In this study, Brian Carrier provides a comprehensive analysis of the role that seismic language plays within the Matthean Gospel narrative. After reconstructing what connotations seismic language likely carried in Matthew's cultural context, the author utilizes an historically informed author-oriented narrative criticism that is complemented with redaction criticism to analyze the relationships that Matthew's seismic references display with regards to each other and to the overall narrative. This analysis leads to the conclusion that Matthew's seismic references collectively indicate (...) that the life, death, and resurrection of Jesus together represent the partial fulfillment of the Old Testament eschatological Day of the Lord. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. (...) The clinical features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

We reconstruct genetic determinism as a reductionist thesis to the effect that the molecular properties of cells can be accounted for to a great extent by their genetic outfit. The non-reductionist arguments offered at this molecular level often use the relationship between structure and function as their point of departure. By contrast, we develop a non-reductionist argument that is confined to the structural characteristics of biomolecules; no appeal to functions is made. We raise two kinds of objections against the reducibility (...) claim underlying genetic determinism. First, some conceptual distinctions at the protein level cannot be captured on a genetic basis. A one-to-many relationship between DNA sequences and proteins emerges from them. Second, the relationship between genes and proteins is characterized by explanatory loops or reciprocal explanatory dependence. The presence of proteins is explained by the transcription from corresponding DNA sequences, and the latter is in turn accounted for by the action of proteins. By contrast, a reductive account requires a unidirectional explanatory dependence. (shrink)

The traditional mutual support of scientific progress and social advancement has given way to public reservation. Research is no longer considered worthwhile in general. Parts of the public have come to fear both scientific error and scientific success. This raises the question of how to deal with findings that could have a detrimental impact on society. In a different vein, fake research poses a serious challenge to science in that it could undermine the credibility of scientific accounts. Fake research actively (...) produces ignorance rather than knowledge (agnotology). The question is how such actively misleading approaches are to be identified and separated from usual scientific error. (shrink)

Many professionals, mainly scientists have told me that a divine being is not necessary to explain why there is something rather than nothing. Theology and even metaphysics are redundant disciplines, they say. To me to reject a discipline a priori is irrational, whereas the methodology of science itself is basically rational. Why do Newton's equations say time is symmetrical, Einstein's relativity and quantum mechanics say time is an illusion and now Smolin says time is reborn - the present moment is (...) a fundamental aspect of reality. Why has matter been the carrier of reality over centuries, then matter dissolves away becoming an ephemeral quantum activity and now information is the carrier of reality? The laws of physics were presumed to be eternal, now Smolin says they are evolving like in biology - natural selection. Why do cosmologists like Brian Greene and Leonard Susskind postulate that there are nearly infinite number of replicas of each and every one of us - doppelgangers - in an infinite number of universes when the gut feeling of each and every one of us that we are unique in this universe? For Newton, gravity was an instantaneous attraction between two masses, for Einstein it was an inherent potential even with a single mass. For Einstein, gravity acts at the speed of light. Plato says that what is observed is phenomena. Reality resides in Platonic Forms. Descartes says that knowledge is acquired through perception and deduction. No reality without the mind. Kant synthesized rationalism and empiricism. Knowledge can be derived without empirical observation. Free will touches almost everything that human beings value. But many scientists postulate that free will is an illusion. Christian theology posits that God created the universe out of nothing. Cosmologists also now say the same thing, but the definition of 'nothing' is disputed. Christian theology once postulated that there is no salvation outside the Church. Now it is not so. Why these confusions? Why these contradictions? On the present methodology of acquisition of knowledge, answers may never be possible. The Theory of Everything (TOE) is more a distant dream than reaching for the stars. However, the discipline of Zygology which is introduced into the academia, a rational explanation why this is not possible has been postulated. Knowledge is holistic - a seamless web runs through all disciplines. Necessity of a new epistemology of reality and existence is inevitable....Zygology may have the answers!". (shrink)

This Paper suggests that the answer to the question “what is domestic labor law for?”—commonly regarded as securing “justice against markets” or a justified tax on market activity—has informed the search for the answer for the question “what is international labor law for.” This is reflected in what this Paper refers to as P2, which provides that “the failure of any country to adopt humane conditions of labor is an obstacle in the way of other nations which desire to improve (...) the conditions in their own countries.” P2 envisions a “race to the bottom” by rational states trapped in a Prisoner’s Dilemma game. The author maintains that this cannot be the objective of ILO which cannot stop “the race” given its deficient enforcement mechanisms to ensure compliance. This Paper suggests an alternative raison d’etre for the ILO, which is called P1, namely social justice: “universal peace can only be established if it is based upon social justice.” P1 reflects what states actually seek to achieve. Following Sen, this Paper suggests that there is no tradeoff between social justice and economic efficiency. Therefore the promotion of labor rights by the ILO will contribute both to social justice and to economic success. Thus the ILO should promote international labor law so as to lead member states to pursue their self-interest which is consistent with the collective goal of humanity. (shrink)

In this article, I suggest that post‐modernism is in essence a return, under radically different circumstances and with a cultural inheritance from the modernist era , to a kind of medievalism. The view that the ‘trend of our times’ is towards a ‘post‐modern medievalism’ is based mainly upon a consideration of the decline of the nation‐state, the replacement of ‘absolute’ with a kind of ‘moderated’ national sovereignty and the fact that the nations and regional assemblies of Europe are beginning to (...) look increasingly like the duchies and baronies of feudal Europe. (shrink)

The article describes the nature of a faceted classification, and its application in document retrieval. The kinds of facet used are illustrated. Procedures are then discussed for identifying facets in a subject field, populating the facets with individual subject terms, arranging these in helpful sequences, using the scheme to classify documents, and searching the resultant classified index, with particular reference to Internet search.

The considerations set out in the paper are intended to suggest that in practical contexts predictive power does not play the outstanding roles sometimes accredited to it in an epistemic framework. Rather, predictive power is part of a network of other merits and achievements. Predictive power needs to be judged differently according to the specific conditions that apply. First, predictions need to be part of an explanatory framework if they are supposed to guide actions reliably. Second, in scientific expertise, the (...) demand for accurate predictions is replaced with the objective of specifying a robust corridor of estimates. Finally, it is highly uncertain to predict the success of research projects. The overall purpose of the paper is to enlarge the debate about predictions by addressing specifically the roles of predictions in application-oriented research. (shrink)

The aim of this paper is to discuss the relation between the observation basis and the theoretical principles of General Relativity. More specifically, this relation is analyzed with respect to constructive axiomatizations of the observation basis of space-time theories, on the one hand, and in attempts to complete them, on the other. The two approaches exclude one another so that a choice between them is necessary. I argue that the completeness approach is preferable for methodological reasons.

In Bielefeld, Germany in April, 1997 an author conference was devoted to Arthur C. Danto's 1995 Mellon Lectures After the End of Art: Contemporary Art and the Pale of History . This essay provides an introduction to seven essays given at that conference and expanded for this Theme Issue of History and Theory. Danto presented his view of the nature of art in The Transfiguration of the Commonplace . He then added in the Mellon lectures a sociological perspective on the (...) current situation of the visual arts, and an Hegelian historiography. The history of art has ended, Danto claims, and we now live in a posthistorical era. Since in his well-known book on historiography, Analytical Philosophy of History , Danto is unsympathetic to Hegel's speculative ways of thinking about history, his adaptation of this Hegelian framework is surprising. Danto's strategy in After the End of Art is best understood by grasping the way in which he transformed the purely philosophical account of The Transfiguration into a historical account. Recognizing that his philosophical analysis provided a good way of explaining the development of art in the modern period, Danto radically changed the context of his argument. In this process, he opened up discussion of some serious but as yet unanswered questions about his original thesis, and about the plausibility of Hegel's claim that the history of art has ended. (shrink)

Following Karni's seminal work, Walker and other researchers have recently provided gradually convincing evidence that sleep is critical for the consolidation-based enhancement (CBE) of motor sequence learning. Studies in our laboratory using a motor adaptation paradigm, however, show that CBE can also occur after the simple passage of time, suggesting that sleep effects on memory consolidation are task-related, and possibly dependent on anatomically dissociable circuits.

Résumé Appuyée sur une collation systématique — incluant l’orthographe — de l’unique manuscrit subsistant, cette nouvelle édition critique du début de la Logica « Ingredientibus » : Super Porphyrium, accompagnée d’une traduction française inédite et complétée par une abondante annotation, rend ainsi accessible l’exposé le plus détaillé d’Abélard sur les universaux, des pages célèbres où, dans une approche sémantique non exempte de perspectives métaphysiques, on trouve, comme l’étude précédente l’a laissé voir, des développements philosophiques importants relatifs à l’intellection et à (...) l’abstraction.Based on a systematic collation — including the orthography — of the only surviving manuscript, this new critical edition of the beginning of Abelard’s Logica “Ingredientibus” : Super Porphyrium, accompanied by an original French translation and an abundant annotation, thus makes accessible Abelard’s most elaborate account on universals, well known pages where, in a semantical approach non exempt of metaphysical perspectives, one finds, as the preceding study as shown, important philosophical developments on intellection and abstraction. (shrink)

Trading on non-public material information is fertile ground for a discussion of ethical behavior. The long-running legal tug-of-war over what constitutes illegal insider trading delivers challenges to regulatory authorities charged with detecting and enforcing the law, and is likely one of the reasons that prosecution of insider trading events remains rather uncommon. One can observe both increased volume in the equity and option markets and run-ups in the stock price prior to the announcement of the acquisitions; however, the detection of (...) illegal or unethical insider trading can be difficult. Given the legal uncertainty around insider trading and the circumstantial evidence from the trading activity, it is almost impossible to identify unethical insider trades unless there is a whistleblower or trades are large in size and impeccable in timing. Using call option trading around two merger announcements with similar firms that resulted in different ultimate treatment from the SEC, we illustrate the struggle regulators and prosecutors have with identifying and enforcing unethical insider trades. (shrink)

United Nations (UN) leaders suggest that the world is not on track to meet the Sustainable Development Goals (SDGs) by 2030. The purpose of this paper is to explore whether the SDGs provide a valuable platform to call for a basic income (BI) globally. Adopting a critical historical studies approach, the article traces the evolution of ‘development’, including the UN decades of development, the Millennium Development Goals, and the SDGs. It subsequently describes the structural adjustment and poverty reduction efforts by (...) the World Bank and International Monetary Fund, and then outlines why the SDG framework may be helpful in advancing a BI. We argue that as climate-related disasters increase, a BI will be vital in providing a modicum of security in an increasingly unstable world. Calls for BI must be anchored to a broader change agenda that recognizes the causes of poverty and income inequality, and seeks their dismantling and redress. (shrink)

This chapter contains sections titled: Why Do We Climb? Why Should We Climb? Building the Best Person Climbing and Self‐Cultivation The Only Rule Is There Are No Rules (Except the Ones That Matter) Courage Humility Reverence for the Natural World Cultivating Virtue in a Domesticated World Why Climb? Notes.

Is critical disinterestedness possible? Or, is it, for that matter, even desirable? These are the major questions that hover above this essay - large questions which we face at the outset. For the moment we need to establish, first, what might be meant by 'disinterestedness'. For those whose major business is with the English literary tradition, the first name that will unfailingly come to mind when the term is mentioned is that of Matthew Arnold. The word 'disinterestedness' famously occurs in (...) what remains one of the most widely read of Arnold's critical essays, 'The Function of Criticism at the Present Time'. Arnold pauses to ask, what rule ought to condition the activity of English criticism? His answer is as follows: The rule may be summed up in one word - disinterestedness. And how is criticism to show disinterestedness? By keeping aloof from what is called 'the practical view of things'; by resolutely following the law of its own nature, which is to be a free play of the mind on all subjects which it touches. (shrink)

T. J. Clark’s two early books, The Absolute Bourgeois: Artists and Politics in France, 1848–1851 and Image of the People: Gustave Courbet and the 1848 Revolutio.

Drawing from both theoretical and empirical research, the literature on basic income (BI) is now voluminous, pronouncing both its merits and its limitations. Burgeoning research documents the impacts of un/conditional cash transfers and negative income tax programs, with many studies highlighting the effectiveness of these programs in reducing poverty, and improving a host of social, economic and health outcomes. We consider possible avenues for BI architecture to be adopted within Canada’s existing constellation of income security programs, to the benefit of (...) disadvantaged groups in society. Identifying key federal and provincial (i.e., Ontario) transfer and tax benefit programs, we highlight which programs might best be maintained or converted to a BI. While opponents decry the (alleged) exorbitant costs of BI schemes, we suggest that the existing approach not only produces an ineffective system—which actually engenders poverty and the health and social problems that accompany it—but an excessively costly one. (shrink)