T cells, which are derived from hematopoietic stem cells (HSCs), are the most important components of adaptive immune system. Based on the expression of αβ and γδ receptors, T cells are mainly divided into αβ and γδ T cells. In the thymus, they share common progenitor cells, while undergoing a series of well‐characterized and different developmental processes. N6‐Methyladenosine (m6A), one of the most abundant modifications in mRNAs, plays critical roles in cell development and maintenance of function. Recently, we have demonstrated (...) that the depletion of m6A demethylase ALKBH5 in lymphocytes specifically induces an expansion of γδ T cells through the regulation of Jag1/Notch2 signaling, but not αβ T cells, indicating a checkpoint role of ALKBH5 and m6A modification in the early development of γδ T cells. Based on previous studies, many key pathway molecules, which exert dominant roles in γδ T cell fate determination, have been identified as the targets regulated by m6A modification. In this review, we mainly summarize the potential regulation between m6A modification and these key signaling molecules in the γδ T cell lineage commitment, to provide new perspectives in the checkpoint of γδ T cell development. (shrink)

本书从存在论的角度,分析了舜文化的普遍意义,挖掘了舜帝的普世伦理资源,肯定后来的儒,墨,道三家的理论创造都是从这里出发的.

Emotion plays a crucial role, both in general human experience and in psychiatric illnesses. Despite the importance of emotion, the relative lack of objective methodologies to scientifically studying emotional phenomena limits our current understanding and thereby calls for the development of novel methodologies, such us the study of illustrative animal models. Analysis of Drosophila and other insects has unlocked new opportunities to elucidate the behavioral phenotypes of fundamentally emotional phenomena. Here we propose an integrative model of basic emotions based on (...) observations of this animal model. The basic emotions are internal states that are modulated by neuromodulators, and these internal states are externally expressed as certain stereotypical behaviors, such as instinct, which is proposed as ancient mechanisms of survival. There are four kinds of basic emotions: happiness, sadness, fear, and anger, which are differentially associated with three core affects: reward (happiness), punishment (sadness), and stress (fear and anger). These core affects are analogous to the three primary colors (red, yellow, and blue) in that they are combined in various proportions to result in more complex “higher order” emotions, such as love and aesthetic emotion. We refer to our proposed model of emotions as called the “ Three Primary Color Model of Basic Emotions.”. (shrink)

Kann man das Leben führen? Die in diesem Band versammelten Beiträge stellen sich in kritischer Absicht dem modernen Konzept der »Lebensführung«, das die Technikphilosophie mit der Lebensphilosophie im frühen 20. Jahrhundert eng verbunden hat und teilweise bis heute verbindet. Auch relevante soziologische Positionen wurden in diesem Kontext entwickelt. Anhand zentraler Autoren wie Simmel, Bergson, Husserl, Heidegger, Blumenberg, Berdjajew, Reuleaux, von Uexküll, Plessner, Freyer, Jonas und Günter Ropohl (dem dieser Band aus Anlass seines 75. Geburtstags gewidmet ist) werden die Bezugnahmen zwischen (...) Technik- und Lebensphilosophie analysiert, aber auch die Abgrenzungsversuche voneinander. Die Verhältnisbestimmung der Konzepte »Leben« und »Technik« kann systemischen Charakter annehmen und deshalb die Idee einer lebensbejahenden oder -verneinenden Technik nach sich ziehen, z.B. artikuliert als Technikoptimismus/-pessimismus oder als emanzipatorische Frage nach dem eigenen Leben und dessen Selbstverwirklichung. Wenn es um Lebensführung geht, werden also gleichzeitig die Ausgangsbedingungen der Identitätskonstruktion moderner Subjekte und die Frage thematisiert, inwieweit Systementwürfe jene ermöglichen oder begrenzen. (shrink)

In einer kühnen Metapher haben einst Hieronymus, Erasmus und Luther die Heilige Schrift als ein Labyrinth bezeichnet, das die Leser bei fortgesetztem Lesen in eine sich sogar steigernde Verwirrung stürze. Beinah im selben Atemzug wird eben dieselbe Heilige Schrift von eben denselben Autoren als der einzige Faden gepriesen, der die Leser aus dem Labyrinth ihres Lebens herausführe. Eines und dasselbe als Labyrinth und als Faden: Diese Figur ist paradigmatisch. Im Labyrinth der Ethik geht es nicht anders zu. Nur wer sich (...) ihm überläßt, findet aus ihm heraus. 24 Beiträge von namhaften Theologen und Theologinnen zur Theologischen Ethik finden sich in den fünf Abschnitten des vorliegenden Buches, das nacheinander "Biblische Grundlagen", "Theologische Systematik", "Ethische Modelle", "Ethische Leitbegriffe" und "Ethik und die Religionen" behandelt: Hans-Dieter Bastian: Zwischen Glauben und Handeln: Bibel-Lesen - Werner H. Schmidt: Glaube und Handeln. Aspekte des Alten Testaments - Wolfgang Schrage: Der 1. Korintherbrief als Paradigma paulinischer Ethik - Michael Wolter: Der Kompromiß bei Paulus - Jörg Haustein: Beobachtungen zum Schriftverständnis ökumenischer Dokumente - Gerhard Sauter: "Schrifttreue" in ethischer Urteilsbildung Günter Bader: Handeln im Namen Gottes - Erich Gräßer: Die ersten und die letzten Dinge. Bemerkungen zur theologischen und ethischen Schöpfungswahrnehmung - Marcin Hintz: Glaube, Tradition, Vernunft: Auf den Spuren theologischer Urteilsbildung im polnischen Protestantismus - Rolf Schäfer: Christliche Glaubens- und Sittenlehre bei Schleiermacher - Karl-Wilhelm Dahm: Herausforderungen für Selbstverständnis und Rolle des protestantischen Pfarrers im Zuge des Modernisierungsprozesses Traugott Jähnichen: Sozialethik auf dem Weg der Ausbildung von Bereichsethiken - Historische Traditionen und perspektivische Herausforderungen - Ulrich Eibach: Christengemeinde und christliches Leben und Handeln in der pluralistischen Gesellschaft - Ludger Honnefelder: Gesundheit unser "höchstes Gut"? Wertentscheidungen im Rahmen der Ressourcenallokation im Gesundheitswesen - Jörg Hübner: Kollektives Handeln im Zeitalter der Globalisierung. Perspektiven für eine zukünftige politische Ethik - Gottfried Hütter: Menschenwürde und Menschenrechte für Tiere? - Tobias Schlingensiepen: Adam, wo bist du? Die Entkontextualisierung menschlichen Lebens als Problem u. Herausforderung evangelischer Ethik Edgar Thaidigsmann: "Ehrfurcht vor dem Leben". Das Problem der Begründung einer Ethik der Verantwortung für das Lebendige bei Albert Schweitzer und Hans Jonas - Konrad Stock: Laster - der "vielnamige Frevel". Eine theologische Erinnerung an ein vergessenes Problem - Ulrich H. J. Körtner: Bildung und Wertebewußtsein. Anmerkungen zum Wertbegriff in der aktuellen Bildungsdiskussion - Hans G. Ulrich: Güter oder Werte? Zur Aufgabe der Theoriebildung in der evangelischen Sozialethik - Hartmut Kreß: Toleranz als Verpflichtung protestantischer Ethik Hans Waldenfels: Unterwegs zu einer interreligiösen Theologie - Sung-Hee Lee-Linke: Interreligiöse Ethik. Ein Modell für die Zukunft? (shrink)

Das Buch bietet eine systematische Aufarbeitung der Forschung zum moralpsychologischen Ansatz von Lawrence Kohlberg und insbesondere seiner zahlreichen Kritiker.

The time-lag argument seems to put some pressure on naïve realism to agree that seeing must happen simultaneously with what is seen; meanwhile, a wide-accepted empirical fact suggests that light takes time to transmit from objects at a distance to perceivers—which implies what is seen happened before seeing, and, accordingly, naïve realism must be false. In this paper, I will, first of all, show that the time-lag argument has in fact involves a misunderstanding concept of simultaneity: according to Special Relativity, (...) simultaneity is a matter of convention rather than a matter of fact, so, in principle, we can stipulate a perceptual conception of simultaneity, according to which what is seen is simultaneous with seeing. Secondly, the generalized time-lag argument has a mistaken view on the perceived events and perceiving; it has a doubtful assumption that these events are momentary in the mathematical sense. Such idealization is the main reason why we have the intuition that the time-lag effect of perceiving is in conflict with our ordinary perceptual experiences. Finally, I argue that the naïve realist account of the perceptual relation is a nontemporal constitutive relation; and hence naïve realism is compatible with the claim that we can perceive things as they were, and it should not be weakened by the time-lag argument. (shrink)

In this article, drawing from a relational perspective, we explore the relationship between moral leadership and employee creativity, treat employee identification with leader and leader–member exchange as two mediators, and develop a new theoretical model of employee creativity. Our data collected from 160 supervisor–subordinate dyads in the People’s Republic of China demonstrate that moral leadership is positively related to both employee identification with leader and LMX. Further, employee identification with leader partially mediates the relationship between moral leadership and LMX. In (...) particular, employee identification with leader greatly enhances LMX which leads to high creativity. Overall, the relationship between moral leadership and employee creativity is mediated by not only employee identification with leader but also LMX. Our findings offer a new theoretical framework for future theory development and testing on creativity as well as practical implications for researchers and managers in business ethics. (shrink)

A number of recent environmental philosophers (Vogel, Morton, Latour) have proclaimed the end of nature. They oppose what they consider to be an outdated view of nature as a basis for environmental philosophy and political ecology. Instead of “thinking like a mountain” (Leopold), we should begin “thinking like a mall” (Vogel). These end-of-nature thinkers claim that the concept of nature in environmental discourses is bound to be something that is outside of us because man is understood as doing something to (...) nature. Without putting forth a clearly defined concept of “nature,” we argue that proclaiming the end of nature is misguided. This proclamation means forgetting the body. If we really want to get beyond understanding nature as something outside of us, and truly sense and understand ourselves as natural or environmental beings who are a part of the earth’s ecosystem, we should direct our attention to how nature as the biotic, inner/outer environment is experienced and sensed in and through our bodies. We thus suggest that environmental philosophy should encourage sensing like embodied beings before introducing notions like thinking like a mountain, mall, water, or a plant for that matter. This approach is among other things based on the phenomemology of the body (Merleau-Ponty) and phenomenology of the real (Conrad-Martius).”. (shrink)

Im 18. Jahrhundert bestand ein uberraschend grosses Interesse am Denker, Schriftsteller und Menschen David Hume (1711-1776), das die ganze Vielheit in den Voraussetzungen und Zielen der deutschen Aufklarung widerspiegelt. Zunachst standen die religionsphilosophischen Thesen Humes im Vordergrund; sie wurden durchweg abgelehnt und haufig nur polemisch zuruckgewiesen. Gerade als sich die Chance einer sachgerechteren Beurteilung Humes bot, revolutionierte Kant die gesamte Philosophie, und Hume wurde nur noch als der auslosende Faktor der Kantischen Metaphysikkritik gesehen. Die umstrittene Frage, wann und durch welches (...) seiner Werke Hume Kants dogmatischen Schlummer unterbrach, wird zur Entscheidung gebracht und damit zugleich eine neue These zu Kants philosophischer Entwicklung prasentiert. In the 18th century there was a surprisingly large amount of interest in the thinker, author and human being David Hume (1711-1776), and this interest reflected the entire range of requirements and goals of the German Enlightenment. To begin with, the focus was on Humes theories of the philosophy of religion, theories which were rejected without exception and often only polemically repudiated. Just when there was a chance of having an objective assessment of Humes work, Kant revolutionized philosophy, and Hume was seen merely as the factor which triggered Kants metaphysics. The controversial question of when and in which of his works Hume interrupted Kant's dogmatic slumber is brought to a head, and thus at the same time a new theory pertaining to Kant's philosophical development is presented. (shrink)

The present book is the English version of a monograph 'Die aristotelische Syllogistik', which first appeared ten years ago in the series of Abhand 1 lungen edited by the Academy of Sciences in Gottingen. In the preface to the English edition, I would first like to express my indebtedness to Mr. J. Barnes, now fellow of Oriel College, Oxford. He not only translated what must have been a difficult text with exemplary precision and ingenuity, but followed critically every argument and (...) check ed every reference. While translating it, he has improved the book. Of those changes which I have made on Mr. Barnes' suggestion I note only the more important ones on pages 4, 12, 24sq, 32, 39, 6lsq, and 158. Since the second edition of the German text appeared in 1963 some further reviews have been published, or come to my notice, which I have 2 been able to make use of in improving the text of this new edition. I must mention here especially the detailed critical discussions of my results and arguments published by Professor W. Wieland in the Philosophische Rundschau 14 (1966), 1-27 and by Professor E. Scheibe in Gnomon 39 (1967), 454-64. Both scholars, while agreeing with the main drift and method of my interpretation, criticise some of my results and disagree with some of my arguments. It would not be possible to discuss these technical matters here with the necessary thoroughness. (shrink)

For a set x, let ${\cal S}\left$ be the set of all permutations of x. We prove in ZF several results concerning this notion, among which are the following: For all sets x such that ${\cal S}\left$ is Dedekind infinite, $\left| {{{\cal S}_{{\rm{fin}}}}\left} \right| < \left| {{\cal S}\left} \right|$ and there are no finite-to-one functions from ${\cal S}\left$ into ${{\cal S}_{{\rm{fin}}}}\left$, where ${{\cal S}_{{\rm{fin}}}}\left$ denotes the set of all permutations of x which move only finitely many elements. For all sets (...) x such that ${\cal S}\left$ is Dedekind infinite, $\left| {{\rm{seq}}\left} \right| < \left| {{\cal S}\left} \right|$ and there are no finite-to-one functions from ${\cal S}\left$ into seq, where seq denotes the set of all finite sequences of elements of x. For all infinite sets x such that there exists a permutation of x without fixed points, there are no finite-to-one functions from ${\cal S}\left$ into x. For all sets x, $|{[x]^2}| < \left| {{\cal S}\left} \right|$. (shrink)

Bd. 1. Adolph Goldschmidt, Ernst Meumann, Wilhelm Waetzoldt und Arnold Schering -- Bd. 2. Paul Frankl, Emilt Utitz, Gustav Johann von Allesch und Wilhelm Worringer.

The reasons conception is the most prominent account of the nature of critical thinking. It consists in responding appropriately to reasons. Responding to reasons can be following a rule, it can be making an exception to a rule, it can be responding to a situation that is unique. It depends on the context each time what is the appropriate response. Critical thinking is the educational cognate of rationality and is a sine qua non for a reasonable life in a modern (...) democratic society. Reasons are generally normative. If this is true then it is to be expected that critical thinking is normative and also rationality. Critical thinking consists in being appropriately moved by reasons. The normative element of reasons moves us to beliefs or actions. It depends on our character how reasons move us. This indicates that our character must be well formed to enable us to be appropriately moved. (shrink)

For a set x, let S(x) be the set of all permutations of x. We prove by the method of permutation models that the following statements are consistent with ZF: (1) There is an infinite set x such that |p(x)|<|S(x)|<|seq^1-1(x)|<|seq(x)|, where p(x) is the powerset of x, seq(x) is the set of all finite sequences of elements of x, and seq^1-1(x) is the set of all finite sequences of elements of x without repetition. (2) There is a Dedekind infinite set (...) x such that |S(x)|<|[x]^3| and such that there exists a surjection from x onto S(x). (3) There is an infinite set x such that there is a finite-to-one function from S(x) into x. (shrink)

With its long history of the rule of men, particularly during its first three decades of communist rule, China has experienced arbitrary governance and social control that heavily relied on "giants" who arose from peasant wars. Even today, the personal orders of administrative and Party officials often take the place of legal rules and procedures. China's human rights record, because of practices such as the imprisonment of some citizens for political conscience and the suppression of free speech, remains an object (...) of international criticism and disputes. On the other hand, in the past twenty years China has shown remarkable progress in implementing the rule by law. Because progress and problems in the rule of law are two sides of a coin in China, the legal circumstances of the country are complicated, and research and evaluation of China's legal system and culture are difficult. (shrink)

Trotz der Krise institutionalisierter Religion beschaftigen religiose Fragen das philosophische Nachdenken starker denn je. Im Band werden unterschiedliche religionsphilosophische Zugange gebundelt, die zugleich aktuelle Themen exemplarisch behandeln. Wichtige Zugange aus der Philosophiegeschichte finden ebenso ihren Niederschlag wie politische oder kunsttheoretische Implikationen. Dadurch wird ein Uberblick uber gegenwartige Debatten geboten, die nicht nur christliche Konfessionen, sondern auch andere Religionen einbeziehen. Nicht zuletzt geht es um Probleme moglicher Neuansatze phanomenologisch bestimmter Religionsphilosophie sowie um deren Bedingungen in der spaten Moderne"-- Back cover.

A diferencia de todos los demás sistemas de imputación, Jakobs ubica el acento de la relevancia jurídico-penal del hecho en su significado normativo, como algo que trasciende la mera causalidad exterior y la finalidad del autor, de manera que lo decisivo para la imputación jurídico-penal no es ni lo psíquicoreal querido por el autor, ni la causalidad desplegada por su conducta, sino el significado normativo de esa conducta como la expresión de un sentido objetivo de desautorización de la vigencia de (...) la norma en un determinado contexto social. (shrink)