Direct-to-consumer television advertisements for Lyrica in the United States create narratives of gendered domestic normalcy to which women with fibromyalgia are encouraged to aspire through pharmaceutical intervention. This paper unpacks images and narratives within these advertisements to demonstrate that they rely on metaphors that represent gendered expectations in order to evoke guilt and provoke a desire for what Joseph Dumit calls “health as risk reduction,” and what I argue is an attempt to show disability being erased. Following Stuart Hall’s Encoding/Decoding (...) model of communication, viewers play a role in constructing societal expectations for women with chronic pain and for themselves. (shrink)

In a previous article we have shown that Kuhn's theory of concepts is independently supported by recent research in cognitive psychology. In this paper we propose a cognitive re-reading of Kuhn's cyclical model of scientific revolutions: all of the important features of the model may now be seen as consequences of a more fundamental account of the nature of concepts and their dynamics. We begin by examining incommensurability, the central theme of Kuhn's theory of scientific revolutions, according to two different (...) cognitive models of concept representation. We provide new support for Kuhn 's mature views that incommensurability can be caused by changes in only a few concepts, that even incommensurable conceptual systems can be rationally compared, and that scientific change of the most radical sort—the type labeled revolutionary in earlier studies—does not have to occur holistically and abruptly, but can be achieved by a historically more plausible accumulation of smaller changes. We go on to suggest that the parallel accounts of concepts found in Kuhn and in cognitive science lead to a new understanding of the nature of normal science, of the transition from normal science to crisis, and of scientific revolutions. The same account enables us to understand how scientific communities split to create groups supporting new paradigms, and to resolve various outstanding problems. In particular, we can identify the kind of change needed to create a revolution rather precisely. This new analysis also suggests reasons for the unidirectionality of scientific change. (shrink)

In A Philosophical Defense of Culture, Shuchen Xiang draws on the Confucian philosophy of "culture" and Ernst Cassirer's philosophy of symbolic forms to argue for the importance of "culture" as a philosophic paradigm. A defining ideal of Confucian-Chinese civilization, culture (wen) spans everything from natural patterns and the individual units that make up Chinese writing to literature and other refining vocations of the human being. Wen is thus the soul of Confucian-Chinese philosophy. Similarly, as a philosopher who bridged the (...) classical age of German humanism and postwar modernity, Cassirer implored his and future generations to think of humankind in terms of their culture and to think of the human being as a "symbolic animal." The philosophies of culture of these two traditions, very much compatible, are of urgent relevance to our contemporary epoch. Xiang describes the similarity of their projects by way of their conception of the human being, her relationship to nature, the relationship of human culture to nature, the importance of cultural pluralism, and the role of the arts in human life, as well as the metaphysical frameworks that gave rise to such conceptions. Combining textual exegesis in classical Chinese texts and an exposition of Cassirer's most important insights against the backdrop of post-Kantian philosophy, this book is philosophy written in a cosmopolitan mode, arguing for the contemporary philosophical relevance of "culture" by drawing on and bringing together two different but strikingly similar streams in our world tradition. (shrink)

Many empirical studies have been conducted to investigate self-regulated learning in the Western countries. Less well investigated is the SRL in the Chinese Mainland students and how it affects their academic achievement. On the basis of PISA 2009, this paper is aimed at exploring the SRL of 15-year-old Shanghai students, as measured by cognitive strategy, metacognition, and motivational belief. In the aspect of SRL nature, the results reveal that 15-year-old students in Shanghai use elaboration strategy frequently and seldom use memorization (...) strategy, and that they have high metacognition in understanding, remembering, and summarizing but have low control strategy, and that their enjoyment of reading is relatively high. In the aspect of SRL’s consequence for reading literacy, findings from multilevel linear regression corroborate previous evidence from the Western countries about the effect of SRL on academic achievement. Specifically, elaboration strategy, metacognition in understanding and remembering, metacognition in summarizing, control strategy, and enjoyment of reading are conducive to students’ reading literacy, while memorization strategy exerts a significantly negative effect on reading literacy. The findings could be useful in helping us to gain a better understanding of Shanghai students’ SRL. (shrink)

Kuhn regards local incommensurability as an unavoidable result of changes in worldview, but his account fails to explain both historical cases in which rivals with different paradigms obtained consensus, and psychological experiments in which people with different cultural backgrounds accurately presented other points of view. Although the conditions required to generate local incommensurability were present in the dispute between Brewster and Herschel on light absorption, they succeeded in communicating. Ultimately Brewster understood his opponent's position, in the same way that subjects (...) in Barsalou's recent psychological experiments proved able to comprehend alien conceptual structures. Building upon recent cognitive theories of graded conceptual structures, I offer a new account of incommensurability, which accommodates these historical cases and psychological results. By correcting and extending Kuhn's account I show that local incommensurability may be a matter of degree. (shrink)

This research presents findings from a study of gender-based differences in an ethical decision situation. The study focuses on gender as it relates to situational factors and accounting experience. The primary element of interest is how the gender of the actor (the person described in each vignette) influences the evaluation/assessment of the ethical/unethical decisions. While previous research has provided evidence of ethical differences relating to the gender of the responding subjects, limited evidence has been presented relating to situational issues that (...) may influence assessments of ethical decisions.This research uses four accounting environment vignettes to survey the responses of accountants and accounting students to the ethical/unethical nature of the actions that are taken. In addition, how likely the accountants believe they are to take the same actions is also surveyed. The subjects are a representative sample of practicing accountants in the U.S. and senior/graduate accounting majors at a state university in the southwestern United States. (shrink)

Rising numbers of ageing prisoners and goals on implementing equivalent health care in prison raise issues surrounding end-of-life care for prisoners. The paucity of research on this topic in Europe means that the needs of older prisoners contemplating death in prison have not been established. To investigate elderly prisoners’ attitudes towards death and dying, 35 qualitative interviews with inmates aged 51 to 71 years were conducted in 12 Swiss prisons. About half of the prisoners reported having thought about dying in (...) prison, with some mentioning it in relation with suicidal thoughts and others to disease and old age. Themes identified during data analysis included general thoughts about death and dying, accounts of other prisoners’ deaths, availability of end-of-life services, contact with social relations, and wishes to die outside of prison. Study findings are discussed using Allmark’s concept of “death without indignities,” bringing forth two ethical issues: fostering autonomy and removing barriers. Attributing the identified themes to these two ethical actions clarifies the current needs of ageing prisoners in Switzerland and could be a first step towards the implementation of end-of-life services in correctional systems. (shrink)

Through a key passage (Xici 2.2) from the Book of Changes, this paper shows that Ernst Cassirer’s philosophy of symbolic forms shares similarities with the canonical account of symbolic formation in the Chinese tradition: the genesis of xiang (象), often translated as image or symbol. xiang became identified with the origins of culture/civilisation itself. In both cases, the world is understood as primordially (phenomenologically) meaningful; the expressiveness of the world requires a human subject to consummate it in a (...) symbol, whilst the symbol in turn gives us access to higher orders of meaning. It is the self-conscious creation of the symbol that then allows for the higher forms of culture. For both the Xici and Cassirer, symbols and the symbolic consciousness that comes with it is the pre-condition for the freedom, ethics and the cultivation of agency. As for both the Xici and Cassirer, it is human agency that creates these symbols, it will be argued that the Xici is making a Cassirerian argument about the (ethical) relationship between human agency, symbols and ethics/freedom. (shrink)

Kirk Lougheed argues that active euthanasia (here ‘euthanasia’) is impermissible for people who are extremely sick and cannot exercise their vital force i because (1) exercising vital force does not require volition but only being an object of caring relationships and (2) African philosophy entails other-regarding deontological duties to stay alive. 1 In this commentary, we point out an implication of Lougheed’s view that is morally problematic and offer a revision that avoids this implication. We also argue for an additional (...) advantage of this revision. Lougheed’s view implies that a person who is the object of very few relationships has a much weaker duty to stay alive than a person who is well-loved and the object of many relationships. This is because he seems to think that duties to stay alive are derived entirely from one’s relationship with other people. While he is clear that a person,... (shrink)

Neo-Confucianism of the Han and Tang dynasties is an indispensable part of the history of Chinese philosophy. From Han dynasty Confucians to Tang dynasty Confucians, the study of Confucian classics evolved progressively from textual research to conceptual explanation. A significant sign of this transformation is the book Lunyu Bijie 论语笔解 (A Written Explanation of the Analects), co-authored by Han Yu and Li Ao. Making use of the tremendous room for interpretation within the Analects, the book studied and reorganized the relationship (...) between the study of literature and the Dao and principles. It clearly shows an inevitable development of Confucianism, shifting its focus from phenomena to the nature of the heart-mind in order to comprehend nature and heavenly Dao, both of which cannot be heard (from Confucius). (shrink)

This paper revisits two fundamental issues in question semantics—what does a question mean, and how is this meaning compositionally derived? Drawing on observations with the distribution of wh-words in questions and free relatives as well as quantificational variability effects in question-embeddings, I argue that the nominal meanings of short answers must be derivable from question denotations, which therefore calls for a categorial approach to defining questions, including embedded questions. I provide a novel hybrid categorial approach to compose questions. This approach (...) overcomes the problems with traditional categorial approaches in defining bare wh-indefinites, composing multi-wh questions, and accounting for coordinations of questions. (shrink)

This paper offers a solution to a problem in Herschel studies by drawing on the dynamic frame model for concept representation offered by cognitive psychology. Applying the frame model to represent the conceptual frameworks of the particle and wave theories, this paper shows that discontinuity between the particle and wave frameworks consists mainly in the transition from a particle notion ‘side’ to a wave notion ‘phase difference’. By illustrating intraconceptual relations within concepts, the frame representations reveal the ontological differences between (...) these two concepts. ‘Side’ is an object concept built on spatial relations, but ‘phase difference’ is an event concept built on temporal relations. The conceptual analyses display a possible cognitive source of Herschel’s misconception of polarization. Limited by his experimental works and his philosophical beliefs, Herschel comprehended polarization solely in terms of spatial relations, which prevented him from replacing the object concept ‘side’ with the event concept ‘phase difference’, and eventually resulted in his failure to understand the wave account of polarization.Author Keywords: Herschel; Polarization; Object concept; Event concept; Frame; Cognitive psychology. (shrink)

In most cases, a wh-question calls for an answer that names an entity in the set denoted by the extension of the wh-complement. However, evidence from questions with necessity modals and questions with collective predicates argues that sometimes a wh-question must be interpreted with a higher-order reading, in which this question calls for an answer that names a generalized quantifier. This paper investigates the distribution and compositional derivation of higher-order readings of wh-questions. First, I argue that the generalized quantifiers that (...) can serve as semantic answers to wh-questions must be homogeneously positive. Next, on the distribution of higher-order readings, I observe that questions in which the wh-complement is singular-marked or numeral-modified can be answered by elided disjunctions but not by conjunctions. I further present two ways to account for this disjunction–conjunction asymmetry. In the uniform account, these questions admit disjunctions because disjunctions may satisfy the atomicity requirement of singular-marking and the cardinality requirement of numeral modification. In the reconstruction account, the wh-complement is syntactically reconstructed, which gives rise to local uniqueness and yields a contradiction for conjunctive answers. (shrink)

In this article I explain why scientists cannot always resolve their disagreements about experiments even if they do not hold conflicting theoretical assumptions, and how incommensurability in experiments can occur even if experiments are not deeply encumbered by theoretical assumptions. On the basis of recent discoveries in cognitive psychology and an extended analysis of a historical case, I explore a cognitive mechanism that may generate incommensurability in experiment appraisal. I find that, because of the involvement of goal-derived categories, incommensurability in (...) experiments may result from the conflict of goals that scientists pursue in their researches, from the differences of goal-derived classification schemata that they employ in analyzing experiments, and from discrepancies between skills that they have developed in their practices. This account differs from the conventional interpretation of Kuhn’s thesis, which attributes the cause of incommensurability solely to theoretical differences. In the conclusion, I further discuss the implications of this new account of incommensurability for both philosophical and historical studies of science. (shrink)

Since their introduction in the early 2000s, the use of social networking websites has exploded. Many businesses are seeing increased revenue due to their social commerce strategy. Despite the popularity of social commerce websites, some consumers are still hesitate to use them. This study aims to evaluate the factors that influence the adoption of social commerce. A sample of 721 Chinese We Chat users took part in the research. The findings reveal that social capital mediates the positive effect of social (...) commerce adoption and perceived ease of use on techno-stress and online impulse purchasing. Likewise, information overloading mediates the positive effect of social commerce adoption and PERU on techno-stress and online impulse purchasing. The findings have implications for both practice and research in understanding social commerce adoption in emerging economies. (shrink)

IntroductionDuring the COVID-19 outbreak, many citizens were asked to stay at home in self-quarantine, which can pose a significant challenge with respect to remaining physically active and maintaining mental health. This study aimed to evaluate the prevalence of inadequate physical activity, anxiety, and depression and to explore the relationship of physical activity with anxiety and depression symptoms among Chinese college students during quarantine.MethodUsing a web-based cross-sectional survey, we collected data from 1,396 Chinese college students. Anxiety and depression were assessed with (...) the Self-Rating Anxiety Scale and the Self-Rating Depression Scale, respectively. The data on physical activity were collected by types of physical activity and the International Physical Activity Questionnaire.ResultsDuring the COVID-19 outbreak, about 52.3% of Chinese college students had inadequate physical activity. The rates of anxiety and depression symptoms were 31.0 and 41.8%, respectively. A high level of physical activity was significantly closely associated with low anxiety, while a moderate, or high level of physical activity was significantly closely associated with reduced depression after adjusting confounding demographic factors. Moreover, specific types of physical activity, such as stretching and resistance training, were negatively correlated with both anxiety and depression; doing household chores was negatively correlated with depression.ConclusionOur findings highlight specific levels and types of home-based physical activities that need to be taken into consideration to protect the mental health of college students during the COVID-19 epidemic. (shrink)

本书系统梳理了中国传统忠伦理的起源,演变等脉络和轨迹,深入挖掘了其在不同历史时期的内涵及价值,从而汲取传统忠伦理的尽心尽力,忠心奉公等丰厚滋养,使忠的核心观念与社会主义核心价值观中的"爱国""敬业"" 诚信""友善"等有机衔接,融通, 建构现代忠诚观念,以更好地将忠于国家和人民的社会公德,忠于职守的职业道德,忠于家庭的家庭美德,忠于他人的个人品德等伦理原则付诸实践.

_Wh_-questions with the modal verb _can_ admit both mention-some (MS) and mention-all (MA) answers. This paper argues that we should treat MS as a grammatical phenomenon, primarily determined by the grammar of the _wh_-interrogative. I assume that MS and MA answers can be modeled using the same definition of answerhood (Fox in Mention-some interpretations, MIT seminar, 2013 ) and attribute the MS/MA ambiguity to structural variations within the question nucleus. The variations are: (i) the scope ambiguity of the higher-order _wh_-trace (...) and (ii) the absence/presence of an anti-exhaustification operator. However, treating MS answers as complete answers in this way contradicts the widely adopted analysis of uniqueness effects in questions of Dayal (Locality in _wh_ quantification: Questions and relative clauses in Hindi, 1996 ), according to which the uniqueness effects of singular _which_-phrases arise from an exhaustivity presupposition, namely that a question must have a unique exhaustive true answer. To solve this dilemma, I propose that question interpretations presuppose Relativized Exhaustivity: roughly, the exhaustivity in questions is evaluated relative to the accessible worlds as opposed to the anchor/utterance world. Relativized Exhaustivity preserves the merits of Dayal’s exhaustivity presupposition while permitting MS; moreover, it explains the local-uniqueness effects in modalized singular _wh_-questions. (shrink)

This volume brings the first English translation of the Confucian classics Four Books for Women, with extensive commentaries, to the English-speaking world. Written by women for women's education, this work provides an invaluable look at the tradition of Chinese women's writing, education, history, and philosophy, from the 1st to the 16th century.

This article argues that Cassirer’s thinking about the relationship between the different symbolic forms is best elucidated via the paradigm of “organic harmony.” Although Cassirer did not use the term himself, the harmonious cooperation between the parts found in the organic world provided him with a welcome alternative to traditional accounts of order (i.e., identity or hierarchy). This article gives three examples of “organic harmony” from which Cassirer drew inspiration: Goethe’s idealistic morphology, Wilhelm von Humboldt’s account of language, and Herder’s (...) account of history. Through “organic harmony” we can make better sense of and better articulate the pluralism of Cassirer’s PSF. Finally, this article shows how the motif of organic harmony is the normative moment in Cassirer’s own challenge to twentieth-century fascism and argues that the Cassirerian emphasis on finding a coherence which does justice to the uniqueness of particulars—harmony—is an ethical injunction relevant for our times. (shrink)

The overwhelming motif of nineteenth century anti-Semitic discourse is the metaphor of the Jew as a ghost. In all cultures, the ghost represents the antithesis of what is categorically human: it represents the other par excellence. By using the heuristic of the ghost to interpret how Enlightenment discourse has dealt with the other, this article will argue that the Enlightenment model of the self and its relation to others was a contributing factor to Modern Racism. Enlightenment discourse on subjectivity finds (...) its counterpart in Confucian notions of subjectivity. By looking at how ghosts are understood within Confucian discourse and how they are evoked in popular literature, I argue that Confucian philosophy’s model of subjectivity contributed to the success of the Chinese empire’s assimilation project. (shrink)

In online communities, such as Twitter, Facebook, or Reddit, millions of pieces of contents are generated by users every day, and these user-generated contents show a great variety of topics discussed that make the online community vivid and attractive. However, the reasons why UGCs show great variety and how a firm can influence this variety was unknown, which had been an obstacle to understanding and managing UGCs’ variety. This study fills these two gaps based on variety-seeking theory and topic modeling, (...) which is a technique in machine learning. We extract, quantitatively, the topic of the UGCs using topic modeling and divide UGCs into two types: single topic and multiple topics. The user’s tendency to choose the type of UGC is used to measure variety-seeking behavior. We found that users have an intrinsic preference for variety when producing UGCs; the more single topic UGCs were produced in the past, the higher the probability of producing multiple topics UGC and the lower the probability of producing single topic UGC would be in the next, and vice versa. Furthermore, we discussed the effect of language/linguistic style matching between firm feedbacks and UGCs on users’ variety-seeking tendencies in UGCs’ production. This study makes three contributions: broadening variety-seeking theory to new behavior, that is content production behavior, and the results demonstrated that people would show a variety-seeking behavior in producing UGCs. a new feasible method to measure the variety of UGCs by using topic modeling to extract the topics of UGCs and then measure the variety-seeking behavior in producing UGCs by analyzing the choice between single topic and multiple topics. guidance for the firm to alter LSM of feedbacks to influence the variety of UGCs. (shrink)

This discussion seeks to highlight the ability of poetry to combat loneliness, a growing public health problem with significant negative health outcomes that potentially impact millions of Americans. We argue that poetry can play a very relevant role and have an impact in medicine. Through a brief literature review of previous studies on poetry in medicine, we demonstrate that poetry can not only combat loneliness but can also play important roles in helping patients, physicians, and other healthcare professionals/providers. Because of (...) the COVID-19 pandemic, we believe now is the perfect opportunity to utilize poetry because the benefits can be experienced even in solitude, which is why this is such a timely and pertinent issue today. (shrink)

This paper argues that the ‘processual holism’ of Chinese metaphysics explains its characteristic attitude towards non-humans such as animals and demons. As all things are constantly in process and form a continuum, it follows that ontological distinctions between ‘species’ become impossible to delimit. The distinctions one makes are instead understood as perspectival and provisional. These metaphysical assumptions explain the lack of interest in the Chinese tradition for classifying the distinctions between humans and non-human. We see many examples of the different (...) schools of philosophy espousing the view that the distinction between humans and non-humans is tenuous, precarious and subject to change. A key implication that follows is that the Chinese worldview saw no ontological distinction between those considered as ‘Chinese’ and as ‘non-Chinese.’ The unavailability of ontological distinction as an explanation for the existence of difference means that phenomena that are perceived as anomalous, such as ghosts and spirits, are attributed to the perspective of the human agent; anomaly/difference is not understood as ontological. (shrink)

Abstract The leadership of the black community is concerned with welfare, with equality, with unemployment, with discrimination, with racism, with the pay gap, and with dozens of other such traditional issues. Oh, yes, they are also apprehensive about the use of addictive drugs. But, as we speak, young male members of this community are being incarcerated at frightful rates, and, even worse, are killing each other to boot. One would think that this latter issue would occupy the interest of black (...) leaders front and center. After all, there are few worse problems than being jailed or killed. The present paper is dedicated to making the case that the black leadership has its priorities all wrong; that if they were to exercise true leadership, they would see the jailing and murder of young black men as perhaps the greatest threat to their community; and, if so, they would fervently support the legalization of all drugs. (shrink)

By integrating conservation of resources and social comparison perspectives, we seek to investigate how employees’ own i-deals, independently from and jointly with their coworker’s i-deals, determine their emotional exhaustion and subsequent deviant behaviors. We conducted a field study focusing on task i-deals, and used Actor–Partner Interdependence Model and polynomial regression to test the hypotheses. We found that emotional exhaustion not only mediated the negative relationship between employees’ own task i-deals and deviant behaviors, but also mediated the positive relationship between upward (...) social comparison of task i-deals and deviant behaviors. These results demonstrated the intra- and interpersonal implications of task i-deals for emotional exhaustion and subsequent deviant behaviors. The current research not only shifts the attention from a predominantly positive view on i-deals to a more balanced and nuanced view on i-deals’ implications, but also sheds light on the interpersonal nature of i-deals and the emotional exhaustion implication of upward social comparison. (shrink)

This paper argues that Confucianism had an antiessentialist conception of selfhood. This understanding of self means that they did not have, and could not have had, a concept of “race” in the sense that one's essence determines one's becoming. In the Confucian canon, the embodiment of cultural norms/performance of culturally appropriate actions defines one's human-ness. This account of human agency in becoming human can be seen in the Confucian explanation of moral failure. This assumption of human agency also means that (...) the Confucian understanding of hierarchy is social as opposed to ontological and that differences between peoples are understood to be a result of culture–custom variation. (shrink)

This paper examines older people’s access to care experiences in rural China by integrating anthropological investigation with ethical inquiry. Six months of fieldwork in a post-reform primary hospital show how rural residents struggle to access gerontological and nursing care under socially disadvantageous conditions. This anthropological investigation highlights the unmet needs in medical and nursing care for older people, as well as some social, institutional and structural elements that impede access to care. Centring on protecting the vulnerable as informed by feminist (...) ethics scholarship, this paper argues that the failure to meet older people’s dependency needs is unjust, on the premise that it suggests a denial of the inherent value, rights and dignity of older people. This paper appeals for the provision of greater care and support by the state through putting in place social arrangements that better advance older people’s access to care. Some policy recommendations concerning health and social care reform for older people in rural China are also proposed. (shrink)

Although previous studies primarily claim that government-dependent firms can actively engage in compliance activities in order to achieve political legitimacy, access government resources, and build competitive advantages, these studies largely ignore how firms react when firm-dependent governments exert coercive pressures. We thus introduce institutional theory and the behavioral theory of social performance to develop a model of modest imitation, and we propose that the more governments depend on privately owned firms, the more firms demonstrate average social performance in order to (...) balance efficiency concerns with political legitimacy threats. Meanwhile, whether firms imitate peers’ social performance depends on the magnitude of institutional rigidity. In turn, issue salience and spatial proximity undermine modest imitation, and political connections strengthen modest imitation. We study how all listed, privately owned firms react to the Chinese government’s call for social engagement in poverty alleviation initiated in 2015. This study uses a two-stage Heckman selection model to correct for sample-selection bias, and the results provide strong support for our arguments. This research thus extends our understanding of modest imitation in response to coercive pressure from-dependent governments. (shrink)

This article argues that Ernst Cassirer's views about the concept of substance and his views on mythic consciousness are applicable to the concept of race. By analyzing examples from the most influential and representative racial theories, this article shows that the concept of race functions like the concept of substance whereby random, large-scale, and irreducibly complex phenomena is explained through the deterministic behavior of a smaller, material, constituent part. Given that mythic consciousness explains causality in the same way, this substance-mode (...) explanation of becoming can also be termed “mythic.” Further, under this substance/racial understanding of personhood, humans have no agency to determine their own fates. It is this fatalism that Cassirer railed against in The Myth of the State. In place of this substance (racial) understanding of personhood, and as this article will describe, Cassirer argued for a “functional” (cultural) understanding of personhood. (shrink)

Lysine acetylation has been shown to occur in many protein targets, including core histones, about 40 transcription factors and over 30 other proteins. This modification is reversible in vivo, with its specificity and level being largely controlled by signal‐dependent association of substrates with acetyltransferases and deacetylases. Like other covalent modifications, lysine acetylation exerts its effects through “loss‐of‐function” and “gain‐of‐function” mechanisms. Among the latter, lysine acetylation generates specific docking sites for bromodomain proteins. For example, bromodomains of Gcn5, PCAF, TAF1 and CBP (...) are able to recognize acetyllysine residues in histones, HIV Tat, p53, c‐Myb or MyoD. In addition to the acetyllysine moiety, the flanking sequences also contribute to efficient recognition. The relationship between acetyllysine and bromodomains is reminiscent of the specific recognition of phosphorylated residues by phospho‐specific binding modules such as SH2 domains and 14‐3‐3 proteins. Therefore, lysine acetylation forges a novel signaling partnership with bromodomains to govern the temporal and spatial regulation of protein functions in vivo. BioEssays 26:1076–1087, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

On January 1, 1958, in the journal Democratic Critique, Zhang Junmai, Mou Zongsan, Tang Junyi, and Xu Fuguan published the "Manifesto on Chinese Culture for the World: Our Common Understanding of Chinese Scholarship Research and of the Future of Chinese Culture and World Culture."1 This manifesto is commonly seen as the founding statement of the New Confucianism movement. Section 2 of the manifesto, "Three Motives, Approaches, and their Shortcomings in the Study of Chinese Culture in World Scholarship," claimed that Chinese (...) culture had not been understood by three kinds of people who had approached it, namely, Christian missionaries, sinologists, and students of present world history. For the New Confucians, the... (shrink)