BackgroundBiobanking biospecimens and consent are common practice in paediatric research. We need to explore children and young people’s (CYP) knowledge and perspectives around the use of and consent to biobanking. This will ensure meaningful informed consent can be obtained and improve current consent procedures.MethodsWe designed a survey, in co-production with CYP, collecting demographic data, views on biobanking, and consent using three scenarios: 1) prospective consent, 2) deferred consent, and 3) reconsent and assent at age of capacity. The survey was disseminated (...) via the Young Person’s Advisory Group North England (YPAGne) and participating CYP’s secondary schools. Data were analysed using a qualitative thematic approach by three independent reviewers (including CYP) to identify common themes. Data triangulation occurred independently by a fourth reviewer.ResultsOne hundred two CYP completed the survey. Most were between 16–18 years (63.7%, N = 65) and female (66.7%, N = 68). 72.3% had no prior knowledge of biobanking (N = 73).Acceptability of prospective consent for biobanking was high (91.2%, N = 93) with common themes: ‘altruism’, ‘potential benefits outweigh individual risk’, 'frugality', and ‘(in)convenience’.Deferred consent was also deemed acceptable in the large majority (84.3%, N = 86), with common themes: ‘altruism’, ‘body integrity’ and ‘sample frugality’. 76.5% preferred to reconsent when cognitively mature enough to give assent (N = 78), even if parental consent was previously in place. 79.2% wanted to be informed if their biobanked biospecimen is reused (N = 80).ConclusionProspective and deferred consent acceptability for biobanking is high among CYP in the UK. Altruism, frugality, body integrity, and privacy are the most important themes. Clear communication and justification are paramount to obtain consent. Any CYP with capacity should be part of the consenting procedure, if possible. (shrink)

Individual neurons display characteristic firing patterns determined by the number and kind of ion channels in their membranes. We describe experimental and computational studies that suggest that neurons use activity sensors to regulate the number and kind of ion channels and receptors in their membrane to maintain a stable pattern of activity and to compensate for ongoing processes of degradation, synthesis and insertion of ion channels and receptors. We show that similar neuronal and network outputs can be produced by a (...) number of different combinations of ion channels and synapse strengths. This suggests that individual neurons of the same class may each have found an acceptable solution to a genetically determined pattern of activity, and that networks of neurons in different animals may produce similar output patterns by somewhat variable underlying mechanisms. BioEssays 24:1145–1154, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Putting laypeople in an active role as direct expert contributors in the design of service robots becomes more and more prominent in the research fields of human–robot interaction and social robotics. Currently, though, HRI is caught in a dilemma of how to create meaningful service robots for human social environments, combining expectations shaped by popular media with technology readiness. We recapitulate traditional stakeholder involvement, including two cases in which new intelligent robots were conceptualized and realized for close interaction with humans. (...) Thereby, we show how the robot narrative together with aspects of power balancing stakeholders, such as hardware constraints and missing perspectives beyond primary users, and the adaptivity of robots through machine learning that creates unpredictability, pose specific challenges for participatory design processes in HRI. We conclude with thoughts on a way forward for the HRI community in developing a culture of participation that considers humans when conceptualizing, building, and using robots. (shrink)

Dans le contexte pénitentiaire actuel de la lutte contre la désocialisation, des associations offrent un soutien psychologique et social aux familles des prisonniers. La recherche-action « Regards d’enfants sur l’incarcération » dont rend compte cet article, menée en collaboration avec deux de ces associations, consiste à créer des groupes de soutien pour les enfants qui ont un parent ou un proche en prison. L’objectif de cette recherche-action est d’évaluer les conditions, moyens et outils qui permettraient d’offrir une possibilité d’échange aux (...) enfants pour leur rendre possible de partager leurs expériences et d’exprimer ce qui ne peut être dit à des parents, des proches et à leur environnement social (amis, école, voisins...). Les résultats confirment le besoin manifeste de renforcer les pratiques professionnelles autour des familles, et notamment des enfants, grands absents dans nos dispositifs d’accompagnement français. (shrink)

Demoting Vishnu: Ritual, Politics, and the Unraveling of Nepal’s Hindu Monarchy. By Anne T. Mocko. New York: Oxford University Press, 2016. Pp. ix + 246.

A new analytical framework for understanding literary videogames, the literary-ludic spectrum, illustrated by close readings of selected works. In this book, Astrid Ensslin examines literary videogames—hybrid digital artifacts that have elements of both games and literature, combining the ludic and the literary. These works can be considered verbal art in the broadest sense (in that language plays a significant part in their aesthetic appeal); they draw on game mechanics; and they are digital-born, dependent on a digital medium (unlike, for (...) example, conventional books read on e-readers). They employ narrative, dramatic, and poetic techniques in order to explore the affordances and limitations of ludic structures and processes, and they are designed to make players reflect on conventional game characteristics. Ensslin approaches these hybrid works as a new form of experimental literary art that requires novel ways of playing and reading. She proposes a systematic method for analyzing literary-ludic (L-L) texts that takes into account the analytic concerns of both literary stylistics and ludology. After establishing the theoretical underpinnings of her proposal, Ensslin introduces the L-L spectrum as an analytical framework for literary games. Based on the phenomenological distinction between deep and hyper attention, the L-L spectrum charts a work's relative emphases on reading and gameplay. Ensslin applies this analytical toolkit to close readings of selected works, moving from the predominantly literary to the primarily ludic, from online hypermedia fiction to Flash fiction to interactive fiction to poetry games to a highly designed literary “auteur” game. Finally, she considers her innovative analytical methodology in the context of contemporary ludology, media studies, and literary discourse analysis. (shrink)

Consolation is needed when a human being suffers (i.e. feels alienated from him-or herself, from other people, from the world or from his or her ultimate source of meaning). The aim of this study was to illuminate the meaning of consolation. Tape-recorded narrative interviews were carried out with 18 professionals from various spheres. The transcribed interviews were interpreted hermeneutically. A model of consolation is outlined in a drawing. It states that the mediator and the receiver of consolation must become ready (...) for consolation before it can take place. To be ready means to be present and available. Availability means expressing suffering and listening respectively, and thereby opening up for communion and consoling dialogue. Communion brings about contact with the sacred dimension that human beings share and thus with goodness, light, joy, beauty and life. Consolation involves a shift of perspective and an experience of meaning in spite of suffering. (shrink)

Subliminal perception occurs when prime stimuli that participants claim not to be aware of nevertheless influence subsequent processing of a target. This claim, however, critically depends on correct methods to assess prime awareness. Typically, d9 (‘‘d prime’’) tasks administered after a priming task are used to establish that people are unable to discriminate between different primes. Here, we show that such d9 tasks are influenced by the nature of the target, by attentional factors, and by the delay between stimulus presentation (...) and response. Our results suggest that the standard d9 task is not a straightforward measure of prime visibility. We discuss the implications of our findings for subliminal perception research. (shrink)

In Arequipa, Peru’s second largest city, engineers work hard to control water flows and provide different sectors with clean and sufficient water. In 2011, only 10 percent of the totality of water used daily by Arequipa’s then close to 1 million people—in households, tourism, industry, and mining—was treated before it was returned to the river where it continues its flow downstream towards cultivated fields and, finally, into the Pacific Ocean. It takes specialized knowledge and manifold technologies to manage water and (...) sustain life in Arequipa, and engineers are central actors for making water flow. Examining the ecology of water management, this article asks to what extent we can talk of a way of knowing and enacting water that is particular to engineers. Through engineering practices, a technical domain emerges as separate from and superior to political and social domains. This production of categories can be understood as practices of purification. However, a purely technical grip on water is never possible. Unruly elements, like weather, contamination, urban dwellers, and competing interests, interfere and make processes of intervention unstable. Water is never completely cleaned, and, equally, the continuous processes of purification of categories and domains take place while other processes work to blur their boundaries. (shrink)

Theories are processes modelled by thought. When they evolve in time, they are transformed and become new theories. They may cross from one academic discipline to another, then open up to new areas of human knowledge, mixing together the humanities, art, science and even spirituality. The way they are modelled reveals their plasticity and their elasticity is tested in their potential for transfer from one domain to another, while the different contacts they make and mergers they undergo generate a certain (...) hybridity. Plasticity, elasticity and hybridity are the triad which make the transfer of theories possible. (shrink)

Meat production in South Africa is on an increasing trend. In South Africa rising wealth, urbanisation and a growing middle class means South Africans are eating more processed and high-protein foods, especially meat and dairy products. These foods are more land- and water-intensive than fruit, vegetable and grain crops, and further stress existing resources. Traditional agricultural farms cannot keep up with the increasing demand for animal products and these farms are being replaced with concentrated animal feeding operations. There are a (...) wide variety of problems caused by intensive livestock production. The concerns regarding factory farming in South Africa are social issues affecting food security, health concerns, environmental concerns and ethical concerns. In order to ensure food security in future we need to consider these concerns and support more sustainable systems to produce our food. Animal agriculture, like many other industries, works on the principles of supply and demand. By decreasing the demand for these products, we can decrease their production. Individuals can do this by becoming vegetarian or vegan, but also by simply cutting down one’s consumption of meat, eggs, and milk produced in intensive livestock farms. Less meat would be produced, and there would be less harm to local communities, lower risk of zoonotic disease outbreaks, fewer greenhouse gas emissions, less land degradation and decrease of biodiversity, less damage to our water supplies and fewer animals living lives of suffering in factory farms. (shrink)

This dissertation presents an account of fictional discourse which is teleological. According to it, questions about what is said in fiction and how it ought to be said are answerable in terms of the goals and methods belonging specifically to fiction-making as a practice. Viewed in such a way, it is argued that the incompleteness of fictional discourse and its apparent tolerance of inconsistency are distinctive of it. Moreover, it is argued that there is a sense in which one can (...) produce true statements in fiction without thereby committing one self to the thesis that words made use of in fiction are endowed with reference. Throughout the dissertation, the view espoused in it is contrasted with rival positions on the issues of what fiction is about, and whether it can be true. It is argued that a teleological account of fictional discourse can present a coherent alternative to these. (shrink)

This article addresses a number of phenomena in the field of digital communication - disinformation, infodemics and conspiracy mania - that promote indifference regarding the distinction between truth and lies, fact and fiction, opinion and knowledge. They have thus decisively altered users' patterns of rationality and common sense and contributed to the rise of anti-democratic and anti-scientific positions. To address this complex problem, a systemic approach is provided that considers these phenomena to be factors that disturb the ethical-epistemic equilibrium between (...) uncertainty, trust and responsibility. After identifying a set of dynamics generated by these disruptive factors, three aspects are explored in depth: the polarisation and lack of a deliberative culture, the necessary correction of the social image of scientific practice, and the impact of the post-truth discourse. The article concludes with reflections on redefining the three key concepts of uncertainty, trust and responsibility in light of the demands of the digital sphere. (shrink)

At a time when humanity experiences its greatest advances, major conflicts and abuses arise around the world due to a lack of humanism and reason within the meaning of the Enlightenment. Modernity and western comfort in our globalized society have not helped share and balance the wealth, nor preserve the natural resources; it has not prevented crimes against humanity nor the most insane dictatorial actions of the 20th and early 21st centuries. This went hand in hand with a massive degradation (...) of the environment. Could the animal be the solution to all the mistakes we have made during the last century, instead of being considered an inferior, a slave? Could he not be the one who has managed the best in the fields of intelligence, self-regulation and respect of his vital environment? Should we not rather turn toward the animal to find a new balanced model? Respecting the environment and his peers seems to be the most striking evidence of intelligence, does it not? The animal has achieved this. Man has not. Focusing on the way man has treated animals may therefore help us to understand why we have treated our peers so badly. (shrink)

The paper examines the relationship between the sexual and linguistic and their mutual influence within the fields of political philosophy, linguistics, and theory of text, in selection from Adriana Cavarero’s work. First, we begin from the knowledge of poststructuralist text theory, psychoanalytic feminism and psycholinguistics, which are later expanded with the results from political philosophy with special emphasis on ancient texts. Cavarero’s texts are being analysed to describe the features through which the relationship between gender, sex and text is established. (...) Through a critical exploration of Cavarero’s texts and previous theoretical discussions and the analysis results, a conclusion about the influence of the sexual on language and culture and the influence of language and cultural symbols on social and gender roles is reached. (shrink)

Images from the nanoworld are not at all disorienting or bewildering, as one might expect from contemplating the strange and surprising features that arise where classical physics comes to an end and quantum effects begin to appear. Instead, we see the traces of explorers in a world that appears to be infinitely malleable. The paper shows that the capability to visualize processes and phenomena at the nanoscale is a matter not only of research technologies and the advancement of observational techniques, (...) but also a matter of developing a visual setting that exhibits knowledge and practice, surprise and control. The surface is such a stage and so is the landscape: they invite us to become immersed and move around like someone who goes for a walk. In order to appreciate this pictorial, as well as discursive, setting we turn to “strollology” as a method of reconstructing the world that is experienced in the manner of walking. With the notion of imagescape this method is applied to the modes of partaking in the nanoworld and its specific features. Rather than articulate theoretical or metaphysical presuppositions these nanoscapes serve to validate the very idea of nanotechnology. (shrink)

What are the essential features that a phenomenology of eros should take into account in order to do justice to the complexity of this reality? In order to put some light on this phenomenon, we have compared two contemporary French studies, that of Emmanuel Levinas in 'Totality and Infinity' and that of Sartre in 'Being and Nothingness'. We started by pointing at the new way in which subjectivity is experienced in eros. Sartre emphasizes the fact of feeling justified in one's (...) life, Levinas accentuates the feeling of being liberated from the burden of oneself . Both authors nevertheless agree on the fact that eros is fundamentally ambivalent . Unless Levinas, according to whom the ambiguities constitute the richness of the erotic relation, Sartre has shown that those ambiguities can always be experienced as a threat. They indeed threaten the typically human desire of the lover to control the other . Sartrian love is not only ambiguous, but has an essentially paradoxical character. Nevertheless, if the lover tries to free himself from this threatening feature, perversion is imminent. As such, love is threatened from within by perversion. Sartre uncovers an essential feature of eros, whereas Levinas can only consider perversion to be the consequence of an inauthentic desire of fusion . The essentially conflictual character of eros is illustrated by an analysis of the erotic gaze . In conclusion it can be stated that true love cannot be found in a relation without conflicts, but supposes lovers to handle the tension proper to the erotic relation without ever being sure of the result. (shrink)

This paper proposes an analytical framework for the analysis of organizational cognition that borrows from distributed and ecological cognition. In so doing, we take a case study featuring a decision on the topic of agreeing on a set point in the agenda of a meeting. It is through the analysis of a few minutes of video-recording used in the case that enables us to demonstrate the power of applying distributed and ecological cognition to organizing processes. Cognitive mechanism, resources, and processes (...) are identified within this combined framework. Mechanisms are described as “socio-material” (CM1)—where “people” and “artifacts” are the related cognitive resources—and as “conceptual” (CM2)—with “group” identity, “topic” understanding, meaning of “procedures,” and perception of “time” as resources. Processes are defined as “coupling,” “de-coupling,” and “un-coupled” depending on the type of relation in place. Finally, the paper presents an agent-based computational simulation to demonstrate the potentials of operationalizing this approach. (shrink)

How can a confederation of business and industry influence companies and make them more aware of ethical issues? This article examines the work of Norwegian Business and Industry , and the results it has achieved. The author is Assistant Director of NHO, P.b. 5250, Majorstua, 0303 Oslo, and she has been responsible for its business ethics programme for the past three years. This article comes to us through the agency of our Associate Editor for Norway, Dr Heidi von Weltzien Høivik, (...) of the Norwegian School of Management, who has recently been instrumental in founding a Norwegian Centre for Business Ethics. (shrink)