Background Policy decisions about childhood vaccination require consideration of multiple, sometimes conflicting, public health and ethical imperatives. Examples of these decisions are whether vaccination should be mandatory and, if so, whether to allow for non-medical exemptions. In this article we argue that these policy decisions go beyond typical public health mandates and therefore require democratic input.Methods We report on the design, implementation, and results of a deliberative public forum convened over four days in Ontario, Canada, on the topic of childhood (...) vaccination.Results 25 participants completed all four days of deliberation and collectively developed 20 policy recommendations on issues relating to mandatory vaccinations and exemptions, communication about vaccines and vaccination, and AEFI (adverse events following immunization) compensation and reporting. Notable recommendations include unanimous support for mandatory childhood vaccination in Ontario, the need for broad educational communication about vaccination, and the development of a no-fault compensation scheme for AEFIs. There was persistent disagreement among deliberants about the form of exemptions from vaccination (conscience, religious beliefs) that should be permissible, as well as appropriate consequences if parents do not vaccinate their children.Conclusions We conclude that conducting deliberative democratic processes on topics that are polarizing and controversial is viable and should be further developed and implemented to support democratically legitimate and trustworthy policy about childhood vaccination. (shrink)

Life scientists increasingly rely upon abstraction-based modeling and reasoning strategies for understanding biological phenomena. We introduce the notion of constraint-based reasoning as a fruitful tool for conceptualizing some of these developments. One important role of mathematical abstractions is to impose formal constraints on a search space for possible hypotheses and thereby guide the search for plausible causal models. Formal constraints are, however, not only tools for biological explanations but can be explanatory by virtue of clarifying general dependency-relations and patterning between (...) functions and structures. We describe such situations as constraint-based explanations and argue that these differ from mechanistic strategies in important respects. While mechanistic explanations emphasize change-relating causal features, constraint-based explanations emphasize formal dependencies and generic organizational features that are relatively independent of lower-level changes in causal details. Our distinction between mechanistic and constraint-based explanations is pragmatically motivated by the wish to understand scientific practice. We contend that delineating the affordances and assumptions of different explanatory questions and strategies helps to clarify tensions between diverging scientific practices and the innovative potentials in their combination. Moreover, we show how constraint-based explanation integrates several features shared by otherwise different philosophical accounts of abstract explanatory strategies in biology. (shrink)

Feminism is sensational -- On being directed -- Willfulness and feminist subjectivity -- Trying to transform -- Being in question -- Brick walls -- Fragile connections -- Feminist snap -- Lesbian feminism -- Conclusion 1: A killjoy survival kit -- Conclusion 2: A killjoy manifesto.

The paper suggests that we can usefully approach whiteness through the lens of phenomenology. Whiteness could be described as an ongoing and unfinished history, which orientates bodies in specific directions, affecting how they `take up' space, and what they `can do'. The paper considers how whiteness functions as a habit, even a bad habit, which becomes a background to social action. The paper draws on experiences of inhabiting a white world as a non-white body, and explores how whiteness becomes worldly (...) through the noticeability of the arrival of some bodies more than others. A phenomenology of whiteness helps us to notice institutional habits; it brings what is behind to the surface in a certain way. (shrink)

We have no interest whatever in minimizing the continuing history of racist, sexist, homophobic, or otherwise abusive biologisms, or the urgency of their exposure, that has made the gravamen of so many contemporary projects of critique. At the same time, we fear — with installation of an automatic antibiologism as the unshifting tenet of `theory' — the loss of conceptual access to an entire thought-realm. I was left wondering what danger had been averted by the exclusion of biology. What does (...) the nominative `biological or anatomical body' actually refer to? And what secures the separation of its inadmissible matter from the proper purview of Irigaray's textual interventions? When I asked a question to this effect it was met with a certain nervous comprehension. Deciding, perhaps, that I must still be immersed in a precritical understanding of the body, the speaker dismissed me with a revealing theatrical gesture. As if to emphasize the sheer absurdity of my question she pinched herself and commented `Well I don't mean this body'. And so it seemed with a gesture so matter of fact that it required no further comment, the fact of matter was both decided and dispatched. Feminism has been as deeply implicated in routinized antiessentialism as any of our critical procedures. Even though questions of `the body' have become increasingly fashionable in all manner of feminist projects, the schedule of feminism's antibiologism has been little altered. In most of these projects on `the body', the body in question is pursued in its socially, experientially, or psychically constituted forms, but rarely in its physiologically, biochemically, or microbiologically constituted form, the idea of biological construction having been rendered either unintelligible or naive. Despite an avowed interest in the body, there is a persistent distaste for biological detail. These feminist theories have usually been reluctant to engage with biological data: they retain, and encourage, the fierce antibiologism that marked the emergence of second wave feminism. That feminist scholars are particularly prone to a `knee jerk constructivism' helps explain the reluctance of those in the humanities to engage seriously with the claims of science. This book functions primarily as a reminder to social, political, and cultural theorists, particularly those interested in feminism, antiracism and questions of the politics of globalisation, that they have forgotten a crucial dimension of research, if not necessary to, then certainly useful for more incisively formulating the concepts on which they so heavily, if implicitly rely. It is written as a remembrance of what we have forgotten — not just the body, but that which makes it possible and which limits its actions: the precarious, accidental, contingent, expedient, striving, dynamic status of life in a messy, complicated, resistant, brute world of materiality, a world regulated by the exigencies, the forces, of space and time. We have forgotten the nature, the ontology, of the body, the conditions under which bodies are encultured, psychologized, given identity, historical location, and agency. We have forgotten where we come from. (shrink)

We consider an approach to propositional synonymy in proof-theoretic semantics that is defined with respect to a bilateral G3-style sequent calculus $\mathtt{SC2Int}$ for the bi-intuitionistic logic $\mathtt{2Int}$. A distinctive feature of $\mathtt{SC2Int}$ is that it makes use of two kind of sequents, one representing proofs, the other representing refutations. The structural rules of $\mathtt{SC2Int}$, in particular its cut rules, are shown to be admissible. Next, interaction rules are defined that allow transitions from proofs to refutations, and vice versa, mediated through (...) two different negation connectives, the well-known implies-falsity negation and the less well-known coimplies-truth negation of $\mathtt{2Int}$. By assuming that the interaction rules have no impact on the identity of derivations, the concept of inherited identity between derivations in $\mathtt{SC2Int}$ is introduced and the notions of positive and negative synonymy of formulas are defined. Several examples are given of distinct formulas that are either positively or negatively synonymous. It is conjectured that the two conditions cannot be satisfied simultaneously. (shrink)

This essay contends that postcolonial migrants have a right to enter their former colonizing nations, and that these should accept them. Our novel argument challenges well-established justifications for restrictions in immigration-policies advanced in liberal nationalism, which links immigration controls to the nation’s self-determination and the legitimate preservation of national identity. To do so, we draw on postcolonial analyses of colonialism, in particular on Edward Said’s notion of “intertwined histories,” and we offer a more sophisticated account of national identity than that (...) of liberal nationalists. In our view, the national identity of former colonizing nations cannot be understood in isolation from their ex-colonies. This entails that liberal nationalists cannot justify the restriction on the entrance of members of the nation’s former colonies by resorting to an argument about the preservation of national identity: the former colonized constitute an inseparable element of that national identity, because they are already historically part of it. (shrink)

In this paper I will develop a lambda-term calculus, lambda-2Int, for a bi-intuitionistic logic and discuss its implications for the notions of sense and denotation of derivations in a bilateralist setting. Thus, I will use the Curry-Howard correspondence, which has been well-established between the simply typed lambda-calculus and natural deduction systems for intuitionistic logic, and apply it to a bilateralist proof system displaying two derivability relations, one for proving and one for refuting. The basis will be the natural deduction system (...) of Wansing's bi-intuitionistic logic 2Int, which I will turn into a term-annotated form. Therefore, we need a type theory that extends to a two-sorted typed lambda-calculus. I will present such a term-annotated proof system for 2Int and prove a Dualization Theorem relating proofs and refutations in this system. On the basis of these formal results I will argue that this gives us interesting insights into questions about sense and denotation as well as synonymy and identity of proofs from a bilateralist point of view. (shrink)

The purpose of this paper is to introduce a bi-intuitionistic sequent calculus and to give proofs of admissibility for its structural rules. The calculus I will present, called SC2Int, is a sequent calculus for the bi-intuitionistic logic 2Int, which Wansing presents in [2016a]. There he also gives a natural deduction system for this logic, N2Int, to which SC2Int is equivalent in terms of what is derivable. What is important is that these calculi represent a kind of bilateralist reasoning, since they (...) do not only internalize processes of verifcation or provability but also the dual processes in terms of falsifcation or what is called dual provability. In [Wansing, 2017] a normal form theorem for N2Int is stated, here, I want to prove a cut-elimination theorem for SC2Int, i.e., if successful, this would extend the results existing so far. (shrink)

It is unclear whether the regulatory distinction between non-identifiable and identifiable information—information used to determine informed consent practices for the use of clinically derived samples for genetic research—is meaningful to patients. The objective of this study was to examine patients' attitudes and preferences regarding use of anonymous and identifiable clinical samples for genetic research. Telephone interviews were conducted with 1,193 patients recruited from general medicine, thoracic surgery, or medical oncology clinics at five United States academic medical centers. Wanting to know (...) about research being done was important to 72% of patients when samples would be anonymous and to 81% of patients when samples would be identifiable. Only 17% wanted to know about the identifiable scenario but not the anonymous scenario. Curiosity-based reasons were the most common among patients who wanted to know about anonymous samples. Of patients wanting to know about either scenario, approximately 57% would require researchers to seek permission, whereas 43% would be satisfied with notification only. Patients were more likely to support permission in the anonymous scenario if they had more education, were Black, less religious, in better health, more private, and less trusting of researchers. The sample, although not representative of the general population, does represent patients at academic medical centers whose clinical samples may be used for genetic research. Few patients expressed preferences consistent with the regulatory distinction between non-identifiable and identifiable information. Data from this study should cause policy-makers to question whether this distinction is useful in relation to research with previously collected clinically derived samples. (shrink)

The timing of this special issue of AJOB probing whether public engagement (PE)1 might help achieve equity in genomics is no coincidence. While many issues discussed by the authors are not entirely...

This comment addresses opportunities for understanding the social functions of emotion by taking a developmental perspective. I agree that understanding emotions and their development will meaningf...

Background Families whose child has unexplained intellectual or developmental differences often hope that a genetic diagnosis will lower barriers to community-based therapeutic and support services. However, there is little known about efforts to mobilize genetic information outside the clinic or how socioeconomic disadvantage shapes and constrains outcomes.Methods We conducted an ethnographic study with predominantly socioeconomically disadvantaged families enrolled in a multi-year genomics research study, including clinic observations and in-depth interviews in English and Spanish at multiple time points. Coding and thematic (...) development were used to collaboratively interpret fieldnotes and transcripts.Results Thirty-two families participated. Themes included familial expectations that a genetic diagnosis could be translated into information, understanding, and assistance to improve the quality of a child’s day-to-day life. After sequencing, however, genetic information was not readily converted into improved access to services beyond the clinic, with families often struggling to use a genetic diagnosis to advocate for their child.Conclusion Families’ ability to use a genetic diagnosis as an effective advocacy tool beyond the clinic was limited by the knowledge and resources available to them, and by the eligibility criteria used by therapeutic service providers’ – which focused on clinical diagnosis and functional criteria more than etiologic information. All families undertaking genomic testing, particularly those who are disadvantaged, need additional support to understand the limits and potential benefits of genetic information beyond the clinic. (shrink)

Near-death experiences (NDEs) have been defined as any conscious perceptual experience occurring in individuals pronounced clinically dead or who came very close to physical death. They are frequently reported by patients surviving a critical injury and, intriguingly, they show common features across different populations. The tool traditionally used to assess NDEs is the NDE Scale, which is available in the original English version. The aim of this study was to develop the Italian version of the NDE Scale and to assess (...) its reliability in a specific clinical setting. A process of translation of the original scale was performed in different stages in order to obtain a fully comprehensible and accurate Italian translation. Later, the scale was administered to a convenience sample of patients who had experienced a condition of coma and were, at the time of assessment, fully conscious and able to provide information as requested by the scale. Inter-rater and test–retest reliability, assessed by the weighted Cohen’s kappa ( K w ), were estimated. A convenience sample of 20 subjects [mean age ± standard deviation (SD) 51.6 ± 17.1, median time from injury 3.5 months, interquartile range (IQR) 2–10] was included in the study. Inter-rater [ K w 0.77 (95% CI 0.67–0.87)] and test–retest reliability [ K w 0.96 (95% CI 0.91–1.00)] showed good to excellent values for the total scores of the Italian NDE Scale and for subanalyses of each single cluster of the scale. An Italian Version of the NDE Scale is now available to investigate the frequency of NDE, the causes for NDE heterogeneity across different life-threatening conditions, and the possible neural mechanisms underlying NDE phenomenology. (shrink)

This paper explores how diversity is used as a key term to describe the social and educational mission of universities in Australia. The paper suggests that we need to explore what diversity ‘does’ in specific contexts. Drawing on interviews with diversity and equal opportunities practitioners, the paper suggests that ‘diversity’ is used in the face of what has been called ‘equity fatigue’. Diversity is associated with what is new, and allows practitioners to align themselves and their units with the existing (...) values of their universities. However, given this, diversity can mean potentially anything: and practitioners have to re‐attach the term ‘diversity’ to other more marked terms such as equality and justice if it is to ‘do anything’. The paper explores the appeal of diversity, the strategic nature of diversity work, and the role of commitment, leadership and training. It also offers some more general reflections on how language works within organisations by showing that words, although they do things, are not finished as forms of action: what they do depends not only on how they are used, but how they get taken up. (shrink)

It has been argued that reduction procedures are closely connected to the question about identity of proofs and that accepting certain reductions would lead to a trivialization of identity of proofs in the sense that every derivation of the same conclusion would have to be identified. In this paper it will be shown that the question, which reductions we accept in our system, is not only important if we see them as generating a theory of proof identity but is also (...) decisive for the more general question whether a proof has meaningful content. There are certain reductions which would not only force us to identify proofs of different arbitrary formulas but which would render derivations in a system allowing them meaningless. To exclude such cases, a minimal criterion is proposed which reductions have to fulfill to be acceptable. (shrink)

A case study in the kinds of problems to expect from this increasingly popular marketing tactic.

On the Viśiṣṭādvaita philosophy of Rāmānuja, 1017-1137.

Emotions are complex phenomena. We all have an intuitive understanding of what they are because we experience them in everyday life. They occur in response to triggering situations in the external environment and play a major role in our perception, cognition, and motivation. Despite their paramount importance in our lives, attempts to provide a general definition or complete taxonomy of emotions have failed. To date, both the definition and classification of emotions remain controversial and depend on the theory of emotions (...) one favours. (shrink)

Advances in genetic research have created the need to inform consumers. Yet, the communication of hereditary risk and of the options for how to deal with it is a difficult task. Due to the abstract nature of genetics, people tend to overestimate or underestimate their risk. This paper addresses the issue of how to communicate risk information on hereditary breast and ovarian cancer through an online application. The core of the paper illustrates the design of OPERA, a risk assessment instrument (...) that applies the UK National Institute of Health and Clinical Excellence's guidelines on the basis of (i) the number of relatives on the same side of the family with the same cancer or cancers that are known to run together; (ii) the ages of these relatives at diagnosis and (iii) the closeness of the family relationship with the person who is doing the assessment. By relying on the argumentation theory, we explain how the communication strategy that OPERA implements is essentially based on Perelman and Olbrechts-Tyteca's deductive argumentation by association. By using as premises “facts” (propositions about reality that can be assumed without further justification) and “truths” (propositions that make connections about facts), OPERA delivers its claims with an ex auctoritate causal link aimed at transferring the audience's acceptance of the cause to the effect. Overall, the design of OPERA rests on its capacity to induce users' active processing of risk information through an appeal to their reasoning faculty. In the conclusion, we present some results from a pilot evaluation of users' acceptance of OPERA. (shrink)

Receiving a diagnosis of cancer can be devastating. Cancer continues to be one of the most feared diagnoses, and experiencing pain is a major fear for people diagnosed with cancer. Cancer pain is complex in aetiology and can be acute or chronic and can be caused by various compression, ischaemic, neuropathic or inflammatory processes. Many people with cancer will experience excruciating pain, which is often underreported and undertreated. The reasons for this are complex and include various factors including fears and (...) beliefs held by patients. Cognitive factors are important modulators of pain and the appraisals, meanings and beliefs that people have in relation to illness, cancer, and pain, have implications in regard to help-seeking behaviours and the coping strategies people adopt. Cancer pain can impact a range of psycho-social factors across its course. Cancer pain relates to higher rates of psychological distress, anxiety and low mood, and the perception of pain intensity is, in turn, influenced by psychological factors. Cancer pain can negatively affect psychological health, and psycho-social factors can affect the pain experience. It has been suggested that people with a life-limiting illness experience ‘total pain’, and this can encompass psychological, social, practical, spiritual domains. Research demonstrates that cancer is predominantly an illness affecting older people, yet there is a higher risk of under-treated pain in this age group and there is a paucity of research into the subjective experiences of older people managing their cancer pain. Many older people are required to self-manage cancer pain at home as outpatients, due to drivers to keep people out of inpatient care, such as the high healthcare costs of inpatient treatment, and patients wanting to manage their illness, and die, at home. Our own research into this area found that the self-management of cancer pain involves a sequential and temporal process, which centres on perceptions of control. We describe how the older people in our study experienced a perceived loss of control, followed by a sense of gaining control over pain through various experience of certain internal and external factors. The assessment and treatment of physical pain should be done in combination with assessment and treatment of psycho-social and spiritual pain, and interventions for cancer pain need to focus on increasing positive affect and reducing helplessness. No person should suffer with poorly controlled pain and we argue for the need for further research in this area to ensure adequate treatment for all.Clinical Implications: Assessment and treatment of physical pain in people with cancer needs to be conducted in combination with assessment and treatment of psycho-social issues and spiritual pain. Psychological and behavioural approaches have strong evidence supporting their efficacy for reducing cancer pain. Interventions should target helplessness and focus on increasing positive affect through positive psychological states including fighting spirit and resilience. Person-centred interventions that focus on helping people with the search for meaning may help those with cancer pain derive positive benefits. (shrink)

Mind &Language, Volume 34, Issue 5, Page 667-680, November 2019.

The present study examines the comorbidity between specific learning disorders and attention deficit and hyperactivity disorder by comparing the neuropsychological profiles of children with and without this comorbidity. Ninety-seven schoolchildren from 8 to 14 years old were tested: a clinical sample of 49 children with ADHD, SLD or SLD in comorbidity with ADHD, and 48 typically-developing children matched for age and intelligence. Participants were administered tasks and questionnaires to confirm their initial diagnosis, and a battery of executive function tasks testing (...) inhibition, shifting, and verbal and visuospatial updating. Using one-way ANOVAs, our results showed that all children in the clinical samples exhibited impairments on EF measures when compared with TD children. A more specific pattern only emerged for the updating tasks. Only children with SLD had significant impairment in verbal updating, whereas children with ADHD, and those with SLD in comorbidity with ADHD, had the worst performance in visuospatial updating. The clinical and educational implications of these findings are discussed. (shrink)

Clark and Fischer's three levels of depiction of social robots can be conceptualized as cognitive schemas. When interacting with social robots, humans shift between schemas similarly to how they shift between identity category schemas when interacting with other humans. Perception of mind, context cues, and individual differences underlie perceptions of which level of depiction is most situationally relevant.