BackgroundBiobanking biospecimens and consent are common practice in paediatric research. We need to explore children and young people’s (CYP) knowledge and perspectives around the use of and consent to biobanking. This will ensure meaningful informed consent can be obtained and improve current consent procedures.MethodsWe designed a survey, in co-production with CYP, collecting demographic data, views on biobanking, and consent using three scenarios: 1) prospective consent, 2) deferred consent, and 3) reconsent and assent at age of capacity. The survey was disseminated (...) via the Young Person’s Advisory Group North England (YPAGne) and participating CYP’s secondary schools. Data were analysed using a qualitative thematic approach by three independent reviewers (including CYP) to identify common themes. Data triangulation occurred independently by a fourth reviewer.ResultsOne hundred two CYP completed the survey. Most were between 16–18 years (63.7%, N = 65) and female (66.7%, N = 68). 72.3% had no prior knowledge of biobanking (N = 73).Acceptability of prospective consent for biobanking was high (91.2%, N = 93) with common themes: ‘altruism’, ‘potential benefits outweigh individual risk’, 'frugality', and ‘(in)convenience’.Deferred consent was also deemed acceptable in the large majority (84.3%, N = 86), with common themes: ‘altruism’, ‘body integrity’ and ‘sample frugality’. 76.5% preferred to reconsent when cognitively mature enough to give assent (N = 78), even if parental consent was previously in place. 79.2% wanted to be informed if their biobanked biospecimen is reused (N = 80).ConclusionProspective and deferred consent acceptability for biobanking is high among CYP in the UK. Altruism, frugality, body integrity, and privacy are the most important themes. Clear communication and justification are paramount to obtain consent. Any CYP with capacity should be part of the consenting procedure, if possible. (shrink)

With the continual development of artificial intelligence and smart computing in recent years, quantitative approaches have become increasingly popular as an efficient modeling tool as they do not necessitate complicated mathematical models. Many nations have taken steps, such as transitioning to online schooling, to decrease the harm caused by coronaviruses. Inspired by the demand for technology in early education, the present research uses a radial basis function neural network modeling technique to predict preschool instructors’ technology usage in classes based on (...) recognized determinant characteristics of technology acceptance. In this regard, this study utilized the RBFNN approach to predict preschool teachers’ technology acceptance behavior, based on the theory of planned behavior, which states that behavioral achievement, in our case the actual technology use in class, depends on motivation, intention and ability, and behavioral control. Thus, this research design is based on an adapted version of the technology acceptance model with eight dimensions: D1. Perceived usefulness, D2. Perceived ease of use, D3. Perceived enjoyment, D4. Intention to use, D5. Actual use, D6. Compatibility, D7. Attitude, and D8. Self-efficacy. According to the TAM, actual usage is significantly predicted by the other seven dimensions used in this research. Instead of using the classical multiple linear regression statistical processing of data, we opted for a NN based on the RBF approach to predict the actual usage behavior. This study included 182 preschool teachers who were randomly chosen from a project-based national preschool teacher training program and who responded to our online questionnaire. After designing the RBF function with the actual usage as an output variable and the other seven dimensions as input variables, in the model summary, we obtained in the training sample a sum of squares error of 37.5 and a percent of incorrect predictions of 43.3%. In the testing sample, we obtained a sum of squares error of 14.88 and a percent of incorrect predictions of 37%. Thus, we can conclude that 63% of the classified data are correctly assigned to the models’ dependent variable, i.e., actual technology use, which is a significant rate of correct predictions in the testing sample. This high significant percentage of correct classification represents an important result, mainly because this is the first study to apply RBFNN’s prediction on psychological data, opening up a new interdisciplinary field of research. (shrink)

Although the topic of value congruence has attracted considerable attention from researchers and practitioners, evidence for the link between person–supervisor value congruence and followers’ reactions is less robust than often assumed. This study addresses three central issues in our understanding of person–supervisor value congruence by assessing the impact of objective person–supervisor value congruence rather than subjective value congruence, by examining the differential effects of value congruence in strongly versus moderately held values, and by exploring perceived empowerment as a central mediating (...) mechanism. Results of a multi-source study comprising 116 person–supervisor dyads reveal that objective value congruence relates to followers’ job satisfaction and affective commitment and that this link can be explained by followers’ perceived empowerment. Moreover, polynomial regression and response surface analyses reveal that congruence effects vary with the importance that leaders and followers ascribe to a certain value: Congruency in strongly held values have more robust relations with followers’ outcomes than congruence in moderately held values. (shrink)

Objectives:Social isolation is increasing in aging societies and several studies have shown a relation with worse cognition in old age. However, less is known about the association in the oldest-old (85+); the group that is at highest risk for both social isolation and dementia. Methods:Analyses were based on follow-up 5 to 9 of the longitudinal German study on aging, cognition, and dementia in primary care patients (AgeCoDe) and the study on needs, health service use, costs, and health-related quality of life (...) in a large sample of oldest-old primary care patients (AgeQualiDe), a multi-center population-based prospective cohort study. Measurements included the Lubben Social Network Scale (LSNS-6), with a score below 12 indicating social isolation, as well as the Mini-Mental Status Examination (MMSE) as an indicator of cognitive function. Results:Dementia-free study participants (n = 942) were M = 86.4 (SD = 3.0) years old at observation onset, 68.2% were women. One third (32.3%) of them were socially isolated. Adjusted linear hybrid mixed effects models revealed significantly lower cognitive function in individuals with smaller social networks (β = 0.5, 95% CI = 0.3-0.7, p <.001). Moreover, changes in an individual's social network size were significantly associated with cognitive changes over time (β = 0.2, 95% CI = 0.1-0.4, p =.003), indicating worse cognitive function with shrinking social networks. Conclusion:Social isolation is highly prevalent among oldest-old individuals, being a risk factor for decreases in cognitive function. Consequently, it is important to maintain a socially active lifestyle into very old age. Likewise, this calls for effective ways to prevent social isolation. (shrink)

This article is a review of the rise and development of women’s studies and the sociology of women/gender, two interrelated academic fields in China. Informed by the sociology of knowledge, the authors analyze how historical and sociopolitical factors such as the legacy of Marxism, state/party control, economic reform, political upheavals, local conditions, and global influences have greatly shaped what and how women’s and gender issues are studied and the resultant characteristics and knowledge production of the two fields in China. Specifically, (...) the authors examine the dynamic process of knowledge development in sociology of women/gender in terms of its academic positioning, standpoint, content, research methodology, curriculum transformation, and teaching in China. Finally, the authors demonstrate how the characteristics and issues shared by the two fields have evolved in a dynamic interplay between Chinese Marxism and feminism. (shrink)

The nature of motion -- Causes, forces, and resistance -- The concept of the function in fourteenth-century physics -- The significance of the theory of impetus for Scholastic natural philosophy -- Galileo and the Scholastic theory of impetus -- The theory of the elements and the problem of their participation in compounds -- The achievements of late Scholastic natural philosophy.

The overall goal of this target article is to demonstrate a mechanism for an embodied cognition. The particular vehicle is a much-studied, but still widely debated phenomenon seen in 7–12 month-old-infants. In Piaget's classic “A-not-B error,” infants who have successfully uncovered a toy at location “A” continue to reach to that location even after they watch the toy hidden in a nearby location “B.” Here, we question the traditional explanations of the error as an indicator of infants' concepts of objects (...) or other static mental structures. Instead, we demonstrate that the A-not-B error and its previously puzzling contextual variations can be understood by the coupled dynamics of the ordinary processes of goal-directed actions: looking, planning, reaching, and remembering. We offer a formal dynamic theory and model based on cognitive embodiment that both simulates the known A-not-B effects and offers novel predictions that match new experimental results. The demonstration supports an embodied view by casting the mental events involved in perception, planning, deciding, and remembering in the same analogic dynamic language as that used to describe bodily movement, so that they may be continuously meshed. We maintain that this mesh is a pre-eminently cognitive act of “knowing” not only in infancy but also in everyday activities throughout the life span. Key Words: cognitive development; dynamical systems theory; embodied cognition; infant development; motor control; motor planning; perception and action. (shrink)

A number of philosophical projects require a proper understanding of the modal aspects of agency, or of what I call ‘the agentive modalities.’ I propose a general account of the agentive modalities, one which takes as its primitive the decision-theoretic notion of an option. I relate this account to the standard semantics for ‘can’ and to the viability of some positions in the free will debates.

In the accounts we give of one another, claims about our abilities appear to be indispensable. Some abilities are so widespread that many who have them take them for granted, such as the ability to walk, or to write one's name, or to tell a hawk from a handsaw. Others are comparatively rare and notable, such as the ability to hit a Major League fastball, or to compose a symphony, or to tell an elm from a beech. In either case, (...) however, when we ascribe such abilities to one another we have the impression that we are making claims that, whether they are worth saying or not, are at least sometimes true. The impression of truth exerts a pressure towards giving a philosophical theory of ability. It is not an option, at least at the outset, to dismiss all our talk of ability as fiction or outright falsehood. A theory of ability can be reasonably expected to say what it is to have an ability in a way that vindicates the appearance of truth. Such a theory will deserve the name “philosophical” insofar as it gives an account, not of this or that range of abilities, but of abilities generally. (shrink)

Abstract[I] want to single out one phenomenon that could be called the ‘politics of sources’. It points to the extent to which the histories that both scientists and historians can write are artifacts of the available sources. The Rockefeller Foundation not only opened its archives very early on for historical work but also invested a lot in making the archives readily available for historical exploration. During the 1980s, many young historians took advantage of this opportunity. Thus, in a relatively early (...) phase of the professional historiography of molecular biology, one could have gained the impression that the development of the new biology as a whole was a bio‐politically directed enterprise of the Rockefeller Foundation sustained by the vision that social processes could ultimately be controlled by biological processes. (shrink)

I provide a novel semantic analysis of proper names and indexicals, combining insights from the competing traditions of referentialism, championed by Kripke and Kaplan, and descriptivism, introduced by Frege and Russell, and more recently resurrected by Geurts and Elbourne, among others. From the referentialist tradition, I borrow the proof that names and indexicals are not synonymous to any definite description but pick their referent from the context directly. From the descriptivist tradition, I take the observation that names, and to some (...) extent indexicals, have uses that are best understood by analogy with anaphora and definite descriptions, that is, following Geurts, in terms of presupposition projection. The hybrid analysis that I propose is couched in Layered Discourse Representation Theory. Proper names and indexicals trigger presuppositions in a dedicated layer, which is semantically interpreted as providing a contextual anchor for the interpretation of the other layers. For the proper resolution of DRSs with layered presuppositions, I add two constraints to van der Sandt's algorithm. The resulting proposal accounts for both the classic philosophical examples and the new linguistic data, preserving a unified account of the preferred rigid interpretation of both names and indexicals, while leaving room for non-referential readings under contextual pressure. (shrink)

This paper deals with the semantics of de dicto , de re and de se belief reports. First, I flesh out in some detail the established, classical theories that assume syntactic distinctions between all three types of reports. I then propose a new, unified analysis, based on two ideas discarded by the classical theory. These are: (i) modeling the de re/de dicto distinction as a difference in scope, and (ii) analyzing de se as merely a special case of relational de (...) re attitudes. The resurrection of these ideas takes place in a dynamic setting. My formalization of the first idea involves a modification of the presupposition-as-anaphora resolution algorithm for DRT. The second involves treating acquaintance relations as second-order presuppositions, to be bound in the context by means of higher-order unification, or accommodated if necessary. The resulting framework requires no syntactic distinctions between different modes of attitude, with the exception of a specific subclass of de se reports characterized by special ‘ de se pronouns’ (i.e. PRO and logophors). These special pronouns are handled in syntax; everything alse is passed on to the pragmatic resolution module as it appears on the surface. The more sophisticated contextual resolution process nonetheless ensures adequate output truth conditions for a variety of classical and novel puzzles. In particular, I compare the new pragmasemantic system to the classical, syntactic analysis with respect to iterated and quantified reports, and monstrously shifted indexicals. (shrink)

Rebbetzin Esther Greenberg was famous throughout Israel as a mentor to countless women, including some of the best-known teachers and counselors.

In this commentary, we point to guidelines for performing human neuroimaging studies and their reporting in microbiota-gut-brain articles. Moreover, we provide a view on interpretational issues in MGB studies, with a specific focus on gut microbiota–derived metabolites. Thus, extending the target article, we provide recommendations to the field to increase reproducibility and relevance of this type of MGB study.

Resumen El presente trabajo tiene por objeto el análisis de partículas intensificadoras en el discurso humorístico planificado. Partimos de la hipótesis de que el uso de expresiones que intensifican la verdad de lo dicho, como en serio, de verdad o lo juro, es una de las estrategias argumentativas que emplean las cómicas españolas para que su discurso resulte más verosímil. En aras de verificar dicha conjetura, esta investigación recoge un corpus de 15 monólogos humorísticos en español, representados por cómicas de (...) la actualidad, en diversas salas y teatros del territorio español durante los años 2017 y 2018. La transcripción y segmentación de dichas muestras nos ha permitido extraer la frecuencia de uso de los distintos procedimientos de intensificación empleados en este tipo de discurso, así como analizar qué funciones cumple la intensificación como estrategia argumentativa y pragmática. Los resultados obtenidos certifican que las humoristas españolas analizadas recurren a la intensificación durante sus actuaciones para fomentar el efecto humorístico, hacer que su discurso sea más creíble y, por tanto, lograr la adhesión del público. (shrink)

Zusammenfassung Der Beitrag widmet sich der Einführung und Etablierung des Mädchenturnens mit Schwerpunkt auf den preußischen Schulen, wie es sich an der Wende vom 19. zum 20. Jahrhundert bis zum Ersten Weltkrieg vollzogen hat. Die Frage richtet sich dabei auf die Art und Weise, wie dieser Prozess verlief, aber auch darauf, weshalb die Ausdehnung des Schulturnens auf die Mädchen mit einiger Verzögerung gegenüber dem Knabenturnen zu einem bestimmten Zeitpunkt schließlich stattgefunden hat. Als Grundlage der Untersuchung dienen normative Quellen ebenso wie (...) einschlägige Zeitschriftenliteratur, anhand derer sich der die Entwicklungen begleitende Diskurs rekonstruieren lässt. Ein besonderer Fokus richtet sich dabei auf die Rolle des sich wandelnden Körper- und Geschlechterwissens, wie es sich in zeitgenössischen wissenschaftlichen Texten und populären Büchern zum Thema Leibesübungen und Gesundheit manifestiert hat. (shrink)

Global discussions are ongoing on how to stimulate antibiotic research and development in order to provide patients with new antibiotics able to address the challenges of antimicrobial resistance. In this supplement, we present nine articles derived from the research performed as part of the Innovative Medicine Initiative-funded DRIVE-AB project and others. These publications provide new evidence and arguments in the debate around economic incentives to stimulate antibiotic innovation, including characteristics, implementation and governance.

L'auteure, riche de son expérience de scripte cinéma, analyse l'organisation spatio-temporelle des éléments constituants un film de fiction pour définir le concept de continuité apparente. Celui-ci est ensuite réinvesti dans l'étude de la stéréoscopie au cinéma. Ces deux notions sont à l'origine de la création de deux courts-métrages en 3D visant à les réunir.

Medicine and Ethics in Black Women's Speculative Fiction engages the complex nexus of black women's health, the fraught history of medicine as it relates to black women, and the problems with the inconsistent application of medical ethics that should concern us all through the lens of black women's literary speculation.

Este artículo utiliza las investigaciones de James C. Scott sobre lenguajes resistentes en contextos de dominación para mostrar que el discurso parabó-lico del evangelio de Marcos puede entenderse como un ejemplo de dis-curso resistente, y para determinar la función que dicho texto habría tenido en la comunicación del men-saje evangélico a sus destinatarios originales. Valiéndose de las herra-mientas utilizadas por Scott para detectar este tipo de lenguajes, tam-bién propone una interpretación de Mc 4,1-34 que pretende dar razón, no sólo del (...) sentido de sus distin-tos contenidos, sino también de los silencios, opacidades, tensiones y ambigüedades que cubren el texto. (shrink)

En las últimas décadas el campo de la creación artística ha constituido un espacio privilegiado de reflexión, crítica cultural, cuestionamiento ético, y experimentación tanto estética como técnica en el que se han ensayado las más variadas visiones de la evolución, de la transformación de las relaciones con la naturaleza y de la auto-comprensión del ser humano. Dentro del debate abierto por la biología sintética, este artículo aspira a remarcar que tanto el bioarte como el arte genético, el arte transgénico y (...) el biohacking, constituyen poderosas herramientas de debate social cuyas dimensiones éticas y estéticas deben ser revisadas y tratadas detalladamente. (shrink)

En contexte de protection de la jeunesse, dans plusieurs situations, il arrive que le développement d’un lien d’attachement ne puisse s’établir suite à du rejet, de l’abandon ou par l’incapacité des parents à reconnaître ou répondre aux besoins de l’enfant. Dans de telles situations, au Québec, on envisage de plus en plus une approche « projet de vie » pour l’enfant avec l’objectif de mettre fin à l’ambivalence et au vide affectif, ceci dans des délais qui ne compromettent pas sa (...) capacité de se développer harmonieusement. Dans cette perspective, nous présentons ici les résultats d’une étude exploratoire qui a pour objectif de dresser un premier portrait des jeunes pour qui un « projet de vie » fut élaboré dans sept centres jeunesse du Québec. (shrink)

Durch einen Vergleich nicht-jüdischer und jüdischer Philosophiegeschichten werden unterschiedliche Behandlungsweisen und vielfältige inhaltliche Ausprägungen von «jüdischer Philosophie» vor dem Hintergrund der jeweils vertretenen philosophischen Haltung wie auch des religiösen Standpunktes der einzelnen Philosophiehistoriker aufgezeigt. Darüber hinaus werden Anregungen gegeben für mögliche Definitionen dessen, was «jüdische Philosophie» zu beinhalten hätte, und wie die künftige philosophiehistorische Forschung, jüdische wie nicht-jüdische, die gewonnenen unterschiedlichen Konzeptionen für Darstellung, Beurteilung und Einordnung in das Gesamt der Philosophiegeschichte berücksichtigen und fruchtbar machen könnte.

Reasoning about bedrock abstract concepts such as time, number, and valence relies on spatial metaphor and often on multiple spatial metaphors for a single concept. Previous research has documented, for instance, both future-in-front and future-to-right metaphors for time in English speakers. It is often assumed that these metaphors, which appear to have distinct experiential bases, remain distinct in online temporal reasoning. In two studies we demonstrate that, contra this assumption, people systematically combine these metaphors. Evidence for this combination was found (...) in both directly elicited and spontaneous co-speech gestures about time. These results provide first support for the hypothesis that the metaphorical representation of time, and perhaps other abstract domains as well, involves the continuous co-activation of multiple metaphors rather than the selection of only one. (shrink)

International business organizations are regularly addressed on their corporate social responsibility (CSR). As illustrated in this paper, it is not yet clear exactly what CSR means to organizations and how to deal with it. In this paper, the authors explore how a sensemaking approach helps to understand the business challenges of CSR within an organizational context. The theories of Karl Weick are applied to the experiences of CSR in Royal Dutch Shell. The authors argue that the key to CSR in (...) international business organizations is to engage stakeholders and start a process of joint sensemaking. Three main competencies are crucial in this: the competency to engage stakeholders through listening and understanding; the creation of an organizational language so that CSR makes sense to members of the organization; and recognizing the momentum of taking action. (shrink)

This chapter surveys essentialist and anti-essentialist theories of sex and gender. It does so by engaging three approaches to sex and gender: externalism, internalism, and contextualism. The chapter also draws attention to two key debates about sex and gender in the feminist literature: the debate about the sex/gender distinction (the distinction debate) and the debate about whether sex and gender have essences (the essentialism/anti-essentialism debate). In addition, it describes three problems that theories of sex and gender tend to face: the (...) Inclusion Problem, the Definition Problem, and the Exclusion Problem. Lastly, the chapter highlights why the division between essentialist and anti-essentialist accounts of sex and gender is not clear. (shrink)

In several jurisdictions, irremediable suffering from a medical condition is a legal requirement for access to assisted dying. According to the expressivist objection, allowing assisted dying for a specific group of persons, such as those with irremediable medical conditions, expresses the judgment that their lives are not worth living. While the expressivist objection has often been used to argue that assisted dying should not be legalised, I show that there is an alternative solution available to its proponents. An autonomy-based approach (...) to assisted suicide regards the provision of assisted suicide (but not euthanasia) as justified when it is autonomously requested by a person, irrespective of whether this is in her best interests. Such an approach has been put forward by a recent judgment of the German Federal Constitutional Court, which understands assisted suicide as an expression of the person’s right to a self-determined death. It does not allow for beneficence-based restrictions regarding the person’s suffering or medical diagnosis and therefore avoids the expressivist objection. I argue that on an autonomy-based approach, assisted suicide should not be understood as a medical procedure but rather as the person’s autonomous action. (shrink)

I argue that free indirect discourse should be analyzed as a species of direct discourse rather than indirect discourse. More specifically, I argue against the emerging consensus among semanticists, who analyze it in terms of context shifting. Instead, I apply the semantic mechanisms of mixed quotation and unquotation to offer an alternative analysis where free indirect discourse is essentially a quotation of an utterance or thought, but with unquoted tenses and pronouns.

This paper borrows from philosopher John Macmurray's insightsin order to advance work in feminist theology relating to perceptions of God. Mac-murray argues that we cannot have an adequate concept of a personalGod, if our concept of the human person is inadequate.He asserts that we are persons by virtue of our agency and our personal relationships; hence, the growth and development of persons requires communities of equals. Beliefin God, then, is an attitude expressed through behaviour that creates and sustains such communities. (...) As feminist theologians indicate, a‘male’ God is a stumbling block to equality; yet, thealogy remains on the periphery of mainstream academic and Christian circles. Hence, this paper sets the groundwork for a truly gender-transcendent concept of God, examining some contemporary language liturgies and employing Macmurray's portrayal of a supreme agent, in an attempt to resolve the main problems encountered by inclusive God-language. (shrink)

Given the negative costs of exclusion and the relevance of belongingness for humans, the experience of exclusion influences social affiliation motivation, which in turn is a relevant predictor of prosocial behavior. Skin conductance is a typical measure of the arousal elicited by emotions. Hence, we argued that both inclusion and exclusion will increase skin conductance level due to the increase of either positive affect or anger affects, respectively. Moreover, we argued that emotional arousal is also related to social affiliation motivation (...) and prosocial behavior. A total of 48 students were randomly allocated to either an inclusionary or exclusionary condition and their skin conductance levels were recorded during an experiment in which they completed an online questionnaire and played the game “Cyberball.” Results indicated that (a) individuals who perceived high exclusion felt angrier than individuals perceiving high inclusion, who feel positive affect; (b) no differences were evidenced in terms of skin conductance between exclusion and inclusion situations; (c) over-aroused individuals were less motivated to affiliate; and (d) individuals with lower affiliation motivation behaved in a less prosocial way. The results were congruent to the argument that behaving prosocially may be a way to gain the desired affiliation. (shrink)