the T-cell surface is dramatically converted to a branched hexasaccharide, called core2 O-glycan. The same structural change in O-glycans is also found on the lymphocytes from patients with immunodeficiency conditions such as Wiskott-Aldrich syndrome and AIDS. Several studies revealing the roles of core2 O-glycans in immune (...) responses show that this is a biologically significant change. In particular, core2 O-glycans expressed on the cell surface reduce cell–cell interactions, thereby regulating immune responses. Furthermore, core2 O-glycan is a key backbone structure in forming selectin ligands. Thus, O-linked oligosaccharides, in particular those containing core2 branches, play vital roles in immune responses and may play dual roles in certain situations. This review will summarize the results obtained from various studies investigating the roles of O-glycans in immunological processes. BioEssays 23:46–53, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Meaning Solipsism says that it is possible for there to be a meaningful state without any other meaningful state. The meaning of such a solo meaningful state should be non-natural. The best strategy for establishing Meaning Solipsism is to argue for the determination of the meaning of a possible solo meaningful state via the set of entities the meaning of the state fits. Embracing merely possible and impossible entities is the most straightforward way to do so. Also, a good way (...) to honor analayticities the meaning of a solo meaningful state gives rise to is to insist on certain facts about impossible entities as non-negotiable brute facts. (shrink)

Inspired by Rick Grush's emulation theory, we reinterpreted a series of our neuroimaging experiments which were intended to examine the representations of complex movement, modality-specific imagery, and supramodal imagery. The emulation theory can explain motor and cognitive activities observed in cortical motor areas, through the speculation that caudal areas relate to motor-specific imagery and rostral areas embrace an emulator for amodal imagery.

This article provides a simple decision theoretic model in which elements of the world successively enter the decision maker’s scope and the state space expands over time, which is intended to be the closest correspondence to the standard subjective expected utility theory. We propose a dynamic consistency condition that after any expansion of the scope, the preference ranking should remain unchanged over acts to which the expansion is irrelevant. Together with other natural axioms, it characterizes a model in which the (...) decision maker’s belief extends over time in order that the marginal distribution of the new belief induced over the old state space coincides with the old belief. It is extended to encompass both expansion of scope and learning events, and we characterize the model with an additional property that the decision maker’s belief updating follows Bayes’ rule when she learns events. (shrink)

1. Ronri to gengo -- 2-3. Imi to yōsō -- 4. Shinri to imi.

DNA with a curved trajectory of its helix axis is called bent DNA, or curved DNA. Interestingly, biologically important DNA regions often contain this structure, irrespective of the origin of DNA. In the last decade, considerable progress has been made in clarifying one role of bent DNA in prokaryotic transcription and its mechanism of action. However, the role of bent DNA in eukaryotic transcription remains unclear. Our recent study raises the possibility that bent DNA is implicated in the “functional packaging” (...) of transcriptional regulatory regions into chromatin. In this article, I review recent progress in bent DNA research in eukaryotic transcription, and summarize the history of bent DNA research and several subjects relevant to this theme. Finally, I propose a hypothesis that bent DNA structures that mimic a negative supercoil, or have a right‐handed superhelical writhe, organize local chromatin infrastructure to help the very first interaction between cis‐acting DNA elements and activators that trigger transcription. BioEssays 23:708–715, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This article explores the diversity of the European idea of peace in the late thirteenth and early fourteenth centuries. In the late Middle Ages, a literary genre of “peace writings” emerged. Despite the ubiquitous academic interest in peace, however, late medieval scholastic conceptions of peace have hitherto escaped serious scholarly investigation. Drawing on Johan Galtung's classic typology of the idea of peace, this essay offers an examination of the discussions of Thomas Aquinas, Remigio de’ Girolami, and Dante on peace, which (...) not only illustrates the diversity of late medieval visions of peace but also argues that late medieval thinkers shared the recognition that temporal peace was possible: a significant departure from the Christian skepticism of this-worldly peace. (shrink)

This paper is intended to offer an analysis of William of Ockham's and Guido Terreni's discourses on papal authority; it illuminates how their polemical use of the same authority -- Thomas Aquinas -- resulted in two diametrically opposed views. Guido Terreni's precarious understanding of Aquinas' commentary on the gospel of Luke stretched papal authority on doctrinal definition to the point of papal infallibility. Whereas, William of Ockham's use (and transformation) of Aquinas' idea of the object of explicit faith resulted in (...) a demand that every ecclesiastical authority should have thorough knowledge of the Christian faith and take every caution in doctrinal decision making. The paper shows that, in the context of polemics, Aquinas' ecclesiology was dissolved and different aspects of it were exaggerated by Terreni and Ockham. Thus, the paper also highlights Ockham's polemical skill in turning Aquinas -- the papalists' favourite authority -- against them. (shrink)