本书包括:尼采体验的永恒回归、基督教道德与愤恨、尼采对意志的拒拆、查拉图斯特拉的戏剧、游牧思想、尼采的形而上学等内容。.

Seventeenth-century optics naturalizes the eye while estranging the mind from objects. A mere screen, on which rests a blurry array of light stains, the eye no longer furnishes the observer with genuine re-presentations of visible objects. The intellect is thus compelled to decipher flat images of no inherent epistemic value, accidental effects of a purely causal process, as vague, reversed reflections of wholly independent objects. Reflecting on and trespassing the boundaries between natural and artificial, orderly and disorderly, this optical paradox (...) is a Baroque phenomenon; and it is the origin of Descartes’ celebrated doubt---whether we know anything at all. (shrink)

Background: Chinese Taoist cognitive therapy (CTCT), a culture-oriented psychological therapy for Chinese mental well-being, has been proposed for decades. However, the evidence for its effects is unclear. This study aimed to systematically assess the effect of this therapy on symptoms of depression and anxiety in Chinese adults. Methods: Relevant studies were searched from major electronic databases through November 2018 without language limits. Several search terms used include “anxiety” OR “depression” AND “Taoism” OR “Daoism” OR “Chinese Taoist Cognitive Therapy”. A total (...) of 11 clinical trials focusing on CTCT were included in this meta-analysis. Random-effects meta-analytical models were conducted. Heterogeneity and publication bias were also explored. Results: Eight clinical trials for 580 subjects were included. The majority of these studies explored samples with depressive symptoms. Overall, CTCT significantly reduced depressive symptoms with a small positive effect (SMD = 0.16, 95% CI: -0.36-0.68). Medium-to-large effect sizes were observed across individuals with clinical or nonclinical depression and chronic physical diseases (SMD = 0.70, 95%CI: 0.27-1.13 and SMD = 0.72, 95%CI: 0.09-1.35, respectively). However, the effectiveness for anxiety symptoms remains debatable. Conclusions: Our findings hold promise that CTCT can help reduce depressive symptoms in Chinese adults, including patients with chronic physical diseases and clinical or nonclinical depression. Our findings may be generalized to Chinese communities in other countries. (shrink)

In the recent years, gesture recognition based on the surface electromyography (sEMG) signals has been extensively studied. However, the accuracy and stability of gesture recognition through traditional machine learning algorithms are still insufficient to some actual application scenarios. To enhance this situation, this paper proposed a method combining feature selection and ensemble extreme learning machine (EELM) to improve the recognition performance based on sEMG signals. First, the input sEMG signals are preprocessed and 16 features are then extracted from each channel. (...) Next, features that mostly contribute to the gesture recognition are selected from the extracted features using the recursive feature elimination (RFE) algorithm. Then, several independent ELM base classifiers are established using the selected features. Finally, the recognition results are determined by integrating the results obtained by ELM base classifiers using the majority voting method. The Ninapro DB5 dataset containing 52 different hand movements captured from 10 able-bodied subjects was used to evaluate the performance of the proposed method. The results showed that the proposed method could perform the best (overall average accuracy 77.9%) compared with decision tree (DT), ELM, and random forest (RF) methods. (shrink)

Due in large part to the trends towards economic globalization, English has become the most widely disseminated and ubiquitous international language. The purpose of the study was to investigate what Taiwan?s EFL teachers at the elementary level believe about the policy of English as a compulsory subject and how they perceive the benefits and obstacles of the policy?s implementation. Ten elementary English teachers in Tainan City and its suburban areas participated in this study. Data were collected through teachers? interviews, classroom (...) observation and document analysis. Results found that all ten teachers agreed with the policy for English as a compulsory subject at the elementary level. They observed both positive and negative sides of this top?down policy. Classroom observation and interview data revealed that EFL teachers had to plan their English classes with the constraints on a large class of students with mixed levels of proficiency, limited teaching hours and resources. Parents? expectations of and attitudes towards English learning also became an obstacle. (shrink)

Histone post-translational modifications play important roles in transcriptional regulation. It is known that multiple histone modifications can act in a combinatorial manner. In this study, we investigated the effects of multiple histone modifications on expression levels of five gene categories in coding regions. The combinatorial patterns of modifications for the five gene categories were also studied in the regions. Our results indicated that the differences in the expression levels between any two gene categories were significant. There were some corresponding differences (...) in multiple histone modification levels among the five gene categories. Multiple histone modifications jointly impacted expression levels of every gene category. Four mutual combinations of histone modifications were found and analyzed. (shrink)

With the advent of the era of artificial intelligence, deep reinforcement learning has achieved unprecedented success in high-dimensional and large-scale artificial intelligence tasks. However, the insecurity and instability of the DRL algorithm have an important impact on its performance. The Soft Actor-Critic algorithm uses advanced functions to update the policy and value network to alleviate some of these problems. However, SAC still has some problems. In order to reduce the error caused by the overestimation of SAC, we propose a new (...) SAC algorithm called Averaged-SAC. By averaging the previously learned action-state estimates, it reduces the overestimation problem of soft Q-learning, thereby contributing to a more stable training process and improving performance. We evaluate the performance of Averaged-SAC through some games in the MuJoCo environment. The experimental results show that the Averaged-SAC algorithm effectively improves the performance of the SAC algorithm and the stability of the training process. (shrink)

Educators themselves and their knowledge are the most significant elements in learners’ success and achievement; however, there is little information about the specialized knowledge held by educators. Recently, conceptualizing educator knowledge has become a complicated issue that involves that the comprehension of important basic phenomena, such as the procedure of educating and learning, the notion of knowledge, and the way educators’ knowledge, has become practical within the class. Technological Pedagogical Content Knowledge was presented as a theoretical structure for the knowledge (...) base because educators have to efficiently instruct with technology and it is regarded as a valuable framework for explaining and understanding technology integration into various academic environments, such as English as a Foreign Language class. This paper is intended to review the related literature on the role of an English teacher using the TPACK framework for teaching English and their role in students’ achievement. Based on the related literature, there is a significant and direct association between EFL teachers’ TPACK and EFL students’ achievement. Succinctly, some recommendations have been proposed for educational stakeholders. (shrink)

Fezf1 and Fezf2 are highly conserved transcription factors that were first identified by their specific expression in the anterior neuroepithelium of Xenopus and zebrafish embryos. These proteins share an N‐terminal domain with homology to the canonical engrailed repressor motif and a C‐terminal DNA binding domain containing six C2H2 zinc‐finger repeats. Over a decade of study indicates that the Fez proteins play critical roles during nervous system development in species as diverse as fruit flies and mice. Herein we discuss recent progress (...) in understanding the functions of Fezf1 and Fezf2 in neurogenesis and cell fate specification during mammalian nervous system development. Going forward we believe that efforts should focus on understanding how expression of these factors is precisely regulated, and on identifying target DNA sequences and interacting partners. Such knowledge may reveal the mechanisms by which Fezf1 and Fezf2 accomplish both independent and redundant functions across diverse tissue and cell types. (shrink)

Ethiopian Jewish immigrants in Israel are one of the most ancient communities in the world, one that has been detached from the known Jewish world for about 2,500 years. Throughout this very long period of isolation, the Ethiopian Jewish community maintained Jewish tradition and dreamed over the centuries to unite with the rest of the Jewish world and immigrate to the Jewish state—Israel. But this transition occurred within a short time from an agrarian society in Ethiopia (traditional culture) with an (...) oral culture to a knowledge society in Israel (modern culture) with a written culture. Most studies that examine cultural transition focus on anthropological, sociological, and cultural aspects; but there are nearly no studies that examine the technological knowledge of non-literate populations. The purpose of this study is to examine and characterize technological knowledge among this population—the case of Ethiopian non-literate immigrants in Israel. The study involved in-depth interviews to examine technological knowledge through using technological appliances in their everyday life, assembly of two simple technological systems, and a home technology profile compared to the general population in Israel. Participants included 50 non-literate Ethiopian immigrants between the ages of 40–60. The results of our study are surprising in that we have shown that non-literate immigrants adapt to a technology-rich environment at an average degree with respect to the general population in Israel. Also, comparing technological knowledge between traditional and modern cultures shows participants’ wide range of knowledge without ability to read and write. Illiteracy does not preclude the development of knowledge in general, technological knowledge particularly, and does not prevent non-literate populations from acquiring knowledge in a new environment. (shrink)

This book is an abridged version of Feng Qi’s two major works on the history of philosophy, The Logical Development of Ancient Chinese Philosophy and The Revolutionary Course of Modern Chinese Philosophy. It is a comprehensive history of Chinese philosophy taking the reader from ancient times to the year 1949. It illuminates the characteristics of traditional Chinese philosophy from the broader vantage point of epistemology. The book revolves around important debates including those on “Heaven and humankind” (tian ren天人), “names and (...) actualities” (mingshi名實), “principle and vital force” (liqi理氣), “the Way and visible things” (daoqi道器), “mind and matter/things” (xinwu心物), and “knowledge and action” (zhixing知行). Through discussion of these debates, the course of Chinese philosophy unfolds. Modern Chinese philosophy has made landmark achievements in the development of historical and epistemological theory, namely the “dynamic and revolutionary theory of reflection”. However, modern Chinese philosophy is yet to construct a systematic overview of logic and methodology, as well as questions of human freedom and ideals. Amid this discussion, the question of how contemporary China is to “take the baton” from the thinkers of the modern philosophical revolution is addressed. (shrink)

Background: Greater vulnerability to negative emotions appears associated with the development and maintenance of eating disorders. A systematic review of psychophysiological studies using emotion-eliciting film clips reveals that there are no studies examining the effect of standardized validated film clips on psychophysiological response across a range of EDs.Methods: Using standardized validated film clips without ED-specific content, the present study examined self-reported emotions and psychophysiological responses of women with Binge-Eating Disorder, Anorexia Nervosa, Bulimia Nervosa, and Healthy Controls at Baseline, during Neutral, (...) Sad, Happy, and Fear-inducing film clips, and at Recovery.Results: Throughout the protocol, the ED groups reported significantly greater sadness and anxiety than HCs. Additionally, the AN group reported more fear, the BED group more frustration, and the BED and BN groups more tension than HCs. Compared to HCs, the BED group reported stronger urges to binge throughout the protocol, whereas BN group reported stronger urges to binge relative to the HC group only at Baseline and Recovery. The BN and BED groups experienced decreased urges to binge during all film clips compared to Baseline. Respiratory Sinus Arrhythmia levels were significantly lower in the BED group compared to HCs and the BN group throughout the protocol.Discussion: Standardized validated film clips can be used to elicit expected self-reported emotion and skin conductance responses in ED groups, although individuals with EDs compared HCs report greater negative emotions. Interestingly, film clips appeared to reduce urges to binge in binge-eating groups. (shrink)

For unmanned aerial vehicle, object detection at different scales is an important component for the visual recognition. Recent advances in convolutional neural networks have demonstrated that attention mechanism remarkably enhances multiscale representation of CNNs. However, most existing multiscale feature representation methods simply employ several attention blocks in the attention mechanism to adaptively recalibrate the feature response, which overlooks the context information at a multiscale level. To solve this problem, a multiscale feature filtering network is proposed in this paper for image (...) recognition system in the UAV. A novel building block, namely, multiscale feature filtering module, is proposed for ResNet-like backbones and it allows feature-selective learning for multiscale context information across multiparallel branches. These branches employ multiple atrous convolutions at different scales, respectively, and further adaptively generate channel-wise feature responses by emphasizing channel-wise dependencies. Experimental results on CIFAR100 and Tiny ImageNet datasets reflect that the MFFNet achieves very competitive results in comparison with previous baseline models. Further ablation experiments verify that the MFFNet can achieve consistent performance gains in image classification and object detection tasks. (shrink)

Transcutaneous auricular vagus nerve stimulation, a non-invasive alternative to vagus nerve stimulation with implantable devices, has shown promise in treating disorders such as depression, migraine, and insomnia. Studies of these disorders with resting-state functional magnetic resonance imaging have found sustained changes in resting-state functional connectivity in patients treated with low frequency taVNS. A recent study has reported reductions in pain scores in patients with rheumatoid arthritis after a 12-week treatment of high-frequency sub-threshold taVNS. However, no studies to date have examined (...) the effects of high-frequency sub-threshold taVNS on rsFC. The objective of this study was to determine whether high-frequency sub-threshold taVNS induces changes in rsFC using seed regions from the cingulate cortex and insula, brain regions that play a key role in interoception and processing of pain. With a single-blind placebo-controlled repeated measures experimental design, rsfMRI scans were acquired before and after 15 min of either sub-threshold taVNS treatment or a sham control. Significant taVNS-related changes in functional connections to the cingulate cortex were detected between the anterior cingulate cortex and right superior temporal gyrus and between the midcingulate cortex and right inferior parietal lobule. In addition, significant changes in functional connections to the insula were detected between the posterior insula and right precuneus and between the anterior insula and right cuneus gyrus. These results suggest that high-frequency sub-threshold taVNS can lead to sustained effects on the rsFC of brain regions involved in interoception and processing of pain in a cohort of healthy subjects. This study lays the foundation for future rsfMRI studies of high-frequency sub-threshold taVNS in clinical populations. (shrink)

In this final lecture, I used instructions coming from the outside as well as rhetorical philosophy up to the achievements of the United States in the way, cited the following as high as 20 U.S. I think that the achievements in philosophy, this 20 achievements are as follows: 1. Re- definition of hermeneutics, resulting in a "philosophical hermeneutics" . understand the concern of the moment rather than the ability to explain the object. 3 allows us to explain thus an awareness (...) event. 4 to become a historical understanding of events . 5 from the hermeneutic methodology In order to understand the events into ontology. 6 to understand a sight change and self-understanding of the event. 7 principles of change as history, literature and art. 8 offers a new aesthetic and poetics. 9 provides a way to deal with representational and abstract art of art. 10 and then regardless of the art real management problem. 11 reaffirmed the non-scientific literature and hermeneutics in true sense. 12 In order to read the classical works of the original to provide a new treatment. 13 new associate with the traditional relationship. 14 the art of interpretation be linked to a reading process. 15 In order to have affected the critical nursing science, history, sociology, etc. methods. 16 criticism of the limitations of the natural scientific thinking. 17 critique of modernity . 18 provides a large amount of pull on the Park map , Hegel and Heidegger books. 19 He described the dialogue by way of consultations In order to understand the contribution. 20. Tree up hermeneutics of tradition and openness to other cultures of the ancient model. With this eight p.m. description of achievements, but also showing a structure of these nine days the future of speech. In this final lecture I take an approach from the outside and ask what Gadamer has achieved in philosophy, then list twenty of what I see as his philosophical accomplishments. These achievements are as follows: 1. Redefines hermeneutics, creating a "philosophical hermeneutics." 2. Focuses on the moment of uptake instead of the object of interpretation. 3. Makes us aware of interpretation as an event. 4. Makes the event of understanding an historical event. 5. Changes hermeneutics from a methodology to an ontology of the event of understanding. 6. Makes understanding an event of transformation of horizon and self-understanding. 7. Transforms history, literature and art as disciplines. 8. Offers a new aesthetics and a new poetics. 9. Offers a view of art that is able to deal with representation and nonrepresentational art. 10. Reintroduces the question of truth in art. 11. Revalidates literature and humanities as true in a nonscientific sense. 12. Offers a new rationale for reading the classics. 13. Forges a new relationship to tradition . 14. Relates interpretation of art to the reading process. 15. Offers a critique of method that has influenced nursing, history, sociology, etc. 16. Offers a critique of the limits of scientific thinking. 17. Offers a critique of modernity. 18. Offers major books on Plato, Hegel, and Heidegger. 19. In describing dialogue in understanding, he contributes to understanding negotiation. 20. Sets an example of hermeneutical openness to tradition, antiquity, and other cultures. The framework of these lectures during these nine day is presented through accounting for the twenty achievements. (shrink)

Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort antibiotic has been challenged by the recent emergence of the mobile Tet(X) orthologs that can confer high‐level tigecycline resistance. As it is reviewed here, these novel tetracycline destructases represent a growing threat to the next‐generation tetracyclines, and a basic framework for understanding the molecular epidemiology and (...) resistance mechanisms of them is presented. However, further large‐scale epidemiological and functional studies are urgently needed to better understand the prevalence and dissemination of these newly discovered Tet(X) orthologs among Gram‐negative bacteria in both human and veterinary medicine. (shrink)

本书介绍了证据法学的基本知识、基本理论,并以科学性、准确性为原则来解决实务问题。.

This study investigated the possible prosodic transfer influences native regional dialects may have in the perception of English lexical stress by speakers of three Chinese dialects [Beijing (BJ), Changsha (CS), and Guangzhou (GZ)] compared to 20 American English (AE) speakers. F0, duration, intensity, and vowel reduction were manipulated in nonce disyllabic words. Participants performed four-word sequence recall tasks to identify lexical stress location. They performed better with natural sounds than with manipulated words. This study focused on the performance differences in (...) manipulating words. The results showed that all four-group members performed similarly processing F0 condition nonce words. BJ and CS participants were more accurate than GZ participants in duration and vowel reduction cues. Reaction time (RT) suggested that the processing time of acoustic cues differed significantly across language groups. The findings indicate that first language (L1) dialect effect is robust in second language (L2) stress perception tasks. (shrink)

In tone languages, some case studies showed that the word-level tonal representation was closely related to the underlying metrical pattern. Based on different tonal patterns in prosodic units, the metrical structures could generally be divided into the left- and right-dominant types in Chinese dialects. Yet the cross-dialectal phonetic realizations (e.g., duration and pitch) between or within these two metrical structures were still unrevealed. The current study investigated the duration and pitch realizations of disyllabic prosodic words in Changsha and Chengdu dialects (...) (the left-dominant structure), and in Fuzhou and Xiamen dialects (the right-dominant structure). Results showed that not all the duration patterns across four Chinese dialects were sensitive to different metrical structures, indicating that the duration might not be the universal cue for metrical prominence in Chinese dialects. In terms of pitch realization across all the four Chinese dialects, level tones (sometimes falling tones) generally appeared in the metrically weak unit, while underlying pitch forms appeared in the metrically strong unit. Compared with duration, pitch might be more robust for prosodic realizations of metrical structures in Chinese dialects. Furthermore, there was an interaction between duration and pitch patterns in Chinese dialects, which could shed new light on the phenomenon of “metrical tone sandhi”. Meanwhile, this study also provides some references for the judgment of the metrical stress and prosodic realizations in other Chinese dialects. (shrink)

In this study, we conducted a pseudosign repetition task with 22 children acquiring American Sign Language as a first language from deaf parents. Thirty-nine pseudosigns with varying complexity were developed and organized into eight categories depending on number of hands, number of simultaneous movement types, and number of movement sequences. Pseudosigns also varied in handshape complexity. The children’s performance on the ASL pseudosign task improved with age, displaying relatively accurate production of location and orientation, but much less accurate handshape and (...) movement, a finding in line with real sign productions for both L1 and L2 signers. Handshapes with higher complexity were correlated with lower accuracy in the handshape parameter. We found main effects of sequential and simultaneous movement combinations on overall performance. Items with no movement sequence were produced with higher overall accuracy than those with a movement sequence. Items with two simultaneous movement types or a single movement type were produced with higher overall accuracy than those with three simultaneous movement types. Finally, number of hands did not affect the overall accuracy. Remarkably, movement sequences impose processing constraints on signing children whereas complex hands and two simultaneous movement types do not significantly lower accuracy, indicating a capacity for processing multiple simultaneous components in signs. Spoken languages, in contrast, manifest greater complexity in temporal length. Hearing children’s pseudoword repetition still displays high levels of accuracy on disyllabic words, with complexity effects affecting only longer multisyllabic words. We conclude that the pseudosign repetition task is an informative tool for studies of signing children’s phonological development and that sheds light on potential modality effects for phonological development. (shrink)