IntroductionAllocation of research funds relies on peer review to support funding decisions, and these processes can be susceptible to biases and inefficiencies. The aim of this work was to determine which past interventions to peer review and decision-making have worked to improve research funding practices, how they worked, and for whom.MethodsRealist synthesis of peer-review publications and grey literature reporting interventions in peer review for research funding.ResultsWe analysed 96 publications and 36 website sources. Sixty publications enabled us to extract stakeholder-specific context-mechanism-outcomes (...) configurations for 50 interventions, which formed the basis of our synthesis. Shorter applications, reviewer and applicant training, virtual funding panels, enhanced decision models, institutional submission quotas, applicant training in peer review and grant-writing reduced interrater variability, increased relevance of funded research, reduced time taken to write and review applications, promoted increased investment into innovation, and lowered cost of panels.ConclusionsReports of 50 interventions in different areas of peer review provide useful guidance on ways of solving common issues with the peer review process. Evidence of the broader impact of these interventions on the research ecosystem is still needed, and future research should aim to identify processes that consistently work to improve peer review across funders and research contexts. (shrink)

In this paper, we discuss specific epistemic injustices suffered by gender minorities in the Philippines. We also show that societal changes have been evident throughout the years. We review some progressive Philippine Catholic communities' sustainable development efforts toward gender equality or toward the eradication of discrimination, marginalisation, and violence based on a person's sexual orientation, gender identity, or gender expression (SOGIE). Despite these epistemic injustices, we reveal that there are ways by which gender disorientations may be disrupted by progressive Philippine (...) Catholic groups and communities in the era of contemporary Christianities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 27.1 (2003) 211-222 [Access article in PDF] Criticism and the Terror of Nothingness C. Jason Lee DESTINY IS OFTEN ANOTHER NAME for narrative, it being the order we retrospectively find in scattered events. It is traditionally the role of the storyteller to create a believable narrative, with the reader investing attention into believing the story while the critic dissects the results to ascertain whether the magic (...) works. As Wallace Stevens put it, "we orchestrate a whole history and then imprison ourselves in the score, as if someone else had written it." 1 In the author's note to the second edition (1962) of Wise Blood (1949) Flannery O'Connor makes the point that her novel is a comic novel, yet its comedy does not lessen the depth of understanding it offers concerning the complexity of freedom. 2 The obsession with fate and destiny that swamps her characters, leads the reader into a gothic nightmare where humans in their attempt to re-create themselves dig themselves further into the graves of their dead relatives. For O'Connor free will does not mean one will but many wills conflicting in one man, and she explains the integrity of the central character of Wise Blood, Hazel Motes, as stemming from his vigorous attempts to rid himself of the "ragged figure who moves from tree to tree in the back of his mind."This figure is the Jesus of his grandfather, and it is also the religious preoccupation of the Deep South. Destiny has shaped his features and his character in the mold of his grandfather, and whomever he meets believes he too is a preacher. After establishing the Church Without Christ, like many sons attempting to shake off their origin, Hazel Motes realizes that his new way of behaving is in some sense being controlled [End Page 211] by his past and that he must shake off all vestiges to possess freedom. One might argue that, by eventually blinding himself, Hazel Motes is behaving as a soul who has given into the temptation of purgation, as if this is destiny. But it can be argued that this act is going against destiny, as it is an act that is perhaps trying to persuade God of something, despite the Oedipal connotations.Questioned by his landlady why he blinded himself he says to pay, and when asked to pay for what, he replies it does not matter what. Mrs. Flood is frightened of death, particularly death being one long blind existence, and Hazel Motes is a reminder to her of her destiny. This can be read as a judgment on life also. Yet she eventually decides to take care of him, for both altruistic and materialistic reasons, believing that his widow would inherit his war pension. Mrs. Flood, her name evocative of apocalyptic occurrences and Old Testament punishment, is a critic of the text; the text in this instance is nothing written but rather Motes himself. It seems that Hazel Motes, his name a reference to taking the mote out of one's own eye before you try and take the splinter out of another's, is punishing himself for his previous denial of Christ and for his sins, such as fornication, as with Mrs. Watts the prostitute and Sabbath Hawks, and murder, but also something more primal.After trying desperately to break the curse of his biological inheritance, his wise blood, just like the character Enoch Emery, it forces him to once again take on roles that deny him freedom. Hazel Motes may seem to a contemporary reader as a caricature, the mad preacher/antipreacher of the American South, but as V. S. Pritchett puts it, Hazel Motes is "entirely real" (p. viii). His self-blinding is part of his further alienation from the world, the world he has come back to after the "Great War." O'Connor shows how this watershed in human history was so devastating, Motes's new theology entirely rational. After having an insight into the world in reality through war, Hazel Motes is now "going to do some things... (shrink)

Introduction: Maintaining dignity is one of the most important human rights. However, maintaining and promoting the dignity of nursing students as an important caregiver group has scarcely been considered. Dignity can be viewed as an abstract concept particularly in relation to the perspective of male nursing student perspective. Therefore, more investigation is required to explore the male students’ understanding of the concept of dignity. Objectives: The purpose of this study is to define and explain the concept of dignity among male (...) nursing students in the neonatal intensive care unit. Research design: This is a qualitative content analysis study. The data were collected through semi-structured individual interviews. The data were analyzed by conventional content analysis method. Participants and research context: Twenty male nursing students in public health centers in Iran were selected by targeted sampling to achieve data saturation between February 2017 and November 2017. Findings: The findings of this study were presented in three main themes, including “extensive support,” “belief in ability,” and “participation in decision making,” and 7 sub-categories of data were extracted. Ethical considerations: The study’s protocol was approved by the Research Ethics Committee of the Shiraz University of Medical Sciences and the ethical principles were followed throughout the study. Discussion and conclusion: According to the findings of the study, male nursing students required extensive support, and their academic and practical skills required to be respected; in addition, they should be involved in decision making, because in such an environment, the dignity of these students will be maintained and promoted. Therefore, it is suggested that a cultural, professional, and institutional background in which all components of the male nursing student’s dignity are protected and emphasized should be provided. (shrink)

ABSTRACT16p11.2 deletion syndrome is a severe genetic disorder associated with the deletion of 27 genes from a Copy Number Variant region on human chromosome 16. Symptoms associated include cognitive impairment, language and motor delay, epilepsy or seizures, psychiatric disorders, autism spectrum disorder (ASD), changes in head size and body weight, and dysmorphic features, with a crucial need to define genes and mechanisms responsible for symptomatology. In this review, we analyze the clinical associations and biological pathways of 16p11.2 locus genes and (...) identify that a majority of 16p11.2 genes relate to metabolic processes. We present a hypothesis in which changes in the dosage of 16p11.2 metabolic genes contribute to pathology through direct or indirect alterations in pathways that include amino acids or proteins, DNA, RNA, catabolism, lipid, energy (carbohydrate). This hypothesis suggests that research into the specific roles of each metabolic gene will help identify useful therapeutic targets. (shrink)

While the evidential problem of evil has been enormously influential within the contemporary philosophical literature—William Rowe’s 1979 formulation in “The Problem of Evil and Some Varieties of Atheism” being the most seminal—no academic research has explored what cognitive mechanisms might underwrite the appearance of pointlessness in target examples of suffering. In this exploratory paper, we show that the perception of pointlessness in the target examples of suffering that underwrite Rowe’s seminal formulation of the problem of evil is contingent on the (...) absence of broader context. In other words, we show that when such suffering is presented alongside broader contextual information, the appearance of pointlessness, on average, significantly diminishes. In §1 we briefly elucidate Rowe’s formulation of the problem of evil and the thought experiment that motivates a key premise. In §2 and §3 respectively, we briefly explain our hypothesis regarding Rowe’s case and our methods for testing these hypotheses. In §4, we elucidate our results, and in §5 we explore some of the philosophical implications of our findings and gesture towards some areas for future research. Finally, in §6, we briefly connect our research to some of the established philosophical literature on suffering and narrative before concluding. (shrink)

Lectures from experts in scientific research, law, insurance, philosophy, ethics, theology and public policy.

We can assent to a proposition, build a theory around it, base our actions on it, and affirm its truth—without ever taking it to heart. This frequently happens, for example, to recipients of bad news who figure out what is entailed by the news, make appropriate plans, and pass the news on to others—all without really "taking it in." It happens to those who accept a scientific claim without abandoning their more private views of how things work, and it happens (...) to members of a jury who confidently arrive at a verdict of "guilty" yet remain, on some deeper level, unconvinced. Conversely, people may dismiss their prejudices as mere prejudices while continuing to hold onto them, and a friend may acknowledge a remark to be innocuous yet be offended. Such phenomena are widespread, diverse, and philosophically intriguing. They are not simply cases of weak versus strong belief, or belief that something has a low probability versus a high probability ; nor are they cases of accepting on authority what we only partially understand. Rather, in each case, there is certain lack of depth to one's beliefs. (shrink)

The Gettier dilemma facing reductive analyses of knowledge has not been properly appreciated by virtue epistemologist or even virtue epistemology’s most vocal critics. In §1, we start by considering how recent critics of virtue epistemology understand the Gettier Problem facing virtue-theoretic accounts of knowledge. I highlight how the dilemma facing virtue- theoretic analyses of knowledge is more general than these critics seem to suggest. In §2, I elucidate the worry that the threat facing virtue epistemology is really a dilemma between (...) Gettier counterexamples and radical skepticism. In §3, we will consider how some recent virtue epistemologists have tried to viably defuse the Gettier Problem. We will see (i) just how the critiques elucidated in §1 have (mis)shaped the dialectic between virtue epistemology and what is required in solving Gettier counterexamples and (ii) how this has led to virtue epistemologists underestimating the widespread insidiousness of Gettier counterexamples. (shrink)

This study evaluated the biological dimension of meditation and self-transcendent states. A convenience sample of 513 participants was drawn from attendees at a 4-day guided meditation workshop. Half were randomly assigned to an active placebo control intervention. All were assessed on a variety of measures, both psychological [anxiety, pain, posttraumatic stress disorder, positive emotions, and transcendent states], and physiological. Additional biological assessments including salivary immunoglobulin-A, cortisol, and Quantitative Electroencephalography were obtained from subset of the Experimental group. No significant difference in (...) psychological symptoms or positive emotions was observed between Experimental and placebo groups at baseline. At post-test, significant improvements were noted in the Experimental group, including a 49.5% median increase in SIgA, though cortisol remained unchanged. qEEG z-score analysis identified sustained stress reduction, including delta frequency band amplitude increases, high beta decreases, and faster acquisition of sustained alpha states. Psychological symptoms also improved on all measures. At 6-month follow-up, PTSD and somatic symptoms significantly improved from baseline, and post-test versus 6-month follow-up results indicated significant increases in happiness and spiritual and physical oneness, along with decreases in depressive symptoms. These findings suggest that autonomic self-regulation and transcendent states may be measured in both biological and psychological dimensions and are associated with pervasive health benefits. (shrink)

At no point in recorded history has there been an absence of intense, and heated, discussion about the subject of how to conduct relations between women and men. This Handbook provides a comprehensive guide to these omnipresent issues and debates, mapping the present and future of thinking about feminist theory. The chapters gathered here present the state of the art in scholarship in the field, covering: epistemology and marginality; literary, visual and cultural representations; sexuality; macro and microeconomics of gender; conflict (...) and peace. The most important consensus in this volume is that a central organizing tenet of feminism is its willingness to examine the ways in which gender and relations between women and men have been (and are) organized. The authors bring a shared commitment to the critical appraisal of gender relations, as well as a recognition that to think 'theoretically' is not to detach concerns from lived experience but to extend the possibilities of understanding. With this focus on theory and theorizing about the world in which we live, this Handbook asks us, across all disciplines and situations, to abandon our taken-for-granted assumptions about the world and interrogate both the origin and the implications of our ideas about gender relations and feminism."--Publisher description. (shrink)

The brain ventricular system is a series of connected cavities, filled with cerebrospinal fluid (CSF), that forms within the vertebrate central nervous system (CNS). The hollow neural tube is a hallmark of the chordate CNS, and a closed neural tube is essential for normal development. Development and function of the ventricular system is examined, emphasizing three interdigitating components that form a functional system: ventricle walls, CSF fluid properties, and activity of CSF constituent factors. The cellular lining of the ventricle both (...) can produce and is responsive to CSF. Fluid properties and conserved CSF components contribute to normal CNS development. Anomalies of the CSF/ventricular system serve as diagnostics and may cause CNS disorders, further highlighting their importance. This review focuses on the evolution and development of the brain ventricular system, associated function, and connected pathologies. It is geared as an introduction for scholars with little background in the field. (shrink)

There is considerable evidence that animals can time multiple intervals that occur separately or concurrently. Such simultaneous temporal processing occurs both in temporal discrimination procedures and in classical conditioning procedures. The first part of the chapter will consist of the review of the evidence for simultaneous temporal processing, and the conditions under which the different intervals have influences on each other. The second part of the chapter will be a brief description of two timing theories: Scalar Timing Theory and a (...) Packet Theory of Timing. Scalar Timing Theory consists of a pacemaker-switch-accumulator system that serves as a clock, a memory that consists of examples of previously reinforced intervals, and a decision process that involves a comparison of ratios to a criterion; the Packet Theory of Timing consists of a conditional expected time function that serves as a clock, a memory that consists of weighted sums of these values, and a probabilistic decision process that produces packets of responses. Both of these theories will be applied to an example of simultaneous temporal processing by rats, and will serve as the basis for some general comments about the basis for selecting and evaluating quantitative theories of timing. (shrink)

My purpose in this essay is to describe and define the ways in which Afro-American women intellectuals, in the last decade of the nineteenth century, theorized about the possibilities and limits of patriarchal power through its manipulation of racialized and gendered social categories and practices. The essay is especially directed toward two academic constituencies: the practitioners of Afro-American cultural analysis and of feminist historiography and theory. The dialogue with each has its own peculiar form, characterized by its own specific history; (...) yet both groups are addressed in an assertion of difference, of alterity, and in a voice characterized by an anger dangerously self-restrained. For it is not in the nature of Caliban to curse; rather, like Caliban, the black woman has learned from her behaviour of her master and mistress that if accommodation results in a patronizing loosening of her bonds, liberation will be more painful. Hazel V. Carby is assistant professor of English at Wesleyan University. She is the coauthor of the Empire Strikes Back: Race and Racism in Seventies Britain and the author of Uplifting as They Write: The Emergence of the Afro-American Woman Novelist. (shrink)