This paper explores the epistemology of extrapolation from model organisms to humans in molecular medicine. We take into account two common views on the issue, the homology view and the disanalogy view. In response to both interpretations, we argue that the foundational basis of extrapolations cannot simply be provided by homology and that relevant disanalogies can, thanks to the techniques of molecular biology, be experimentally controlled and exploited to allow useful and reliable extrapolations. The case of "humanised mice" in the (...) context of cancer stem cell research provides evidence of how animal models can be construed to approximate bona fide causal analogue models of human diseases. To supplement this view we show how the epistemology of model organisms needs to take into account the engineering side of molecular medicine. Model organisms are often manipulated to create analogies or remove disanalogies with the target system. We maintain that highlighting this feature is fundamental to explain what warrants extrapolation in the search for the molecular causes of disease. (shrink)

Neuroeconomics, neuromarketing, neuroaesthetics, and neurotheology are just a few of the novel disciplines that have been inspired by a combination of ancient knowledge along with recent discoveries about how the human brain works.This fascinating and thought provoking new book critically questions our love affair with brain imaging.

Pierre de Fermat is known as the inventor of modern number theory. He invented–improved many methods useful in this discipline. Fermat often claimed to have proved his most difficult theorems thanks to a method of his own invention: the infinite descent. He wrote of numerous applications of this procedure. Unfortunately, he left only one almost complete demonstration and an outline of another demonstration. The outline concerns the theorem that every prime number of the form 4n + 1 is the sum (...) of two squares. In this paper, we analyse a recent proof of this theorem. It is interesting because: it follows all the elements of which Fermat wrote in his outline; it represents a good introduction to all logical nuances and mathematical variants concerning this method of which Fermat spoke. The assertions by Fermat will also be framed inside their historical context. Therefore, the aims of this paper are related to the history of mathematics and to the logic of proof-methods. (shrink)

The mnemonic arts and the idea of a universal language that would capture the essence of all things were originally associated with cryptology, mysticism, and other occult practices. And it is commonly held that these enigmatic efforts were abandoned with the development of formal logic in the seventeenth century and the beginning of the modern era. In his distinguished book, Logic and the Art of Memory Italian philosopher and historian Paolo Rossi argues that this view is belied by an (...) examination of the history of the idea of a universal language. Based on comprehensive analyses of original texts, Rossi traces the development of this idea from late medieval thinkers such as Ramon Lull through Bruno, Bacon, Descartes, and finally Leibniz in the seventeenth century. The search for a symbolic mode of communication that would be intelligible to everyone was not a mere vestige of magical thinking and occult sciences, but a fundamental component of Renaissance and Enlightenment thought. Seen from this perspective, modern science and combinatorial logic represent not a break from the past but rather its full maturity. Available for the first time in English, this book (originally titled Clavis Universalis ) remains one of the most important contributions to the history of ideas ever written. In addition to his eagerly anticipated translation, Steven Clucas offers a substantial introduction that places this book in the context of other recent works on this fascinating subject. A rich history and valuable sourcebook, Logic and the Art of Memory documents an essential chapter in the development of human reason. (shrink)

According to Ernst Cassirer, the transition from the concept of substance to that of mathematical function as a guide of knowledge coincided with the end of ancient and the beginning of modern theoretical thought. In the first part of this article we argue that a similar transition has also taken place in the practical sphere, where mathematical function occurs in one of its specific forms, which is that of the algorithm concept. In the second part we argue that with the (...) rise of modernity the idea of substance and the related concepts of category and classification, which are deeply embedded in western culture, have not been totally supplanted by that of function. The intertwining of the concepts of substance and function has generated contradictory hybrids. These hybrids are used as a key for the understanding of the different repercussions of algorithmic logic on society in terms of social integration. (shrink)

In a recent paper, Christian List (2014) has argued for the compatibilism of free will and determinism. Drawing on a distinction between physical possibility (used in defining determinism) and agential possibility (used in defining free will), List constructs a formal two-level model in which the two concepts are consistent. This paper's first contribution is to show that though List's model is formally consistent, philosophically it falls short of establishing a satisfactory compatibilist position. Ensuingly, an analysis of the shortcomings of the (...) model leads to the identification of a controversial epistemological assumption implicit in the statements of both compatibilist and incompatibilist positions. Arguing that this assumption is not currently satisfied, the paper's second contribution is to show that neither the compatibilist nor the incompatibilist position is presently well-founded. (shrink)

The present article aims at providing some clarification on the Horkheimer-Neurath 1937 debate, so as to make three main claims: (a) around 1937 (even though perhaps neither in the early 1930s, at the time of his review of Mannheim’s Ideology and Utopia, nor after the Second World War, at the time of Adorno’s disenchanted statement, “the whole is the false”), Horkheimer belonged to the Hegelian-Marxist tradition stemming from Lukács’s History and Class Conscioussness (1923); (b) notwithstanding Neurath’s semantic and epistemological holism, (...) his fallibilism, his rejection of Wertfreiheit in the social sciences, his commitment to socialism, there is still a gulf between his position and Horkheimer’s, for Neurath did not accept the main methodological claim made by the latter, namely, the Lukács-inspired view that what “constitutes the decisive difference between Marxism and bourgeois thought” is the Hegelian “point of view of totality”; (c) highlighting the main differences between Neurath’s and Lukács’s versions of Marxism – one concerning the very idea of dialectic, and the other concerning the epistemic privilege of the proletariat – can throw some light on and help understand better the distinctive features of Lukács’s Hegelianization of Marxism. (shrink)

Part one: the act of speaking -- The speaker as performing artist -- The absolute performative -- The repetition of anthropogenesis -- Part two: toward a critic of interiority -- Second-degree sensualism: a physiognomic project -- In praise of reification -- Part three: from the beginning and right now -- Natural history -- The multitude and the principle of individuation -- Appendix: Wittgenstein and the question of atheism.

The aim of this paper is to explore the status of argumentative discourse. We argue that argumentation can contribute to instances of different discourse genres, regardless of whether it is functional to their purposes. By analyzing examples from the daily press in the light of an approach to discourse analysis inspired by pragmatics, we show that also texts that are not expected to be argumentative have underlying argumentative structures and that a text’s being argumentative is a matter of degree: the (...) understanding of underlying argumentative structures contributes to a varying extent to the understanding of what a text as a whole means and of its point in the speech situation. This role of argumentative structures in text understanding suggests considering argumentation as a cognitively-based dimension of discourse, connected to human rationality. (shrink)

In the last decades, Systems Biology (including cancer research) has been driven by technology, statistical modelling and bioinformatics. In this paper we try to bring biological and philosophical thinking back. We thus aim at making diferent traditions of thought compatible: (a) causality in epidemiology and in philosophical theorizing—notably, the “sufcient-component-cause framework” and the “mark transmission” approach; (b) new acquisitions about disease pathogenesis, e.g. the “branched model” in cancer, and the role of biomarkers in this process; (c) the burgeoning of omics (...) research, with a large number of “signals” and of associations that need to be interpreted. In the paper we summarize frst the current views on carcinogenesis, and then explore the relevance of current philosophical interpretations of “cancer causes”. We try to ofer a unifying framework to incorporate biomarkers and omic data into causal models, referring to a position called “evidential pluralism”. According to this view, causal reasoning is based on both “evidence of diference-making” (e.g. associations) and on “evidence of underlying biological mechanisms”. We conceptualize the way scientists detect and trace signals in terms of information transmission, which is a generalization of the mark transmission theory developed by philosopher Wesley Salmon. Our approach is capable of helping us conceptualize how heterogeneous factors such as micro and macro-biological and psycho-social—are causally linked. This is important not only to understand cancer etiology, but also to design public health policies that target the right causal factors at the macro-level. (shrink)

This article explores the concept of landscape through the lens of performativity, challenging the traditional visual-centric understanding rooted in Western art and culture but without denying the visual and representational character of landscape. It examines the evolution of landscape representation, from its origins in linear perspective and Cartesian dualism to contemporary approaches that integrate performative practices. The analysis highlights the dialectical tension between visual representation and immersive, multisensory experiences, arguing for a more integrated view that acknowledges the performative aspects of (...) the visual. By re-evaluating the role of distance, vision, and representation, the article advocates for a nuanced understanding of landscape that balances the visual with embodied practices, ultimately proposing that landscape should be seen as a dynamic interplay between seeing and performing. (shrink)

During the 1930s the fascist government launched a programme for the reclamation of the Pontine Marshes, one of the largest forested wetlands in Italy. In less than a few years the muddy and uneven ground of the forest was transformed into flat land to be cultivated and into solid surface where three new towns were built. Hegemonic narratives describe the fascist reclamation as a process that imposed a solid form upon the raw materials of nature, thereby establishing an unbridgeable divide (...) between nature and culture, natural and built environment. The article challenges this dualism, drawing on ethnographic and historical materials to explore spatial and temporal zones in-between fluidity and solidity. It suggests an approach in which fluidity and solidity are understood as patterns of social and ecological relations rather than mutually exclusive properties of matter, thus exposing the continuity between them. (shrink)

We review several of de Finetti’s fundamental contributions where these have played and continue to play an important role in the development of imprecise probability research. Also, we discuss de Finetti’s few, but mostly critical remarks about the prospects for a theory of imprecise probabilities, given the limited development of imprecise probability theory as that was known to him.

In this paper the PA-completeness of modal logic is studied by syntactical and constructive methods. The main results are theorems on the structure of the PA-proofs of suitable arithmetical interpretationsS of a modal sequentS, which allow the transformation of PA-proofs ofS into proof-trees similar to modal proof-trees. As an application of such theorems, a proof of Solovay's theorem on arithmetical completeness of the modal system G is presented for the class of modal sequents of Boolean combinations of formulas of the (...) form p i,m i=0, 1, 2, ... The paper is the preliminary step for a forthcoming global syntactical resolution of the PA-completeness problem for modal logic. (shrink)

In this paper, I propose the idea that the French mathematician Michel Chasles developed a foundational programme for geometry in the period 1827–1837. The basic concept behind the programme was to show that projective geometry is the foundation of the whole of geometry. In particular, the metric properties can be reduced to specific graphic properties. In the attempt to prove the validity of his conception, Chasles made fundamental contributions to the theory of polarity and also understood that a satisfactory development (...) of projective geometry has to overcome the specificity of that theory itself. In this perspective, he developed his ideas on duality and homography, showing their dependence on the concept that he was going to pose at the basis of geometry: the anharmonic ratio, today called cross-ratio. The conceptual itinerary that starts from Chasles’ studies on polarity and ends with his results based on the cross-ratio represents the itinerary of his foundational programme. I will follow this complex and interesting line of thought, place it in the context of what was then called descriptive geometry, and outline a connection with the later great results of Von Staudt, Cayley, and Klein. (shrink)

René Girard’s mimetic theory has significantly influenced the fields of comparative literature and cultural studies, as well as sociological anthropology and philosophy. Nevertheless, I argue that a somewhat different line of interpretation, an interdisciplinary one, has not been sufficiently investigated. This involves an interpretation which focuses on the vicissitudes of the mimetic and “victimage” circle not (or not only) in sociological terms, but by analysing their articulation on the level of knowledge. The sociological and epistemological perspectives do not exclude each (...) other, but can be integrated. The main aim of this paper is to clarify this articulation, and to show that integration between these two perspectives is possible only by bringing into play a real ‘literary aesthetics’. The notion of literary aesthetics needs to be considered in both the common and the etymological sense, as a theory of feeling and of experiencing. In doing so, I firstly cover in brief the main stages of Girard’s thought in the light of this perspective, to then focus on the relationship between literary aesthetics and knowledge. Finally I argue that this picture, if seriously considered, could lead to a mystical outcome, and will discuss the possible alternatives to that outcome. (shrink)

The electron is considered as a massless point-particle which moves in a spacetime with (3+3) dimensions subjected to a field that attracts it towards the (3+1) standard spacetime. This field is assumed to be described by the radial time component of the e.m. 6-potential and to be due to the vacuum polarization arising when the charge of the electron is removed from the (3+1) spacetime. The pertinent Klein-Gordon equitation in 6 dimensions is solved and the right values for the electron (...) magnetic moment and spin are derived. The rest mass of the electron, as it appears in the standard (3+1) spacetime, is obtained as an integration constant from the motion in the two extra time dimensions. The very simple form assumed as a first approximation for the attractive potential does not give quantized rest masses. (shrink)

La struttura a livelli modella il tutto e le sue parti con grande generalità. Lo dimostrano le argomentazioni teoriche (4.3), (4.4) e (4.5), e lo comprova la casistica che è stata aggiunta. Una tale struttura non presenta affatto i problemi a), b) e c) che sono tipici della struttura ad albero. Essa corregge inoltre deviazioni concettuali che sono diffuse nel settore informatico. L’immediatezza deviazioni concettuali che sono diffuse nel settore informatico. L’immediatezza visiva, infine, ne facilita la diffusione sul piano professionale (...) e tecnico.Per concludere, ritengo che la struttura a livelli possa fornire un contributo anche alle ricerche di ontologia e in particolare possa favorire i tentativi di unificazione condotti sia sul piano teorico, sia su quello applicativo [Uschold 1996]. Le difficoltà ed i limiti che la teoria degli insiemi oppone ad un formalismo generale (ad esempio quando riduce la casistica della relazione concetto di livello possiede una valenza estremamente ampia e ciò lo predispone per gli auspicati sviluppi ontologici. (shrink)

In this study some typical aspects of human behavior are reconsidered in a new evolutionary perspective. Firstly, a theoretical paradigm is introduced, according to which animals show a natural propensity to maintain behavior far beyond the time when the triggering motivation has been removed;, these drifting conducts are defined as Vestigial Drifting Drives or. Such a paradigm is then applied to those human attitudes that once conferred an adaptive advantage on our species but have now become dysfunctional within the framework (...) of the current ecological crisis. In this context, human beings are considered the repository of VDDs that may play out as evolutionary threats. This thesis is supported by many examples and references that, hopefully, could stimulate scientific debate and further research in evolutionary anthropology, psychology, and related disciplines. (shrink)

The two theories of pancreatic enzyme secretion, those of exocytosis and transmembrane flow, are described. Data thought to support the theory of transmembrane flow of single molecules from pancreatic acinar cells are first reviewed, and the conditions which could allow these data to be explained by the theory of exocytosis of enzyme quanta, i.e. secretory granules, are then discussed.The evidence suggesting short‐term modulation of the composition of pancreatic juice is also considered, and its possible explanations at the organ and cellular (...) level are discussed, in the light of suggested theories on enzyme secretion pathways. (shrink)