Neuropeptides are key modulators of adult neurocircuits, balancing their sensitivity to both excitation and inhibition, and fine‐tuning fast neurotransmitter action under physiological conditions. Here, we reason that transient increases in neuropeptide availability and action exist during brain development for synapse maturation, selection, and maintenance. We discuss fundamental concepts of neuropeptide signaling at G protein‐coupled receptors (GPCRs), with a particular focus on how signaling at neuropeptide GPCRs could underpin neuronal morphogenesis. We use galanin, a 29/30 amino acid‐long neuropeptide, as an example (...) for its retrograde release from the dendrites of thalamic neurons to impact the selection and wiring of sensory afferents originating at the trigeminal nucleus through galanin receptor 1 (GalR1) engagement. Thus, we suggest novel roles for neuropeptides, expressed transiently or permanently during both pre‐ and postnatal neuronal circuit development, with potentially life‐long effects on circuit layout and ensuing behavioral operations. (shrink)

This highly readable theory of life and its origins offers a non-technical discussion of a chemical perspective on the fundamental organisation of living systems. Essays on the biological and philosophical significance of Ganti's work of thirty years indicate not only its enduring theoretical significance, but also the continuing relevance and heuristic power of Ganti's insights.

Are we able to make objective moral judgments? This perennial philosophical topic needs often to be revisited because it is central to human life. Judging how people conduct themselves, the institutions they devise, whether, in short, they are doing what's right or what's wrong, is ubiquitous. In this essay I defend the objectivity of ethical judgments by deploying a neo-Aristotelian naturalism by which to keep the “is-ought” gap at bay and place morality on an objective footing. I do this with (...) the aid of the ideas of Ayn Rand as well as, but only by implication and association, those of Martha Nussbaum and Philippa Foot. (shrink)

When this classic work was first published in 1976, its central tenet--more is not necessarily better--placed it in direct conflict with mainstream thought in economics. Within a few years, however, this apparently paradoxical claim was gaining wide acceptance. Scitovsky's ground-breaking book was the first to apply theories of behaviorist psychology to questions of consumer behavior and to do so in clear, non-technical language. Setting out to analyze the failures of our consumerist lifestyle, Scitovsky concluded that people's need for stimulation is (...) so vital that it can lead to violence if not satisfied by novelty--whether in challenging work, art, fashion, gadgets, late-model cars, or scandal. Though much of the book stands as a record of American post-war prosperity and its accompanying problems, the revised edition also takes into account recent social and economic changes. A new preface and a foreword by economist Robert Frank introduce some of the issues created by those changes and two revised chapters develop them, discussing among others the assimilation of counter-cultural ideas throughout American society, especially ideas concerning quality of life. Scitovsky draws fascinating connections between the new elite of college-educated consumers and the emergence of a growing underclass plagued by drugs and violence, perceptively tracing the reactions of these disparate groups to the problems of leisure and boredom. In the wake of the so-called "decade of greed" and amidst calls for a "kindler, gentler" society, The Joyless Economy seems more timely than ever. (shrink)

The following letters were written by the distinguished British chemist Professor Brian G. Gowenlock in response to Tibor Frank’s article on “Networking, Cohorting, Bonding: Michael Polanyi in Exile,” Tradition and Discovery 23:2 : 5-19. The two letters contribute to the history of the Manchester years of Michael Polanyi with interesting details concerning several of his colleagues and contemporaries. These informative comments by a former student of Michael Polanyi will improve our knowledge of the last years of Polanyi as a (...) physical chemist. (shrink)

This paper focuses on the dynamics of ethical perspectives that embody the Golden Rule of Morality. Based on critical analysis of this rule in various cultural and religious contexts, but also from the perspective of humanism, the author presents its paradoxical character, the essence of which is interpreted here in terms of a pointer to metaphysical reality. It turns out that social conditionality, as well as the self-referential concept as a starting point of any ethical reasoning, are serious epistemological challenges (...) for the application of the Golden Rule in the position of universal normativity that this study addresses. On the other hand, Judeo-Christian cosmology and the related basis for ethical foundations is presented here as an inspirational space of ethical reasoning in which the paradoxical character of the Golden Rule becomes rather an indicator of a deeper metaethical interpretation of one's own particular ethical attitudes and outcomes than a practical guide to the discovery of ethical universals. (shrink)

The tension between naturalism and humanism is at its greatest when it comes to ethics and morality. By drawing on the affinity between the evolutionary humanistic philosophies of classical pragmatist John Dewey and contemporary pragmatist Daniel Dennett, I modify Dennett’s ethical technology, Moral First Aid, to include a kit as well as Dennett’s proposed manual. The contents of this kit draw on Dewey’s reconstructed moral genealogy in which three factors, goods, rights, and virtues, become stock parts for the technoscience of (...) ethics. Lacking in Dennett’s account is an adequate ideal by which to measure moral success. I propose that moral first aid take up Dewey’s moral ideal of democracy as the guide for resolving moral exigencies. (shrink)

The philosophical problem of pictorial conversational implicatures can be summarized as follows: We have three propositions that are independently plausible and jointly inconsistent. -/- (Non-P) Anti-propositionalism: pictures do not have context-independent, conventionally encoded propositional content (propositional function). -/- (C) Only those representations can be used to convey conversational implicatures which have associated with them a context-independent, conventionally encoded propositional content (function). -/- (I) Pictures can be used to convey conversational implicatures. -/- There are three ways of responding to the problem: (...) affirm (Non-P) and (C) while denying (I); affirm (C) and (I) while denying (Non-P); or affirm (Non-P) and (I) while denying (C). (shrink)

I address the problem of caring for our body-mind through neuropragmatism, cybernetics, and Larry Hickman’s work on John Dewey and the philosophy of technology. The problems of body-mind health are related to Emma Dowling’s The Care Crisis. I address this crisis by drawing on Jay Schulkin’s conception of viability as the creative tension between stability and precarity. From this, I extend body-mind health to questions of democracy, leading to the proposal of body-mind-world as an elaboration of neuropragmatism’s evolutionary and ecological (...) conception of experience as Œ and Hickman’s distinction between the merely valued nature-as-nature and the valuable nature-as-culture. I conclude with a reimagination of creative democracy as a moral ideal for dealing with the care crisis. (shrink)

We address Mark Tschaepe’s response to Tibor Solymosi, in which Tschaepe argues that neuropragmatism needs to be coupled with humility in order to redress “dopamine democracy,” Tschaepe’s term for our contemporary situation of smartphone addiction that undermines democracy. We reject Tschaepe’s distinction between humility and fallibility, arguing that audacious fallibility is all we need. We take the opportunity presented by Tschaepe’s constructive criticism of neuropragmatism to reassert some central themes of neuropragmatism. We close with discussion of Bywater’s method of (...) apprenticeship, as an imaginative education for creative democracy, thereby rejecting Tschaepe’s claim that neuropragmatism lacks a pedagogical method. (shrink)

Some consequences of direct realism and William James’s philosophy of mind are considered in terms of American naturalism as seen in the debate between John Dewey and Roy Wood Sellars. Sellars’s critical realism and evolutionary naturalism is compared and contrasted with Dewey’s pragmatic realism and emphatically evolutionary naturalism. Though these naturalisms are similar, there are significant differences between methodology, their critiques of James’s reflex arc concept in his Principles of Psychology, and the mind-body problem. Sellars’s critical realism and naturalism retains (...) a priori commitments to fixed categories and concepts, whereas Dewey’s emphatically evolutionary pragmatic naturalism is empirical and sees continuities where Sellars insists on discontinuities. One significant difference is Sellars’s maintaining a place for introspection as methodologically appropriate and Dewey’s’ rejection of it. These differences are illustrated through Sellars’s modification of the reflex arc to include an organic but interpretative step, and Dewey’s radical criticism of approaches like James’s and Sellars’s as recapitulating the Cartesian dualism that such views intended to overcome. These differences are finally contrasted in Sellars’s maintaining a privacy of mind by constraining it to the brain in a dual-aspect theory, while Dewey advocates mind as sociocultural, expanding mind into body and world. (shrink)

In pathological conditions associated with persistent increases in hemodynamic workload (old myocardial infarction, high blood pressure, valvular heart disease), a number of signalling pathways are activated in the heart, all of which promote hypertrophic growth of the heart, characterised at the cellular level by increases in individual cardiac myocyte size. Some of these pathways are required for a successful adaptation to cardiac injury. Other pathways are maladaptive, however, as they lead to progressive contractile dysfunction and heart failure. The free radical (...) gas nitric oxide and natriuretic peptides, both of which are produced in the heart, have emerged as endogenous inhibitors of maladaptive hypertrophy signalling. Overall, it appears that cardiac hypertrophy is controlled by an interplay of pro‐ and antihypertrophic signalling networks. This delicate balance can tip towards adaptation or heart failure. In the future, patients living with cardiac disease may benefit from therapeutic strategies targeting maladaptive hypertrophy signalling pathways. BioEssays 26:608–615, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

_The Liberty Option_ advances the idea that for compelling moral as well as practical reasons it is the free society -- with the rule of law founded on the principles of private property rights, its complete respect for individual sovereignty and properly limited legal authorities -- not one or another version of statism that serves justice best, is most prosperous and encourages the greatest measure of individual virtue on the part of the citizenry. The work shows why this is so (...) and lays out some of the most crucial implications of the idea. While the book presents a principled approach to politics, it is firmly grounded in the best and most up to date understanding of human community life and history as well as many of its complications, challenges, adversities and prospects. (shrink)

Ben A. Minteer has written a provocative and important book on the current state of affairs in environmental ethics. It is provocative because his version of pragmatism is advocated in a novel and...

The paper analyses the thoughts of Paul Feyerabend in the context of the events and influences he experienced in his life. Drawing/reflecting on the broader context sheds further light on his oeuvre and personality.

Journal for the Theory of Social Behaviour, EarlyView.

We articulate a conception of resilience via allostasis and the free energy principle to augment Nassim Nicholas Taleb’s conception of antifragility. Creative resilience is resilience 3.0, after robustness (1.0) and antifragility (2.0), because creative resilience is the deliberate effort to construct ecological niches toward a more caring and thus more viable world for more people – what Dewey proffered as the moral ideal of creative democracy. Viability is understood as the healthy tension between stability and precarity. Viability is related to (...) regulatory mechanisms of homeostasis and allostasis. Along with discussion of the free energy principle, we situate these processes of the internal milieu within the external milieu. Ecological niche construction and ecological psychological affordances are related to human practices as means of generating culture. Culture is both a product and producer of the process of valuation, which originates in evolution but is further developed by the free energy principle and social allostasis. The collective languishing exacerbated by the Covid-19 pandemic can be ameliorated through creative resilience so conceived as social allostasis writ large. (shrink)

Neuropragmatism offers a non-dualistic conception of experience from which scientific inquiries can provide resources for sociocultural critique. This reconstructive effort addresses what Emma Dowling calls the care crisis without succumbing to what Mike W. Martin calls therapeutic tyranny. This tyranny relies on problematic dualisms, between mind/body, mind/world, and fact/value, that are also found in neuropsychoanalysis. While pragmatism and psychoanalysis more generally share an evolutionary perspective and can overlap in therapeutic approaches, neuropsychoanalysis diverges from this effort in its dual-aspect monism and (...) positivistic conception of science. Where neuropsychoanalysis seeks to reconcile the first-person subjectivity of lived experience with the third-person objectivity of science, neuropragmatism offers reconstruction. In taking the neuropragmatic turn, neuropsychoanalysts can better utilize Freudian therapies in conjunction with active inference principles, such as the free-energy principle and allostasis. Along with neuropragmatism’s conception of experience as organism-environment dynamic engagement, neuropsychoanalysis can benefit from allostatic approaches to experience and inquiry without reducing experience to brute mechanism or denying the utility of such mechanisms for prediction and intervention. Understanding the value-ladenness of experience, primary and secondary, in everyday waking life and in reflective inquiry, empowers people to better care for themselves without succumbing to merely coping with neoliberal oppression. (shrink)

The result of the author's extensive practical experience: a decade in computer process control using large scale systems, another decade in machine pattern-recognition for vision systems, and nearly a decade dealing with artificial intelligence and expert systems. These real-life projects have taught Vámos a critical appreciation of, and respect for, both abstract theory and the practical methodology that grows out of—and, in turn, shapes—those theories.Machine representation means a level of formalization that can be expressed by the instruments of mathematics, whereas (...) programming is not more and not less than a special linguistic translation of these mathematical formulae. How these all are related and controlled is a most practical philosophical and computation professional task. Wide experience in the practical fields of computer science, and the research of the underlying theoretical issues have led Vámos to the development of the attitude and activity of constructive skepticism. (shrink)

This article introduces a novel approach for the analysis of the dynamics of reasoning processes and explores its applicability for the reasoning pattern called reasoning by assumption. More specifically, for a case study in the domain of a Master Mind game, it is shown how empirical human reasoning traces can be formalized and automatically analyzed against dynamic properties they fulfill. To this end, for the pattern of reasoning by assumption a variety of dynamic properties have been specified, some of which (...) are considered characteristic for the reasoning pattern, whereas some other properties can be used to discriminate among different approaches to the reasoning. These properties have been automatically checked for the traces acquired in experiments undertaken. The approach turned out to be beneficial from two perspectives. First, checking characteristic properties contributes to the empirical validation of a theory on reasoning by assumption. Second, checking discriminating properties allows the analyst to identify different classes of human reasoners. (shrink)

To propose a revisionist ontology of art one has to hold that our everyday intuitions about the identity and persistence conditions of various kinds of artworks can be massively mistaken. In my presentation I defend this view: our everyday intuitions about the nature of art can be (and sometimes are) mistaken. First I reconstruct an influential argument of Amie L. Thomasson (2004; 2005; 2006; 2007a; 2007b) against the fallibility of our intuitive judgments about the identity and persistence conditions of various (...) kinds of artworks. Second, I present three objections to this account: two of them concern the semantic and pragmatic rules regulating the use of art-kind terms, while the third one is based on the assumption that the history of art partly comprises a series of successful attempts of transgression of artistic conventions and expectations, therefore our artistic intuitions are dynamic. Taking this point I finally argue that in philosophy of art we need a “reverse” methodology: first we have to provide a general definition, containing all the sufficient and necessary conditions of artworks (“being an artwork”) in any period within the history of art. Only after completing this task are we ready to answer the metaphysical question about the ontological status of works of art. (shrink)

Spencer Dimmock has produced a convincing restatement, defence and update of Robert Brenner’s influential work on the origin of capitalism in England. The book productively engages with many Marxist and non-Marxist critics of the so-called ‘Brenner Thesis’, and presents fresh secondary and primary evidence in favour of it. This review sketches the theoretical background of Brenner’s intervention, summarises Dimmock’s take on Brenner, and comments on a few notable contemporary critiques of Brenner’s general framework which are not explicitly engaged with by (...) Dimmock. (shrink)

Name der Zeitschrift: Byzantinische Zeitschrift Jahrgang: 107 Heft: 2 Seiten: 831-850.

Abstract The Joyless Economy focused on the boredom of the idle rich and neglected the boredom of the idle and idled poor. However, their boredom is much more serious than what the book dealt with, because it is chronic and often incurable. It usually begins with the neglect of destitute children who never learn how to concentrate on learning in school, become unruly and often end up unemployable, and have no better way than violence to release their energies.