Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This collection of essays argues that any valid theory of the modern should—indeed must—reckon with the medieval. Offering a much-needed correction to theorists such as Hans Blumenberg, who in his _Legitimacy of the Modern Age_ describes the “modern age” as a complete departure from the Middle Ages, these essays forcefully show that thinkers from Adorno to Žižek have repeatedly drawn from medieval sources to theorize modernity. To forget the medieval, or to discount its continued effect on contemporary thought, is to (...) neglect the responsibilities of periodization. In _The Legitimacy of the Middle Ages_, modernists and medievalists, as well as scholars specializing in eighteenth-, nineteenth-, and twentieth-century comparative literature, offer a new history of theory and philosophy through essays on secularization and periodization, Marx’s theory of commodity fetishism, Heidegger’s scholasticism, and Adorno’s nominalist aesthetics. One essay illustrates the workings of medieval mysticism in the writing of Freud’s most famous patient, Daniel Paul Schreber, author of _Memoirs of My Nervous Illness_. Another looks at Michael Hardt and Antonio Negri’s _Empire_, a theoretical synthesis whose conscientious medievalism was the subject of much polemic in the post-9/11 era, a time in which premodernity itself was perceived as a threat to western values. The collection concludes with an afterword by Fredric Jameson, a theorist of postmodernism who has engaged with the medieval throughout his career. _Contributors_: Charles D. Blanton, Andrew Cole, Kathleen Davis, Michael Hardt, Bruce Holsinger, Fredric Jameson, Ethan Knapp, Erin Labbie, Jed Rasula, D. Vance Smith, Michael Uebel. (shrink)

This book challenges current thinking on professional ethics and suggests new ways of looking at ethical issues. The contributors to the volume (Michael Goldberg, Richard P. Vance, Deborah Fernhoff, Nancey Murphy, Theophus H. Smith, Jack L. Sammons Jr., William H. Willimon, and Senator John C. Danforth) are outstanding representatives of their respective professions. In this book, using the categories of religion and narrative as methodological tools, they move readers to a more responsive, hopeful, and truthful conduct of the (...) professions. (shrink)

New brain-computer interface and neuroimaging techniques are making differentiation less ambiguous and more accurate between unresponsive wakefulness syndrome patients and patients with higher cognitive function and awareness. As research into these areas continues to progress, new ethical issues will face physicians of patients suffering from total locked-in syndrome, characterized by complete loss of voluntary muscle control, with retention of cognitive function and awareness detectable only with neuroimaging and brain-computer interfaces. Physicians, researchers, ethicists and hospital ethics committees should be aware of (...) and prepared to handle ethical issues unique to these totally locked-in patients. Several thought experiments are discussed, to highlight potential ethical dilemmas surrounding surrogate decision-making, autonomy, end-of-life care, and pediatric care, which will be unique to total LIS patients. These, along with other ethical problems especially relevant to total LIS patients, merit further discussion among physicians, researchers, ethicists and hospital ethics committees, to facilitate consensus regarding these issues, and improve patient care. (shrink)

In previous work I have argued against internalism by means of a dilemma intended to force all internalists to accept one of two undesirable options: either their internalism is unmotivated or it is saddled with vicious regress problems. Recently it has been argued that Phenomenal Conservatism—a theory of justification according to which justification depends on seemings—is a kind of internalism that can escape this dilemma. In this paper, I argue that Phenomenal Conservatism cannot escape my dilemma for internalism. In order (...) to do this, it is helpful to get clear on what Phenomenal Conservatism is saying, and for that reason I begin, in section I, by examining in some detail what seemings are. I then argue, in the remainder of the paper, that, whichever horn of the dilemma for internalism they take, Phenomenal Conservatives are in trouble. (shrink)

Michael Ruse, a leading expert on Charles Darwin, presents a fictional dialogue among characters with sharply contrasting positions regarding the tensions between science and religious belief.

The paper explains why an ontology of permanent point particles that are individuated by their relative positions and that move on continuous trajectories as given by a deterministic law of motion constitutes the best solution to the measurement problem in both quantum mechanics and quantum field theory. This case is made by comparing the Bohmian theory to collapse theories such as the GRW matter density and the GRW flash theory. It is argued that the Bohmian theory makes the minimal changes, (...) concerning only the dynamics and neither the ontology nor the account of probabilities, that are necessary to get from classical mechanics to quantum physics. There is no cogent reason to go beyond these minimal changes. (shrink)

Since heaven is the most perfect state or position possible – namely of loving God perfectly – and sinning is failing to love God, it will not be possible to sin in heaven. However, if freedom is a mark of perfection, and loving God is only possible when one freely loves God, will we be loving God at all if we are not free not to love him? Three cumulative arguments for an affirmative answer are developed. The first is to (...) distinguish the ability to love or sin from the opportunity to do so. In heaven we are loving God in an infinite variety of ways, so we are freely exercising our ability to love, even when God has taken away any opportunities for sinning. However, one might reply that our freedom will only be the freedom to love God in various ways, not the freedom to love God or not. Hence the second argument is that in heaven are only people who have freely chosen to love God while on earth, where there was a real opportunity not to love God. Since the free choice to love God was made before entering heaven, loving God in heaven remains a free choice. Moreover, since in heaven God takes away the opportunity to sin, and stopping to love God would be a sin, you will remain steadfast in that free choice. However, one might reply that also having the opportunity to sin would add an extra possibility for willing something, so one would be 'more free' in heaven, and heaven would be more perfect, if one would also have the opportunity to sin. Hence the third argument is that freedom is a perfection shared by both God and humans, and the freedom of God is in an important respect a freedom to create. Hence, our human freedom is also greater if our creative power is greater. We have no creative power but by participating in God’s creative power, which is necessarily directed towards the good. So by willing what is good we extend and perfect creation and thereby extend and perfect our possibilities for willing, hence we become more free. On the contrary, by sinning we destroy creation and possibilities for willing and we become less free, so an opportunity to sin is not a possibility that increases our freedom. (shrink)

This book, first published in 2000, adopts a balanced perspective on the subject to offer a serious examination of both Darwinism and Christianity. He covers a wide range of topics, from the Scopes Monkey Trial to claims about the religious significance of extraterrestrials. He deals with major figures in the current science/religion debate and considers in detail the claims of the new creationism, revealing some surprising parallels between Darwinian materialists and traditional thinkers such as St. Augustine. Michael Ruse argues (...) that, although it is at times difficult for a Darwinian to embrace Christian belief, it is by no means inconceivable. At the same time he suggests ways in which a Christian believer should have no difficulty accepting evolution in general, and Darwinism in particular. (shrink)

Emmanuel Levinas conceives of our lives as fundamentally interpersonal and ethical, claiming that our responsibilities to one another should shape all of our actions. While many scholars believe that Levinas failed to develop a robust view of political ethics, Michael L. Morgan argues against understandings of Levinas’s thought that find him politically wanting or even antipolitical. Morgan examines Levinas’s ethical critique of the political as well as his Jewish writings—including those on Zionism and the founding of the Jewish state—which (...) are controversial reflections of Levinas’s political expression. Unlike others who dismiss Levinas as irrelevant or anarchical, Morgan is the first to give extensive treatment to Levinas as a serious social political thinker whose ethics must be understood in terms of its political implications. Morgan reveals Levinas’s political commitments to liberalism and democracy as well as his revolutionary conception of human life as deeply interconnected on philosophical, political, and religious grounds. (shrink)

Throughout this compelling work, Jackson demonstrates that existentialism, far from being a philosophy of individual being, enables us to explore issues of ...

After outlining why the notion of conscious control of action matters to us and after distinguishing different challenges to that notion, the contribution focuses on the challenge posed by the literature on unconscious goal pursuit. Based on a conceptual clarification of the notion of consciousness, I argue that the understanding of consciousness in that literature is too restricted. The hypothesis that the behaviors reported can be accounted for by nonconceptual forms of consciousness, such as emotions and motor experiences, rather than (...) by—conscious or unconscious—conceptual level intentions tends to be disregarded, even though it promises to be empirically fruitful. (shrink)

Martin O'Shaughnessy _Jean Renoir_ Manchester and New York: Manchester University Press, 2000 ISBN 0719050626 hb; 0719050634 pb 251 pp.

At a time in medicine where the cost of human clinical labor continues to rise, with an overall shortage of providers at all levels, improved AI performance raises critical, pressing questions with...

The various jurisdictions worldwide that now legally permit assisted suicide (or voluntary euthanasia) vary concerning the medical conditions needed to be legally eligible for assisted suicide. Some jurisdictions require that an individual be suffering from an unbearable and futile medical condition that cannot be alleviated. Others require that individuals must be suffering from a terminal illness that will result in death within a specified timeframe, such as six months. -/- Popular and academic discourse about assisted suicide paradigmatically focuses on individuals (...) with ‘physical,’ i.e., non-psychiatric medical conditions, such as cancer or AIDS. Here I defend analyses of the notions of unbearable suffering, futility, and terminality that imply that, regardless of which of these medical conditions is invoked, at least some individuals with severe and persistent psychiatric illnesses satisfy these conditions and ought to be classified as legally eligible for assisted suicide. The legal and moral case for a right to assisted suicide is therefore not in principle weaker for the severely psychiatrically disordered than for those with ‘typical’ terminal or futile medical conditions. (shrink)

Introduction : from victims and perpetrators to implicated subjects -- The transmission belt of domination : theorizing the implicated subject -- On (not) being a descendant : implicated subjects and the legacies of slavery -- Progress, progression, procession : William Kentridge's implicated aesthetic -- From Gaza to Warsaw : multidirectional memory and the perpetuator -- Under the sign of suitcases : the Holocaust internationalism of Marceline Loridan-Ivens -- "Germany is in Kurdistan" : Hito Steyerl's images of implication -- Conclusion : (...) transfiguring implication : eleven theses. (shrink)

State of affairs (Sachverhalt) is one of the few terms in philosophy, which only came into use for the first time in the twentieth century, mainly via the works of Husserl and Wittgenstein. This makes the task of finding out who introduced this concept into philosophy, and in exactly what sense, of considerable interest. Our thesis is that Lotze introduced the term in 1874 in the sense of the objective content of judgments, which is ipso facto the minimal structured ontological (...) unit. We would argue against authors such as Michael Dummett and Barry Smith, who have tried to prove that Lotze's theory of judgment, and so of states of affairs, was ad-vanced in the wake of psychologism. (shrink)

This collection is the first book devoted to Paulo Freire's ongoing global legacy to provide an analysis of the continuing relevance and significance of Freire's work and the impact of his global legacy. The book contains essays by some of the world's foremost Freire scholars - McLaren, Darder, Roberts, and others - as well as chapters by scholars and activists, including the Maori scholars Graham Hingangaroa Smith and Russell Bishop, who detail their work with the indigenous people of Aotearoa-New Zealand. (...) The book contains a foreword by Nita Freire as well as chapters from scholars around the world including Latin America, Asia, the United States, United Kingdom, New Zealand, and Australia. With a challenging introduction from the editors, Michael A. Peters and Tina Besley, this much-awaited addition to the Freire archive is highly recommended reading for all students and scholars interested in Freire, global emancipatory politics, and the question of social justice in education. (shrink)

One of the most foundational and continually contested questions in the cognitive sciences is the degree to which the functional organization of the brain can be understood as modular. In its classic formulation, a module was defined as a cognitive sub-system with nine specific properties; the classic module is, among other things, domain specific, encapsulated, and implemented in dedicated neural substrates. Most of the examinations—and especially the criticisms—of the modularity thesis have focused on these properties individually, for instance by finding (...) counterexamples in which otherwise good candidates for cognitive modules are shown to lack domain specificity or encapsulation. The current paper goes beyond the usual approach by asking what some of the broad architectural implications of the modularity thesis might be, and attempting to test for these. The evidence does not favor a modular architecture for the cortex. Moreover, the evidence suggests that best way to approach the understanding of cognition is not by analyzing and modelling different functional domains in isolation from the others, but rather by looking for points of overlap in their neural implementations, and exploiting these to guide the analysis and decomposition of the functions in question. This has significant implications for the question of how to approach the design and implementation of intelligent artifacts in general, and language-using robots in particular. (shrink)

This leading scholar draws on extensive research from four plurinational states - the United Kingdom, Spain, Belgium, and Canada - to provide a radical rethink of the very nature of sovereignty and the state. This innovative account demonstrates how transnational integration and other demands on the nation-state have broken the automatic link between state and nation, and goes on to provide a major new analysis of the subsequent challenges of recognition of nationality and democracy.

This paper explores the question of the unity of Transcendental Idealism at the end of Eighteenth Century German philosophy, given that it circulated in different versions, Kant’s Critique [of humans’ rational powers] and Fichte’ System of Science [Wissenschaftslehre]. Both thinkers take the transcendental turn. They base conceptual investigations not on facts or empirical evidence, but on the possibility of a situation; they are idealists since they look inward to the spontaneity of the agent/knower for explanation, not the environment, stimulus, or (...) sensory given. Reason can fathom only what it has constructed. (shrink)

While some conclude from the revolutions of 1989 that socialism is dead, interest in socialism continues because of persisting problems of contemporary capitalism. In this exciting text, Michael W. Howard offers critiques of liberal, communitarian, postmodern and some Marxist perspectives in order to develop a 'left-liberal' defense of a model of self-managed market socialism that includes a basic income for all. Specific applications of his view include analyses of its implications for the global marketplace, the changing nature of workplaces, (...) and media restructuring and ownership. This work is sure to be of interest to social scientists, public policy makers, and economists as well as to feminists, ecologists, and others concerned with how market socialism is relevant to their social issues. (shrink)