Nuclear speckles are eukaryotic nuclear bodies enriched in splicing factors. Their exact purpose has been a matter of debate. The different proposed roles of nuclear speckles are reviewed and an additional layer of function is put forward, suggesting that by accumulating splicing factors within them, nuclear speckles can buffer the nucleoplasmic levels of splicing factors available for splicing and thereby modulate splicing rates. These findings build on the already established model that nuclear speckles function as a storage/recycling site for splicing (...) factors. Many studies have demonstrated proximity between nuclear speckles and sites of active transcription, suggesting that this juxtaposition can enhance the rates of gene expression. It is found that nuclear speckle disassembly increases splicing factor availability in the nucleoplasm, leading to an increase in splicing rates and faster release of nascent transcripts from the gene after transcription. Altogether, this era in which genomic and imaging approaches are applied to study nuclear organization has expanded the outlook on the possible roles of nuclear speckles. (shrink)

Medicine has undergone substantial changes in the way medical dilemmas are being dealt with. Here we explore the attitude of Israeli physicians to two debatable dilemmas: disclosing the full truth to patients...

A collection of essays in French or English on the reception of Cartesian philosphy.

In recent years, facial difference is increasingly on the public and academic agenda. This is evidenced by the growing public presence of individuals with an atypical face, and the simultaneous emergence of research investigating the issues associated with facial variance. The scholarship on facial difference approaches this topic either through a medical and rehabilitation perspective, or a psycho-social one. However, having a different face also encompasses an embodied dimension. In this paper, we explore this embodied dimension by interpreting the stories (...) of individuals with facial limb absence against the background of phenomenological theories of the body, illness and disability. Our findings suggest that the atypical face disrupts these individuals’ engagement with everyday projects when it gives rise to disruptive perceptions, sensations, and observations. The face then ceases to be the absent background to perception, and becomes foregrounded in awareness. The disruptions evoked by facial difference call for adjustments: as they come to terms with their altered face, the participants in our study gradually develop various new bodily habits that re-establish their face’s absence, or relate to its disruptive presence. It is through these emergent habits that facial difference comes to be embodied. By analyzing the everyday experiences of individuals with facial limb absence, this article provides a much-needed exploration of the embodied aspects of facial difference. It also exemplifies how a phenomenological account of illness and disability can do justice both to the impairments and appearance issues associated with atypical embodiment. (shrink)

Judäa—Syria Palästina. By Werner Eck. Texts and Studies in Ancient Judaism, vol. 157. Tübingen: Mohr Siebeck, 2014. Pp. xiv + 307. €119.

Describes Israel's transformation from a society held together by national liberation to a liberal democracy that must make room for individual Israelis.

Words become associated following repeated co-occurrence episodes. This process might be further determined by the semantic characteristics of the words. The present study focused on how semantic and episodic factors interact in incidental formation of word associations. First, we found that human participants associate semantically related words more easily than unrelated words; this advantage increased linearly with repeated co-occurrence. Second, we developed a computational model, SEMANT, suggesting a possible mechanism for this semantic-episodic interaction. In SEMANT, episodic associations are implemented through (...) lateral connections between nodes in a pre-existent self-organized map of word semantics. These connections are strengthened at each instance of concomitant activation, proportionally with the amount of the overlapping activity waves of activated nodes. In computer simulations SEMANT replicated the dynamics of associative learning in humans and led to testable predictions concerning normal associative learning as well as impaired learning in a diffuse semantic system like that characteristic of schizophrenia. (shrink)

KANT’S GOAL IN THE TRANSCENDENTAL DEDUCTION was to demonstrate that the categories are applicable to objects of sensible intuition. He carried out this task by disclosing the necessity of a transcendental synthesis. In the Transcendental Deduction in the second edition of the Critique of Pure Reason transcendental synthesis has two subspecies: synthesis intellectualis and synthesis speciosa. The distinction between the two types of transcendental synthesis is also mirrored in the structure of the proof of the B Deduction. As several commentators (...) have noted, the B Deduction in fact contains two parts. Each part seems to provide an account of a distinctive kind of transcendental synthesis. The first part provides an account of intellectual synthesis while the second part provides an account of figurative synthesis. (shrink)

Responding to growing public anxiety about the current state of democracy, this book will appeal to scholars in political theory, history and anthropology, as well as to the wider educated public. It provides an analysis of changes in the deep structure of Western democracy offering new imaginaries of political order.

In analogy with Rousseau's concept of ?civil religion? as a system of ?positive dogmas?, ?without which?, as he observed, ?a man cannot be a good citizen?, this paper advances the concept of ?civil epistemology? as the positive dogmas without which the agents of government actions cannot be held accountable by democratic citizens. The civil epistemology of democracy shapes the citizen's views on the nature of political reality, on how the facts of political reality can be known and by whom. Modern (...) liberal democratic politics assumes that the exercise of political power can be manifest in a visible domain of publicly accessible facts. It rests on the Enlightenment faith in the powers of light and visibility to demystify political power, render political actors more exposed and therefore more honestly accountable and enlist the sense of sight as a vehicle of universal political participation. It is, in this context, that technology has come to play such an important symbolic role in the construction of the particular democratic genre of public action as a political spectacle. Democratic civil epistemology, and technology ? in the widest sense of the word ? as the prototype of action which can be observed in the field of visual perception, uphold the democratic conception of politics as a view. Together they define political actors as visible performers, journalists as observers (who translate actual seeing into virtual seeing) and the citizens as witnesses. (shrink)

In Kitāb al-Muwashshā, a unique work on good manners and high-culture etiquette, al-Washshāʾ recorded the practices of a group of courtiers and other members of the elite in Abbasid society known as the ẓurafāʾ. This group conducted itself according to a strict etiquette governing dress, posture, speech, and even smell. One of the most interesting practices associated with the ẓurafāʾ is their inscribing of poetry on a variety of objects, from garments, rings, musical instruments, and wine vessels to apples and (...) citron, even on their bodies. This paper examines the practice of inscribing poetry on objects as a unique way of “performing” poetry. In this “refined” practice, poetry was not recited aloud, but rather given a voice by virtue of its physical display in space. (shrink)

Buber proclaims that 'in the beginning was relation'; that man is by his very nature a Homo Dialogus - incapable of realizing himself without communion with man, with the creation and with his Creator.Buber sought to anchor Zionism in what he defined as 'Hebrew Humanism': "the path of holiness" as opposed to "holy egoism".

Most theories and hypotheses in psychology are verbal in nature, yet their evaluation overwhelmingly relies on inferential statistical procedures. The validity of the move from qualitative to quantitative analysis depends on the verbal and statistical expressions of a hypothesis being closely aligned – that is, that the two must refer to roughly the same set of hypothetical observations. Here, I argue that many applications of statistical inference in psychology fail to meet this basic condition. Focusing on the most widely used (...) class of model in psychology – the linear mixed model – I explore the consequences of failing to statistically operationalize verbal hypotheses in a way that respects researchers' actual generalization intentions. I demonstrate that although the “random effect” formalism is used pervasively in psychology to model intersubject variability, few researchers accord the same treatment to other variables they clearly intend to generalize over (e.g., stimuli, tasks, or research sites). The under-specification of random effects imposes far stronger constraints on the generalizability of results than most researchers appreciate. Ignoring these constraints can dramatically inflate false-positive rates, and often leads researchers to draw sweeping verbal generalizations that lack a meaningful connection to the statistical quantities they are putatively based on. I argue that failure to take the alignment between verbal and statistical expressions seriously lies at the heart of many of psychology's ongoing problems (e.g., the replication crisis), and conclude with a discussion of several potential avenues for improvement. (shrink)

Prosthetic devices that replace an absent body part are generally considered to be either cosmetic or functional. Functional prostheses aim to restore (some degree of) lost physical functioning. Cosmetic prostheses attempt to restore a “normal” appearance to bodies that lack (one or more) limbs by emulating the absent body part’s looks. In this article, we investigate how cosmetic prostheses establish a normal appearance by drawing on the stories of the users of a specific type of artificial limb: the facial prosthesis. (...) Given that prostheses are first and foremost devices worn upon the body, such an analysis requires an understanding of the ways in which bodies and technologies interact. We thus interpret users’ stories by critically engaging with the work of disability researcher and Actor-Network theorist Myriam Winance, as well as with the postphenomenological scholarship of Don Ihde and Peter-Paul Verbeek. Using this framework, we explore users’ attempts to achieve a proper fit between their faces and their prostheses, the technological transparency such a fit enables, and the ways in which transparency mediates users’ everyday exchanges with others. We conclude that a normal appearance, when it is achieved by means of prosthetics, enables the device’s user to navigate a precarious social environment as they encounter and interact with others in public. (shrink)

Can a heritability value tell us something about the weight of genetic versus environmental causes that have acted in the development of a particular individual? Two possible questions arise. Q1: what portion of the phenotype of X is due to its genes and what portion to its environment? Q2: what portion of X’s phenotypic deviation from the mean is a result of its genetic deviation and what portion a result of its environmental deviation? An answer to Q1 provides the full (...) information about X’s development, while an answer to Q2 leaves out a large portion unexplained—that portion which corresponds to the phenotypic mean. Q1 is unanswerable, but I show it is nevertheless legitimate under certain quantitative genetics models. With regard to Q2, opinions in the philosophical and biological literature differ as to its legitimacy. I argue that not only is it legitimate, but in particular, under a few simplifying assumptions, it allows for a quantitative probabilistic answer: for normally distributed quantitative traits with no G-E correlation or statistical G × E interaction, we can assess the probability that X’s genes had a greater effect than its environment on its deviation from the mean population value. This probability is expressed as a function the heritability and the individual’s phenotypic value; we can also provide a quantitative probabilistic answer to Q2 for an arbitrary individual where the probability is a function only of heritability. (shrink)

Kant officially argues that the role of the representation of time in the synthetic a priori judgments of arithmetic and the general theory of motion implies that time must be an a priori condition...

Kant's category of reality is an often overlooked element of his Critique of Pure Reason. Tal Glezer shows that it nevertheless belongs at the core of Kant's mature critical philosophy: it captures an issue that motivated his critical turn, shaped his theory of causation, and established the role of his philosophy of science. Glezer's study traces the roots of Kant's category of reality to early modern debates over the intelligibility of substantial forms, fueled by the tension between the idea of (...) non-extended substances and that of extended objects. This tension influenced Kant's pre-critical work, and eventually inspired his radical break towards transcendental idealism. Glezer explores the importance of reality for Kant's conceptions of cause and force, and sheds new light on his philosophy of physical science, including gravity. His book will interest scholars of Kant and of early modern philosophy, as well as historians of scientific ideas. (shrink)

Henri Bergson (1859-1941) is widely regarded as one of the most original and important philosophers of the twentieth century. His work explored a rich panoply of subjects, including time, memory, free will and humor and we owe the popular term élan vital to a fundamental insight of Bergson's. His books provoked responses from some of the leading thinkers and philosophers of his time, including Einstein, William James and Bertrand Russell, and he is acknowledged as a fundamental influence on Marcel Proust. (...) The Bergsonian Mind is an outstanding, wide-ranging volume covering the major aspects of Bergson's thought, from his early influences to his continued relevance and legacy. 36 chapters by an international team of leading Bergson scholars are divided into five clear parts: Sources and Scene Mind and World Ethics and Politics Reception Bergson and Contemporary Thought. In these sections fundamental topics are examined, including time, freedom and determinism, memory, perception, evolutionary theory, pragmatism and art and aesthetics. Bergson's impact beyond philosophy is also explored in chapters on Bergson and spiritualism, modernism, Proust and post-colonial thought. An indispensable resource for anyone in Philosophy studying and researching Bergson's work, The Bergsonian Mind will also interest those in related disciplines such as Literature, Religion, Sociology and French studies. (shrink)

This thesis engages with central debates on the nature of temporal experience, drawing upon the thought of Henri Bergson. Part one, comprising two chapters, critically explores two issues at the forefront of contemporary research on the experience of time. The first chapter examines attempts by B-theorists of time to address the manifest flow of temporal experience, arguing that these have been thus far unsuccessful. The second chapter focuses on recent articulations of the Process View of temporal experience, according to which (...) temporal experience itself has temporal structure. Recent varieties of the Process View, I argue, do not satisfactorily accommodate the experientially robust insight which provides the most powerful motivation for the position. This insight is captured by what I call the Experiential Process Thesis: we have a pre-reflective sense that our experience of change itself unfolds through time. Part two, comprising three chapters, brings to bear perspectives from Bergson's work on debates concerning temporal experience. The third chapter connects themes from the first two. I argue that Bergson's account of temporal experience provides resources for a successful articulation of the Process View, insofar as it can accommodate the Experiential Process Thesis. What allows us to give shape to the thesis, on Bergson's account, is the explanatory role ascribed to an experiential feature of qualitative flow, which Bergson terms durée. The fourth chapter discusses (i) the relation between memory and temporal experience, and (ii) the unity of experience over time. I suggest that Bergson's account cogently motivates a memory theory of temporal experience - which takes memory to be partially constitutive of immediate temporal experience - in contrast with a recent formulation of the memory account. I then argue that a view of experiential unity over time appealing to Bergson's durée is a theoretically parsimonious and phenomenologically attractive alternative to a number of proposals from the recent literature. In the fifth chapter, I focus on a frequently-discussed feature of 'continuous novelty' in temporal experience. I examine a suggestion from Bergson's work, according to which this aspect is paradigmatically found in a sub-class of agential experiences, namely experiences of creative agency. (shrink)

This review-article of Martha Roth's Law Collections focuses on selected sections in the Laws of Ur-Namma, Eshnunna, Hammurabi, Lipit-Ishtar, and the Neo-Babylonian Laws. It discusses potentially misleading divisions of sections and problems of rendering the term awīlum (lú). It also asserts that students of law will benefit from Roth's translations for generations.

This paper draws attention to an increasingly common method of using computer simulations to establish evidential standards in physics. By simulating an actual detection procedure on a computer, physicists produce patterns of data (‘signatures’) that are expected to be observed if a sought-after phenomenon is present. Claims to detect the phenomenon are evaluated by comparing such simulated signatures with actual data. Here I provide a justification for this practice by showing how computer simulations establish the reliability of detection procedures. I (...) argue that this use of computer simulation undermines two fundamental tenets of the Bogen–Woodward account of evidential reasoning. Contrary to Bogen and Woodward’s view, computer-simulated signatures rely on ‘downward’ inferences from phenomena to data. Furthermore, these simulations establish the reliability of experimental setups without physically interacting with the apparatus. I illustrate my claims with a study of the recent detection of the superfluid-to-Mott-insulator phase transition in ultracold atomic gases. (shrink)

The digital age brings with it novel forms of data flow. As a result, individuals are constantly being monitored while consuming products, services and content. These abilities have given rise to a variety of concerns, which are most often framed using “privacy” and “data protection”-related paradigms. An important, oft-noted yet undertheorized concern is that these dynamics might facilitate the manipulation of subjects; a process in which firms strive to motivate and influence individuals to take specific steps and make particular decisions (...) in a manner considered to be socially unacceptable. That it is important and imperative to battle manipulation carries with it a strong intuitive appeal. Intuition, however, does not always indicate the existence of a sound justification or policy option. For that, a deeper analytic and academic discussion is called for. This Article begins by emphasizing the importance of addressing the manipulation-based argument, which derives from several crucial problems and flaws in the legal and policy setting currently striving to meet the challenges of the digital age. Next, the Article examines whether the manipulation-based concerns are sustainable, or are merely a visceral response to changing technologies which cannot be provided with substantial analytical backing. Here the Article details the reasons for striving to block manipulative conduct and, on the other hand, reasons why legal intervention should be, in the best case, limited. The Article concludes with some general implications of this discussion for the broader themes and future directions of privacy law, while trying to ascertain whether the rise of the manipulation-based discourse will lead to information privacy’s expansion or perhaps its demise. (shrink)

This paper examines Bergson’s position concerning the relation between memory and the immediate experience of change. I argue that Bergson’s view, which has not been discussed in significant detail in the literature, can shed new light upon recent debates on the topic. I approach this in three steps. First, I examine the “memory theory” of immediate temporal experience in its two main forms — a “traditional” version and a “modified” account — situating Bergson’s views vis-à-vis this distinction. Second, I explore (...) a contemporary defence of the memory theory and underline a limitation in this account. Finally, I focus on a feature of Bergson’s reflections on memory and temporal experience that can potentially address this limitation. (shrink)

Jewish Travel in Antiquity. By Catherine Hezser. Texts and Studies in Ancient Judaism, vol. 144. Tübingen: Mohr Siebeck, 2011. Pp. x + 529. €139.

This chapter focuses on the potential second “career” of the banality of evil thesis in the profoundly different context of the Arab-Israeli conflict. Considering the continual violence between the sides, the urgent problem in this context is not only how to understand evil committed in the past, but how to frame it in a way congenial for the social psychology and politics of reconciliation between the antagonistic parties.

Bergson’s influential discussion of durée—the concept at the heart of his dynamic view of time’s reality—emerges from an inquiry into the nature of temporal experience. In this chapter, I outline Bergson’s view of the non-inferential or immediate experience of time, and mark out the place of durée within his account. I underscore the relation between Bergson’s controversial argument concerning number and his view of temporal experience, and contrast Bergson’s notion of ‘immediate experience’ with immediacy as typically understood in contemporary thought. (...) Bergson’s view of the experience of time, I suggest, is a dual-aspect theory in which durée is accorded a fundamental role in relation to the temporal properties of succession, intervals, and simultaneity. (shrink)

There is now considerable evidence that human sentence processing is expectation based: As people read a sentence, they use their statistical experience with their language to generate predictions about upcoming syntactic structure. This study examines how sentence processing is affected by readers' uncertainty about those expectations. In a self-paced reading study, we use lexical subcategorization distributions to factorially manipulate both the strength of expectations and the uncertainty about them. We compare two types of uncertainty: uncertainty about the verb's complement, reflecting (...) the next prediction step; and uncertainty about the full sentence, reflecting an unbounded number of prediction steps. We find that uncertainty about the full structure, but not about the next step, was a significant predictor of processing difficulty: Greater reduction in uncertainty was correlated with increased reading times. We additionally replicated previously observed effects of expectation violation, orthogonal to the effect of uncertainty. This suggests that both surprisal and uncertainty affect human RTs. We discuss the consequences for theories of sentence comprehension. (shrink)

The idea that science teaching in schools should prepare the ground for society's future technical and scientific progress has played an important role in shaping modern education. This idea, however, was not always present. In this article, I examine how this idea first emerged in educational thought. Early in the 17th century, Francis Bacon asserted that the study of nature should serve to improve living conditions for all members of society. Although influential, Bacon's idea was not easily assimilated by educational (...) thinkers who remained committed to the traditional aims of teaching about nature. Yet in the second half of the 18th century a change has occurred; educational thinkers started to embrace Baconian ideas and therefore argued that science teaching should be oriented towards generating future scientific progress. Analysing the work of 18th century French and British educational thinkers, this article links the emergence of this new view to developments in the understanding of natural philosophy and to a rising interest in it. It is argued, however, that in themselves, these developments could not adequately explain why Baconian ideas started to influence educational theory in the time in which they did. It is maintained that the incorporation of Baconian ideas into educational thought resulted from a fundamental theoretical shift in the understanding of the role of education itself. (shrink)

The ArgumentThe main subject examined in this paper is Immanuel Kant's controversy withPhilosophisches Magazinregarding Kant's new theory of judgments. J. A. Eberhard, editor ofPhilosophisches Magazin, and his colleagues wanted to vindicate the Wollfian traditional concept of judgments by undermining Kant's claims. As will be demonstrated, their arguments were effective mainly in exposing the ambiguity that was inherent in Kant's concept of the synthetic a priori; an ambiguity that resulted from Kant's desire—central to his critique of metaphysics—to present judgments pertaining to (...) mathematics, (dogmatic) metaphysics, and pure natural science as judgments which shared a common form. Exposing this ambiguity was not the intended result, and it was insufficient for the purpose of vindicating the Wollfian tradition. The contributors toPhilosophisches Magazinignored the important properties shared by the class of judgments falling under Kant's concept of synthetic a priori judgments. They also ignored the fact that their position was unable to account for the logical phenomena that motivated Kant to present a new theory of judgments. On the other hand, Kant's theory of judgments was insensitive to the important differences that exist among the distinct types of judgments falling under his concept of a synthetic a priori judgment. This latter point is clearly shown in the controversy regarding the novelty of Kant's concept of a synthetic a priori judgment, and in the controversy regarding the function of intuitions within synthetic judgments.A result of the controversy was that Kant's concept of the synthetic a priori, which he believed to be an exact concept, was revealed to be a metaphor: no more than an invitation to view certain intellectual fields in the light of others. On the other hand, Eberhard and his colleagues failed to come up with satisfactory answers to Kant's questions within their traditional concept of judgment. Both parties refused to acknowledge this result. Consequently, the search for a new logic, a new architectonic order, and a new unity within reason became a general problem for the new generation of philosophers. (shrink)