We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Why do our intuitive knowledge ascriptions shift when a subject's practical interests are mentioned? Many efforts to answer this question have focused on empirical linguistic evidence for context sensitivity in knowledge claims, but the empirical psychology of belief formation and attribution also merits attention. The present paper examines a major psychological factor (called ?need-for-closure?) relevant to ascriptions involving practical interests. Need-for-closure plays an important role in determining whether one has a settled belief; it also influences the accuracy of one's cognition. (...) Given these effects, it is a mistake to assume that high- and low-stakes subjects provided with the same initial evidence are perceived to enjoy belief formation that is the same as far as truth-conducive factors are concerned. This mistaken assumption has underpinned contextualist and interest-relative invariantist treatments of cases in which contrasting knowledge ascriptions are elicited by descriptions of subjects with the same initial information and different stakes. The paper argues that intellectualist invariantism can easily accommodate such cases. (shrink)

There is a widely accepted family of views in the epistemology of testimony centering around the claim that belief is the central item involved in a testimonial exchange. For instance, in describing the process of learning via testimony, Elizabeth Fricker provides the following: “one language-user has a belief, which gives rise to an utterance by him; as a result of observing this utterance another user of the same language, his audience, comes to share that belief.” In a similar spirit, Alvin (...) Plantinga says that “…a belief on the part of the testifiee has warrant only if that belief has warrant for the testifier.” In both of these passages, we find strands of what I shall call the Belief View of Testimony. (shrink)

It is widely assumed that memory has only the capacity to preserve epistemic features that have been generated by other sources. Specifically, if S knows (justifiedly believes/rationally believes) that p via memory at T2, then it is argued that (i) S must have known (justifiedly believed/rationally believed) that p when it was originally acquired at Tl, and (ii) S must have acquired knowledge that p (justification with respect to p/rationality with respect to p) at Tl via a non-memorial source. Thus, (...) according to this view, memory cannot make an unknown proposition known, an unjustified belief justified, or an irrational belief rational--it can only preserve what is already known, justified, or rational. In this paper, I argue that condition (i) is false and, a fortiori, that condition (ii) is false. Hence, I show that, contrary to received wisdom in contemporary epistemology, memory can function as a generative epistemic source. (shrink)

Many philosophers hold that all dispositions must have independent causal bases. I challenge this view, hence defending the possibility of bare dispositions. In part 1, I explain more fully what I mean by "disposition," "causal basis," and "bare disposition." In part 2, I consider the claim that the concept of a disposition entails that dispositions are not bare. In part 3, I consider arguments, due to Prior, Pargetter, and Jackson, that dispositions necessarily have distinct causal bases. In part 4, I (...) consider arguments by Smith and Stoljar that there can't be bare dispositions because they would make for unwelcome "barely true" counterfactuals. In the end, I find no reason to deny the possibility of bare dispositions. (shrink)

I want to promote what I shall call ‘the identity theory of truth’. I suggest that other accounts put forward as theories of truth are genuine rivals to it, but are unacceptable. A certain conception of thinkables belongs with the identity theory’s conception of truth. I introduce these conceptions in Part I, by reference to John McDowell’s Mind and World; and I show why they have a place in an identity theory, which I introduce by reference to Frege. In Part (...) II, I elaborate on the conception of thinkables, with a view to demonstrating that the identity theory’s conception of truth is defensible. Part III is concerned with the theory’s relation to some recent work on the concept of truth: I hope to show that the identity theorist not only has a defensible conception of truth, but also, in the present state of play, has appropriate ambitions. (shrink)

Aristotle's requirement that virtuous actions be chosen for themselves is typically interpreted, in Kantian terms, as taking virtuous action to have intrinsic rather than consequentialist value. This raises problems about how to reconcile Aristotle's requirement with (a) the fact that virtuous actions typically aim at ends beyond themselves (usually benefits to others); and (b) Aristotle's apparent requirement that everything (including virtuous action) be chosen for the sake of eudaimonia. I offer an alternative interpretation, based on Aristotle's account of loving a (...) friend for herself, according to which choosing a virtuous action for itself involves choosing it on account of those features of it that make it the kind of action it is, where these features include its intended consequences (such as the benefits it seeks to provide to others). I then suggest that Aristotle may take these consequences (including benefits to others) as contributing (and contributing non-instrumentally) to the agent's own eudaimonia, and that there is no conflict here with Aristotle's view that eudaimonia is an activity of the soul. For just as my activity of teaching is actualized in my students (provided they learn from me), so too my virtuous activity can be actualized in its beneficiaries. If this is right, then Aristotle's view is far from the Stoic (and proto-Kantian) view often attributed to him. (shrink)

Norton argues on pragmatic “Deweyan” grounds that we should cease to ask scientists for value neutral definitions of “sustainability,” developed independently of moral and social values, to guide our environmental policy making debates. “Sustainability,” like human “health,” is a normative concept from the start—one that cannot be meaningfully developed by scientists or economists without input by all the stake holders affected. While I endorse Norton’s approach, I question his apparent presumption that concern for sustainability for the future is at odds (...) with and ought to trump concern for enhancement in the present of public opportunities to access the goods nature represents. I argue that the two are not separable in practice. I argue for Passmore’s position that unless we take care to enhance equitable access to the good and services nature represents in the present, we cannot succeed in promoting sustainability for future generations. (shrink)

A disjunctivist conception of acting for reasons is introduced by way of showing that a view of acting for reasons must give a place to knowledge. Two principal claims are made. 1. This conception has a rôle analogous to that of the disjunctive conception that John McDowell recommends in thinking about perception; and when the two disjunctivist conceptions are treated as counterparts, they can be shown to have work to do in combination. 2. This conception of acting for reasons safeguards (...) the connection between considerations that move us to act in particular ways and considerations that favour our acting in particular ways. (shrink)

Painful pains are, paradigmatically, unpleasant and motivating. The dominant view amongst philosophers and pain scientists is that these two features are essentially related and sufficient for painfulness. In this article, I first offer scientifically informed characterizations of both unpleasantness and motivational oomph and argue against other extant accounts. I then draw on folk-characterized cases and current neurobiological and neurobehavioral evidence to argue that both dominant positions are mistaken. Unpleasantness and motivational oomph doubly dissociate and, even taken together, are insufficient for (...) painfulness. (shrink)

Who are the best subjects for judgment tasks intended to test grammatical hypotheses? Michael Devitt ( [2006a] , [2006b] ) argues, on the basis of a hypothesis concerning the psychology of such judgments, that linguists themselves are. We present empirical evidence suggesting that the relevant divide is not between linguists and non-linguists, but between subjects with and without minimally sufficient task-specific knowledge. In particular, we show that subjects with at least some minimal exposure to or knowledge of such tasks tend (...) to perform consistently with one another—greater knowledge of linguistics makes no further difference—while at the same time exhibiting markedly greater in-group consistency than those who have no previous exposure to or knowledge of such tasks and their goals. (shrink)

Categorical perception (CP) refers to how similar things look different depending on whether they are classified as the same category. Many studies demonstrate that adult humans show CP for human emotional faces. It is widely debated whether the effect can be accounted for solely by perceptual differences (structural differences among emotional faces) or whether additional perceiver-based conceptual knowledge is required. In this review, I discuss the phenomenon of CP and key studies showing CP for emotional faces. I then discuss a (...) new model of emotion which highlights how perceptual and conceptual knowledge interact to explain how people see discrete emotions in others’ faces. In doing so, I discuss how language (emotion words included in the paradigm) contribute to CP. (shrink)

According to classical arguments, language learning is both facilitated and constrained by cognitive biases. These biases are reflected in linguistic typology—the distribution of linguistic patterns across the world's languages—and can be probed with artificial grammar experiments on child and adult learners. Beginning with a widely successful approach to typology (Optimality Theory), and adapting techniques from computational approaches to statistical learning, we develop a Bayesian model of cognitive biases and show that it accounts for the detailed pattern of results of artificial (...) grammar experiments on noun-phrase word order (Culbertson, Smolensky, & Legendre, 2012). Our proposal has several novel properties that distinguish it from prior work in the domains of linguistic theory, computational cognitive science, and machine learning. This study illustrates how ideas from these domains can be synthesized into a model of language learning in which biases range in strength from hard (absolute) to soft (statistical), and in which language-specific and domain-general biases combine to account for data from the macro-level scale of typological distribution to the micro-level scale of learning by individuals. (shrink)

Jennifer Hornsby; V*—Which Physical Events are Mental Events?, Proceedings of the Aristotelian Society, Volume 81, Issue 1, 1 June 1981, Pages 73–92, https://do.

It is commonly thought that moral rules and principles, such as ‘Keep your promises,’ ‘Respect autonomy,’ and ‘Distribute goods according to need ,’ should play an essential role in our moral deliberation. Particularists have challenged this view by arguing that principled guidance leads us to engage in worse decision making because principled guidance is too rigid and it leads individuals to neglect or distort relevant details. However, when we examine empirical literature on the use of rules and principles in other (...) domains, we find that people can learn to use rules discriminately and that rule-based models tend to outperform even expert judgment. I argue that this evidence poses a problem for the moral particularist. If the particularist claims that we should not rely on decision-making rules when making practical decisions and it turns out that these rules help us make better decisions, then the particularists’ prescriptive account is deficient. However, if the particularist claims that we should rely on practical decision-making rules but not on moral rules, she needs to explain how practical rules are different from moral rules and why we should rely on the former but not the latter. (shrink)

In this article, we develop a hierarchical Bayesian model of learning in a general type of artificial language‐learning experiment in which learners are exposed to a mixture of grammars representing the variation present in real learners’ input, particularly at times of language change. The modeling goal is to formalize and quantify hypothesized learning biases. The test case is an experiment (Culbertson, Smolensky, & Legendre, 2012) targeting the learning of word‐order patterns in the nominal domain. The model identifies internal biases of (...) the experimental participants, providing evidence that learners impose (possibly arbitrary) properties on the grammars they learn, potentially resulting in the cross‐linguistic regularities known as typological universals. Learners exposed to mixtures of artificial grammars tended to shift those mixtures in certain ways rather than others; the model reveals how learners’ inferences are systematically affected by specific prior biases. These biases are in line with a typological generalization—Greenberg's Universal 18—which bans a particular word‐order pattern relating nouns, adjectives, and numerals. (shrink)

This July 2022 issue of the JME contains several articles addressing ethical issues related to COVID-19 as well as reproductive ethics—a timely topic, given the leaked U.S. Supreme Court document, anticipating the overturn of Roe v. Wade. On the COVID-19 front, original articles in this issue include an analysis of ethical issues related to sharing research samples and data between low/middle-income countries and high-income countries,1 a retrospective analysis of European scientific societies’ triage policies early in the pandemic,2 an assessment of (...) the fairness of the allocation framework used by the WHO for their COVID-19 Vaccines Global Access Facility,3 balancing physicians’ freedom to express opinions on medical matters with public interest when they run contrary to each other,4 and a survey of Americans’ views on race-based and place-based COVID-19 vaccine prioritisation.5 The articles include a mix of looking back and …. (shrink)

A characteristically Humean pattern of explanation starts by claiming that we have a certain kind of feeling in response to some objects and then takes our having such feelings to provide an explanation of how we come to think of those objects as having some feature that we would not otherwise be able to think of them as having. This core pattern of explanation is what leads Simon Blackburn to dub Hume ‘the first great projectivist.’ This paper critically examines the (...) philosophical and textual basis for interpreting Hume as a causal projectivist. I argue that projectivist interpretations of Hume's account of causation are motivated by two convictions: that beliefs about causation, according to Hume, are not just beliefs about regularity relations and that believing that two events are necessarily connected, according to Hume, is not merely having a belief about something that occurs in one's mind. I suggest that the latter conviction is worth revisiting, both for textual and philosophical reasons. (shrink)

Dispositions and potentialities seem importantly similar. To talk about what something has the potential or disposition to do is to make a claim about a future possibilitythe "threats and promises" that fill the world (Goodman 1983, 41). In recent years, dispositions have been the subject of much conceptual analysis and metaphysical speculation. The inspiration for this essay is the hope that that work can shed some light on discussions of potentiality. I compare the concepts of disposition and potentiality, consider whether (...) accounts of these concepts are subject to similar difficulties, and whether having a disposition or a potentiality can depend on extrinsic factors. The concept of a disposition I am working with is drawn from the recent literature in metaphysics and philosophy of science that focuses on the analysis of dispositional concepts and their role in a broader ontology. The concept of a potentiality is drawn from the bioethics literature that focuses on the moral relevance of potentialities that subjects of medical decisions mayor may not possess. Some preliminary conclusions I draw are the following: I. Potentialities are dispositions; 2. Due to problematic cases, potentiality ascriptions, like disposition ascriptions, are not reducible to counterfactual statements; and 3. Like dispositions, some potentialities can be extrinsic. Here I do not aim to draw any conclusions about the moral relevance of potentialities but rather to outline conceptual and metaphysical options available to those who seek to employ this concept. However, to the extent that these options are relevant to answering moral questions, I am skeptical about the prospects of finding a value-neutral way to choose between them. I have tried to outline a number of options regarding the nature of potentialities for those who would like that notion to play some role in their theorizing in bioethics, or elsewhere. There still are a number of decisions to make about how to explicate the concept of potentiality that is most relevant for one's purposes. How should one flesh out the associated counterfactuals, regardless of whether they hope to reduce potentiality claims to counterfactual conditionals? How should one circumscribe the relevant possible circumstances of manifestation for a given potentiality? Are the circumstances necessary for the actualization of a given potentiality to be counted circumstances of possession or circumstances of manifestation? Is the kind of which something is potentially a member a natural kind or a class whose membership is determined by convention? My anticipation, and perhaps my worry, is that these questions do not have answers that can be determined independently from the conclusions about the moral relevance of potentiality that a given theorist aims to establish. (shrink)

The Ainu are still in existence, but their reduced numbers, now around 20,000, indicate how marginal their presence is even in Hokkaido, their ancestral territory. Moreover, they have undergone much metissage, in both ethnic and cultural terms. Legally, the Ainu do not yet constitute an indigenous ethnic minority; they have only recently obtained some gestures of recognition from the government, such as the interruption of a dam project on a ritual site. In 1994, for the first time in history, an (...) Ainu, Kay ano Shigeru, was elected to the senate. The legislation concerning the Ainu lands, dating from 1899, has finally been revised. And with a boost from the International Year of Ethnic Minorities, in 1992, Ainu organizations managed to inflect the official Japanese doctrine that Japanese soil is home to only one community, that of the Japanese. (shrink)

This concluding chapter assesses the debate over humanitarian intervention in the light of the events of September 11, 2001. On the one hand, it can be argued that 9/11 has reversed the momentum behind the norm of ‘sovereignty as responsibility’. In the course of waging the war on terrorism, the powers of sovereign states have been increased and the willingness of Western states to criticize the treatment of civilians within other sovereign jurisdictions appears to have weakened. On the other, there (...) are three reasons why humanitarian intervention – and the issues associated with it – will continue to preoccupy scholars and statesmen in a post-September 11th world. First, the terrorist attacks of 2001 have reinforced the view that instability within or collapse of a state anywhere in the world can have implications that reach far wider than that particular region. Second, the debate about what constraints should be placed on the use of force – particularly those related to proper authority – are as relevant for the ‘war on terror’ as they are for humanitarian intervention. Finally, as the missions in Afghanistan in 2001 and Iraq in 2003 have shown, humanitarian rationale are all-important in justifying the use of force in international society, even when other motives are at work. (shrink)

Objective: To increase our understanding of moral distress experienced by neonatal registered nurses when directly or indirectly involved in the decision-making process of resuscitating infants who are born extremely premature. Design: A secondary qualitative analysis was conducted on a portion of the data collected from an earlier study which explored the ethical decision-making process among health professionals and parents concerning resuscitation of extremely premature infants. Setting: A regional, tertiary academic referral hospital in Ontario offering a perinatal program. Participants: A total (...) of 15 registered nurses were directly or indirectly involved in the resuscitation of extremely premature infants. Methods: Interview transcripts of nurses from the original study were purposefully selected from the original 42 transcripts of health professionals. Inductive content analysis was conducted to identify themes describing factors and situations contributing to moral distress experienced by nurses regarding resuscitation of extremely premature infants. Ethical considerations: Ethical approval was obtained from the research ethics review board for both the initial study and this secondary data analysis. Results: Five themes, uncertainty, questioning of informed consent, differing perspectives, perceptions of harm and suffering, and being with the family, contribute to the moral distress felt by nurses when exposed to neonatal resuscitation of extremely premature infants. An interesting finding was the nurses’ perceived lack of power and influence in the neonatal resuscitation decision-making process. Conclusion: Moral distress continues to be a significant issue for nursing practice, particularly among neonatal nurses. Strategies are needed to help mediate the moral distress experienced by nurses, such as debriefing sessions, effective communication, role clarification, and interprofessional education and collaboration. (shrink)

According to most views of dispositions or powers, they have “triggers” or activation conditions. Fragile things break when they are struck; explosive things explode when ignited. The notion of an activation event, or “trigger,” is central to the notion of a disposition. Dispositions are defined not only by their manifestations, but also by their triggers. Not everyone who grumbles and complains counts as irritable—just those who do so with little inducement. Not everything that can be broken counts as fragile—just things (...) that can be broken with relatively little force. The idea that triggers are part of the identity conditions of powers is evident in conditional analyses of powers, and even in the claim that certain conditionals are typically true of things with certain powers. The antecedent of the conditional corresponds to a trigger of that power: “If it’s struck, it will break” is true of a fragile thing, and “being struck” is the trigger. In this chapter, I explore the nature of activation events and their relation to the powers they activate. In particular, I will consider what triggers would look like if all properties were powers, as the dispositional monist or pandispositionalist tells us they are. While many have expressed worries about manifestations involving instantiations of only dispositional properties, it is also worth noting that, on a pandispositionalist scenario, the activation event must be equally dispositional. If all properties are powers, it seems that a triggering event must be an acquisition of a power. But how does something acquiring a power activate another power to produce its manifestation? I suggest and evaluate possible answers. I will argue that, as with the case of manifestations, a vicious regress threatens the pandispositionalist picture of power activation. I go on to consider several possible pandispositionalist responses. (shrink)

DISCUSSIONS OF JUSTICE within the classical liberal, libertarian tradition have been universalist. They have aspired to apply to any human community, whatever the makeup of its membership. Certainly some feminists have taken issue with this, arguing that the classical liberal, libertarian understanding of justice fails to address the concerns of women, indeed, does women an injustice. Among these we find Susan Moller Okin, and it will be my task in this essay to explore whether Okin's criticism is well founded. Susan (...) Moller Okin's justice, Gender, and the Family is a landmark feminist discussion of distributive justice that raises issues no political philosophy should ignore. However, libertarians have tended to ignore it. That is perhaps not surprising as Okin would have us believe that libertarian feminism is incoherent. Some libertarians seem to agree, leading one to believe that liberty is incompatible with justice for women. Perhaps libertarians and feminists agree on the "facts," but disagree on the values. Whereas the feminist is willing to sacrifice liberty for justice, the libertarian is willing to sacrifice justice for liberty. Although the libertarian might object to this characterization on the grounds that the demands of justice would be met by a libertarian scheme, the feminist can equally object that the "liberty" she is willing to sacrifice means liberty for men and domestic servitude for women. Okin finds libertarianism problematic for two reasons: its philosophical foundations and its unjust consequences for women. (She focuses, as will I, on women in quasi-democratic industrial societies.) I will argue, contra Okin, that neither the philosophical foundations nor the possible implications of libertarianism are as problematic for feminism as she claims. (shrink)

Outlines and evaluates the political, legal, and ethical objections to humanitarian intervention. In so doing, it questions not only whether the doctrine of ‘sovereignty as responsibility’ has taken hold in international society, but also whether it should – particularly in the form suggested by Western states. The author argues that the ethical position of pluralism – as articulated by non-Western states – represents the most compelling case against humanitarian intervention, by emphasizing the impact on international society of relaxing the norm (...) of non-intervention. Despite these pluralist objections, military intervention in cases of supreme humanitarian emergency can be defended on moral grounds, provided the intervention meets certain tests of legitimacy. Given the unintended consequences of military action, the author also suggests that more attention should be paid to the non-military means of operationalizing ‘sovereignty as responsibility’. (shrink)

Three main themes emerge from this edited collection. First, there has been an increased incidence of intervention for humanitarian purposes since the end of the Cold War. In these cases, the alleged conflict between sovereignty and human rights has been addressed in one of two ways: through an evolution in the notion of sovereignty, from ‘sovereignty as authority’ to ‘sovereignty as responsibility’; and through an expanded definition of what constitutes a threat to international peace and security under Chapter VII of (...) the UN Charter. Second, despite this new climate of permissiveness, humanitarian intervention remains a controversial norm in international relations – largely because of continued opposition from certain members of international society, and concerns about its potentially negative consequences. Third, while the post Cold War period has seen some successful cases of intervention to address humanitarian catastrophes, the current capability of international organizations to undertake humanitarian interventions remains limited. Indeed, as the book demonstrates, the issue of humanitarian intervention has the potential to divide international institutions such as the UN and damage their credibility. (shrink)

This essay outlines the possibilities and limits of phenomenology as an ecophilic mode of thought in the context of a heightened, posthuman scrutiny of anthropocentrism, and advocates a self-reflexive environmental humanities informed by phenomenological insight. It aims to demonstrate that, despite its privileging of human consciousness, phenomenology offers important ecocritical resources, including methodological reflection on the constitution and limits of a human perspective; a vision of a meaningful lifeworld; a rendering of subjectivity as embodied within a larger vital materiality; and (...) a critical response to human-induced crisis. It is argued that the methodological openness of phenomenology to imaginative variation can foster explorations beyond the human, while curbing the hubris of claiming to speak for the nonhuman world, and that a phenomenological orientation may avoid neutralizing the perspectives of those suffering intra-human harms in the context of environmental injustice while maintaining the human as the respondent in calls for environmental reckoning. (shrink)

Drawing on a variety of discourses, from religion, philosophy, and political thought, to cultural criticism, social theory, and the arts,The Ideas That Made America: A Brief History shows how ideas have been major forces in American history, driving movements such as transcendentalism, Social Darwinism, conservatism, and postmodernism.

In this commentary, we review evidence that production-based (perceiver-independent) measures reveal few consistent sex differences in emotion. Further, sex differences in perceiver-based measures can be attributed to retrospective or dispositional biases. We end by discussing an alternative view that women might appear to be more emotional because they are more facile with emotion language.

We make decisions all day, don't we? Do I pick up the dog's poop when I take him for his walk? Should I tell Mom where I really went after school? When I see something wrong happening, what should I do? Making a good choice, doing the right thing, or even knowing right from wrong can be hard! In What Would You Do? ​you can practice making hard decisions and have some fun while we explore some everyday dilemmas!​.

These are the words Achilles speaks to Hektor, whom he has just struck with a fatal blow. He reminds the son of Priam how, after stripping Patroklos’ fallen body, Hektor made off with the fallen man's armour, which is Achilles’ own.

As the detrimental effects of human agency loom large in the ‘Anthropocene’, theologians and philosophers have called for restraint by invoking the concept of kenosis. Although a ‘self-emptying’ form of life helps to counter the ways that humans are increasingly driving other species to extinction, we argue that such calls are often compromised by relying on notions of the Creator’s own attenuated or self-limited agency. They therefore trade in a competitive construal that is susceptible to the tendency of human agency (...) to either displace, or project itself upon, all other agencies, inadvertently perpetuating the ‘human epoch’. In their place, we critically develop the new direction in kenotic theology that speaks of divine self-realization in history through ‘deep incarnation’. Our constructive proposal argues for a more thoroughgoing recognition of both the transcendence of divine agency and, as a corollary, the diverse agencies of our fellow creatures. (shrink)