Recent attempts to develop and apply digital ethics principles to address the challenges of the digital transformation leave organisations with an operationalisation gap. To successfully implement such guidance, they must find ways to translate high-level ethics frameworks into practical methods and tools that match their specific workflows and needs. Here, we describe the development of a standardised risk assessment tool, the Principle-at-Risk Analysis (PaRA), as a means to close this operationalisation gap for a key level of the ethics infrastructure at (...) many organisations – the work of an interdisciplinary ethics panel. The PaRA tool serves to guide and harmonise the work of the Digital Ethics Advisory Panel at the multinational science and technology company Merck KGaA in alignment with the principles outlined in the company’s Code of Digital Ethics. We examine how such a tool can be used as part of a multifaceted approach to operationalise high-level principles at an organisational level and provide general requirements for its implementation. We showcase its application in an example case dealing with the comprehensibility of consent forms in a data-sharing context at Syntropy, a collaborative technology platform for clinical research. (shrink)

This paper reviews the origin of inertia according to Mach's principle and Weber's law of gravitation. The resulting theory is based on simultaneous nonlocal gravitational interactions between particles in the solar system and others in the remote universe beyond the Milky Way galaxy. It explains the precession of the perihelion of Mercury. A most important implication of the Mach-Weber theory of the force of inertia is the necessity for a large amount of uniformly distributed matter in the galactic universe. This (...) matter could be the source of the cosmic background radiation. Nonlocal inertia forces are compatible with a static universe and also with an expanding universe but the latter would demand slow changes in the mass of particles and the gravitational constant. (shrink)

The rapid and dynamic nature of digital transformation challenges companies that wish to develop and deploy novel digital technologies. Like other actors faced with this transformation, companies need to find robust ways to ethically guide their innovations and business decisions. Digital ethics has recently featured in a plethora of both practical corporate guidelines and compilations of high-level principles, but there remains a gap concerning the development of sound ethical guidance in specific business contexts. As a multinational science and technology company (...) faced with a broad range of digital ventures and associated ethical challenges, Merck KGaA has laid the foundations for bridging this gap by developing a Code of Digital Ethics (CoDE) tailored for this context. Following a comprehensive analysis of existing digital ethics guidelines, we used a reconstructive social research approach to identify 20 relevant principles and derive a code designed as a multi-purpose tool. Versatility was prioritised by defining non-prescriptive guidelines that are open to different perspectives and thus well-suited for operationalisation for varied business purposes. We also chose a clear nested structure that highlights the relationships between five core and fifteen subsidiary principles as well as the different levels of reference—data and algorithmic systems—to which they apply. The CoDE will serve Merck KGaA and its new Digital Ethics Advisory Panel to guide ethical reflection, evaluation and decision-making across the full spectrum of digital developments encountered and undertaken by the company whilst also offering an opportunity to increase transparency for external partners, and thus trust. (shrink)

One of Descartes’ greatest contributions to modern thought lies in his dualistic conception of mind and body. While the physical body in Descartes assumes a passive role in the ontological structure of reality, subject to mechanistic laws, the mind in Descartes, on the other hand, assumes an active role, as an organizing axis and producer of values and ideas, exercising a rational dominion over reality. physical reality. This dualistic Cartesian conception would generate important effects on the problem of mind-body interaction, (...) becoming the central theme debated by contemporary philosophy of mind. Contemporary theories of philosophy of mind seek to overcome this dualism, through neuroscience and cognitive psychology. These theories attempt to apply the reductionist scientific model to human mental phenomena and processes, describing them in non-mental, physical, and empirical terms. However, the reductionist project of these contemporary theories has not yet proved successful in explaining unobservable phenomena of the mind, such as consciousness, will and human subjectivity. (shrink)

DeMorgan lattice logic is the consecution version of Anderson/Belnap’s calculus of First Degree Entailments [1]. Theorems of DML are of the form Γ ` A, where Γ is a non-empty set of formulae. Let Γ = {A1, . . . , An}, then Γ ` A is a theorem of DML if and only if A1& . . . &An → A is a theorem of F DE. The Gentzenization of DML offered in this paper, LDML, derives from the worlds (...) semantics for F DE, first presented in [3]. It is for this reason that LDML may be called a “Gentzen semantics” for DML. (shrink)

The avocado (Persea americana) is a major crop commodity worldwide. Moreover, avocado, a paleopolyploid, is an evolutionary “outpost” among flowering plants, representing a basal lineage (the magnoliid clade) near the origin of the flowering plants themselves. Following centuries of selective breeding, avocado germplasm has been characterized at the level of microsatellite and RFLP markers. Nonetheless, little is known beyond these general diversity estimates, and much work remains to be done to develop avocado as a major subtropical‐zone crop. Among the goals (...) of avocado improvement are to develop varieties with fruit that will “store” better on the tree, show uniform ripening and have better post‐harvest storage. Avocado transcriptome sequencing, genome mapping and partial genomic sequencing will represent a major step toward the goal of sequencing the entire avocado genome, which is expected to aid in improving avocado varieties and production, as well as understanding the evolution of flowers from non‐flowering seed plants (gymnosperms). Additionally, continued evolutionary and other comparative studies of flower and fruit development in different avocado strains can be accomplished at the gene expression level, including in comparison with avocado relatives, and these should provide important insights into the genetic regulation of fruit development in basal angiosperms. BioEssays 30:386–396, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The T lymphocyte receptor for antigen, which operates in conjunction with gene products of the major histocompatibility complex (MHC), is a molecular complex comprised of five polypeptide chains. Both the 49 kDa alpha and 43 kDa beta chains are immunoglobulin‐like and thus contain variable domains responsible for ligand binding. In contrast, the 20–25 kDa T3 gamma, delta and epsilon chains are monomorphic structures presumably involved in transmembrane signalling. The alpha and beta subunits are disulfide bonded to each other and held (...) in noncovalent association with the T3 chains. T3‐Ti receptor crosslinking leads to conformational modification of a second T lineage specific molecule, termed the 50 kDa T11 structure which in turn leads to protein kinase C activation, elevation in intracytoplasmic free calcium and Na+/H+ antiport stimulation. (shrink)

Recently advocates of the propensity interpretation of fitness have turned critics. To accommodate examples from the population genetics literature they conclude that fitness is better defined broadly as a family of propensities rather than the propensity to contribute descendants to some future generation. We argue that the propensity theorists have misunderstood the deeper ramifications of the examples they cite. These examples demonstrate why there are factors outside of propensities that determine fitness. We go on to argue for the more general (...) thesis that no account of fitness can satisfy the desiderata that have motivated the propensity account. (shrink)

On peut distinguer, dans l'histoire du marxisme contemporain, deux tendances qui n'ont cessé de se confronter sous des formes plus ou moins radicales et qui tiennent à deux lectures apparemment inconciliables de l'oeuvre de Marx. La première, selon laquelle le marxisme se résorbe essentiellement en une théorie scientifique , en une sociologie . Cette tendance trouve son expression culminante dans l'althussérisme, dans le primat des relations constitutives de la structure sociale sur les individus-sujets. La seconde, qui veut que le marxisme (...) soit d'abord et avant tout un humanisme et/ou une philosophie de la praxis, tout travail théorique se trouvant subordonné à sa visée historico-pratique : celle de l'instauration de rapports sociaux dans lesquels seraient abolis les rapports d'exploitation de l'homme par l'homme. Poser la question de l'existence d'une éthique marxiste, c'est tenter de résoudre théoriquement cette épineuse dichotomie entre l'objectivisme des « déterminations » sociales des représentations de conscience morales et la capacité des individus-sujets de produire un ordre social, d'orienter le développement historique conformément à ces représentations . Pour un matérialiste, n'y a-t-il pas là une contradiction interne au marxisme? L'auteur de l'article a tenté de faire voir, à travers quelques propositions sommaires, comment une telle contradiction peut être dépassée.In the history of contemporary Marxism one can distinguish two conflicting tendencies which continue to confront each other in a more or less radical manner, and which give rise to two apparently irreconcilable readings of Marx's work. The first is that by which Marxism is essentially absorbed into a scientific theory , into a sociology. This tendency finds its ultimate expression in 'althussérisme', in the primacy of the constituent relations of the social structure involving individual subjects. In the second, which sees Marxism as essentially humanist and/or a philosophy of praxis, all theoretical work is subordinated to the practical-historical aim, that of establishing social relations in which the exploitation of persons by persons will be done away with. To ask whether a Marxist ethic exists is an attempt to resolve theoretically this thorny dichotomy between the objectivism of the social determinants of the prescriptions of moral conscience, and the capacity of individual subjects to produce a social order to orient historical development in accordance with these prescriptions. For a materialist, is there not here an apparent contradiction within Marxism? The author has attempted to clarify, by means of a few succinct propositions, how such a contradiction may be resolved. (shrink)

André Gombay; XIV*—What You Don't Know Doesn't Hurt You, Proceedings of the Aristotelian Society, Volume 79, Issue 1, 1 June 1979, Pages 239–250, https://doi.or.

Diversität ist eines der zentralen Themen unserer Zeit. Sie durchdringt alle Lebensbereiche unserer Gesellschaften. Das Nachdenken über Diversität reicht von den Naturwissenschaften über die Geschichtswissenschaften, die Gesellschaftswissenschaften, die Philosophie bis zu den Künsten. Diversität ist zudem politisch und emotional beladen. Man denke an gesellschaftliche Minderheiten und ihre Rechte oder an das massive Artensterben unserer Tage. In diesem Buch wird nicht nur über Einzelaspekte von Diversität berichtet, es wird auch eine Synthese versucht. Drei einleitende Kapitel der HerausgeberInnen führen verständlich in komplexe (...) interdisziplinäre Problemzusammenhänge ein. Der Band versammelt 17 Beiträge namhafter Autorinnen und Autoren aus den Bereichen Kunst-, Kultur- und Wissenschaftsgeschichte, Medizin und Gesellschaftstheorie.00. (shrink)

Deep brain stimulation is a well-established therapy for the motor symptoms of Parkinson’s disease, but there remains an opportunity to improve symptom relief. The temporal pattern of stimulation is a new parameter to consider in DBS therapy, and we compared the effectiveness of Temporally Optimized Patterned Stimulation to standard DBS at reducing the motor symptoms of PD. Twenty-six subjects with DBS for PD received three different patterns of stimulation while on medication and using stimulation parameters optimized for standard DBS. Side (...) effects and motor symptoms were assessed after 30 min of stimulation with each pattern. Subjects experienced similar types of side effects with TOPS and standard DBS, and TOPS were well-tolerated by a majority of the subjects. On average, the most effective TOPS was as effective as standard DBS at reducing the motor symptoms of PD. In some subjects a TOPS pattern was the most effective pattern. Finally, the TOPS pattern with low average frequency was found to be as effective or more effective in about half the subjects while substantially reducing estimated stimulation energy use. TOPS DBS may provide a new programing option to improve DBS therapy for PD by improving symptom reduction and/or increasing energy efficiency. Optimizing stimulation parameters specifically for TOPS DBS may demonstrate further clinical benefit of TOPS DBS in treating the motor symptoms of Parkinson’s disease. (shrink)

Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

In Chapter Five of The Mind Doesn’t Work That Way, Jerry Fodor argues that since it is likely that human minds evolved quickly as saltations rather than gradually as the product of an accumulation of small mutations, evolutionary psychologists are wrong to think that human minds are adaptations. I argue that Fodor’s requirement that adaptationism entails gradualism is wrongheaded. So, while evolutionary psychologists may be wrong to endorse gradualism—and I argue that they are wrong—it does not follow that they are (...) wrong to endorse an adaptationist explanation for how the human mind evolved. (shrink)

La pensée fondamentale de Wittgenstein affirme que les constantes logiques ne représentent pas, ne fonctionnent pas sémantiquement comme des noms. En apparence truiviale, cette pensée, nous le montrerons, à des ramifications étonnantes dans la philosophie du premier wittgenstein, en ce qui concerne partmulzer sa conception de la logique. Notre but est d'interpréter l'aphorisme en question (T 4.0312) en montrant comment il se rapporte aux thèses et théories les plus importantes du Tractatus, et comment il permet de les faire tenir ensemble (...) d'une façon cohérente, justifiant par là son caractère "fondamental". Nous tentons également d'apporter une réponse aux questions suivantes: les propositions complexes sont-elles encore — comme les propositions atomiques — des "images" de la réalité? et quelle est cette "logique des faits" dont parle Wittgenstein dans l'aphorisme sous examen? (shrink)

Volume 19, Issue 10, October 2019, Page 93-94.

A critical notice of T. Kouromenos, G. M. Parássoglou, K. Tsantsanoglou, The Derveni Papyrus. Edited with Introduction and Commentary, Studi e Testi per il Corpus dei Papiri Filosofici Greci e Latini 13, Leo Olschki, Firenze, 2006.

The boundary problem is related to the binding problem, part of a family of puzzles and phenomenal experiences that theories of consciousness (ToC) must either explain or eliminate. By comparison with the phenomenal binding problem, the boundary problem has received very little scholarly attention since first framed in detail by Rosengard in 1998, despite discussion by Chalmers in his widely cited 2016 work on the combination problem. However, any ToC that addresses the binding problem must also address the boundary problem. (...) The binding problem asks how a unified first person perspective (1PP) can bind experiences across multiple physically distinct activities, whether billions of individual neurons firing or some other underlying phenomenon. To a first approximation, the boundary problem asks why we experience hard boundaries around those unified 1PPs and why the boundaries operate at their apparent spatiotemporal scale. We review recent discussion of the boundary problem, identifying several promising avenues but none that yet address all aspects of the problem. We set out five specific boundary problems to aid precision in future efforts. We also examine electromagnetic (EM) field theories in detail, given their previous success with the binding problem, and introduce a feature with the necessary characteristics to address the boundary problem at a conceptual level. Topological segmentation can, in principle, create exactly the hard boundaries desired, enclosing holistic, frame-invariant units capable of effecting downward causality. The conclusion outlines a programme for testing this concept, describing how it might also differentiate between competing EM ToCs. (shrink)