Ideas in theoretical biology origin of cancerous cells from tumours

Acta Biotheoretica 46 (4):379-381 (1998)
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Abstract

With a previous paper (Niu & Wang, 1995), a general, hypothetical outline of the mechanism of carcinogenesis was proposed. With reference to the fact of starvation-induced hypermutation in micro-organisms, we propose that the hypoxia commonly seen in the cells at the centre of solid tumours might also result in hypermutation, and then p53-dependent programmed cell death. Like the apparently adaptive mutations in micro-organisms, only those genes (e.g. p53) that enable the cells to escape from apoptosis may be selected.

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Why animals have tumours.Deng K. Niu & Ya F. Wang - 1995 - Acta Biotheoretica 43 (3):279-280.

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