Rare disease are those pathologies that affect a reduced proportion of the population. For this reason, the research on their causes and mechanisms, which is essential to find a way to treat or prevent them, is insufficient. This causes that the patients report a lack of coverage by the health system and the social discrimination that suffering one of these pathologies entails. Among rare diseases, we find the so-called prion diseases or transmissible spongiform encephalopathies. Although they are relatively well-known due (...) to the health crisis provoked by the “mad cow disease” at the end of the last century, there are still many uncertainties about these disorders that affect both animals and humans. This monograph aims at bringing to light the fascinating history and the diversity of prion diseases, which shook the foundations of the biology known before the 1980s by bringing out a new and puzzling type of infectious agent: prions. (shrink)

Guárdate del agua mansa es una de las piezas calderonianas de mayor actualidad. La comedia desarrolla el tema de las apariencias tratado desde una óptica bastante original, en donde el «agua mansa» alude a todas aquellas jóvenes que parecen no tener capacidad de acción, pero que al final son con quienes hay que estar más precavido. Sin embargo, la pieza también nos habla de un fascinante Madrid que seduce a la juventud ya desde el mismo inicio de la pieza, un (...) Madrid visual que entra por los ojos y que conquista al instante.…. (shrink)

Transcending reviewed proximate theories, Van Lange et al.'s CLASH model attempts to ultimately explain the poleward declension of aggression and violence. Seasonal cold is causal, but, we contend, principally as an ecologically relevant evolutionary pressure. We further argue that futurity and restraint are life history variables, and that Life History Theory evolutionarily explains the biogeography of aggression and violence as strategic adaptation.

In 2012, the international PISA survey reinforced the observation that the French educational system is one of the most unequal among OECD countries. The observation of serious inequalities in access to educational success for pupils from disadvantaged backgrounds could lead to a pessimistic vision suggesting that any possibility of transformation of the system is doomed to failure. Thus, the fight against inequalities in access to educational success is a form of runaway object which constitutes a challenge for research which treats (...) the social context as evolving and susceptible to significant and novel transformations. Developmental work research aims to support the work of professionals in the re-elaboration of their practices by seeking to go beyond the status quo of an unequal school. Drawing on this framework within an institutional network of schools, we seek to show how the intervention has highlighted power issues inscribed in the structures and how the actors, through their commitment in the research collaborative process, seek to go beyond the power issues inscribed in their work routines and enacted during the research process by different kinds of antagonism. We will argue that the fight against educational inequality involves overcoming systemic power relations crystallized in institution. This systemic power is expressed by a form of episodic power. Our results show restrictive and constructive effect on the expansive learning process and on the construction of a collective in the formative interventions. The restrictive side of epistemic power should be linked to systemic power which is historically inherited. We discuss the results in the light of the emergence of a fourth generation of activity theory. Our research makes it possible to make conceptual and methodological progress in the construction of a fourth generation of activity theory by showing the need for analysis and expansively learn about problematic power relations in heterogeneous collectives. (shrink)

Neuropeptides are key modulators of adult neurocircuits, balancing their sensitivity to both excitation and inhibition, and fine‐tuning fast neurotransmitter action under physiological conditions. Here, we reason that transient increases in neuropeptide availability and action exist during brain development for synapse maturation, selection, and maintenance. We discuss fundamental concepts of neuropeptide signaling at G protein‐coupled receptors (GPCRs), with a particular focus on how signaling at neuropeptide GPCRs could underpin neuronal morphogenesis. We use galanin, a 29/30 amino acid‐long neuropeptide, as an example (...) for its retrograde release from the dendrites of thalamic neurons to impact the selection and wiring of sensory afferents originating at the trigeminal nucleus through galanin receptor 1 (GalR1) engagement. Thus, we suggest novel roles for neuropeptides, expressed transiently or permanently during both pre‐ and postnatal neuronal circuit development, with potentially life‐long effects on circuit layout and ensuing behavioral operations. (shrink)

The article describes the obstacles to the emancipation of Roma women in the family and Czech society. The theoretical side deals with the recent changes in gender roles in the Roma family, changes in the position of Roma women and their discrimination as well as the concept of emancipation. The article aims to describe the obstacles a Roma woman must overcome in the course of emancipation. The data are based on qualitative socio-ethnographic research conducted through narrative interviews with 30 women (...) of different ages and classes who identify as Roma and live in three Czech regional capitals. The research sample was compiled using the snowball method. The data collected in the field research were analyzed in Atlas.ti using anchored theory. We identified five main obstacles to the emancipation of Roma woman. They include obstacles emanating from the family and the majority society as well as obstacles caused by the hegemony of masculinity and those emanating from the woman. By gaining an understanding of relations in Roma families, the situation regarding the emancipation of Roma women and the associated barriers may help those who come into daily contact with the Roma minority to take appropriate actions and apply the right interventions. (shrink)

Putnam's Model- Theoretic Argument has been generally held as invalid. In this work, attention is addressed to two broad facts understated by critics and commentators: (i) there are, at least, two different model-theoretic arguments. One is directed against realism and the other is directed to naturalistic semantics. The general rejection affects the former, but it is open to discussion if it affects the latter; (ii) on the other hand, the model-theoretic argument construed as a reductio argument has not - prima (...) facia - ontological consequences, but only restrains our methodology to deal with the intentional realm. (shrink)

Resumen En una serie de escritos Timothy Williamson ha argumentado a favor del necesitismo, esto es, la tesis de que es necesario que todo exista necesariamente. Este trabajo discute el necesitismo de segundo orden, esto es, la tesis de que es necesario que toda propiedad exista necesariamente, considerando líneas de argumentación semejantes a las desplegadas en primer orden. Se examinan tres de estos argumentos: el carácter necesario de ser una propiedad, la aparición de las propiedades en proposiciones, y los compromisos (...) ontológicos del metalenguaje en el que se formula la semántica. Se argumenta que ninguno de ellos es realmente convincente. La justificación del necesitismo de segundo orden parece requerir más metafísica sustantiva que resultados formales, al menos si es que los resultados formales de que se trata son aquellos discutidos aquí.In a series of writings Timothy Williamson has argued for necessitism, i. e. the thesis that it is necessary that everything exists necessarily. This work discusses second-order necessitism, i. e. the thesis that it is necessary that every property exists necessarily, considering lines of argument similar to those displayed on first-order. Three of those arguments are examined. the necessary character ofbeing a property, the occurrence of properties in propositions, and the ontological commitments of the metalanguage where the semantics is formulated. It is argued that none of them are compelling. The justification for second-order necessitism seems to require more substantive metaphysics than formal results, at least if the formal results in view are those discussed here. (shrink)

The term etonism is from «Etona» that means flag, marks, evidence, and reason in Kikôngo. The variants in Umbûndu: etonolo or etonuilo means, allegations, reasons, indulgence (tolerance). The Nyaneka form is etŏnya: 1) reasons, 2) allegations, 3) indulgence and 5) the justice and the tolerance. Etona is Angolan artist (sculptor/painter). In his sculpture they are morphologically evidenced three treatments in the surface of the matter, namely 1) flat treatment; 2) rude treatment and finally 3) accidental treatment. Each one is a (...) code: #1. The flat treatment indicates well-knowledge; a man of superior class; race or tribe or religion of majority; thought well-organized and structured. In painting, the hot intensity indicates dominance, prosperity, energy, intense desires; #2. The rude treatment reveals an acquired knowledge without academism, self-taught; medium class men; speech out of the scientific perimeters but with certain admissibility; race, tribe or religion of lot of people, but not of majority. In his painting, the neutral intensity marks the balance and inspires recomfort nurtured from two opposed poles (hot and cold); #3. The accidental part of the sculpture indicates some knowledge’s lack (pure empiricism); inferior class; race, tribe, religion of minority. In the painting, the cold intensity is naturally contrary of #1. Etonism is the tolerant reason between #1=I, #2=YOU and #3=HE. All of them form the coherent society that we call WE: the Etonian jusphilosophy that African peoples need for stability of their democracies and finishing their War. (shrink)

Malgré l’avènement de la figure de l’acteur créateur au tournant des XIXe et XXe siècles, les procédés de copie, d’imitation et de réactivation constituent une part non négligeable des outils convoqués dans les exercices spécifiques au jeu. Cette persistance, qui trouve son origine dans le _Paradoxe sur le comédien_ de Diderot, se lit et se décline tout au long de l’histoire des théories du jeu, dans le recours fréquent à un modèle, dont le type varie. C’est cette double continuité, celle (...) des procédés de copie et du modèle dans les théories du jeu auxquelles s’adossent des pratiques et dont découlent des modes de fabrication, qui a nourri une expérimentation pédagogique pratique au sein de La Manufacture – Haute École des Arts de la Scène de Lausanne. Les ateliers élaborés pour les étudiant.e.s consistant à mettre en œuvre ces trois opérations, à leur proposer une histoire sensible, c’est-à-dire éprouvée, du jeu de l’... (shrink)

We find problems with Vaesen's treatment of the primatological research, in particular his analysis of foresight, function representation, and social intelligence. We argue that his criticism of research on foresight in great apes is misguided. His claim that primates do not attach functions to particular objects is also problematic. Finally, his analysis of theory of mind neglects many distinctions.

Suma Teológica. Primeira Parte, Questão 15: Sobre as Ideias.

We find that the nature and origin of the proposed “dialogical cognitive representations” in the target article is not sufficiently clear. Our proposal is that (triadic) bodily mimesis and in particular mimetic schemas – prelinguistic representational, intersubjective structures, emerging through imitation but subsequently interiorized – can provide the necessary link between private sensory-motor experience and public language. In particular, we argue that shared intentionality requires triadic mimesis.

Se ha sostenido tradicionalmente que los predicados atribuidos a Dios y a las criaturas son análogos. Pero, ¿qué es la analogía? Varios filósofos han pensado que la analogía debe ser considerada como una forma de ambigüedad. Argumentamos aquí que los predicados atribuidos a Dios y a las criaturas no son ambiguos o vagos. Siguiendo algunas sugerencias de McDaniel, proponemos una concepción de la analogía donde el fenómeno semántico está asociado con el carácter más o menos natural de la propiedad o (...) propiedades que instancian las entidades que satisfacen el predicado análogo. Un predicado "θ" es análogo si y sólo si, la propiedad Θ, que algo instancia, si y sólo si es θ, es menos natural que cualquier propiedad Ξ tal que todo lo que instancie Ξ, instancia Θ. Además, se requiere que las entidades de las cuales el término análogo es predicado deban ser ontológica o epistémicamente dependientes unas de otras. || It has been traditionally sustained that predicates attributed to God and to the creatures are analogical predicates. But, what is analogy? Several philosophers have thought that analogy should be taken as a form of ambiguity. Here we argue that predicates attributed to God and to creatures are neither ambiguous nor vague. Following some suggestions given by McDaniel, we propose a view of analogy in which the semantic phenomenon is associated with the more or less natural character of the property or properties that the entities that satisfy the analogous predicate instantiate. A predicate "θ" is analogous if and only if the property Θ, which something instantiates, if and only if it is θ, is less natural that any property Ξ so that anything that instantiates Ξ, instantiates Θ. Furthermore, it is required that the entities of which the analogous term is predicated should be either ontologically or epistemically dependent on each other. (shrink)

Se ha destacado recientemente que la Fórmula de Barcan y la Conversa de la Fórmula de Barcan para lógica modal cuantificacional de orden superior parecen válidas. Si se interpreta que los cuantificadores tienen como rango propiedades, la validez de y de orden superior parece implicar la existencia de universales trascendentes, esto es, universales que no requieren estar instanciados para existir en un mundo posible. Este trabajo discute esta línea de argumentación. En primer lugar, se sostiene que la semántica en la (...) que los resultados de validez se siguen no requiere que las ‘intensiones’ asignadas a las variables de orden superior estén instanciadas en un mundo posible para que la intensión exista ahí. El defensor de universales inmanentes objetaría esta suposición. En una semántica modificada, más neutral, y de orden superior ya no son válidas. En segundo lugar, se sostiene que, incluso si se concediese la validez de y de orden superior, no se obtendrían resultados metafísicos sustantivos, pues diferentes formas de nominalismo y diferentes teorías de tropos no tendrían dificultades en aceptar y de orden superior. (shrink)

El presente trabajo busca puntuar algunas características y usos políticos de la noción de sentido común desde el pensamiento de Michel Foucault. A partir de una breve comparación con la perspectiva gramsciana del sentido común, se intenta especialmente atender a dos cuestiones: por un lado, qué estatuto epistémico se le da al conocimiento general presente en la vida cotidiana y, por otro, qué vínculo respecto a él se sostiene, o bien bajo la figura del “intelectual orgánico”, o bien el estilo (...) foucaulteano del “intelectual específico”. Desde allí, se intenta situar alcances y limitaciones de la noción desde una perspectiva foucaulteana. (shrink)

Este trabajo discute el argumento presentado por Carmichael (2010) para justificar la existencia de universales trascendentes, esto es, universales que no requieren instanciaciones para existir. Se sostiene en este trabajo que una proposición puede describir correctamente un mundo posible sin existir como una parte de ese mundo, esto es, que una proposición puede ser verdadera de un mundo posible, sin ser verdadera en un mundo posible. Se sostiene, además, que las mismas premisas usadas por Carmichael permiten justificar el necesitismo.

This article sets out to throw light on the intellectual and scientific activities of a group of Spanish humanists associated with the diplomat, aristocrat, and writer Diego Hurtado de Mendoza in the course of his fifteen years in Venice, Trent, and Rome, focusing on two aspects that have been neglected to date. These are (a) the integration of practices connected with the study of nature (herborizing expeditions and the production of herbaria) with the work of collating, translating, and commenting on (...) classical texts dealing with natural history and materia medica; and (b) the insertion of these scientific activities in Italy by the Spanish subjects of the Emperor Charles V within the broader context of a specific cultural policy. This policy would later be fleshed out in the scientific project of the Spanish Crown under Philip II, inseparable as it was from the monarch’s political and religious policy. (shrink)

This work promotes the thesis that humans are naturally transhuman. In order to achieve this, we present in the first two sections some examples of technological devices assembled to human beings, and we critically review the assumptions and dichotomies on which the idea of human enhancement is based according to the ordinary transhumanist vision. Thirdly, we present the thesis of the Extended Mind to support our intuition. Fourthly, we dismantle the most relevant philosophical dichotomies that structure the transhumanist position. Finally, (...) we recapitulate the reasons why we should wake up from the transhumanist dream. (shrink)

Malgré l’avènement de la figure de l’acteur créateur au tournant des XIXe et XXe siècles, les procédés de copie, d’imitation et de réactivation constituent une part non négligeable des outils convoqués dans les exercices spécifiques au jeu. Cette persistance, qui trouve son origine dans le Paradoxe sur le comédien de Diderot, se lit et se décline tout au long de l’histoire des théories du jeu, dans le recours fréquent à un modèle, dont le type varie (nature ou réel, arts plastiques, (...) personnage théâtral, performance). C’est cette double continuité, celle des procédés de copie et du modèle dans les théories du jeu auxquelles s’adossent des pratiques et dont découlent des modes de fabrication, qui a nourri une expérimentation pédagogique pratique au sein de La Manufacture – Haute École des Arts de la Scène de Lausanne. Les ateliers élaborés pour les étudiant.e.s consistant à mettre en œuvre ces trois opérations, à leur proposer une histoire sensible, c’est-à-dire éprouvée, du jeu de l’acteur, et à leur faire percevoir l’importance des procédés de copie, d’imitation et de réactivation dans la pensée et dans la pratique du jeu. (shrink)