The potential anesthetic neurotoxicity on the neonate is an important focus of research investigation in the field of pediatric anesthesiology. It is essential to understand how these anesthetics may affect the development and growth of neonatal immature and vulnerable brains. Functional magnetic resonance imaging has suggested that using anesthetics result in reduced functional connectivity may consider as core sequence for the neurotoxicity and neurodegenerative changes in the developed brain. Anesthetics either directly impact the primary structures and functions of the brain (...) or indirectly alter the hemodynamic parameters that contribute to cerebral blood flow in neonatal patients. We hypothesis that anesthetic agents may either decrease the brain functional connectivity in neonatal patients or animals, which was observed by fMRI. This review will summarize the effect and mechanism of anesthesia on the rapid growth and development infant and neonate brain with fMRI through functional connectivity. It is possible to provide the new mechanism of neuronal injury induced by anesthetics and objective imaging evidence in animal developing brain. (shrink)

本书把最新反映邓小平哲学思想特色的论述分为:解放思想,实事求是,照辩证法办事,改革是解放和发展生产力的必由之路,面向世界,吸收人类文明成果等10部分加以编辑。.

I offer an interpretation and a partial defense of Kit Fine's ‘Argument from Passage’, which is situated within his reconstruction of McTaggart's paradox. Fine argues that existing A-theoretic approaches to passage are no more dynamic, i.e. capture passage no better, than the B-theory. I argue that this comparative claim is correct. Our intuitive picture of passage, which inclines us towards A-theories, suggests more than coherent A-theories can deliver. In Finean terms, the picture requires not only Realism about tensed facts, but (...) also Neutrality, i.e. the tensed facts not being ‘oriented towards’ one privileged time. However unlike Fine, and unlike others who advance McTaggartian arguments, I take McTaggart's paradox to indicate neither the need for a more dynamic theory of passage nor that time does not pass. A more dynamic theory is not to be had: Fine's ‘non-standard realism’ amounts to no more than a conceptual gesture. But instead of concluding that time does not pass, we should conclude that theories of passage cannot deliver the dynamicity of our intuitive picture. For this reason, a B-theoretic account of passage that simply identifies passage with the succession of times is a serious contender. (shrink)

PurposeThis study aims to develop and validate a stigma scale for Chinese patients with breast cancer.MethodsPatients admitted to the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, for breast cancer treatment participated in this study. Development of the Breast Cancer Stigma Scale involved the following procedures: literature review, interview, and applying a theoretical model to generate items; the Breast Cancer Stigma Scale’s content validity was assessed by a Delphi study and feedback from patients with breast cancer ; (...) exploratory factor analysis was used to assess the construct validity; convergent validity was assessed with the Social Impact Scale ; internal consistency Cronbach’s α, split-half reliability, and test–retest reliability were used to identify the reliability of the scale.ResultsThe final version of the Breast Cancer Stigma Scale consisted of 15 items and showed positive correlations with the Social Impact Scale. Exploratory factor analysis revealed four components of the Breast Cancer Stigma Scale: self-image impairment, social isolation, discrimination, and internalized stigma, which were strongly related to our perceived breast cancer stigma model and accounted for 69.443% of the total variance. Cronbach’s α for the total scale was 0.86, and each subscale was 0.75–0.882. The test–retest reliability with intra-class correlation coefficients of the total scale was 0.947, and split-half reliability with intra-class correlation coefficients of the total scale was 0.911. The content validity index was 0.73–1.0.ConclusionThe newly developed Breast Cancer Stigma Scale offers a valid and reliable instrument for assessing the perceived stigma of patients with breast cancer in clinical and research settings. It may be helpful for stigma prevention in China. (shrink)

Previous neurological studies of shyness have focused on the hemispheric asymmetry of alpha spectral power. To the best of our knowledge, few studies have focused on the interaction between different frequencies bands in the brain of shyness. Additionally, shy individuals are even shyer when confronted with a group of people they consider superior to them. This study aimed to reveal the neural basis of shy individuals using the delta-beta correlation. Further, it aimed to investigate the effect of evaluators’ facial attractiveness (...) on the delta-beta correlation of shyness during the speech anticipation phase. We recorded electroencephalogram activity of 94 participants during rest and anticipation of the public speaking phase. Moreover, during the speech anticipation phase, participants were presented with high or low facial attractiveness. The results showed that, as predicted, the delta-beta correlation in the frontal region was more robust for high shyness than for low shyness during the speech anticipation phase. However, no significant differences were observed in the delta-beta correlation during the baseline phase. Further exploration found that the delta-beta correlation was more robust for high facial attractiveness than low facial attractiveness in the high shyness group. However, no significant difference was found in the low-shyness group. This study suggests that a stronger delta-beta correlation might be the neural basis for shy individuals. Moreover, high facial attractiveness might enhance the delta-beta correlation of high shyness in anticipation of public speaking. (shrink)

Recent studies have indicated that trait procrastination as a personality factor could lead to mobile phone addiction, however little is known about the mediating and moderating mechanisms underlying this process. The current study investigated the mediating role of stress in the relationship between trait procrastination and mobile phone addiction, and whether the mediating effect was moderated by gender. A sample including 1,004 Chinese college students completed measurements of trait procrastination, stress, mobile phone addiction, and demographic information. The results showed that (...) trait procrastination was positively related to college students’ mobile phone addiction. Mediation analyses revealed that this relationship was partially mediated by stress. Moderated mediation further indicated that the path between trait procrastination and stress was stronger for male students compared with female students. These findings broadened our knowledge of the underlying mechanisms between trait procrastination and mobile phone addiction, the implications and limitations of this study were discussed. (shrink)

Present-bias is the preference, all else being equal, for positive events to be located in the present rather than the non-present, and for negative events to be located in the non-present rather than the present. Very little attention has been given to present-bias in the contemporary literature on time biases. This may be because it is often assumed that present-bias is not a distinctive psychological kind; that what explains people’s being present-biased is just what explains them displaying various other time-biases. (...) According to this view, there is no need to investigate present-bias independently of investigating these other biases, since present-bias is really just a manifestation of these other biases. We call this the manifestation thesis. We take up the question of whether the manifestation thesis is true, and argue that it is not. Thus, by failing to investigate present-bias in its own right we are failing fully to understand the spectrum of ways in which people display time biases. In turn, we suggest, this may have implications for the ways we evaluate whether present-bias is rationally permissible. (shrink)

This article is a response to Clifford Williams’s claim that the debate between A- and B theories of time is misconceived because these theories do not differ. I provide some missing support for Williams’s claim that the B-theory includes transition, by arguing that representative B-theoretic explanations for why we experience time as passing (even though it does not) are inherently unstable. I then argue that, contra Williams, it does not follow that there is nothing at stake in the A- versus (...) B debate. (shrink)

Enactive approaches to psychiatry have recently argued for an understanding of psychiatric conditions based within relational interactions between individuals and their environments. A central motivation for these enactive approaches is the goal of social integration: the integration of a naturalistic approach to psychiatric conditions with their broader sociocultural dimensions. One possible issue, however, is whether appeals to the autonomy and authenticity of relationally constituted enactive individuals can provide a means of adjudicating between harmful and beneficial social constraints upon individual behaviour. (...) This paper seeks to provide enactive approaches to psychiatry with a possible means of evaluating normative influences of social contexts beyond direct interactions with relationally constituted individuals. Some of the most significant influences of the sociocultural dimension of psychiatric conditions consist not in direct interaction with individuals, but in setting the terms for interactions and interactants alike. Insofar as some social influences precede and predefine dyadic relations between individuals and their social context, these cannot be accounted for as features of interactions, but must be assessed as independent structures of the sociocultural dimension. I will provide one potential means for enactive models to assess social norms using Canguilhem’s distinction between health and pathology. I will argue that Canguilhem’s conceptualization of health in terms of adaptive normative structure provides a potential tool for social integration which strongly complements enactive approaches to psychiatry. (shrink)

This article is an evaluation of Le Poidevin’s use of Carnap ’s stance on ontology within the philosophy of religion. Le Poidevin claims that 1) theists need to take God to be a putative entity within space-time in order for their claim that God exists to be meaningful, and that 2) instrumentalism about theology is viable. I argue that although Le Poidevin’s response to Carnap ’s argument is no less problematic than that argument itself, his position is in fact thoroughly (...) un-Carnapian. The upshot is that his discussion provides some support to atheism, but none to either of his two official conclusions. (shrink)

本书共分八章,主要内容包括建构宇宙模式、初创中的分歧、本体论的完成、认知的主体性、顺应生命意题、情的普遍意义、意志主宰生命、历史性的总结。.

With a previous paper (Niu & Wang, 1995), a general, hypothetical outline of the mechanism of carcinogenesis was proposed. With reference to the fact of starvation-induced hypermutation in micro-organisms, we propose that the hypoxia commonly seen in the cells at the centre of solid tumours might also result in hypermutation, and then p53-dependent programmed cell death. Like the apparently adaptive mutations in micro-organisms, only those genes (e.g. p53) that enable the cells to escape from apoptosis may be selected.

Division of labour is a marked feature of multicellular organisms. Margulis proposed that the ancestors of metazoans had only one microtubule organizing center (MTOC), so they could not move and divide simultaneously. Selection for simultaneous movement and cell division had driven the division of labour between cells. However, no evidence or explanation for this assumption was provided. Why could the unicellular ancetors not have multiple MTOCs? The gain and loss of three possible strategies are discussed. It was found that the (...) advantage of one or two MTOC per cell is environment-dependent. Unicellular organisms with only one MTOC per cell are favored only in resource-limited environments without strong predatory pressure. If division of labour occurring in a bicellular organism just makes simultaneous movement and cell division possible, the possibility of its fixation by natural selection is very low because a somatic cell performing the function of an MTOC is obviously wasting resources. Evolutionary biologists should search for other selective forces for division of labour in cells. (shrink)

This essay argues that individual-oriented informed consent is inadequate to protect human research subjects in mainland China. The practice of family-oriented decision-making is better suited to guide moral research conduct. The family’s role in medical decision-making originates from the mutual benevolence that exists among family members, and is in accordance with family harmony, which is the aim of Confucian society. I argue that the practice of informed consent for medical research on human subjects ought to remain family-oriented in mainland China. (...) This essay explores the main features of this model of informed consent and demonstrates the proper authority of the family. The family’s participation in decision-making as a whole does not negate or deny the importance of the individual who is the subject of the choice, but rather acts more fully to protect research subjects. (shrink)

Locus equations contain an economical set of hidden (i.e., not directly observable in the data) parameters of speech that provide an elegant way of characterizing the ubiquitous context-dependent behaviors exhibited in speech acoustics. These hidden parameters can be effectively exploited to constrain the huge set of context-dependent speech model parameters currently in use in modern, mainstream speech recognition technology.

The language of principlism seems to have emerged as the predominant guiding framework in teaching, research and even legislation within contemporary Chinese bioethics. This essay reveals the dissonance between the individualistic orientation of this theoretical language and the familist features of Chinese clinical practice by considering the principle of respect for autonomy and its discordance with the Confucian tradition of virtue ethics and medical rituals. Several representative clinical cases in mainland China are presented to illustrate the incongruity between the current (...) state of Confucian medical rituals and the language game of the principle of respect for autonomy. While there is a recognized need in contemporary Chinese medical practice to promote patient involvement in decision-making in the cases of terminal illness, we argue that this approach should be implemented in alignment with Confucian virtue ethics and medical rituals. Resolving the linguistic discordance between Chinese bioethics and principlism should not entail a shift towards principlism. (shrink)

Comrade Hu Qili, on behalf of the Central Secretariat, has delivered a speech of congratulations at the Fourth Congress of the National Writers' Association. This speech is very important. In it, Comrade Hu Qili stated: "As regards the freedom of [artistic] creation, the Party and state should provide the necessary conditions [for it] and create the necessary environment and atmosphere. At the same time, the writers' own thoughts and feelings and their creative activities as a whole should be in step (...) with the environment of freedom provided by the Party and state." Demands are made on both sides. On the one hand, the Party and state should create the requisite conditions, environment, and atmosphere for literary creation. The civil liberties stipulated in the Constitution include the freedom of creation. For writers who are Party members, the rights of Party members, stipulated by the Party constitution and by the Party's criteria for political life, also include the right of freedom of creation. Many problems still exist in this respect; situations still exist wherein no active measures are being taken to create the conditions, environment, and atmosphere for writers to fully enjoy the freedom of creation due to them. [The authorities] in some localities even obstruct or willfully interfere with the realization of this freedom, or they suppress democracy, resort to persecution and retaliation, or employ crude and simplistic means to deal with writers and with artistic creation—a meticulous form of mental labor that has its own special regularities. The thorough solution of problems of this sort still requires great efforts on our part. On the other hand, Comrade Hu Qili also said in his congratulatory speech that the writers' own thoughts and feelings and their creative activities as a whole should be in step with the environment of freedom provided the Party and state. That is to say, they must remain in step with the Constitution, and where Party-member writers are concerned, they should remain in step with the Party constitution, and they should ensure the implementation of relevant stipulations in the Constitution and Party constitution. Many efforts must be made, whether by Party committees and governments at various levels or by the writers, to promote the healthy development and continued flourishing of socialist literature and art. Hence, the two sentences in Comrade Qili's congratulatory speech address the matter very comprehensively. (shrink)

To cope with the water deficit resulting from saline environment, plant cells accumulate three kinds of osmotica: salts, small organic solutes and hydrophillic, glycine-rich proteins. Salts such as NaCl are cheap and available but has ion toxicity in high concentrations. Small organic solutes are assistant osmotica, their main function is to protect cytoplasmic enzymes from ionic toxicity and maintain the integrity of cellular membranes. Hydrophillic, glycine-rich proteins are the most effective osmotica, they have some characteristics to avoid crystallization even in (...) high concentration, but because they are expensive they are not as commonly used as salts or organic solutes. In addition there is the question of whether the genetic information for growth in saline environment is present in all kinds of plants, both halophytes and nonhalophytes. (shrink)

From the viewpoint of an evolutionary biologist, carcinogenesis should be looked upon as a protective mechanism against destruction of DNA. Because genes expressed in embryonic cells are covered and protected by heterochromatinization, they are the most appropriate ‘alternate genes’ compared to genes that are expressed already in somatic cells. When DNA-damage occurs, the embryonic genes can be activated. Some somatic cells exhibit some features of embryonic cells.

Writing, or calligraphy, in China is strongly influenced by ancient techniques of making art. Chinese characters have evolved from the patterns of bronze drawings, and China’s earliest hieroglyphs usually retain the traces of their origin in paintings. These paintings usually recorded daily life, and the related Chinese characters have evolved from these with general, simplified and abstract features. The composition that makes Chinese characters is a manifestation of ancient Chinese philosophy, of which Confucianism, Taoism and Buddhism are the three key (...) strands. They have affected Chinese culture and aesthetics in all dynasties. Chinese philosophy emphasizes the integration of individuals in their surrounding environment. The art of ancient China consequently combines skills that relate to the artificial, or constructed, and to natural patterns. Chinese characters make a perfect example of this. The article/presentation will outline the research that I have so far undertaken on the relation between Chinese calligraphy and architectural space, between writing and constructing environments. It will also present some experimental design research that aims at developing from the above-mentioned basic research new architectural typologies that are contemporary, resonant and sensitive to the Chinese context. (shrink)

The response of consumers to a firm’s ethical behavior and the underlying factors influencing/forming each consumer’s response outcome is analyzed in this article based on information obtained through interviews. The results indicate that, in the Chinese context, the responding outcome can be boiled down to five types, namely, resistance, questioning, indifference, praise, and support. Additionally, consumers’ responses were mainly influenced by the specific consumer’s ethical consciousness, ethical cognitive effort, perception of ethical justice, motivation judgment, institutional rationality, and corporate social responsibility–corporate (...) ability (CSR–CA) belief. Based on these results, a generalized framework of consumer’s ethical responses is developed which provides a number of insightful suggestions upon how to motivate a consumer’s support of a firm’s ethical behavior and to transfer this kind of support into truly positive purchasing behavior. (shrink)

Resumen: Merleau-Ponty es el fundador de la fenomenología corporal moderna. Su obra maestra Phenomenology of Perception ha influido enormemente en la dirección del desarrollo de la ciencia cognitiva occidental contemporánea. La teoría del cuerpo recorre el principio y el final de su pensamiento filosófico, adopta el método fenomenológico para continuar con el panorama de la ontología de la teoría del cuerpo y convierte el cuerpo en el campo del sujeto cognitivo. A través de la literatura y el análisis lógico, este (...) artículo intenta resumir la connotación y extensión de la teoría del cuerpo de Merleau-Ponty, describir e interpretar la dimensión ontológica del deporte desde la perspectiva fenomenológica, y acercar el deporte a la comprensión y comunicación del ejercicio mismo. De esta manera, se desea desencadenar el pensamiento para brindar múltiples referencias para el desarrollo del deporte en cada campo. (shrink)

In order to establish his "school of principle" system of thought, which was founded on objective idealism, Zhu Xi proposed a theory of "investigating things and exhausting principles" [gewu qiongli]. This became the epistemological foundation for his system of thought. This epistemology formed an organic whole with his world view. On the one hand, his "theory-of-investigating-things" epistemology opened up pathways for his system of objective idealism; on the other hand, his "school-of-principle" system formed the theoretical foundation for his epistemology of (...) "investigating things" and gave this epistemology its obviously metaphysical characteristics. (shrink)

在当代中国, 探讨文化复兴问题不仅具有重要的学术价值, 而且具有重大的现实意义.本书是一本直接以文化复兴为研究对象的专著, 分为上下两篇.上篇是理论篇, 严格地探究了文化复兴的生存论基础, 即历史文化对生活的建构功能; 下篇是应用篇.

本书分上下卷,共八章。通过研究人际行为事实如何的客观规律,阐述人际行为应遵守的道德原则,从而创立了一种新伦理学理论。.

Cognitive scaffolding is typically conceptualized in terms of environmental design which serves to offload, facilitate, or enhance the cognitive capacities of interacting agents. Recent contributions to the literature on scaffolding have noted that environmental design might likewise scaffold cognition in ways that undermine the interests of interactant agents—giving rise to notions of problematic or hostile scaffolding. Given the pervasiveness of social and technological scaffolding in contemporary life, the importance of understanding and assessing its effects can hardly be overstated. At the (...) same time, however, the very pervasiveness of scaffolding raises a challenge to the current criteria for evaluating its effects by comparison with agents’ interests. This is because human agents and their interests alike are themselves the results of various forms of social and technological scaffolding. This paper explores the relationship between scaffolding and the formation of agents along with their interests, as well as the implications of this relationship for evaluating scaffolding as being hostile, neutral, or beneficial. I will argue that the formative aspect of scaffolding imparts a degree of uncertainty to evaluations of scaffolding based on agents’ interests. I will then demonstrate the relevance of the formative aspect of scaffolding in evaluating and assessing the potentially pernicious effects of contemporary social and technological scaffolding focusing on the examples of servitization marketing models and social and vocational digital infrastructures. (shrink)

Zusammenfassung Das Projekt einer philosophischen Umgestaltung des Daoismus begleitet mich schon seit langem als vorläufige Idee. In der 1995er Ausgabe der Philosophical Dynamics Nr. 4 veröffentlichte ich einen kurzen Artikel mit dem Titel Ein vorläufiger Überblick über die Umgestaltung der daoistischen Philosophie, der später als Vortrags Transkript in meine Vierzehn Vorlesungen über die Methodologie der Geschichte der Philosophie aufgenommen wurde. 邓晓芒: 道家哲学改造德临时纲要, 收入《哲学史方法论十四讲》, 重庆大学出版社, 2015 年, 第 246–283 页 [Deng Xiaomang: Siebte Vorlesung: Ein vorläufiger Überblick über die Transformation der (...) daoistischen Philosophie, in: Vierzehn Vorlesungen über die Methodologie der Geschichte der Philosophie, Chongqing: Verlag der Universität Chongqing, 2015, S. 246–283.]. Im Prozess der Kritik der traditionellen chinesischen Philosophie durch den Vergleich chinesischer und westlicher Kulturtraditionen kam ich auf die Idee, dass, wenn wir westliche Elemente in unsere traditionelle chinesische Kultur aufnehmen und ein neues Gedankengebäude errichten wollen, dieses Projekt als ein gemeinsamer Ausgangspunkt dienen kann. Während der moderne Neukonfuzianismus auf der „kreativen Transformation“ der Tradition des Konfuzianismus basiert, beruht meine Wiedergeburt der traditionellen chinesischen Kultur auf der Kritik am Konfuzianismus und der Umgestaltung der daoistischen Philosophie. Vor zwanzig Jahren jedoch befand sich dieses Projekt noch im Stadium einer Skizze und ich hatte keine Zeit, sie zu entwickeln, also nannte ich sie einen „vorläufigen Entwurf“. Im vorliegenden Aufsatz möchte ich diese Fragestellung auf den historischen Spuren der daoistischen Philosophie weiter vertiefen. (shrink)

In the discussion of global ethics, philosophical ethics risks losing its distinct theoretical horizons. This predicament arises primarily from philosophy's failure to anchor its own object and to provide a rational basis for global justice from within its current confined theoretical paradigm. Against this background, this paper will first prioritize global co-existence as the primary concern of global ethics, then propose ontological co-existence justice as its foundational principle, and finally argue that the normative validity of co-existence justice is predicated on (...) the nations fulfilling the critical requirements of modern civilization, namely, the advancement of individual freedom. (shrink)