Most clinical neurofeedback studies based on functional magnetic resonance imaging use the patient's own neural activity as feedback. The objective of this study was to create a subject-independent brain state classifier as part of a real-time fMRI neurofeedback system that can guide patients with depression in achieving a healthy brain state, and then to examine subsequent clinical changes. In a first step, a brain classifier based on a support vector machine was trained from the neural information of happy autobiographical imagery (...) and motor imagery blocks received from a healthy female participant during an MRI session. In the second step, 7 right-handed female patients with mild or moderate depressive symptoms were trained to match their own neural activity with the neural activity corresponding to the “happiness emotional brain state” of the healthy participant. The training was carried out using the rt-fMRI NF system guided by the brain-state classifier we had created. Thus, the informative voxels previously obtained in the first step, using SVM classification and Effect Mapping, were used to classify the Blood-Oxygen-Level Dependent activity of the patients and converted into real-time visual feedback during the neurofeedback training runs. Improvements in the classifier accuracy toward the end of the training were observed in all the patients [Session 4–1 Median = 6.563%; Range = 4.10–27.34; Wilcoxon Test, 2-tailed p = 0.031]. Clinical improvement also was observed in a blind standardized clinical evaluation [HDRS CE2-1 Median = 7; Range 2 to 15; Wilcoxon Test, 2-tailed p = 0.016], and in self-report assessments [BDI-II CE2-1 Median = 8; Range 1–15; Wilcoxon Test, 2-tailed p = 0.031]. In addition, the clinical improvement was still present 10 days after the intervention [BDI-II CE3-2_Median = 0; Range −1 to 2; Wilcoxon Test, 2-tailed p = 0.50/ HDRS CE3-2 Median = 0; Range −1 to 2; Wilcoxon Test, 2-tailed p = 0.625]. Although the number of participants needs to be increased and a control group included to confirm these findings, the results suggest a novel option for neural modulation and clinical alleviation in depression using noninvasive stimulation technologies. (shrink)

Drawing on social cognitive theory, this study extends our understanding of the relationship between ethical leadership and employee work engagement, by exploring self-efficacy as an important mediating variable. In addition, we propose that the quality of LMX moderates the relationships such that the direct and indirect relationships between ethical leadership, self-efficacy, and work engagement are stronger when the quality of LMX is high. Data collected in two-waves from 373 respondents working in different manufacturing organizations of Pakistan supported our hypothesized theoretical (...) model. Theoretical and practical implications are discussed. (shrink)

Plato's Ion develops a concept of fiction distinct from the mimetic accounts of poetry found in the Republic and Aristotle's Poetics. The dialogue dramatically exposes the fictionality of poetry by (1) revealing a disparity between propositional and poetic semantics, (2) identifying the paradox of belief in imaginary worlds, and (3) showing that fictional constructions emerge from novel arrangements of real-world facts. Ultimately, the Ion examines the fraught relationship between literature and the real world, and the peculiar nature of literary knowledge, (...) which takes both fact and fiction as its objects. (shrink)

This book offers a resolution of the paradox posed by the pleasure of tragedy by returning to its earliest articulations in archaic Greek poetry and its subsequent emergence as a philosophical problem in Plato's Republic. Socrates' claim that tragic poetry satisfies our 'hunger for tears' hearkens back to archaic conceptions of both poetry and mourning that suggest a common source of pleasure in the human appetite for heightened forms of emotional distress. By unearthing a psychosomatic model of aesthetic engagement implicit (...) in archaic poetry and philosophically elaborated by Plato, this volume not only sheds new light on the Republic's notorious indictment of poetry, but also identifies rationally and ethically disinterested sources of value in our pursuit of aesthetic states. In doing so the book resolves an intractable paradox in aesthetic theory and human psychology: the appeal of painful emotions. (shrink)

This article examines the development of the ritual of mubāhala, a category of oaths and mutual self-cursing, during which two individuals seek to confirm the veracity of their creedal position by appealing to God’s curse upon them. Based on a prophetic precedent embedded in Q 3:61 and reported as a challenge purportedly employed by the Companions Ibn Masʿūd and Ibn ʿAbbās, I argue that the practice of resorting to mubāhala in the Sunni tradition goes through two main phases of reinvention (...) and legitimation before its reappearance in the contemporary Muslim world. The first phase belongs to the anti-Monist controversies of the seventh to ninth/thirteenth to fifteenth centuries, while the second appears among reformist scholars starting in the late eighteenth century. (shrink)

Mitter's study argues that until the late Qing, concepts of international order and justice were alien to China's imperial rulers. Subsequently, however, in the nineteenth and early twentieth centuries, China perceived itself to be the victim in an unjust world of aggressive, powerful, Western states. Contemporary Chinese perceptions of a just international order have been shaped by such past experiences and encompass a strong element of restitution. Its justice claims start with the Chinese state itself rather than with the needs (...) of a broader global community. (shrink)

Research on human subjects is ethically justified when its anticipated results would ultimately benefit the society or public and not only the individuals participating in this research. Besides contributing to scientific knowledge, social benefits of scientific research may extend to all aspects of the public’s life including health, education, and security. In this paper, we aimed to discuss the social benefits principle as an ethical requirement for the conduct of scientific research in general and nursing research in particular. We critically (...) examined the current situation of nursing research in developing countries including its adherence to the social benefits principle and provided exemplars of both hindered and successful utilization of nursing research evidence in developing countries. We concluded that the utilization of nursing research evidence in clinical practice, education, and policy making is almost nonexistent and faces many challenges in most developing countries. Thus, most nursing research in developing countries are not currently meeting the social benefit principle of the ethical conduct of scientific research. We provided recommendations to promote the utilization of nursing research in evidence-based practice, nursing education, and health policy. (shrink)

In the age of rapid AI advancement, digital colonialism poses a significant threat to Indigenous communities, perpetuating inequalities and exploiting their data. This commentary delves into the concept of Indigenous data sovereignty as a powerful framework for resisting digital colonialism and promoting ethical AI development.

This study attempts to scrutinize Herbert George Wells’ The Island of Doctor Moreau according to Francesca Ferrando’s Posthumanism Theory (2009). It approaches vital issues and questions via the posthumanist criticism of the main character Dr. Moreau in the novel depending on the application issues of Ferrando’s theory. Wells’ The Island of Doctor Moreau (1896) presents a realistic reading of the modern debate of Posthumanism according to the moral and social world of human identity. Furthermore, this study exposes the importance of (...) Posthumanism as an essential concept in highlighting techno-science in current studies and futuristic ones. Thus, Wells’ novel deals with the effect of biotechnology and medicine on human identity, reflected in the theory of evolution and the posthuman theory. Embodied by Ferrando’s work, the study significantly aims to stimulate a new dimension of understanding, sympathy, interconnectedness, like-mindedness, and honor all species. Such a standpoint exposes the historical and scientific technology context of the novel. On the other hand, it shows the conceptual foundations of posthumanity embedded in the delusion of Charles Darwin’s On the Origin of Species (1859). The novel mirrors the impossible ethics of evolution theory in addition to the common problematic sympathy for all species whether human or nonhuman. (shrink)

Our research explores the application of Large Language Models for enhancing legal advice through AI-driven conversational agents, focusing on the analysis and interpretation of user-generated content from a prominent online legal community. By leveraging BERTopic for topic modeling and GPT-3.5 for labeling of user intents, we constructed a dataset that served as the foundation for fine-tuning the Mistral 7B language model. This process involved Supervised Fine Tuning and Direct Preference Optimization, culminating in the creation of a Domain Specific Language Model (...) for legal expertise. This model was then employed to guide GPT-3.5 responses, ensuring domain-specific relevance and contextual appropriateness. The evaluation of these responses was conducted using GPT-4, supplemented by human assessment, to gauge the quality of the models' outputs. We leverage an innovative end-to-end pipeline, building upon the framework proposed by Wang et al. (Empower large language model to perform better on industrial domain-specific question answering, 2023. arXiv:2305.11541), specifically adapted for the legal domain. This pipeline provides a foundational framework for developing sophisticated and scalable user-facing chatbots, presenting an alternative to the more common retrieval augmented generation techniques. Our contributions include providing datasets for further research on Legal Question Answering systems and advancements in human alignment of responses from chatbots. This research advances the technical frontier in AI-driven legal assistance and opens new avenues for enhancing the accessibility and quality of legal support through conversational AI technologies. (shrink)

Rhythm is a poetic necessity for constructing a poem, which in turn gives us other rhythms and other phonemes in the background of the meter, and behind the words, and hence the meter does not constitute a major value in constructing a poem unless it is linked to other artistic elements of writing poetry. In this section, we address the rhythmic phenomenon in the introductions to poetry collections in various forms of Arabic poetry: classical, free metrical, and prose poetry, by (...) reading a number of diverse poetic models, starting from the fact that poetry is not poetry, and that poetic meters do not form a poem except to the extent that the poet invests in other elements of poetry, in the image, style, density and depth of language, and rhetorical diversification in performing the poem, and also departing from the pattern by renewing and developing and striving to create advanced innovations in the broad rhythmic horizon, and in the formative and linguistic horizon of poetic introductions, and in this section we have monitored a group of rhythmic phenomena such as: repetition, phonemes of language, the rhythm of the visual space of writing, and the relationship between effect and reception. In light of this awareness, poetic introductions may come in a multi-rhythmic form that does not necessarily stop at the inherited poetic form, but rather varies in its performance and in the methods of delivery, investing the space of the poetic page in conveying the poet’s semantic vision. (shrink)

GANDHIAN HUMANISM : Inroads to Inner Awakening Tnii BIRTH of man is a mystery as well as a muse. It is a mystery because it is born in the womb of ...

The paper discusses anumāna and its variety in general from the point of view of inferential cognition for the sake of oneself as well as for the sake of others; i.e. svārthānumāna and parārthānumāna as given in the Buddhist tradition of logic, especially with parārthānumāna, its nature and role. The paper argues that the Buddhist intent of division of anumāna into svārthānumāna and parārthānumāna was to bring Buddha-vacanas under the category of parārthānumāna and to save them from being classified under (...) śabda pramāṇa. It contends that such a division was not just an epistemological demand, but had a deeper philosophical significance in the Buddhist conceptual framework. Such a division is, therefore, intended to reject the role of śabda as an extra causal means or pramāṇa. The paper identifies the logical commitment in Buddhist tradition as hetu-centric commitment as it differs from the Nyāya tradition of vyāpti-centric one. (shrink)

This article is a preliminary draft for initiating and commencing a new pioneer dimension of expression. To deal with higher-dimensional data or information flowing in this modern era of information technology and artificial intelligence, some innovative super algebraic structures are essential to be formulated. In this paper, we have introduced such matrices that have multiple layers and clusters of layers to portray multi-dimensional data or massively dispersed information of the plithogenic universe made up of numerous subjects their attributes, and sub-attributes. (...) For grasping that field of parallel information, events, and realities flowing from the micro to the macro level of universes, we have constructed hypersoft and hyper-super-soft matrices in a Plithogenic Fuzzy environment. These Matrices classify the non-physical attributes by accumulating the physical subjects and further sort the physical subjects by accumulating their non-physical attributes. We presented themasPlithogenicAttributiveSubjectivelyWholeHyper-Super-Soft-Matrix(PASWHSS-Matrix)andPlithogenic Subjective Attributively Whole-Hyper-Super-Soft-Matrix (PSAWHSS-Matrix). Several types of views and level-layers of these matrices are described. In addition, some local aggregation operators for Plithogenic Fuzzy Hypersoft Set (PPFHS-Set) are developed. Finally, few applications of these matrices and operators are used as numerical examples of COVID-19 data structures. (shrink)

This seminar report discusses the low-voltage current-mode analog circuits and their various aspects. The need of high speed, high performance, low power circuits because of the advent of the portable electronic and mobile communication systems and difficulties faced in achieving that in today’s scenario are presented. Current mode circuits are the best suited candidates for the above. Their advantages are discussed here and a comparison with the conventional voltage mode circuits has been presented. The principle and the implementation of the (...) most common current mode circuits i.e. the current conveyors, has been described. The basic device level techniques also play important role in the design of smarter and efficient circuits. Some of those techniques have also been discussed here. For illustration of these techniques, low power V-I converter using current mirrors and a low- voltage power efficient operational amplifier cell topology is presented. (shrink)

This paper intends to show the evolution of Ethics on the High Middle Ages. The penitential books written in this period are taken as a basis for the reflection.

Interleukin‐1 receptor‐associated kinase‐1 (IRAK1) is linked to the pathogenesis of atherosclerosis; however, its role in macrophage foam cell formation is not known. Therefore, the present study investigated the role of IRAK1 in lipid uptake, biosynthesis, and efflux in THP‐1 derived macrophages and human monocyte‐derived macrophages (HMDMs). Ox‐LDL (40 μg/mL, 15 minutes–48 hours) treatment induced time‐dependent increase in IRAK1, IRAK4, and Stat1 activation in THP‐1 derived macrophages. IRAK1/4 inhibitor (INH) or IRAK1 siRNA significantly attenuated cholesterol accumulation, DiI‐Ox‐LDL binding, and uptake while (...) cholesterol efflux to apoAI and HDL was enhanced in THP‐1 derived macrophages and HMDMs. Ox‐LDL treatment significantly increased the mRNA expression of CD36, LOX‐1, SR‐A, ABCA1, ABCG1, Caveolin‐1, CYP27A1 while that of SR‐BI was decreased. IRAK1/4 inhibition or IRAK1 knockdown, however, attenuated Ox‐LDL‐induced CD36 expression; augmented ABCA1 and ABCG1 expression while expression of others was unaffected in THP‐1 derived macrophages and HMDMs. Moreover, IRAK1/4 inhibition had no significant effect on genes involved in lipid biosynthesis. In IRAK1/4 INH pre‐treated THP‐1 derived macrophages Ox‐LDL‐induced Stat1 phosphorylation and its binding to CD36 promoter was significantly attenuated while LXRα expression and its binding to the ABCA1/ABCG1 locus, NFATc2 activation and its binding to ABCA1 locus was enhanced. The present study thus demonstrates that IRAK regulates lipid accumulation by modulating CD36‐mediated uptake and ABCA1‐, ABCG1‐dependent cholesterol efflux. Therefore, IRAK1 can be a potential target for preventing macrophage foam cell formation. (shrink)

Goat is a small ruminant with hollow horn that is found throughout the world. A survey was carried out to evaluate the performance of locally adopted goats under farmers’ management practices in Sundarbazar municipality of Lamjung district between February and August, 2017. The study focused on two breeds, Khari and Jamunaparias well as their crossbred. Individual goats’ primary data, collected using a convenient sampling technique and pretested questionnaires with open and close ended questions, were analyzed using SPSS 20 and MS (...) Excel 2010. Results revealed significant effects of a Doe’s breed on age at first estrus, age at first kidding, gestation length, postpartum estrus, and kidding interval. Age at first estrus and age at first kidding were lowest for Khari. Highly significant lowest kidding interval and significantly shortest gestation length were found for Khari. No significant effect of parity was observed on age at first estrus, age at first kidding, kidding interval, and postpartum estrus, but a significant effect was observed on gestation length with lowest values in 4th to 6th parity. Doe’s breed showed a significant effect on litter size at birth. However, no significant effect of the breed was found on litter birth weight and litter size at weaning. The results demonstrated Khari as the desirable breed for the locality. (shrink)

Codes of ethics in journalism in the light of Koran and Hadith (Islamic traditions).

Wittgenstein’s philosophical methods have had a wide influence in the fields of ethics and moral philosophy. The aim of the volume Ethics After Wittgenstein: Contemplation and Critique is to outlin...

Ethical research conduct is a cornerstone of research practice particularly when research participants include vulnerable populations. This study mapped the extent of reporting ethical research practices in studies conducted among refugees and war-affected populations in the Arab World, and assessed variations by time, country of study, and study characteristics. An electronic search of eight databases resulted in 5668 unique records published between 2000 and 2013. Scoping review yielded 164 eligible articles for analyses. Ethical research practices, including obtaining institutional approval, access (...) to the community/research site, and informed consent/assent from the research participants, were reported in 48.2, 54.9, and 53.7% of the publications, respectively. Institutional approval was significantly more likely to be reported when the research was biomedical in nature compared to public health and social, when the study employed quantitative compared to qualitative or mixed methodologies, and when the journal required a statement on ethical declarations. Institutional approval was least likely to be reported in papers that were sole-authored, when these did not mention a funding source, or when published in national journals. Similar results were obtained for access to the community site and for seeking informed consent/assent from study participants. The responsibility of inadequacies in adherence to ethical research conduct in crisis settings is born by a multitude of stakeholders including funding agencies, institutional research boards, researchers and international relief organizations involved in research, as well as journal editors, all of whom need to play a more proactive role for enhancing the practice of ethical research conduct in conflict settings. (shrink)

The focus of this study is an examination of what it means to be a legal person and the role that the law plays in bestowing the legal status of being a person. This study highlights the underpinning rationalities and human interest that establish a hierarchy between person, defined as “human”, at a superior level to everything else, defined as “nonhuman”. In this respect, there is a core notion concerning human exceptionalism based on the rational sovereignty that justifies and consolidates (...) the mastery of nature. To understand the fundamental premises of legal personhood, it begins from the first usage of person in history and philosophy, since the concept of legal personhood has been established through historical and philosophical developments. Analysing the meaning of person through different conceptualisations can allow a deeper insight into the legal interpretation of personhood. As a result of such investigation, two main dualistic structures of legal personhood reveal: the person-property dualism and the human being-person dualism. Thus, legal personhood simultaneously includes personalisation and depersonalisation, and always operates in a hierarchical array. Although the division between persons and things in the concept of personhood is rigid, being a “person” or a “thing” is open to interpretation in different circumstances through legal practices of exclusion and inclusion. Recently, there have been an increasing number of court rulings and a tendency of legislation to recognise the legal personhood of natural entities as a legal way of conserving the environment. This leads to an interpretation that legal recognition is a matter of institutional interest and attempts. Nevertheless, legal practitioners mostly prefer to confer certain rights or the status of a legal person on nature without the consideration of legal personhood’s background as seen in the case discussed in this study - the Tierra Digna case in Colombia. While this study endeavours to demonstrate the anthropocentric standard view of legal personhood, its principal purpose is to indicate the malleable nature of legal personhood as a product of legal fiction. In this context, this study aims to conclude that law’s imaginary nature should be used for producing a new legal reasoning and for offering a real paradigm shift that is congruent with the plasticity of and the fluidity of nature. (shrink)

Religion (dharma) plays a vital role in the Hindu (Sanatana) quest for understanding and practicing harmony between nature and humanity that result into the formation of a cosmological awakening, i.e. 'transcending the universe.' The importance and applicability of such new consciousness is a sign in promoting global humanism in the 21st century, where environmental ethics and sustainability are the wheels of making the future more humane and peaceful. Arne Naess, who coined the term 'deep ecology' conceiving humankind as an integral (...) part of its environment, gives credit to Gandhi. Gandhi’s contributions help to re-awaken the human spirit to self-realisation, finally leading to revelation promoting human coexistence with nature sustainably, mostly through re-interpretation of Vedantic thought. Under the SDGs (Sustainable Development Goals) the ideas of Gandhi are recognised as a path that makes human coexistence stronger, feasible and co-sharedness, sustainable in peace and harmony with nature. This essay presents ecospiritual contextuality and its vitality concerning a sustainable perspective in line with Gandhi's vision and way of life. (shrink)

This paper presents a profile of the welfare regime in Lebanon which is posited on the twin precepts of human ethics and welfare particularism. It highlights the key role that moral values play in the conceptualization and implementation of social policy, as well as in the measurement of welfare outcomes. This is marked by the dominance of duty, traditionalism and elitism in the ethics of religious welfare in Lebanon. The paper argues that the social welfare regime in Lebanon overlaps with (...) the debates on the ethics of care and on virtue ethics in Western moral philosophy. This is also linked in with contemporary conceptualizations of religious ethics in Judaism, Christianity and Islam. The paper asserts that religious ethics is a valid endeavour in its own right and an ever more pertinent subject matter for the study of social welfare and social policy. This challenges the traditional dichotomy between reason and faith which has subdued the relevance of religion to public life. Indeed, religion, the nuclear family and clientelism networks are shown to play a critical role in Lebanese social welfare, such that, in spite of state incapacity, the welfare regime there cannot be considered rudimentary. The method adopted for this research was a large qualitative case study involving service providers and users at the Ministry of Social Affairs and five leading Christian and Muslim religious welfare organizations in Lebanon. (shrink)

This paper intends to enhance the great relevance that the promotion of reason received in the XIIth century. The main representatives of thought in this century can be considered, at least in a certain sense, as antecedents to what later was the European Illustration. Indeed their emphasis on rationality is huge.

In this paper we introduce the great innovation that takes place in the XIIth century in relation to individual responsibility; this novelty is analyzed in contraposition to what happened in previous centuries of the Early Middle Ages. The main source used are the Penitential Books, specially the one by Alan of Lille.

Considered an iconic symbol of indigenous legal heritage, Islamic law is adopted nowadays in whole or in part in the legal systems of the Muslim world and is also of significance in Muslim-minority European countries, where it typically finds its niche in civil and financial domains. This article sets out to investigate the norms of translating Islamic family law discourse using a mixed methods approach based on ‘qualitising’ quantitative data, i.e., an approach in which quantitative data are interpreted qualitatively. Drawing (...) on a self-built monolingual English corpus of over three million words covering diverse genres, the analysis will harness the power of corpus processing to enable the study of ten iconic lexical profiles (individual concepts/conceptual systems and their corresponding Arabic and English terms) that are specific to Islamic family law. Profile-based correspondence is also employed to investigate the probability of lexical variation in expressing a conceptual category—a profile refers to a set of synonymous variants or linguistic labels that can be used to designate the same concept. The corpus analysis seeks to identify the key loanwords that represent cultural icons featured in the English-language discourse of Islamic family law and to explore the different mechanisms used to render shariʿa-based concepts. The aim is to investigate concomitant translation norms based on linguistic frequency in the corpus and to interpret ideological implications with reference to the theory of translation norms, which postulates that translation decision making is subject to norms dictated by extralinguistic factors (e.g., socio-political or ideological). The study finds that Islamic family law relies significantly on Arabic loanwords (constructing an ‘Islamgish’ discourse) to maintain shariʿa-based linguistic heritage, which can be seen as a kind of ‘working for one’s own good’. Thus, what is at play here is the ethics of self-interest, which is very typical of postcolonial agendas. (shrink)

The correlation coefficient between two variables plays an important role in statistics. Also, the accuracy of relevance assessment depends on information from a set of discourses. The data collected from numerous statistical studies are full of exceptions. The Pythagorean fuzzy hypersoft set is a parameterized family that deals with the subattributes of the parameters and an appropriate extension of the Pythagorean fuzzy soft set. It is also the generalization of the intuitionistic fuzzy hypersoft set, which is used to accurately assess (...) insufficiency, anxiety, and uncertainties in decision-making. The PFHSS can accommodate more uncertainties compared to the IFHSS, and it is the most substantial methodology to describe fuzzy information in the decision-making process. The core objective of the this study is to develop the notion and features of the correlation coefficient and the weighted correlation coefficient for PFHSS and to introduce the aggregation operators such as Pythagorean fuzzy hypersoft weighted average and Pythagorean fuzzy hypersoft weighted geometric operators under the PFHSS scenario. A prioritization technique for order preference by similarity to the ideal solution under PFHSS based on correlation coefficients and weighted correlation coefficients is presented. Through the developed methodology, a technique for solving multiattribute group decision-making problem is planned. Also, the importance of the developed methodology and its application in indicating multipurpose antivirus mask throughout the COVID-19 pandemic period is presented. A brief comparative analysis is described with the advantages, effectiveness, and flexibility of numerous existing studies that demonstrate the effectiveness of the proposed method. (shrink)

The literature on Black youth culture, especially hip-hop culture, has focused primarily on the experiences of young men, with the experiences of Black girls being all but ignored. However, the recent appearance of Black women performers, songwriters, and producers in Black popular culture has called attention to the ways in which young Black women use popular culture to negotiate social existence and attempt to express independence, self-reliance, and agency. This article is an exploration of the representations of Black womanhood as (...) expressed in the music videos of Black women performers. The author first identifies themes that reflect controlling images of Black womanhood, then those that exemplify an expression of agency, and finally those appearing ambivalent and contradictory. Overall, the music videos express how young Black women must negotiate sexuality and womanhood in their everyday lives. (shrink)

Understanding the impact of the p53 tumor suppressor pathway on the regulation of genome integrity, cancer development, and cancer treatment has intrigued scientists and clinicians for decades. It appears that the p53 pathway is a central node for nearly all cell stress responses, including: gene expression, DNA repair, cell cycle arrest, metabolic adjustments, apoptosis, and senescence. In the past decade, it has become increasingly clear that p53 function is directly regulated by poly(ADP‐ribose) polymerase‐1 (PARP‐1), a nuclear enzyme involved in DNA (...) repair signaling. Here, we will discuss the impact of PARP‐1 on p53 function, along with a recently described novel role for the reciprocal regulation of p53 regulated, PARP‐1 dependent necrosis following DNA damage. (shrink)