Recent studies indicate that plakoglobin may have a similar function to that of β-catenin within the Wnt signaling pathway. β-catenin is known to be an oncogene in many forms of human cancer, following acquisition of stabilizing mutations in amino terminal sequences. Kolligs1 and coworkers show, however, that unlike β-catenin, plakoglobin induces neoplastic transformation of rat epithelial cells in the absence of such stabilizing mutations. Cellular transformation by plakoglobin also appears to be distinct from that of β-catenin in that it requires (...) activation of the proto-oncogene c-myc. Surprisingly, c-myc is activated more efficiently by plakoglobin than β-catenin, despite its previous identification as a target of Tcf/β-catenin.2 In contrast, a synthetic Tcf reporter gene is activated to a much greater extent by β-catenin than plakoglobin. Plakoglobin and β-catenin may therefore have different roles in Wnt signaling and cancer, which reflect their differential effects on target gene activity. BioEssays 22:961–965, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

This paper reviews Benjamin Noys’ recent attempt in Malign Velocities: Accelerationism and Capitalism to mount a critique of accelerationism. The book, persuasive in certain respects, bypasses the institutional dynamics of accelerationism’s theoretical progenitors, viz. Nick Land and the Cybernetic Culture Research Unit of Warwick University, and instead portrays it as a “defeatist strategy” of the post-’68 conjuncture of “Deleuzian Thatcherism.” Such portrayal is debatable to the extent that it exhibits a questionable appropriation of “theory” in the strict sense of (...) the term; a term the paper attempts to define with reference to Matthew Arnold, Louis Althusser and Gilles Grelet. (shrink)

What is the difference between belief and desire? In order to explain the difference, recent philosophers have appealed to the metaphor of.

Articulate and perceptive, Intersubjectivity is a text that explains the notions of intersubjectivity as a central concern of philosophy, sociology, psychology, and politics. Going beyond this broad-ranging introduction and explication, author Nick Crossley provides a critical discussion of intersubjectivity as an interdisciplinary concept to shed light on our understanding of selfhood, communication, citizenship, power, and community. The volume traces the contributions of key thinkers engaged within the intersubjectivist tradition, including Husserl, Buber, Kojeve, Merlau-Ponty, Mead, Wittgenstein, Schutz, and Habermas. A (...) clear, concise introduction to a range of difficult concepts and thinkers, Intersubjectivity demystifies this very interdisciplinary subject for advanced and graduate-level students of philosophy, sociology, social psychology, and social and political theory. (shrink)

Although Kuhn, Lakatos and Laudan disagree on many points, these three widely accepted accounts of scientific growth do agree on certain key features of scientific revolutions. This minimal agreement is sufficient to place stringent restraints on the historical development of science. In particular it follows from the common features of their accounts that scientific history can never repeat. Using the term 'supertheory' to denote indifferently the large scale historical entitites employed in all three accounts, it is shown that a supertheory (...) cannot succeed itself, or reappear after a number of intervening scientific revolutions. The relation of these arguments to the details of the three accounts is briefly examined. (shrink)

This paper argues that the introduction of access agreements following the establishment of the Office for Fair Access (OFFA) has consolidated how English higher education institutions (HEIs) position themselves in the marketplace in relation to widening participation. However, the absence of a national bursary scheme has led to obfuscation rather than clarification from the perspective of the consumer. This paper analyses OFFA's 2008 monitoring report and a sample of twenty HEIs' original 2006 and revised or updated access agreements (2008) to (...) draw conclusions about the impact of these agreements on notions of 'fair access' and widening participation. The authors conclude that, unsurprisingly in an increasingly market-driven system, institutions use access agreements primarily to promote enrolment to their own programmes rather than to promote system-wide objectives. As a consequence of this marketing focus, previous differences between pre-1992 and post-1992 institutions in relation to widening participation and fair access are perpetuated, leading to both confusion for consumers and an inequitable distribution of bursary and other support mechanisms for the poorest applicants to HE. (shrink)

This article delivers an account of what it is for a physical system to be programmable. Despite its significance in computing and beyond, today’s philosophical discourse on programmability is impoverished. This contribution offers a novel definition of _physical programmability_ as the degree to which the selected operations of an automaton can be reconfigured in a controlled way. The framework highlights several key insights: the constrained applicability of physical programmability to material automata, the characterization of selected operations within the neo-mechanistic framework, (...) the understanding of controlled reconfiguration through the causal theory of interventionism, and the recognition of physical programmability as a gradual notion. The account can be used to individuate programmable (computing) systems and taxonomize concrete systems based on their programmability. The article closes by posing some open questions and offering avenues for future research in this domain. (shrink)

Touching on Nancy and Derrida offers a glimpse not only into the thesis both of Jean-Luc Nancy's critique of touch and of Derrida's Le Toucher, but also into the threshold of a technology of (the) sense to come. This glimpse is an interrogation, and one that is both historic and historical, in the sense that Derrida, in addressing Jean-Luc Nancy's work, has presented us with an encyclopedic history of touch in the philosophic tradition from Aristotle to Nancy, one in which (...) what Derrida calls “transcendental archifacticity” is accorded its proper value, and within which any seeming anthropological privilege, as an inherent aspect of the Phenomenological Reduction is, as Derrida says, ‘overshadowed.’ Such an overshadowing is both strategic, in terms of a historical phenomenological project, and tactical, in Derrida's investigative sense: tactical in terms of implementation, manifestation, manipulation (i.e. through the application of the hand, manus) and in terms of tact, tactility; to which must be tacked on, à la Nancy, con-tact, ‘with touch,’ a ‘with-touch’ in which a béance, a gash or dash, opens out in-between, ‘at the very point’ to use Derrida's repeated specification, of bifurcation and of con-tact, at the junction point of the ‘spacing out’ of a laminated différance con-noting more than it has or had ever done in Derrida's work itself. *. (shrink)

The Evidential Problem of Evil The evidential problem of evil is the problem of determining whether and, if so, to what extent the existence of evil (or certain instances, kinds, quantities, or distributions of evil) constitutes evidence against the existence of God, that is to say, a being perfect in power, knowledge and goodness. Evidential […].

The Logical Reasoning with Diagrams and Sentences courseware package teaches the principles of analytical reasoning and proof construction using a carefully crafted combination of textbook, desktop, and online materials. This package is sure to be an essential resource in a range of courses incorporating logical reasoning, including formal linguistics, philosophy, mathematics, and computer science. Unlike traditional formal treatments of reasoning, this package uses both graphical and sentential representations to reflect common situations in everyday reasoning where information is expressed in many (...) forms, such as finding your way to a location using a map and an address. It also teaches students how to construct and check the logical validity of a variety of proofs--of consequence and non-consequence, consistency and inconsistency, and independence--using an intuitive proof system which extends standard proof treatments with sentential, graphical, and heterogeneous inference rules, allowing students to focus on proof content rather than syntactic structure. Building upon the widely used Tarski's World and Language, Proof and Logic courseware packages, Logical Reasoning with Diagrams and Sentences contains more than three hundred exercises, most of which can be assessed by the Grade Grinder online assessment service; is supported by an extensive website through which students and instructors can access online video lectures by the authors; and allows instructors to create their own exercises and assess their students' work. Logical Reasoning with Diagrams and Sentences is an expanded revision of the Hyperproof courseware package. (shrink)

Excerpt from Nietzsche and Treitschke: The Worship of Power in Modern Germany The State is the highest thing in the external society of man; above it there is nothing at all in the history of the world. This once assumed, its self-preservation, and to that end its power, become imperative. To care for its power is the highest moral duty of the State. Of all litiosl weaknesses that of feeble most a minable and despicable it is the sin against the (...) Holy Spirit of politics. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

We question Mark Evan Bonds’ interpretation of the deleted ending of Eduard Hanslick’s On the Musically Beautiful. We argue that there is no evidence that it reveals a commitment to Pythagoreanism or Idealism. We supply an alternative explanation of the deletion.