Here we review and discuss the link between regeneration capacity and tumor suppression comparing mammals (embryos versus adults) with highly regenerative vertebrates. Similar to mammal embryo morphogenesis, in amphibians (essentially newts and salamanders) the reparative process relies on a precise molecular and cellular machinery capable of sensing abnormal signals and actively reprograming or eliminating them. As the embryo's evil twin, tumor also retains common functional attributes. The immune system plays a pivotal role in maintaining a physiological balance to provide surveillance (...) against tumor initiation or to support its initiation and progression. We speculate that susceptibility to cancer development in adult mammals may be determined by the loss of an advanced regenerative capability during evolution and believe that gaining mechanistic insights into how regenerative capacity linked to tumor suppression is postnatally lost in mammals might illuminate an as yet unrecognized route to cancer treatment. (shrink)

本书分上下册,主要内容包括格言联壁,交友论,小窗幽记,安得长者言,菜根潭,围炉夜话,六事箴言,居官格言三十三条.

本书共分九章,内容包括:儒家概说、儒家追求的理想境界、内与外的和谐统一、家庭的和谐、人与人的和谐、人与社会的和谐等。.

volume 1. Zou xiang xin xue de jue wu zhi lu -- volume 2. Wen tao wu lüe de xin xue zong shi -- volume 3. Liang zhi xin xue de ren wen qing huai.

This paper discusses the philosophy of Zhu Xi, "a sub-Shu" concept, and that "a sub-Shu," Zhu Xi's philosophy in the concept of moral ethics, metaphysics, cosmology and so many different face. By "a sub-Shu," Zhu Xi's view, ethics has its objective basis for its endless from the Heaven. And this seems to be constructed for the contemporary world, to provide some contribution to the work ethic.

Dans la Chine de la fin du XVIIe siècle, les missionnaires jésuites français ont importé de Paris à Pékin une méthode de recherche scientifique typiquement française et aussi typiquement académique. Ce début prometteur a subi un infléchissement négatif dans le développement ultérieur des ambitions de la mission dans le champ des activités scientifiques del' Ancien Régime. On analyse ici les différences substantielles qui caractérisent la mission scientifique française jésuite à la fin du XVIIe siècle et au siècle suivant. À travers (...) une étude des éditions parisiennes de la production scientifique française jésuite en provenance de Chine, les Observations (1688, 1692, 1729), est expliqué le déclin de la mission scientifique française jésuite par la dissolution de ses liens avec l'Académie des sciences et par ses difficultés à construire et à maintenir une vision collective et une identité de corps dans l'analyse des phénomènes naturels. (shrink)

The effect of emotion on memory often leads to the trade-off: enhanced memory for emotional items comes at the cost of memory for background information. Although this effect is usually attributed...

Previous research has explored how emotional valence affected face-context associative memory, while little is known about how arousing stimuli that share the same valence but differ in emotionality are bound together and retained in memory. In this study, we manipulated the emotional similarity between the target face and the face associated with the context emotion, and examined the effect of emotional similarity of negative emotion on face-context associative memory. Our results showed that the greater the emotional similarity between the faces, (...) the better the face memory and face-context associative memory were. These findings suggest that the processing of facial expression and its associated context may benefit from taking into account the emotional similarity between the faces. (shrink)

The puzzle has played a significant role in Chinese culture since its formation. The Lo-shu and the Ba-gua, the most prominent number puzzle in ancient China, with its instinctual quest for universal order, has constructed a philosophical system that has incorporated human being as an integral part of nature. The system has exerted great influence on Chinese culture to this day. Because of its mysterious origin and magical evolution, the Ba-gua has been used to predict the fortune of both the (...) nation and the individual. The Chinese character-deconstructing puzzle has also functioned as a foreshadow of one’s fate. By analyzing the components of a character, written by the subject in a specific context, divination was made. In contrast to the solemn mission of the number puzzle, and the character-deconstructing puzzle, the wedding puzzle and the riddle are lighthearted, and intended to provoke humor, and to function pedagogically. A latecomer, once the mysteriousness of number and character has faded, the riddle is used to promote the intellectual development of children. The wedding puzzle has been popular among those who are illiterate and make analogy by using common occurrence to allude to taboo in the oral dialect. Since their illiteracy has excluded them from reading and writing, they are free to make puzzles in their own dialect without being limited by a reverence for the written character. (shrink)

Background: Informed consent is essential for the ethical conduct of clinical research and is a culturally sensitive issue. But, a measurable Chinese version of the scale to evaluate the informed consent process has not yet been explored in the existing literature. Research objectives: This study aimed to develop and psychometrically test the Chinese version of the Informed Consent Process Scale. Research design: Back-translation was conducted to develop the Chinese version of the questionnaire. A cross-sectional survey was administered, after which an (...) exploratory factor analysis was conducted. Participants: We recruited a total of 375 participants who had experience in signing an informed consent form within the previous 3 years in Taiwan. Ethical considerations: This study was approved by two Institutional Review Boards and the autonomy of the participants was respected. Findings: The Chinese version of the Informed Consent Process Scale is composed of three factors with 23 items showing evidence of acceptable reliability and validity. Three major factors were extracted and labeled: Factor 1 – ‘Understanding of the research’, Factor 2 – ‘Trust and confidence’ and Factor 3 – ‘Doubt and uncertainty’. The three factors accounted for is 52.954 of the total variance with Cronbach’s α of.917. Discussion and conclusion: The finding corroborates previous studies showing that participants had too little understanding on the informed consent forms they signed and implied the need to clarify the critical points in clinical research. The psychometric results indicated good internal consistency and validity for this newly constructed instrument, and it was found worthy of conducting further testing and application. (shrink)

Around 1716, the French astronomer and academician Joseph-Nicolas Delisle took up a new project: the twinned topics of Chinese chronology and astronomy. Unable to access Chinese sources and not knowing any fellow savants who shared this particular interest, Delisle methodically made extracts and compiled data from the existing European literature. Among Delisle's papers at the Observatoire de Paris still exist the results of this research, including a list of the books he found relevant. This paper develops a close reading of (...) Delisle's notes from this period to stage his journey into a recondite arena of technical and textual analysis, and to examine the scholarly practices and generic conventions through which early modern European savants confronted the Chinese astronomical tradition. (shrink)

Molecular chaperones assist de novo protein folding and facilitate the refolding of stress‐denatured proteins. The molecular chaperone concept was coined nearly 35 years ago, and since then, tremendous strides have been made in understanding how these factors support protein folding. Here, we focus on how various chaperone proteins were first identified to play roles in protein folding. Examples are used to illustrate traditional routes of chaperone discovery and point out their advantages and limitations. Recent advances, including the development of folding (...) biosensors and promising methods for the stabilization of proteins in vivo, provide new routes for chaperone discovery. (shrink)

Resumo: No processo de desenvolvimento de longo prazo, a cultura tradicional chinesa gradualmente formou características próprias. Ela é conhecida por sua extensa e longa história, que, em certa medida, proporciona um bom ambiente para a sobrevivência e reprodução do povo chinês. A introdução da filosofia marxista na China desempenhou um papel importante no trabalho prático da construção revolucionária do país. Ao mesmo tempo, a comunidade acadêmica explora constantemente o terreno comum entre a filosofia marxista e a cultura tradicional chinesa. Na (...) nova era da construção socialista, é necessário ter uma compreensão aprofundada da cultura tradicional chinesa. A fim de levar a China a realizar o sonho chinês o mais rápido possível e o grande renascimento da nação chinesa, este artigo trata da integração da cultura tradicional chinesa e da filosofia marxista, explorando a nova evolução da sinicização da filosofia marxista no novo período histórico. (shrink)

あらゆる事象はゆくりないめぐり逢いであり、その邂逅の源泉に原始偶然が厳存する―。偶然性を定言的偶然、仮説的偶然、離接的偶然の三つに大別し、偶然性の本質を解明した九鬼周造(1888‐1941)の主著。ヘ ラクレイトスの偶然論とパルメニデスの必然論の対立以来くりかえし問い続けられてきた「偶然と必然」の問題への九鬼独自の解答。.

大胆に切り捨てる一方、多様な要素を隔てなく取りこむ...それは、私たちの感性にも通じるから。センス・オブ・ニッポンの本質を日本美術に検証する。.