The Restoration settlement, the political backcloth to Aubrey's essay, proceeded in two stages. The first, in, saw the rehabilitation of the King and the ...

The feasibility of reversing human aging within a matter of decades has traditionally been dismissed by all professional biogerontologists, on the grounds that not only is aging still poorly understood, but also many of those aspects that we do understand are not reversible by any current or foreseeable therapeutic regimen. This broad consensus has recently been challenged by the publication, by five respected experimentalists in diverse subfields of biogerontology together with three of the present authors, of an article (Ann NY (...) Acad Sci 959, 452–462) whose conclusion was that all the key components of mammalian aging are indeed amenable to substantial reversal (not merely retardation) in mice, with technology that has a reasonable prospect of being developed within about a decade. Translation of that panel of interventions to humans who are already alive, within a few decades thereafter, was deemed potentially feasible (though it was not claimed to be likely). If the prospect of controlling human aging within the foreseeable future cannot be categorically rejected, then it becomes a matter of personal significance to most people presently alive. Consequently, we suggest that serious public debate on this subject is now warranted, and we survey here several of the biological, social and political issues relating to it. BioEssays 24:667–676, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

In recent years, historians of science have increasingly turned their attention to the “print culture” of early modern science. These studies have revealed that printing, as both a technology and a social and economic system, structured the forms and meanings of natural knowledge. Yet in early modern Europe, naturalists, including John Aubrey, John Evelyn, and John Ray, whose work is discussed in this paper, often shared and read scientific texts in manuscript either before or in lieu (...) of printing. Scribal exchange, exemplified in the circulation of writings like commonplace books, marginalia, manuscript treatises, and correspondence, was the primary means by which communities of naturalists constructed scientific knowledge. Print and manuscript were necessary partners. Manuscript fostered close collaboration, and could be circulated relatively cheaply; but, unlike print, it could not reliably secure priority or survival for posterity. Naturalists approached scribal and print communication strategically, choosing the medium that best suited their goals at any given moment. As a result, print and scribal modes of disseminating information, constructing natural knowledge, and organizing communities developed in tandem. Practices typically associated with print culture manifested themselves in scribal texts and exchanges, and vice versa. “Print culture” cannot be hived off from “scribal culture.” Rather, in their daily jottings and exchanges, naturalists inhabited, and produced, one common culture of communication. (shrink)

'almost every branch of modern science can trace phases of its origin in his writings... in the broad field of science Boyle made a greater number and variety of discoveries than one man is ever likely to make again' - John Fulton, Boyle's bibliographer Robert Boyle (1627-91) was one of the most influential scientists and philosophers of the seventeenth century. The founder of modern chemistry, he headed the movement that turned it from an occult science into a subject well-grounded (...) in experiment, sound methodology and observation. His pioneering experiments on the properties of gases and his mechanistic theory of matter are the forerunners of the modern theories of chemical elements and atomic theory. He is best known for founding the renowned Boyle Lectures and for Boyle's Law that states that the pressure and volume of a gas are inversely proportional. A founding fellow of the Royal Society, three consecutive kings of England conversed familiarly with him. Philosophically, he wrote with sophistication on atheism, atomism, epistemology, miracles and natural laws. He influenced Berkeley, Spinoza, Henry More and especially John Locke, who relied on Boyle's theory of primary and secondary qualities in his Essay Concerning Human Understanding. Boyle's circle of correspondents included Newton, Locke, Aubrey, Oldenburg and Hartlib, and his influence on both British and European scholars was enormous. He also took a lead part in examining the relation of science to theology. This is the standard edition of Boyle's works and the only complete collection currently available. First published in 1772, it brings together his many and varied writings in one comprehensive, fully-indexed source. Covering his work in chemistry, philosophy and theology, it includes a Life of Boyle by Thomas Birch. The Thoemmes reprint of the second and best English edition features a new introduction by Peter Alexander, one of the world authorities on Boyle. --includes a Life of Boyle by Thomas Birch --features letters to and from Boyle --this rare edition is the only complete collected edition currently available and the standard text to which literature on Boyle refers --engraved frontispieces and several fold-out illustrations. (shrink)

There are two main groups of essays in this volume. The first centres on Locke's theories of religion and their relation to contemporary scientific thought and the work of Descartes, Leibniz and Hume. The second group explores the relation between biology and physiology, and the science of man.

Will enable the ordinary person to discover his or her own unique life myth and live it from moment to moment.

The principle of "organism"—of intrinsic and dynamic unity—and the existence of "organized bodies"—of living things—in the physical world represented crucial preoccupations for philosophers of nature and experimental naturalists across the eighteenth century. How to make sense of these in a manner consistent with a unified scientific understanding of the physical world became the inevitable challenge that accompanied these recognitions. In just this theoretical enterprise, Leibniz emerges to historical scrutiny as an indispensable and pervasive influence. Thus, we are very fortunate to (...) have the body of scholarship that François Duchesneau has devoted to this topic over the course of his illustrious career. In this... (shrink)

Double effect reasoning is central to Catholic moral theology. It is the principle which enables it to maintain absolute moral standards while effectively handling morally difficult choices which entail bringing about some evil as well as the good. DER has been focused on the way in which it applies to human agents and their relation to bringing about evil as well as the good. According to DER, only the good can be brought about intentionally; evil can only be brought about (...) as the side effect of the good. It will be argued that DER also applies to God’s choices. It is our best resource for understanding God’s relation to evil in the world He creates. (shrink)

I told the workers they had to be prepared for the tortures of success. Success in our business, the trade union business, means getting workers to middle-class status. You succeed and Huelga is just going to be an exciting recollection. The guy who carried a banner in 1966—well, in five years you're going to have a hard time getting him to a union meeting: Revolutions become institutions, that's a truism of our business.

It is in the complex interplay of silence, speech, and action that Zumbrunnen teases out the meaning of democracy for Thucydides in both its domestic and international dimensions and shows how we may benefit from the Thucydidean text in ...

"John Anton introduces the reader to the poetry and poetics of Constantine P. Cavafy from a different perspective. He traces Cavafy's development during the early phases of the poet's creativity, when he was gradually discovering his poetic self, until he finally created his own authentic voice. Autobiographical elements in Cavafy's poems are introduced mainly as guides to explore one aspect of Cavafy's world: how he gradually learned to control the transformation of experience into "work in progress". Professor Anton clearly (...) portrays Cavafy's quality of thought, his originality, the freshness of his imagery and his penetrating commentary on the human condition. The author also provides details of the historical background of ancient Alexandria, which formed one of the key ways whereby Cavafy recreated the city for himself and used it to develop his unique poetic vision."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:All was this land full fill'd of faerie," or Magic and the Past in Early Modern EnglandLauren KassellI.In 1625 Gabriel Naudé (1600–53), student of medicine and up-and-coming librarian, wrote a history of magic.1 Paracelsianism had been debated in France for decades, and in 1623 Naudé had lent his pen to the controversy following the hoax appearance of bills posted in Paris announcing the arrival of the Fraternity of the (...) Rosy Cross and the wonders they could provide. The impetus for Naudé's history of magic was a pamphlet that described Homer and Virgil, abusively, as magicians. As Didier Kahn has shown, Naudé's 1623 intervention against the Rosicrucians wrested a brewing dispute about Paracelsianism from the hands of theologians and settled it in the name of reason, not religion; his medical training no doubt informed his intervention.2 In his history of magic Naudé complained that everyone who ever did anything clever was now reputed to be a magician, which meant in league with the devil. His project was to clear the ground of the [End Page 107] false histories that had been written for the previous two hundred years. Adopting a mode of historia litteraria, he redeemed the reputations of several dozen learned men—including Zoroaster, Socrates, Roger Bacon, Agrippa, and ultimately Virgil—whose names had been sullied by the term magician.3The branding of natural philosophers and especially mathematical practitioners as magicians had been an enduring problem.4 As John Aubrey would later reflect in notes on the life of the Oxford scholar Thomas Allen, "In those darke times Astrologer, Mathematician, and Conjurer, were accounted the same thing."5 But Naudé provides an elaborate account of why these accusations initially might have been fabricated—jealousy, incredulity, malice, fear of technology—and demonstrates a method for unmasking these errors. Follow the simple rules of good scholarship, he insists: read the best authors, think logically, and acquire "a certain familiarity with the most profitable Sciences, and the most universal and general account of the affairs of this World that may be had, which is to be gained partly by our own industry, partly by the endeavors of those who have gone before us, such as may be those of Historians."6 That is, through hard work and the help of other historians, understand the context in which these texts were written. Perfect historians are indispensable; false historians should be read with caution.7 If one encounters a fabulous tale, locate its textual sources, read critically, and remember that (many) historians vend rubbish.8 Naudé surveys a vast literature dating from antiquity through the sixteenth century, demonstrating that misreadings of tropes and irony, for instance, have led to the labeling of poets and natural philosophers as magicians.9 Likewise, where people have professed their magical powers, Naudé is careful to show that writing books about magic and boasting about one's expertise are not the same thing as practicing magic.10 These fables persist because authors repeat what others have written without applying the above principles of good research; they write for their own glory instead of doing proper research; and they show off their polymathic skills by assembling great [End Page 108] heaps of examples instead of making sense of them. Thus the noble name of history is built upon a monstrous edifice of fables.11In short, prompted by festering occultism and religious controversies in Paris, Naudé wrote a history of magic in order to release the great men of learning from the label of magician. This is a history of the "first appearance of learning, the first rising of the great wits, the time they flourished, the ages which have brought forth most, and take notice by the way, how that ignorance hath always persecuted them with this calumny"; he defines magic historically.12 Great learning and suspicion of its demonic sources are inseparable. Through pragmatic reading, Naudé redeems scholars who have been called magicians, and shifts the onus of explanation away from these learned men and onto historians and their incredulous readers.13 Poor histories are written by men guilty of pride and malice. These fables persist because... (shrink)

Abstract: Contrary to received opinion, Descartes' view on the merits of the ontological proof may actually agree with that of Thomas Aquinas, whose rejection of the a priori existence proof has stocked the armories of anti-Anselmians ever since. In a rarely noted passage of the First Replies, Descartes claims not to differ in any respect from Thomas on the proof, a claim that gains sense in light of recent work on the Fifth Meditation. That work in turn reveals a well-founded, (...) if surprising, understanding of the Cartesian proof and of Cartesianism's true relation to Thomism. (shrink)

When a collective is blamed, the responsibility does not escape individuals. Spheres of influence are designed to determine the scale of blame; namely, by proximity and ability to influence a different result. Agents in the respective role types will be responsible upon our examining their extent of influence. Although you may be inclined to say that the responsibility lies with those who have access to policy-making, this doesn't allow for the deviants we expect at appropriate times. Here we are compelled (...) to seek a new moral outlook that maintains our perception of ourself: “what is not worthy of me must not be confused with special requirements of my ‘station and its duties’.”This essay offers a direction to assuage Lewis's fears toward collective responsibility. The challenges to individual responsibility behind such an ascription is complex but need not obliterate it. The delineation of roles by spheres of influence and activity gives some markers to the culpable agents. (shrink)

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.